메뉴 건너뛰기




Volumn 7, Issue 2, 2004, Pages 123-131

Tumor-derived prostaglandin E 2 and transforming growth factor-β stimulate endothelial cell motility through inhibition of protein phosphatase-2A and involvement of PTEN and phosphatidy linositide 3-kinase

Author keywords

angiogenesis; endothelial cells; motility; Phosphatidylinositide 3 kinase (PI3K); PP 2A; Prostaglandin E 2(PGE 2); PTEN; transforming growth factor (TGF ); tumor

Indexed keywords

PHOSPHATASE; PHOSPHATASE 2A; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROSTAGLANDIN E2; SERINE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; PHOSPHOPROTEIN PHOSPHATASE; PTEN PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

EID: 8544268688     PISSN: 09696970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10456-004-1027-2     Document Type: Article
Times cited : (13)

References (36)
  • 1
    • 0037374468 scopus 로고    scopus 로고
    • Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer
    • Gupta RA, Tejada LV, Tong BJ et al. Cyclooxygenase-1 is overexpressed and promotes angiogenic growth factor production in ovarian cancer. Cancer Res 2003; 63: 906-11.
    • (2003) Cancer Res , vol.63 , pp. 906-911
    • Gupta, R.A.1    Tejada, L.V.2    Tong, B.J.3
  • 2
    • 0038407310 scopus 로고    scopus 로고
    • Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors
    • Stoeltzing O, Ahmad SA, Liu W et al. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. Cancer Res 2003; 63: 3370-7.
    • (2003) Cancer Res , vol.63 , pp. 3370-3377
    • Stoeltzing, O.1    Ahmad, S.A.2    Liu, W.3
  • 3
    • 0038745370 scopus 로고    scopus 로고
    • Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer
    • Zhang L, Yang N, Park JW et al. Tumor-derived vascular endothelial growth factor up-regulates angiopoietin-2 in host endothelium and destabilizes host vasculature, supporting angiogenesis in ovarian cancer. Cancer Res 2003; 63: 3403-12.
    • (2003) Cancer Res , vol.63 , pp. 3403-3412
    • Zhang, L.1    Yang, N.2    Park, J.W.3
  • 4
    • 0036483512 scopus 로고    scopus 로고
    • Role of c-Fyn in FGF-2-mediated tube-like structure formation by murine brain capillary endothelial cells
    • Tsuda S, Ohtsuru A, Yamashita S et al. Role of c-Fyn in FGF-2-mediated tube-like structure formation by murine brain capillary endothelial cells. Biochem Biophys Res Commun 2002; 290: 1354-60.
    • (2002) Biochem Biophys Res Commun , vol.290 , pp. 1354-1360
    • Tsuda, S.1    Ohtsuru, A.2    Yamashita, S.3
  • 5
    • 0034791087 scopus 로고    scopus 로고
    • Transforming growth factor β1 (TGF-β1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-α signaling
    • Vinals F, Pouyssegur J. Transforming growth factor β1 (TGF-β1) promotes endothelial cell survival during in vitro angiogenesis via an autocrine mechanism implicating TGF-α signaling. Mol Cell Biol 2001; 21: 7218-30.
    • (2001) Mol Cell Biol , vol.21 , pp. 7218-7230
    • Vinals, F.1    Pouyssegur, J.2
  • 6
    • 0034283023 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts
    • Rofstad EK, Halsor EF. Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts. Cancer Res 2000; 60: 4932-8.
    • (2000) Cancer Res , vol.60 , pp. 4932-4938
    • Rofstad, E.K.1    Halsor, E.F.2
  • 7
    • 0031867648 scopus 로고    scopus 로고
    • Differential binding characteristics and cellular inhibition by soluble VEGF receptors 1 and 2
    • Roeckl W, Hecht D, Sztajer H et al. Differential binding characteristics and cellular inhibition by soluble VEGF receptors 1 and 2. Exp Cell Res 1998; 241: 161-70.
    • (1998) Exp Cell Res , vol.241 , pp. 161-170
    • Roeckl, W.1    Hecht, D.2    Sztajer, H.3
  • 8
    • 0030378093 scopus 로고    scopus 로고
    • Regulation of the steps of angiogenesis by human head and neck squamous cell carcinomas
    • Benefield J, Petruzzelli GJ, Fowler S et al. Regulation of the steps of angiogenesis by human head and neck squamous cell carcinomas. Invasion Metast 1996; 16: 291-301.
    • (1996) Invasion Metast , vol.16 , pp. 291-301
    • Benefield, J.1    Petruzzelli, G.J.2    Fowler, S.3
  • 9
    • 0033947162 scopus 로고    scopus 로고
    • Human caco-2 motility redistributes FAK and paxillin and activates p38 MAPK in a matrix-dependent manner
    • Yu CF, Sanders MA, Basson MD. Human caco-2 motility redistributes FAK and paxillin and activates p38 MAPK in a matrix-dependent manner. Am J Physiol Gastrointest Liver Physiol 2000; 278: G952-66.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.278
    • Yu, C.F.1    Sanders, M.A.2    Basson, M.D.3
  • 10
    • 0033518128 scopus 로고    scopus 로고
    • Serine phosphorylation of paxillin by heregulin-β1: Role of p38 mitogen activated protein kinase
    • Vadlamudi R, Adam L, Talukder A et al. Serine phosphorylation of paxillin by heregulin-β1: Role of p38 mitogen activated protein kinase. Oncogene 1999; 18: 7253-64.
    • (1999) Oncogene , vol.18 , pp. 7253-7264
    • Vadlamudi, R.1    Adam, L.2    Talukder, A.3
  • 11
    • 0037143091 scopus 로고    scopus 로고
    • Protein phosphatase-2A regulates endothelial cell motility and both the phosphorylation as well as stability of focal adhesion complexes
    • Young MRI, Kolesiak K, Meisinger J. Protein phosphatase-2A regulates endothelial cell motility and both the phosphorylation as well as stability of focal adhesion complexes. Int J Cancer 2002; 100: 276-82.
    • (2002) Int J Cancer , vol.100 , pp. 276-282
    • Young, M.R.I.1    Kolesiak, K.2    Meisinger, J.3
  • 12
    • 0026976953 scopus 로고
    • Signaling between the extracellular matrix and the cytoskeleton: Tyrosine phosphorylation and focal adhesion assembly
    • Romer LH, Burridge K, Turner CE. Signaling between the extracellular matrix and the cytoskeleton: Tyrosine phosphorylation and focal adhesion assembly. Cold Spring Harb Symp Quant Biol 1992; 57: 193-202.
    • (1992) Cold Spring Harb Symp Quant Biol , vol.57 , pp. 193-202
    • Romer, L.H.1    Burridge, K.2    Turner, C.E.3
  • 13
    • 0035844250 scopus 로고    scopus 로고
    • Inhibition of cell migration by Abl-family tyrosine kinases through uncoupling of Crk/CAS complexes
    • Kain KH, Klemke RL. Inhibition of cell migration by Abl-family tyrosine kinases through uncoupling of Crk/CAS complexes. J Biol Chem 2001; 11: 16185-92.
    • (2001) J Biol Chem , vol.11 , pp. 16185-16192
    • Kain, K.H.1    Klemke, R.L.2
  • 14
    • 0033617357 scopus 로고    scopus 로고
    • Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration
    • Reiske HR, Kao SC, Cary LA et al. Requirement of phosphatidylinositol 3-kinase in focal adhesion kinase-promoted cell migration. J Biol Chem 1999; 274: 12361-6.
    • (1999) J Biol Chem , vol.274 , pp. 12361-12366
    • Reiske, H.R.1    Kao, S.C.2    Cary, L.A.3
  • 15
    • 0035836770 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
    • Ozes ON, Akca H, Mayo LD et al. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad SCi USA 2001;
    • (2001) Proc Natl Acad SCi USA
    • Ozes, O.N.1    Akca, H.2    Mayo, L.D.3
  • 16
    • 0033946740 scopus 로고    scopus 로고
    • Phosphorylation of the PTEN tail regulates protein stability and function
    • Vazquez F, Ramaswamy S, Nakamura N et al. Phosphorylation of the PTEN tail regulates protein stability and function. MoL Cell Biol 2000; 20: 5010-8.
    • (2000) MoL Cell Biol , vol.20 , pp. 5010-5018
    • Vazquez, F.1    Ramaswamy, S.2    Nakamura, N.3
  • 17
    • 0032856186 scopus 로고    scopus 로고
    • TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: Selective role of PKCα and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment
    • Shimao Y, Nabeshima K, Inoue T et al. TPA-enhanced motility and invasion in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1: Selective role of PKCα and its inhibition by a combination of PDBu-induced PKC downregulation and antisense oligonucleotides treatment. Clin Exp Metast 1999; 17: 351-60.
    • (1999) Clin Exp Metast , vol.17 , pp. 351-360
    • Shimao, Y.1    Nabeshima, K.2    Inoue, T.3
  • 18
    • 0027082845 scopus 로고
    • Activation of protein kinase a increases the in vitro invasion, migration, and adherence to reconstituted basement membrane by Lewis lung carcinoma tumor cells
    • Young MRI, Young ME, Lozano Y et al. Activation of protein kinase A increases the in vitro invasion, migration, and adherence to reconstituted basement membrane by Lewis lung carcinoma tumor cells. Invasion Metast 1992; 12: 253-63.
    • (1992) Invasion Metast , vol.12 , pp. 253-263
    • Young, M.R.I.1    Young, M.E.2    Lozano, Y.3
  • 19
    • 0025063772 scopus 로고
    • Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene
    • Montesano R, Pepper MS, Mohle-Steinlein U et al. Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene. Cell 1990; 62: 435-45.
    • (1990) Cell , vol.62 , pp. 435-445
    • Montesano, R.1    Pepper, M.S.2    Mohle-Steinlein, U.3
  • 20
    • 0032987757 scopus 로고    scopus 로고
    • Protein phosphatase 2A suppresses MAP kinase signalling and ectopic protein expression
    • Chung H, Brautigan DL. Protein phosphatase 2A suppresses MAP kinase signalling and ectopic protein expression. Cell Signal 1999; 11: 575-80.
    • (1999) Cell Signal , vol.11 , pp. 575-580
    • Chung, H.1    Brautigan, D.L.2
  • 21
    • 0030299307 scopus 로고    scopus 로고
    • Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A
    • Metz R, Vellody K, Patel S et al. Vitamin D3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A. Invasion Metast 1997; 16: 280-90.
    • (1997) Invasion Metast , vol.16 , pp. 280-290
    • Metz, R.1    Vellody, K.2    Patel, S.3
  • 22
    • 0034959182 scopus 로고    scopus 로고
    • Differences in association of the serine/threonine protein phosphatase PP-2A with microtubules of metastatic and nonmetastatic tumor cells
    • Young MRI, Liu SW, Meisinger J. Differences in association of the serine/threonine protein phosphatase PP-2A with microtubules of metastatic and nonmetastatic tumor cells. Clin Exp Metast 2001; 18: 407-13.
    • (2001) Clin Exp Metast , vol.18 , pp. 407-413
    • Young, M.R.I.1    Liu, S.W.2    Meisinger, J.3
  • 23
    • 0026677532 scopus 로고
    • HMEC-1: Establishment of an immortalized human microvascular endothelial cell line
    • Ades EW, Candal FJ, Swerlick RA et al. HMEC-1: Establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol 1992; 99: 683-90.
    • (1992) J Invest Dermatol , vol.99 , pp. 683-690
    • Ades, E.W.1    Candal, F.J.2    Swerlick, R.A.3
  • 24
    • 0025953404 scopus 로고
    • Use of okadaic acid to inhibit protein phosphatases in intact cells
    • Hardie DG, Haystead AJ, Sim ATR. Use of okadaic acid to inhibit protein phosphatases in intact cells. Meth Enzymol 1991; 201: 469-76.
    • (1991) Meth Enzymol , vol.201 , pp. 469-476
    • Hardie, D.G.1    Haystead, A.J.2    Sim, A.T.R.3
  • 25
    • 0034798524 scopus 로고    scopus 로고
    • Tumor autocrine motility factor is an angiogenic factor that stimulates endothelial cell motility
    • Funasaka T, Haga A, Raz A et al. Tumor autocrine motility factor is an angiogenic factor that stimulates endothelial cell motility. Biochem Biophys Res Commun 2001; 285: 118-28.
    • (2001) Biochem Biophys Res Commun , vol.285 , pp. 118-128
    • Funasaka, T.1    Haga, A.2    Raz, A.3
  • 26
    • 0345267246 scopus 로고    scopus 로고
    • Endothelial cell response to human head and neck squamous cell carcinoma cells involves downregulation of protein phosphatases-1/2A, cytoskeletal depolymerization and increased motility
    • Benefield J, Meisinger J, Petruzzelli GJ et al. Endothelial cell response to human head and neck squamous cell carcinoma cells involves downregulation of protein phosphatases-1/2A, cytoskeletal depolymerization and increased motility. Invasion Metast 1997; 17: 210-20.
    • (1997) Invasion Metast , vol.17 , pp. 210-220
    • Benefield, J.1    Meisinger, J.2    Petruzzelli, G.J.3
  • 27
    • 0034030266 scopus 로고    scopus 로고
    • Inter-relationship between protein phosphatase-2A and the cytoskeletal architecture during the endothelial cell response to soluble products produced by human head and neck cancer
    • Witt CJ, Meisinger J, Werra G et al. Inter-relationship between protein phosphatase-2A and the cytoskeletal architecture during the endothelial cell response to soluble products produced by human head and neck cancer. Otolaryngol Head Neck Surg 2000; 122: 721-7.
    • (2000) Otolaryngol Head Neck Surg , vol.122 , pp. 721-727
    • Witt, C.J.1    Meisinger, J.2    Werra, G.3
  • 28
    • 0842345425 scopus 로고    scopus 로고
    • Electrical stimulation directly induces pre-angiogenic responses in vascular endothelial cells by signaling through VEGF receptors
    • Zhao M, Bai H, Wang E et al. Electrical stimulation directly induces pre-angiogenic responses in vascular endothelial cells by signaling through VEGF receptors. J Cell Sci 2004; 117: 397-405.
    • (2004) J Cell Sci , vol.117 , pp. 397-405
    • Zhao, M.1    Bai, H.2    Wang, E.3
  • 29
    • 0037192768 scopus 로고    scopus 로고
    • PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects
    • Huang J, Kontos CD. PTEN modulates vascular endothelial growth factor-mediated signaling and angiogenic effects. J Biol Chem 2002; 277: 10760-6.
    • (2002) J Biol Chem , vol.277 , pp. 10760-10766
    • Huang, J.1    Kontos, C.D.2
  • 30
    • 0032822591 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced migration of vascular smooth muscle cells in vitro
    • Grosskreutz CL, Anand-Apte B, Dupl et al. Vascular endothelial growth factor-induced migration of vascular smooth muscle cells in vitro. Microvasc Res 1999; 58: 128-36.
    • (1999) Microvasc Res , vol.58 , pp. 128-136
    • Grosskreutz, C.L.1    Anand-Apte, B.2    Dupl3
  • 31
    • 0029166407 scopus 로고
    • Angiogenic factors stimulate mast-cell migration
    • Gruber BL, Marchese MJ, Kew R. Angiogenic factors stimulate mast-cell migration. Blood 1995; 86: 2488-93.
    • (1995) Blood , vol.86 , pp. 2488-2493
    • Gruber, B.L.1    Marchese, M.J.2    Kew, R.3
  • 32
    • 0038604436 scopus 로고    scopus 로고
    • PP2A activation by beta2-adrenergic receptor agonists: Novel regulatory mechanism of keratinocyte migration
    • Pullar CE, Chen J, Isseroff RR. PP2A activation by beta2-adrenergic receptor agonists: Novel regulatory mechanism of keratinocyte migration. J Biol Chem 2003; 278: 22555-62.
    • (2003) J Biol Chem , vol.278 , pp. 22555-22562
    • Pullar, C.E.1    Chen, J.2    Isseroff, R.R.3
  • 33
    • 0036584733 scopus 로고    scopus 로고
    • Dephosphorylation of endothelial nitric oxide synthase contributes to the anti-angiogenic effects of endostatin
    • Urbich C, Reissner A, Chavakis E et al. Dephosphorylation of endothelial nitric oxide synthase contributes to the anti-angiogenic effects of endostatin. FASEB J 2002; 16: 706-8.
    • (2002) FASEB J , vol.16 , pp. 706-708
    • Urbich, C.1    Reissner, A.2    Chavakis, E.3
  • 34
    • 0141731299 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of betal-integrin and phosphatidylinositol 3′-kinase/AKT signaling
    • Tai YT, Podar K, Catley L et al. Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of betal-integrin and phosphatidylinositol 3′-kinase/AKT signaling. Cancer Res 2003; 63: 5850-8.
    • (2003) Cancer Res , vol.63 , pp. 5850-5858
    • Tai, Y.T.1    Podar, K.2    Catley, L.3
  • 35
    • 0346218206 scopus 로고    scopus 로고
    • Participation of PI3K and ERK1/2 pathways are required for human brain vascular smooth muscle cell migration
    • Yang GY, Yao JS, Huey M et al. Participation of PI3K and ERK1/2 pathways are required for human brain vascular smooth muscle cell migration. Neurochem Int 2004; 44: 441-6.
    • (2004) Neurochem Int , vol.44 , pp. 441-446
    • Yang, G.Y.1    Yao, J.S.2    Huey, M.3
  • 36
    • 0037228960 scopus 로고    scopus 로고
    • PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter
    • Pore N, Liu S, Haas-Kogan DA et al. PTEN mutation and epidermal growth factor receptor activation regulate vascular endothelial growth factor (VEGF) mRNA expression in human glioblastoma cells by transactivating the proximal VEGF promoter. Cancer Res 2003; 63: 236-41.
    • (2003) Cancer Res , vol.63 , pp. 236-241
    • Pore, N.1    Liu, S.2    Haas-Kogan, D.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.