Moesin-dependent cytoskeleton remodelling is associated with an anaplastic phenotype of pancreatic cancer

Journal of Cellular and Molecular Medicine

Volumn 14, Issue 5, 2010, Pages 1166-1179

  Abiatari, Ivane ^a   Esposito, Irene ^a,b   Oliveira, Tiago De ^a   Felix, Klaus ^c   Xin, Hong ^a   Penzel, Roland ^c   Giese, Thomas ^c   Friess, Helmut ^a   Kleeff, Jörg ^a,d  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

catenin; Anaplastic cancer; Cytoskeleton; Extracellular matrix; Moesin; Pancreatic ductal adenocarcinoma

Indexed keywords

ACTIN BINDING PROTEIN; BETA CATENIN; CADHERIN; MOESIN; SMALL INTERFERING RNA;

ADULT; AGED; ANIMAL; ARTICLE; CANCER INVASION; CARCINOMA; CELL ADHESION; CELL MOTION; CELL PROLIFERATION; CYTOSKELETON; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GENE SILENCING; GENETICS; HUMAN; METABOLISM; MIDDLE AGED; MOUSE; PANCREAS CARCINOMA; PANCREAS TUMOR; PATHOLOGY; PHENOTYPE; PROTEIN TRANSPORT; TUMOR CELL LINE; TUMOR INVASION; YOUNG ADULT;

ADULT; AGED; ANIMALS; BETA CATENIN; CADHERINS; CARCINOMA; CARCINOMA, PANCREATIC DUCTAL; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CYTOSKELETON; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; MICE; MICROFILAMENT PROTEINS; MIDDLE AGED; NEOPLASM INVASIVENESS; PANCREATIC NEOPLASMS; PHENOTYPE; PROTEIN TRANSPORT; RNA, SMALL INTERFERING; YOUNG ADULT;

MUS MUSCULUS;

EID: 77954725226     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00772.x     Document Type: Article

References (35)

1. Welsch T, Kleeff J, Friess H. Molecular pathogenesis of pancreatic cancer: advances and challenges. Curr Mol Med. 2007, 7:504-21.
2. Jones S, Zhang X, Parsons DW. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008, 321:1801-6.
3. Jemal A, Siegel R, Ward E. Cancer statistics, 2008. CA Cancer J Clin. 2008, 58:71-96.
4. Kleeff J, Michalski C, Friess H. Pancreatic cancer: from bench to 5-year survival. Pancreas. 2006, 33:111-8.
5. Hoorens A, Prenzel K, Lemoine NR. Undifferentiated carcinoma of the pancreas: analysis of intermediate filament profile and Ki-ras mutations provides evidence of a ductal origin. J Pathol. 1998, 185:53-60.
6. Tsukita S, Yonemura S, Tsukita S. ERM proteins: head-to-tail regulation of actin-plasma membrane interaction. Trends Biochem Sci. 1997, 22:53-8.
7. Speck O, Hughes SC, Noren NK. Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity. Nature. 2003, 421:83-7.
8. Miller KG. A role for moesin in polarity. Trends Cell Biol. 2003, 13:165-8.
9. Pilot F, Philippe JM, Lemmers C. Spatial control of actin organization at adherens junctions by a synaptotagmin-like protein Btsz. Nature. 2006, 442:580-4.
10. Akisawa N, Nishimori I, Iwamura T. High levels of ezrin expressed by human pancreatic adenocarcinoma cell lines with high metastatic potential. Biochem Biophys Res Commun. 1999, 258:395-400.
11. Ohtani K, Sakamoto H, Rutherford T. Ezrin, a membrane-cytoskeletal linking protein, is involved in the process of invasion of endometrial cancer cells. Cancer Lett. 1999, 147:31-8.
12. Yeh TS, Tseng JH, Liu NJ. Significance of cellular distribution of ezrin in pancreatic cystic neoplasms and ductal adenocarcinoma. Arch Surg. 2005, 140:1184-90.
13. Hustinx SR, Fukushima N, Zahurak ML. Expression and prognostic significance of 14-3-3sigma and ERM family protein expression in periampullary neoplasms. Cancer Biol Ther. 2005, 4:596-601.
14. Torer N, Kayaselcuk F, Nursal TZ. Adhesion molecules as prognostic markers in pancreatic adenocarcinoma. J Surg Oncol. 2007, 96:419-23.
15. McClatchey AI. Merlin and ERM proteins: unappreciated roles in cancer development. Nature Rev. 2003, 3:877-83.
16. Bretscher A, Edwards K, Fehon RG. ERM proteins and merlin: integrators at the cell cortex. Nat Rev Mol Cell Biol. 2002, 3:586-99.
17. Hughes SC, Fehon RG. Understanding ERM proteins - the awesome power of genetics finally brought to bear. Curr Opin Cell Biol. 2007, 19:51-6.
18. Erkan M, Kleeff J, Gorbachevski A. Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity. Gastroenterology. 2007, 132:1447-64.
19. Erkan M, Kleeff J, Esposito I. Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene. 2005, 24:4421-32.
20. Abiatari I, Kleeff J, Li J. Hsulf-1 regulates growth and invasion of pancreatic cancer cells. J Clin Pathol. 2006, 59:1052-8.
21. Michl P, Ramjaun AR, Pardo OE. CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness. Cancer Cell. 2005, 7:521-32.
22. Frisch SM, Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol. 1994, 124:619-26.
23. Pasca di Magliano M, Sekine S, Ermilov A. Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev. 2006, 20:3161-73.
24. Guerra C, Schuhmacher AJ, Canamero M. Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice. Cancer Cell. 2007, 11:291-302.
25. Bergmann F, Esposito I, Michalski CW. Early undifferentiated pancreatic carcinoma with osteoclastlike giant cells: direct evidence for ductal evolution. Am J Surg Pathol. 2007, 31:1919-25.
26. Nakajima S, Doi R, Toyoda E. N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma. Clin Cancer Res. 2004, 10:4125-33.
27. Brabletz T, Jung A, Spaderna S. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer. 2005, 5:744-9.
28. Kobayashi H, Sagara J, Kurita H. Clinical significance of cellular distribution of moesin in patients with oral squamous cell carcinoma. Clin Cancer Res. 2004, 10:572-80.
29. Lankes W, Griesmacher A, Grunwald J. A heparin-binding protein involved in inhibition of smooth-muscle cell proliferation. Biochem J. 1988, 251:831-42.
30. Bretscher A, Reczek D, Berryman M. Ezrin: a protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures. J Cell Sci. 1997, 110:3011-8.
31. Kreimann EL, Morales FC, de Orbeta-Cruz J. Cortical stabilization of beta-catenin contributes to NHERF1/EBP50 tumor suppressor function. Oncogene. 2007, 26:5290-9.
32. Heiser PW, Cano DA, Landsman L. Stabilization of beta-catenin induces pancreas tumor formation. Gastroenterology. 2008, 135:1288-300.
33. Belbin TJ, Singh B, Smith RV. Molecular profiling of tumor progression in head and neck cancer. Arch Otolaryngol Head Neck Surg. 2005, 131:10-8.
34. Tokunou M, Niki T, Saitoh Y. Altered expression of the ERM proteins in lung adenocarcinoma. Lab Invest. 2000, 80:1643-50.
35. Ulrich AB, Schmied BM, Standop J. Pancreatic cell lines: a review. Pancreas. 2002, 24:111-20.