Protein phosphatase-2A modulates the serine and tyrosine phosphorylation of paxillin in Lewis lung carcinoma tumor variants

Clinical and Experimental Metastasis

Volumn 19, Issue 5, 2002, Pages 409-415

  Jackson, Jodi L ^a   Young, M Rita I ^a,b  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b HINES VA HOSPITAL   (United States)

Author keywords

Focal adhesions; Metastasis; Paxillin; Phosphorylation; Protein phosphatase 2A

Indexed keywords

OKADAIC ACID; PAXILLIN; PHOSPHOPROTEIN PHOSPHATASE 2A; SERINE; TYROSINE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL MOTILITY; CONTROLLED STUDY; ENZYME REGULATION; FOCAL ADHESION; LEWIS CARCINOMA; METASTASIS; MOUSE; NONHUMAN; PROTEIN PHOSPHORYLATION;

ANIMALS; CARCINOMA, LEWIS LUNG; CELL MOVEMENT; CYTOSKELETAL PROTEINS; ENZYME INHIBITORS; FOCAL ADHESIONS; MICE; NEOPLASM PROTEINS; OKADAIC ACID; PAXILLIN; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTYROSINE; PROTEIN PROCESSING, POST-TRANSLATIONAL;

EID: 0036345183     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016385027013     Document Type: Article

References (33)

1. The biochemistry of cancer dissemination
2. 2-producing non-metastatic Lewis lung carcinoma tumor variants
3. Regulation of Lewis lung carcinoma invasion and metastasis by protein kinase A
4. Protein kinase A regulates Lewis lung carcinoma adherence to extracellular matrix components and spontaneous metastasis
5. Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons
6. Signal transduction by integrin receptors for extracellular matrix: Cooperative processing of extracellular information
7. Characterization of tyrosine phosphorylation of paxillin in vitro by focal adhesion kinase
8. Proteins associated with the cytoplasmic surface of adhesion molecules
9. Role of adhesion molecule cytoplasmic domains in mediating interactions with the cytoskeleton
10. Integrins and signal transduction pathways: The Road Taken
11. Adhesions of fibroblasts to substratum during contact inhibition observed by interference: Reflection microscopy
12. Cell-to-substrate contacts in living fibroblasts: An interference reflexion study with evaluation of the technique
13. Cell to substratum contacts of chick fibroblasts and their relation to the microfilament system. A correlated interference-reflection and high voltage electron-microscope study
14. Focal adhesions: Transmembrane junctions between extracellular matrix and the cytoskeleton
15. The molecular architecture of focal adhesions
16. Assembly of focal adhesions: Progress, paradigms, and potents
17. Roles of protein tyrosine phosphatases in cell migration and adhesion
18. Paxillin and focal adhesion signaling
19. FAK accompanies cell adhesion to extracellular matrix: A role in cytoskeletal assembly
20. Signaling between the extracellular matrix and cytoskeleton: Tyrosine phosphorylation and focal adhesion assembly
21. Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin
22. Serine and tyrosine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin
23. Regulatin of cytoskeleton organization and paxillin dephosphorylation by cAMP
24. Hormonal regulation of focal adhesions in bovine adrenocortical cells: Induction of paxillin dephosphorylation by adrenocorticotropic hormone
25. NO alters cell shape and motility in aortic smooth muscle cells via protein tyrosine phosphatase-1B activation
26. The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas and paxillin
27. Transformation of rat fibroblasts by phospholipase C-γ1 overexpression is accompanied by tyrosine dephosphorylation of paxillin
28. A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation
29. Protein phosphatases limit tumor cell motility
30. 2 secretion by cloned variants of Lewis lung carcinoma
31. Differential inhibition of posttranslational modification of protein phosphatases 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin
32. Cell migration: A physically integrated molecular process
33. Tyrosine dephosphorylation of pp60-c-src is stimulated by a serine/threonine phosphatase inhibitor