-
1
-
-
33846457870
-
Cancer statistics, 2007
-
Jemal A, Siegel R, Ward E, Murray T, Xu J, Thun MJ. Cancer statistics, 2007. CA Cancer J Clin 2007;57:43-66.
-
(2007)
CA Cancer J Clin
, vol.57
, pp. 43-66
-
-
Jemal, A.1
Siegel, R.2
Ward, E.3
Murray, T.4
Xu, J.5
Thun, M.J.6
-
4
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB. Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 2005;4:988-1004.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
Lu, Y.4
Mills, G.B.5
-
5
-
-
27844445642
-
Perturbations of the AKT signaling pathway in human cancer
-
Altomare DA, Testa JR. Perturbations of the AKT signaling pathway in human cancer. Oncogene 2005;24:7455-64.
-
(2005)
Oncogene
, vol.24
, pp. 7455-7464
-
-
Altomare, D.A.1
Testa, J.R.2
-
6
-
-
30944442856
-
The Akt pathway in human breast cancer: A tissue-array-based analysis
-
Bose S, Chandran S, Mirocha JM, Bose N. The Akt pathway in human breast cancer: a tissue-array-based analysis. Mod Pathol 2006;19:238-45.
-
(2006)
Mod Pathol
, vol.19
, pp. 238-245
-
-
Bose, S.1
Chandran, S.2
Mirocha, J.M.3
Bose, N.4
-
7
-
-
23944523430
-
The emerging role of the PI3-K-Akt pathway in prostate cancer progression
-
Li L, Ittmann MM, Ayala G, et al. The emerging role of the PI3-K-Akt pathway in prostate cancer progression. Prostate Cancer Prostatic Dis 2005;8:108-18.
-
(2005)
Prostate Cancer Prostatic Dis
, vol.8
, pp. 108-118
-
-
Li, L.1
Ittmann, M.M.2
Ayala, G.3
-
8
-
-
33745260930
-
AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling
-
Riemenschneider MJ, Betensky RA, Pasedag SM, Louis DN. AKT activation in human glioblastomas enhances proliferation via TSC2 and S6 kinase signaling. Cancer Res 2006;66:5618-23.
-
(2006)
Cancer Res
, vol.66
, pp. 5618-5623
-
-
Riemenschneider, M.J.1
Betensky, R.A.2
Pasedag, S.M.3
Louis, D.N.4
-
9
-
-
0038615946
-
Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo
-
Choe G, Horvath S, Cloughesy TF, et al. Analysis of the phosphatidylinositol 3′-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res 2003;63:2742-46.
-
(2003)
Cancer Res
, vol.63
, pp. 2742-2746
-
-
Choe, G.1
Horvath, S.2
Cloughesy, T.F.3
-
10
-
-
21044444976
-
Immunohistochemical analysis of PTEN in endometrial carcinoma: A tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities
-
Pallares J, Bussaglia E, Martinez-Guitarte JL, et al. Immunohistochemical analysis of PTEN in endometrial carcinoma: a tissue microarray study with a comparison of four commercial antibodies in correlation with molecular abnormalities. Mod Pathol 2005;18:719-27.
-
(2005)
Mod Pathol
, vol.18
, pp. 719-727
-
-
Pallares, J.1
Bussaglia, E.2
Martinez-Guitarte, J.L.3
-
11
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004;304:1497-500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
-
12
-
-
33746864883
-
Novel combinations based on epidermal growth factor receptor inhibition
-
Adjei AA. Novel combinations based on epidermal growth factor receptor inhibition. Clin Cancer Res 2006;12:4446-50.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4446-4450
-
-
Adjei, A.A.1
-
13
-
-
11244297916
-
Dysregulation of the TSC-mTOR pathway in human disease
-
Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005;37:19-24.
-
(2005)
Nat Genet
, vol.37
, pp. 19-24
-
-
Inoki, K.1
Corradetti, M.N.2
Guan, K.L.3
-
14
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti MA, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer 2004;4:335-48.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 335-348
-
-
Bjornsti, M.A.1
Houghton, P.J.2
-
15
-
-
33750044299
-
When translation meets transformation: The mTOR story
-
Averous J, Proud CG. When translation meets transformation: the mTOR story. Oncogene 2006;25:6423-35.
-
(2006)
Oncogene
, vol.25
, pp. 6423-6435
-
-
Averous, J.1
Proud, C.G.2
-
16
-
-
8844222002
-
Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions
-
Balsara BR, Pei J, Mitsuuchi Y, et al. Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis 2004;25:2053-9.
-
(2004)
Carcinogenesis
, vol.25
, pp. 2053-2059
-
-
Balsara, B.R.1
Pei, J.2
Mitsuuchi, Y.3
-
17
-
-
31544464931
-
Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways
-
Han S, Khuri FR, Roman J. Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways. Cancer Res 2006;66:315-23.
-
(2006)
Cancer Res
, vol.66
, pp. 315-323
-
-
Han, S.1
Khuri, F.R.2
Roman, J.3
-
18
-
-
23844438209
-
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
-
Sun SY, Rosenberg LM, Wang X, et al. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res 2005;65:7052-8.
-
(2005)
Cancer Res
, vol.65
, pp. 7052-7058
-
-
Sun, S.Y.1
Rosenberg, L.M.2
Wang, X.3
-
19
-
-
0031857122
-
Loss of heterozygosity in the tuberous sclerosis gene associated regions in adenocarcinoma of the lung accompanied by multiple atypical adenomatous hyperplasia
-
Suzuki K, Ogura T, Yokose T, et al. Loss of heterozygosity in the tuberous sclerosis gene associated regions in adenocarcinoma of the lung accompanied by multiple atypical adenomatous hyperplasia. Int J Cancer 1998;79:384-9.
-
(1998)
Int J Cancer
, vol.79
, pp. 384-389
-
-
Suzuki, K.1
Ogura, T.2
Yokose, T.3
-
20
-
-
0035149254
-
Loss of heterozygosity on chromosomes 9q and 16p in atypical adenomatous hyperplasia concomitant with adenocarcinoma of the lung
-
Takamochi K, Ogura T, Suzuki K, et al. Loss of heterozygosity on chromosomes 9q and 16p in atypical adenomatous hyperplasia concomitant with adenocarcinoma of the lung. Am J Pathol 2001;159:1941-8.
-
(2001)
Am J Pathol
, vol.159
, pp. 1941-1948
-
-
Takamochi, K.1
Ogura, T.2
Suzuki, K.3
-
21
-
-
2442648845
-
The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis
-
Ruggero D, Montanaro L, Ma L, et al. The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis. Nat Med 2004;10:484-6.
-
(2004)
Nat Med
, vol.10
, pp. 484-486
-
-
Ruggero, D.1
Montanaro, L.2
Ma, L.3
-
22
-
-
33750068623
-
mTOR, translation initiation and cancer
-
Mamane Y, Petroulakis E, LeBacquer O, Sonenberg N. mTOR, translation initiation and cancer. Oncogene 2006;25:6416-22.
-
(2006)
Oncogene
, vol.25
, pp. 6416-6422
-
-
Mamane, Y.1
Petroulakis, E.2
LeBacquer, O.3
Sonenberg, N.4
-
23
-
-
0029070762
-
Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrumof transformed cell lines
-
Miyagi Y, Sugiyama A, Asai A, Okazaki T, Kuchino Y, Kerr SJ. Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrumof transformed cell lines. Cancer Lett 1995;91:247-52.
-
(1995)
Cancer Lett
, vol.91
, pp. 247-252
-
-
Miyagi, Y.1
Sugiyama, A.2
Asai, A.3
Okazaki, T.4
Kuchino, Y.5
Kerr, S.J.6
-
24
-
-
2342489456
-
eIF-4E expression and its role in malignancies and metastases
-
De Benedetti A, Graff JR. eIF-4E expression and its role in malignancies and metastases. Oncogene 2004;23:3189-99.
-
(2004)
Oncogene
, vol.23
, pp. 3189-3199
-
-
De Benedetti, A.1
Graff, J.R.2
-
25
-
-
32944482803
-
Molecular context of the EGFR mutations: Evidence for the activation of mTOR/S6K signaling
-
Conde E, Angulo B, Tang M, et al. Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling. Clin Cancer Res 2006;12:710-7.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 710-717
-
-
Conde, E.1
Angulo, B.2
Tang, M.3
-
26
-
-
20244367301
-
Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras
-
Wislez M, Spencer ML, Izzo JG, et al. Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras. Cancer Res 2005;65:3226-35.
-
(2005)
Cancer Res
, vol.65
, pp. 3226-3235
-
-
Wislez, M.1
Spencer, M.L.2
Izzo, J.G.3
-
27
-
-
0036796009
-
Expression of eukaryotic initiation factor 4E in atypical adenomatous hyperplasia and adenocarcinoma of the human peripheral lung
-
Seki N, Takasu T, Mandai K, et al. Expression of eukaryotic initiation factor 4E in atypical adenomatous hyperplasia and adenocarcinoma of the human peripheral lung. Clin CancerRes 2002;8:3046-53.
-
(2002)
Clin CancerRes
, vol.8
, pp. 3046-3053
-
-
Seki, N.1
Takasu, T.2
Mandai, K.3
-
28
-
-
0035886531
-
Expression of eukaryotic translation initiation factors 4E and 2α is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung
-
Rosenwald IB, Hutzler MJ, Wang S, Savas L, Fraire AE. Expression of eukaryotic translation initiation factors 4E and 2α is increased frequently in bronchioloalveolar but not in squamous cell carcinomas of the lung. Cancer 2001;92:2164-71.
-
(2001)
Cancer
, vol.92
, pp. 2164-2171
-
-
Rosenwald, I.B.1
Hutzler, M.J.2
Wang, S.3
Savas, L.4
Fraire, A.E.5
-
29
-
-
69949189840
-
Overexpression of eukaryotic initiation factor 4E (eIF4E) and its clinical significance in lung adenocarcinoma
-
Wang R, Geng J, Wang JH, Chu XY, Geng HC, Chen LB. Overexpression of eukaryotic initiation factor 4E (eIF4E) and its clinical significance in lung adenocarcinoma. Lung Cancer 2009.
-
(2009)
Lung Cancer
-
-
Wang, R.1
Geng, J.2
Wang, J.H.3
Chu, X.Y.4
Geng, H.C.5
Chen, L.B.6
-
30
-
-
62549083454
-
Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer
-
Khoury T, Alrawi S, Ramnath N, et al. Eukaryotic initiation factor-4E and cyclin D1 expression associated with patient survival in lung cancer. Clin Lung Cancer 2009;10:58-66.
-
(2009)
Clin Lung Cancer
, vol.10
, pp. 58-66
-
-
Khoury, T.1
Alrawi, S.2
Ramnath, N.3
-
31
-
-
59449103857
-
Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung
-
McDonald JM, Pelloski CE, Ledoux A, et al. Elevated phospho-S6 expression is associated with metastasis in adenocarcinoma of the lung. Clin Cancer Res 2008;14:7832-7.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 7832-7837
-
-
McDonald, J.M.1
Pelloski, C.E.2
Ledoux, A.3
-
33
-
-
34248591612
-
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
-
Roberts PJ, Der CJ. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 2007;26:3291-310.
-
(2007)
Oncogene
, vol.26
, pp. 3291-3310
-
-
Roberts, P.J.1
CJ, D.2
-
34
-
-
20244389188
-
Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib
-
Han SW, Kim TY, Hwang PG, et al. Predictive and prognostic impact of epidermal growth factor receptor mutation in non-small-cell lung cancer patients treated with gefitinib. J Clin Oncol 2005;23:2493-501.
-
(2005)
J Clin Oncol
, vol.23
, pp. 2493-2501
-
-
Han, S.W.1
Kim, T.Y.2
Hwang, P.G.3
-
35
-
-
33646418681
-
Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation
-
Han SW, Kim TY, Jeon YK, et al. Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation. Clin Cancer Res 2006;12:2538-44.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2538-2544
-
-
Han, S.W.1
Kim, T.Y.2
Jeon, Y.K.3
-
36
-
-
1942521000
-
ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours
-
Vicent S, Lopez-Picazo JM, Toledo G, et al. ERK1/2 is activated in non-small-cell lung cancer and associated with advanced tumours. Br J Cancer 2004;90:1047-52.
-
(2004)
Br J Cancer
, vol.90
, pp. 1047-1052
-
-
Vicent, S.1
Lopez-Picazo, J.M.2
Toledo, G.3
-
37
-
-
0038505594
-
Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC)
-
Mukohara T, Kudoh S, Yamauchi S, et al. Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC). Lung Cancer 2003;41:123-30.
-
(2003)
Lung Cancer
, vol.41
, pp. 123-130
-
-
Mukohara, T.1
Kudoh, S.2
Yamauchi, S.3
-
38
-
-
3042851775
-
Chromatin remodeling factors and BRM/BRG1 expression as prognostic indications in non-small cell lung cancer
-
Fukuoka J, Fujii T, Shih JH, et al. Chromatin remodeling factors and BRM/BRG1 expression as prognostic indications in non-small cell lung cancer. Clin Cancer Res 2004;10:4314-24.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4314-4324
-
-
Fukuoka, J.1
Fujii, T.2
Shih, J.H.3
-
39
-
-
33644825286
-
Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors
-
Tsurutani J, Fukuoka J, Tsurutani H, et al. Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors. J Clin Oncol 2006;24:306-14.
-
(2006)
J Clin Oncol
, vol.24
, pp. 306-314
-
-
Tsurutani, J.1
Fukuoka, J.2
Tsurutani, H.3
-
40
-
-
33744726186
-
-
UICC, International Union Against Cancer, 6th ed. New York: Wiley and Sons;
-
UICC, International Union Against Cancer. TNM classification of malignant tumours. 6th ed. New York: Wiley and Sons; 2002.
-
(2002)
TNM classification of malignant tumours
-
-
-
41
-
-
34547645033
-
Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer
-
Ma L, Teruya-Feldstein J, Bonner P, et al. Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer. Cancer Res 2007;67:7106-12.
-
(2007)
Cancer Res
, vol.67
, pp. 7106-7112
-
-
Ma, L.1
Teruya-Feldstein, J.2
Bonner, P.3
-
42
-
-
6044230919
-
Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage
-
David O, Jett J, LeBeau H, et al. Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage. Clin Cancer Res 2004;10:6865-71.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 6865-6871
-
-
David, O.1
Jett, J.2
LeBeau, H.3
-
43
-
-
31344479312
-
Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis
-
Tang JM, He QY, Guo RX, Chang XJ. Phosphorylated Akt overexpression and loss of PTEN expression in non-small cell lung cancer confers poor prognosis. Lung Cancer 2006;51:181-91.
-
(2006)
Lung Cancer
, vol.51
, pp. 181-191
-
-
Tang, J.M.1
He, Q.Y.2
Guo, R.X.3
Chang, X.J.4
-
44
-
-
0037191045
-
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
-
Jaeschke A, Hartkamp J, Saitoh M, et al. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. J Cell Biol 2002;159:217-24.
-
(2002)
J Cell Biol
, vol.159
, pp. 217-224
-
-
Jaeschke, A.1
Hartkamp, J.2
Saitoh, M.3
-
45
-
-
22544455676
-
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
-
Holz MK, Blenis J. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem 2005;280:26089-93.
-
(2005)
J Biol Chem
, vol.280
, pp. 26089-26093
-
-
Holz, M.K.1
Blenis, J.2
-
46
-
-
67449138837
-
High expression of mammalian target of rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma
-
Anagnostou VK, Bepler G, Syrigos KN, et al. High expression of mammalian target of rapamycin is associated with better outcome for patients with early stage lung adenocarcinoma. Clin Cancer Res 2009;15:4157-64.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 4157-4164
-
-
Anagnostou, V.K.1
Bepler, G.2
Syrigos, K.N.3
-
47
-
-
33947716942
-
Expression levels of eIF4E, VEGF, and cyclin D1, and correlation of eIF4E with VEGF and cyclin D1 in multi-tumor tissue microarray
-
Yang SX, Hewitt SM, Steinberg SM, et al. Expression levels of eIF4E, VEGF, and cyclin D1, and correlation of eIF4E with VEGF and cyclin D1 in multi-tumor tissue microarray. Oncol Rep 2007;17:281-7.
-
(2007)
Oncol Rep
, vol.17
, pp. 281-287
-
-
Yang, S.X.1
Hewitt, S.M.2
Steinberg, S.M.3
-
48
-
-
0141733228
-
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin
-
Tee AR, Anjum R, Blenis J. Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. J Biol Chem 2003;278:37288-96.
-
(2003)
J Biol Chem
, vol.278
, pp. 37288-37296
-
-
Tee, A.R.1
Anjum, R.2
Blenis, J.3
-
49
-
-
17444431201
-
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
-
Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005;121: 179-93.
-
(2005)
Cell
, vol.121
, pp. 179-193
-
-
Ma, L.1
Chen, Z.2
Erdjument-Bromage, H.3
Tempst, P.4
Pandolfi, P.P.5
|