Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway

Journal of Cancer Research and Clinical Oncology

Volumn 137, Issue 11, 2011, Pages 1629-1640

  Liu, Dan ^a   Huang, Yi ^b   Zeng, Jing ^a   Chen, Bojiang ^a   Huang, Na ^a   Guo, Na ^a   Liu, Lunxu ^a   Xu, Hong ^a   Mo, Xianming ^a   Li, Weimin ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Crosstalk; Janus kinase 1; Mammalian target of rapamycin; Non small cell lung cancer; Phosphatidyl inositol 3 kinase; RNA interference

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3ALPHA; JANUS KINASE 1; LENTIVIRUS VECTOR; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL XL; PROTEIN KINASE B BETA; S6 KINASE; SHORT HAIRPIN RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER INVASION; CARCINOGENICITY; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LUNG CANCER; LUNG NON SMALL CELL CANCER; MOLECULAR INTERACTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; DOWN-REGULATION; HUMANS; JANUS KINASE 1; LUNG NEOPLASMS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; PHOSPHATIDYLINOSITOL 3-KINASES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES; TRANSPLANTATION, HETEROLOGOUS;

EID: 80054729042     PISSN: 01715216     EISSN: 14321335     Source Type: Journal    
DOI: 10.1007/s00432-011-1037-6     Document Type: Article

References (55)

1. U Akar B Ozpolat K Mehta G Lopez-Berestein D Zhang NT Ueno GN Hortobagyi B Arun 2010 Targeting p70S6K prevented lung metastasis in a breast cancer xenograft model Mol Cancer Ther 9 5 1180 1187 20423989 10.1158/1535-7163.MCT-09- 1025 1:CAS:528:DC%2BC3cXlsleksLs%3D
2. LP Cousens FA Goulette JW Darnowski 2005 JAK-mediated signaling inhibits Fas ligand-induced apoptosis independent of de novo protein synthesis J Immunol 174 1 320 327 15611255 1:CAS:528:DC%2BD2cXhtFaiurvK (Pubitemid 40007419)
3. J Dal Col P Zancai L Terrin M Guidoboni M Ponzoni A Pavan M Spina S Bergamin S Rizzo U Tirelli A De Rossi C Doglioni R Dolcetti 2008 Distinct functional significance of Akt and mTOR constitutive activation in mantle cell lymphoma Blood 111 10 5142 5151 18339899 10.1182/blood-2007-07-103481 1:CAS:528:DC%2BD1cXmtlahs7o%3D
4. JA Diehl M Cheng MF Roussel CJ Sherr 1998 Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization Genes Dev 12 22 3499 3511 9832503 10.1101/gad.12.22.3499 1:CAS:528:DyaK1cXnvVOgs7s%3D (Pubitemid 28553242)
5. A Ferrajoli S Faderl F Ravandi Z Estrov 2006 The JAK-STAT pathway: a therapeutic target in hematological malignancie Curr Cancer Drug Targets 6 8 671 679 17168672 10.2174/156800906779010227 1:CAS:528:DC%2BD28Xht1yjsLrL (Pubitemid 44875961)
6. DH Freed AM Borowiec T Angelovska IM Dixon 2003 Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways Cardiovasc Res 60 2 365 375 14613866 10.1016/S0008-6363(03) 00534-0 1:CAS:528:DC%2BD3sXovVGhurc%3D (Pubitemid 37412370)
7. S Freitas DH Moore H Michael MR Kelley 2003 Studies of apurinic/apyrimidinic endonuclease/ref-1 expression in epithelial ovarian cancer: correlations with tumor progression and platinum resistance Clin Cancer Res 9 13 4689 4694 14581338 1:CAS:528:DC%2BD3sXosVGjs74%3D (Pubitemid 37323270)
8. AM Gamero AC Larner 2001 Vanadate facilitates interferon alpha-mediated apoptosis that is dependent on the Jak/Stat pathway J Biol Chem 276 17 13547 13553 11278370 1:CAS:528:DC%2BD3MXjt12kt78%3D
9. B Gao X Shen G Kunos Q Meng ID Goldberg EM Rosen S Fan 2001 Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells FEBS Lett 488 3 179 184 11163768 10.1016/S0014-5793(00)02430-3 1:CAS:528: DC%2BD3MXhsVSrsb4%3D (Pubitemid 32103593)
10. M Gómez-Benito P Balsas X Carvajal-Vergara A Pandiella A Anel I Marzo J Naval 2007 Mechanism of apoptosis induced by INF-α in human myeloma cells: role of Jak1 and Bim and potentiation by rapamycin Cell Signal 19 4 844 854 17158029 10.1016/j.cellsig.2006.10.009 (Pubitemid 46275374)
11. Harris TE, Lawrence JC Jr. (2003) TOR signaling. Sci STKE 212: re15
12. N Hay N Sonenberg 2004 Upstream and downstream of mTOR Genes Dev 18 16 1926 1945 15314020 10.1101/gad.1212704 1:CAS:528:DC%2BD2cXmvFKqsLk%3D (Pubitemid 39071573)
13. B He L You Z Xu J Mazieres AY Lee DM Jablons 2004 Activity of the suppressor of cytokine signaling-3 promoter in human non-small-cell lung cancer Clin Lung Cancer 5 6 366 370 15217536 10.3816/CLC.2004.n.015 1:CAS:528:DC%2BD2cXlvFSmt7k%3D (Pubitemid 39004334)
14. HM Huang YL Lin CH Chen TW Chang 2005 Simultaneous activation of JAK1 and JAK2 confers IL-3 independent growth on Ba/F3 pro-B cells J Cell Biochem 96 2 361 375 15988755 10.1002/jcb.20513 1:CAS:528:DC%2BD2MXhtFajurvK (Pubitemid 41437868)
15. JN Ihle 1995 The Janus protein tyrosine kinase family and its role in cytokine signaling Adv Immunol 60 1 35 8607368 10.1016/S0065-2776(08)60582-9 1:CAS:528:DyaK28XhvFWnt7o%3D
16. A Jemal R Siegel E Ward Y Hao J Xu MJ Thun 2009 Cancer statistics, 2009 CA Cancer J Clin 59 4 225 249 19474385 10.3322/caac.20006
17. EG Jeong MS Kim HK Nam CK Min S Lee YJ Chung NJ Yoo SH Lee 2008 Somatic mutations of JAK1 and JAK3 in acute leukemias and solid cancers Clin Cancer Res 14 12 3716 3721 18559588 10.1158/1078-0432.CCR-07-4839 1:CAS:528: DC%2BD1cXntlWrsrg%3D
18. N Kaur AL Wohlhueter SW Halvorsen 2002 Activation and inactivation of signal transducers and activators of transcription by ciliary neurotrophic factor in neuroblastoma cells Cell Signal 14 5 419 429 11882386 10.1016/S0898-6568(01)00280-7 1:CAS:528:DC%2BD38Xhs1ylsrY%3D (Pubitemid 34214846)
19. D Kong S Banerjee W Huang Y Li Z Wang HR Kim FH Sarkar 2008 Mammalian target of rapamycin repression by 3, 3′-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells Cancer Res 68 6 1927 1934 18339874 10.1158/0008-5472.CAN-07-3241 1:CAS:528:DC%2BD1cXjtFOhtr8%3D (Pubitemid 351416579)
20. M Kurdi GW Booz 2007 Jak inhibition, but not Stat1 knockdown, blocks the synergistic effect of IFN-gamma on Fas-induced apoptosis of A549 human non-small cell lung cancer cells J Interferon Cytokine Res 27 1 23 31 17266440 10.1089/jir.2007.0074 1:CAS:528:DC%2BD2sXhtFGlt7w%3D (Pubitemid 46185058)
21. P Lam K Sian Lim S Mei Wang KM Hui 2005 A microarray study to characterize the molecular mechanism of TIMP-3-mediated tumor rejection Mol Ther 12 1 144 152 15963930 10.1016/j.ymthe.2005.02.028 1:CAS:528: DC%2BD2MXlt1Glsrg%3D (Pubitemid 40862366)
22. P Langlais Z Yi LJ Mandarino 2011 The Identification of Raptor as a Substrate for p44/42 MAPK Endocrinology 152 4 1264 1273 21325048 10.1210/en.2010-1271 1:CAS:528:DC%2BC3MXkvVOksb4%3D
23. A Le CR Cooper AM Gouw R Dinavahi A Maitra LM Deck RE Royer DL Vander Jagt GL Semenza CV Dang 2009 Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression Proc Natl Acad Sci USA 107 5 2037 2042 10.1073/pnas.0914433107
24. J Li M Favata JA Kelley E Caulder B Thomas X Wen RB Sparks A Arvanitis JD Rogers AP Combs K Vaddi KA Solomon PA Scherle R Newton JS Fridman 2010 INCB16562, a JAK1/2 selective inhibitor, is efficacious against multiple myeloma cells and reverses the protective effects of cytokine and stromal cell support Neoplasia 12 1 28 38 20072651 1:CAS:528:DC%2BC3cXmtlGhsw%3D%3D
25. G Manning DB Whyte R Martinez T Hunter S Sudarsanam 2002 The protein kinase complement of the human genome Science 298 5600 1912 1934 12471243 10.1126/science.1075762 1:CAS:528:DC%2BD38Xpt1Wisb0%3D (Pubitemid 35425239)
26. RM Memmott PA Dennis 2009 The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis Clin Cancer Res 16 1 4 10 20028747 10.1158/1078-0432.CCR-09-0234
27. M Noguchi V Ropars C Roumestand F Suizu 2007 Proto-oncogene TCL1: more than just a coactivator for Akt FASEB J 21 10 2273 2284 17360849 10.1096/fj.06-7684com 1:CAS:528:DC%2BD2sXptFKhtLg%3D (Pubitemid 47230657)
28. H Oh Y Fujio K Kunisada H Hirota H Matsui T Kishimoto K Yamauchi-Takihara 1998 Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes J Biol Chem 273 16 9703 9710 9545305 10.1074/jbc.273.16.9703 1:CAS:528: DyaK1cXivVOrtb8%3D (Pubitemid 28183061)
29. JJ O'Shea M Gadina RD Schreiber 2002 Cytokine signaling in 2002: new surprises in the Jak/Stat pathway Cell 109 Suppl S121 S131 11983158 10.1016/S0092-8674(02)00701-8 (Pubitemid 34457857)
30. C Petritsch H Beug A Balmain M Oft 2000 TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest Genes Dev 14 24 3093 3101 11124802 10.1101/gad.854200 1:CAS:528:DC%2BD3MXhs1WgsQ%3D%3D (Pubitemid 32015128)
31. A Ramanathan SL Schreiber 2009 Direct control of mitochondrial function by mTOR Proc Natl Acad Sci USA 106 52 22229 22232 20080789 10.1073/pnas. 0912074106 1:CAS:528:DC%2BC3cXmtlajug%3D%3D
32. SG Rane EP Reddy 2000 Janus kinases: components of multiple signaling pathways Oncogene 19 49 5662 5679 11114747 10.1038/sj.onc.1203925 1:CAS:528:DC%2BD3cXosl2nurY%3D
33. B Ravikumar S Sarkar JE Davies M Futter M Garcia-Arencibia ZW Green-Thompson M Jimenez-Sanchez VI Korolchuk M Lichtenberg S Luo DC Massey FM Menzies K Moreau U Narayanan M Renna FH Siddiqi BR Underwood AR Winslow DC Rubinsztein 2011 Regulation of mammalian autophagy in physiology and pathophysiology Physiol Rev 90 4 1383 1435 10.1152/physrev.00030.2009
34. NK Saxena D Sharma X Ding S Lin F Marra D Merlin FA Anania 2007 Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells Cancer Res 67 6 2497 2507 17363567 10.1158/0008-5472.CAN-06-3075 1:CAS:528:DC%2BD2sXivV2gu7s%3D (Pubitemid 46548934)
35. CW Schindler 2002 Series introduction. JAK-STAT signaling in human disease J Clin Invest 109 9 1133 1137 11994400 1:CAS:528:DC%2BD38XjsFalsL4%3D (Pubitemid 34496589)
36. I Shiojima K Walsh 2006 Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway Genes Dev 20 24 3347 3365 17182864 10.1101/gad.1492806 1:CAS:528:DC%2BD2sXhs1aqtA%3D%3D (Pubitemid 44969154)
37. L Song B Rawal JA Nemeth EB Haura 2011 JAK1 activates STAT3 activity in non-small-cell lung cancer cells and IL-6 neutralizing antibodies can suppress JAK1-STAT3 signaling Mol Cancer Ther 10 3 481 494 21216930 10.1158/1535-7163. MCT-10-0502 1:CAS:528:DC%2BC3MXivVCrsr0%3D
38. MA Sussman M Volkers K Fischer B Bailey CT Cottage S Din N Gude D Avitabile R Alvarez B Sundararaman P Quijada M Mason MH Konstandin A Malhowski Z Cheng M Khan M McGregor 2011 Myocardial AKT: the omnipresent nexus Physiol Rev 91 3 1023 1070 21742795 10.1152/physrev.00024.2010 1:CAS:528:DC%2BC3MXhtFyjurzN
39. JM Tang QY He RX Guo XJ Chang 2006 Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis Lung Cancer 51 2 181 191 16324768 10.1016/j.lungcan.2005.10.003
40. M Tsikitis Z Zhang W Edelman D Zagzag GV Kalpana 2005 Genetic ablation of Cyclin D1 abrogates genesis of rhabdoid tumors resulting from Ini1 loss Proc Natl Acad Sci USA 102 34 12129 12134 16099835 10.1073/pnas.0505300102 1:CAS:528:DC%2BD2MXps1yqsrg%3D (Pubitemid 41291140)
41. M Upreti EN Galitovskaya R Chu AJ Tackett DT Terrano S Granell TC Chambers 2008 Identification of the major phosphorylation site in Bcl-xL induced by microtubule inhibitors and analysis of its functional significance J Biol Chem 283 51 35517 35525 18974096 10.1074/jbc.M805019200 1:CAS:528: DC%2BD1cXhsVylsrrF
42. A Verma S Kambhampati S Parmar LC Platanias 2003 Jak family of kinases in cancer Cancer Metastasis Rev 22 4 423 434 12884916 10.1023/A:1023805715476 1:CAS:528:DC%2BD3sXjslyiu7g%3D (Pubitemid 36791897)
43. S Vignot S Faivre D Aguirre E Raymond 2005 mTOR-targeted therapy of cancer with rapamycin derivatives Ann Oncol 16 4 525 537 15728109 10.1093/annonc/mdi113 1:STN:280:DC%2BD2M7kvVWmsQ%3D%3D (Pubitemid 40613318)
44. W Wilson 3rd AS Baldwin 2008 Maintenance of constitutive IkappaB kinase activity by glycogen synthase kinase-3alpha/beta in pancreatic cancer Cancer Res 68 19 8156 8163 18829575 10.1158/0008-5472.CAN-08-1061 1:CAS:528: DC%2BD1cXhtF2msLjN
45. Z Xiang Y Zhao V Mitaksov DH Fremont Y Kasai A Molitoris RE Ries TL Miner MD McLellan JF DiPersio DC Link JE Payton TA Graubert M Watson W Shannon SE Heath R Nagarajan ER Mardis RK Wilson TJ Ley MH Tomasson 2008 Identification of somatic JAK1 mutations in patients with acute myeloid leukemia Blood 111 9 4809 4812 18160671 10.1182/blood-2007-05-090308 1:CAS:528:DC%2BD1cXlsVSrsb8%3D
46. HJ Xie HJ Bae JH Noh JW Eun JK Kim KH Jung JC Ryu YM Ahn SY Kim SH Lee NJ Yoo JY Lee WS Park SW Nam 2009 Mutational analysis of JAK1 gene in human hepatocellular carcinoma Neoplasma 56 2 136 140 19239328 10.4149/neo-2009-02-136 1:CAS:528:DC%2BD1MXjs12qtLw%3D
47. H Xiong ZG Zhang XQ Tian DF Sun QC Liang YJ Zhang R Lu YX Chen JY Fang 2008 Inhibition of JAK1, 2/STAT3 signaling induces apoptosis, cell cycle arrest, and reduces tumor cell invasion in colorectal cancer cells Neoplasia 10 3 287 297 18320073 1:CAS:528:DC%2BD1cXltleit7c%3D (Pubitemid 351328587)
48. YT Yeh F Ou-Yang IF Chen SF Yang JH Su MF Hou SS Yuan 2007 Altered p-JAK1 expression is associated with estrogen receptor status in breast infiltrating ductal carcinoma Oncol Rep 17 1 35 39 17143475 1:CAS:528:DC%2BD2sXhtFagtrc%3D
49. A Yoshizawa J Fukuoka S Shimizu K Shilo TJ Franks SM Hewitt T Fujii C Cordon-Cardo J Jen WD Travis 2010 Overexpression of phospho-eIF4E is associated with survival through AKT pathway in non-small cell lung cancer Clin Cancer Res 16 1 240 248 20008839 10.1158/1078-0432.CCR-09-0986 1:CAS:528:DC%2BC3cXotF2k
50. ZZ Zeng CR Yellaturu I Neeli GN Rao 2002 5(S)-hydroxyeicosatetraenoic acid stimulates DNA synthesis in human microvascular endothelial cells via activation of Jak/STAT and phosphatidylinositol 3-kinase/Akt signaling, leading to induction of expression of basic fibroblast growth factor 2 J Biol Chem 277 43 41213 41219 12193593 10.1074/jbc.M204508200 1:CAS:528:DC%2BD38XnvFymsb4%3D (Pubitemid 35215713)
51. F Zhang CJ Phiel L Spece N Gurvich PS Klein 2003 Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3 J Biol Chem 278 35 33067 33077 12796505 10.1074/jbc.M212635200 1:CAS:528:DC%2BD3sXms1als78%3D (Pubitemid 37055753)
52. MX Zhang X Zhao ZG Wang WM Zhao YS Wang 2010 Constitutive activation of signal transducer and activator of transcription 3 regulates expression of vascular endothelial growth factor in human meningioma differentiation J Cancer Res Clin Oncol 136 7 981 988 20052595 10.1007/s00432-009-0743-9 1:CAS:528:DC%2BC3cXmtlyis7g%3D
53. H Zhou S Huang 2010 The complexes of mammalian target of rapamycin Curr Protein Pept Sci 11 6 409 424 20491627 10.2174/138920310791824093 1:CAS:528:DC%2BC3cXhtFersLfK
54. HY Zhou AS Wong 2006 Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells Endocrinology 147 5 2557 2566 16469801 10.1210/en.2005-1404 1:CAS:528:DC%2BD28XjvFOqs7g%3D
55. X Zhou M Tan V Stone Hawthorne KS Klos KH Lan Y Yang W Yang TL Smith D Shi D Yu 2004 Activation of the Akt/mammalian target of rapamycin/4E-BP1 pathway by ErbB2 overexpression predicts tumor progression in breast cancers Clin Cancer Res 10 20 6779 6788 15501954 10.1158/1078-0432.CCR-04-0112 1:CAS:528:DC%2BD2cXpslGlt7c%3D (Pubitemid 39383026)