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Volumn 11, Issue 10, 2011, Pages 1543-1553

Where now for anti-EGF receptor therapies in colorectal cancer?

Author keywords

biomarkers; cetuximab; colorectal cancer; EGFR; monoclonal antibody; panitumumab

Indexed keywords

AMPHIREGULIN; B RAF KINASE; BIOLOGICAL MARKER; CAPECITABINE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR 3; EPIDERMAL GROWTH FACTOR RECEPTOR 4; EPIREGULIN; FLUOROURACIL; FOLINIC ACID; GANITUMAB; IRINOTECAN; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MUCIN; OXALIPLATIN; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOTRANSFERASE; PROTEIN KINASE B; PROTEIN P53; PROTEIN PIK3CA; PROTEIN TYROSINE KINASE; RILOTUMUMAB; SOMATOMEDIN C; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

EID: 80054724227     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/era.11.143     Document Type: Review
Times cited : (2)

References (104)
  • 1
    • 0031034668 scopus 로고    scopus 로고
    • Incidence and patterns of recurrence following curative resection for colorectal carcinoma
    • DOI 10.1007/BF02055676
    • Obrand DI, Gordon PH. Incidence and patterns of recurrence following curative resection for colorectal carcinoma. Dis. Colon Rectum 40(1), 15-24 (1997). (Pubitemid 27056393)
    • (1997) Diseases of the Colon and Rectum , vol.40 , Issue.1 , pp. 15-24
    • Obrand, D.I.1    Gordon, P.H.2
  • 2
    • 15744374441 scopus 로고    scopus 로고
    • Clinical trial designs for predictive marker validation in cancer treatment trials
    • DOI 10.1200/JCO.2005.01.112
    • Sargent DJ, Conley BA, Allegra C et al. Clinical trial designs for predictive marker validation in cancer treatment trials. J. Clin. Oncol. 23(9), 2020-2027 (2005). (Pubitemid 46211382)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.9 , pp. 2020-2027
    • Sargent, D.J.1    Conley, B.A.2    Allegra, C.3    Collette, L.4
  • 3
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • DOI 10.1200/JCO.2004.10.182
    • Saltz LB, Meropol NJ, Loehrer PJ Sr et al. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J. Clin. Oncol. 22(7), 1201-1208 (2004). (Pubitemid 41079832)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.7 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr., P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 5
    • 26844457534 scopus 로고    scopus 로고
    • The distinctive nature of HER2-positive breast cancers
    • DOI 10.1056/NEJMp058197
    • Burstein HJ. The distinctive nature of HER2-positive breast cancers. N. Engl. J. Med. 353(16), 1652-1654 (2005). (Pubitemid 41464703)
    • (2005) New England Journal of Medicine , vol.353 , Issue.16 , pp. 1652-1654
    • Burstein, H.J.1
  • 9
    • 79956070052 scopus 로고    scopus 로고
    • On behalf of the MRC COIN Trial Investigators. Epidermal growth factor receptor (EGFR) as a predictive and prognostic marker in patients with advanced colorectal cancer (aCRC): The MRC COIN trial experience. ASCO 2011 Gastrointestinal Cancers Symposium 2011
    • Abstract 359
    • Adams RA, Smith CS, Wilson RH et al; on behalf of the MRC COIN Trial Investigators. Epidermal growth factor receptor (EGFR) as a predictive and prognostic marker in patients with advanced colorectal cancer (aCRC): the MRC COIN trial experience. ASCO 2011 Gastrointestinal Cancers Symposium 2011: J. Clin. Oncol. 29(Suppl. 4) (2011) (Abstract 359).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.SUPPL. 4
    • Adams, R.A.1    Smith, C.S.2    Wilson, R.H.3
  • 13
    • 70349939382 scopus 로고    scopus 로고
    • Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
    • Siena S, Sartore-Bianchi A, Di Nicolantonio F et al. Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. J. Natl Cancer Inst. 101(19), 1308-1324 (2009).
    • (2009) J. Natl Cancer Inst. , vol.101 , Issue.19 , pp. 1308-1324
    • Siena, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3
  • 15
    • 34249662360 scopus 로고    scopus 로고
    • Epidermal growth factor receptor analyses in colorectal cancer: A comparison of methods
    • Spindler KL, Lindebjerg J, Nielsen JN et al. Epidermal growth factor receptor analyses in colorectal cancer: a comparison of methods. Int. J. Oncol. 29(5), 1159-1165 (2006).
    • (2006) Int. J. Oncol. , vol.29 , Issue.5 , pp. 1159-1165
    • Spindler, K.L.1    Lindebjerg, J.2    Nielsen, J.N.3
  • 17
    • 73349098041 scopus 로고    scopus 로고
    • Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab
    • Jacobs B, De Roock W, Piessevaux H et al. Amphiregulin and epiregulin mRNA expression in primary tumors predicts outcome in metastatic colorectal cancer treated with cetuximab. J. Clin. Oncol. 27(30), 5068-5074 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.30 , pp. 5068-5074
    • Jacobs, B.1    De Roock, W.2    Piessevaux, H.3
  • 18
    • 77949887855 scopus 로고    scopus 로고
    • Pharmacogenomic and pharmacoproteomic studies of cetuximab in metastatic colorectal cancer: Biomarker analysis of a Phase i dose-escalation study
    • Tabernero J, Cervantes A, Rivera F et al. Pharmacogenomic and pharmacoproteomic studies of cetuximab in metastatic colorectal cancer: biomarker analysis of a Phase I dose-escalation study. J. Clin. Oncol. 28(7), 1181-1189 (2011).
    • (2011) J. Clin. Oncol. , vol.28 , Issue.7 , pp. 1181-1189
    • Tabernero, J.1    Cervantes, A.2    Rivera, F.3
  • 19
    • 79551580548 scopus 로고    scopus 로고
    • Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer
    • Baker JB, Dutta D, Watson D et al. Tumour gene expression predicts response to cetuximab in patients with KRAS wild-type metastatic colorectal cancer. Br. J. Cancer 104, 488-495 (2011).
    • (2011) Br. J. Cancer , vol.104 , pp. 488-495
    • Baker, J.B.1    Dutta, D.2    Watson, D.3
  • 20
    • 44249111440 scopus 로고    scopus 로고
    • EPIC: Phase III trial of cetuximab plus irinotecan after fuoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer
    • Sobrero AF, Maurel J, Fehrenbacher L et al. EPIC: Phase III trial of cetuximab plus irinotecan after fuoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer. J. Clin. Oncol. 26(14), 2311-2319 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.14 , pp. 2311-2319
    • Sobrero, A.F.1    Maurel, J.2    Fehrenbacher, L.3
  • 21
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Kohne CH, Hitre E et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N. Engl. J. Med. 360(14), 1408-1417 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.14 , pp. 1408-1417
    • Van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3
  • 24
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lievre A, Bachet JB, Le Corre D et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 66(8), 3992-3995 (2006).
    • (2006) Cancer Res. , vol.66 , Issue.8 , pp. 3992-3995
    • Lievre, A.1    Bachet, J.B.2    Le Corre, D.3
  • 25
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab effcacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M et al. Wild-type KRAS is required for panitumumab effcacy in patients with metastatic colorectal cancer. J. Clin. Oncol. 26(10), 1626-1634 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.10 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 26
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and beneft from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ et al. K-ras mutations and beneft from cetuximab in advanced colorectal cancer. N. Engl. J. Med. 359(17), 1757-1765 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , Issue.17 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 27
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the frst-line treatment of metastatic colorectal cancer
    • Bokemeyer C, Bondarenko I, Makhson A et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the frst-line treatment of metastatic colorectal cancer. J. Clin. Oncol. 27(5), 663-671 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.5 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 28
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, Phase III trial of panitumumab with infusional fuorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as frst-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
    • Douillard JY, Siena S, Cassidy J et al. Randomized, Phase III trial of panitumumab with infusional fuorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as frst-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J. Clin. Oncol. 28(31), 4697-4705 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.31 , pp. 4697-4705
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3
  • 29
    • 78149239651 scopus 로고    scopus 로고
    • Randomized phase III study of panitumumab with fuorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer
    • Peeters M, Price TJ, Cervantes A et al. Randomized phase III study of panitumumab with fuorouracil, leucovorin, and irinotecan (FOLFIRI) compared with FOLFIRI alone as second-line treatment in patients with metastatic colorectal cancer. J. Clin. Oncol. 28(31), 4706-4713 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.31 , pp. 4706-4713
    • Peeters, M.1    Price, T.J.2    Cervantes, A.3
  • 30
    • 80054738165 scopus 로고    scopus 로고
    • Addition of panitumumab to irinotecan: Results of PICCOLO, a randomized controlled trial in advanced colorectal cancer (aCRC)
    • Abstract 3523
    • Seymour MT. Addition of panitumumab to irinotecan: results of PICCOLO, a randomized controlled trial in advanced colorectal cancer (aCRC). J. Clin. Oncol. 29(Suppl.) (2011) (Abstract 3523).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.SUPPL.
    • Seymour, M.T.1
  • 31
    • 84898700850 scopus 로고    scopus 로고
    • Cetuximab with chemotherapy (CT) as frst-line treatment for metastatic colorectal cancer (mCRC) a meta-analysis of the CRYSTAL and OPUS studies according to K-RAS and BRAF mutation status
    • CA, USA 21-22 January
    • Kohne CH, Rougier, P, Stroh C et al. Cetuximab with chemotherapy (CT) as frst-line treatment for metastatic colorectal cancer (mCRC), a meta-analysis of the CRYSTAL and OPUS studies according to K-RAS and BRAF mutation status. Presented at: Gastrointestinal Cancers Symposium. CA, USA, 21-22 January 2011.
    • (2011) Presented At: Gastrointestinal Cancers Symposium
    • Kohne, C.H.1    Rougier, P.2    Stroh, C.3
  • 32
    • 78649745934 scopus 로고    scopus 로고
    • Identifcation of potentially responsive subsets when cetuximab is added to oxaliplatin-fuoropyrimidine chemotherapy (CT) in frst-line advanced colorectal cancer (aCRC): Mature results of the MRC COIN trial
    • Abstract 3502
    • Maughan TS, Adams RA, Smith CS et al. Identifcation of potentially responsive subsets when cetuximab is added to oxaliplatin-fuoropyrimidine chemotherapy (CT) in frst-line advanced colorectal cancer (aCRC): mature results of the MRC COIN trial. J. Clin. Oncol. 28(Suppl. 15s) (2010) (Abstract 3502).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.SUPPL. 15S
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.S.3
  • 33
    • 58749087713 scopus 로고    scopus 로고
    • Toxicity associated with combination oxaliplatin plus fuoropyrimidine with or without cetuximab in the MRC COIN trial experience
    • Adams RA, Meade AM, Madi A et al. Toxicity associated with combination oxaliplatin plus fuoropyrimidine with or without cetuximab in the MRC COIN trial experience. Br. J. Cancer 100(2), 251-258 (2009).
    • (2009) Br. J. Cancer , vol.100 , Issue.2 , pp. 251-258
    • Adams, R.A.1    Meade, A.M.2    Madi, A.3
  • 34
    • 77955230057 scopus 로고    scopus 로고
    • Targeted therapy in advanced colorectal cancer: More data, more questions
    • Ochenduszko SL, Krzemieniecki K. Targeted therapy in advanced colorectal cancer: more data, more questions. Anticancer Drugs 21(8), 737-748 (2010).
    • (2010) Anticancer Drugs , vol.21 , Issue.8 , pp. 737-748
    • Ochenduszko, S.L.1    Krzemieniecki, K.2
  • 35
    • 79959337678 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatin-based frst-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomised Phase 3 MRC COIN trial
    • Maughan TS, Adams RA, Smith CG et al. Addition of cetuximab to oxaliplatin-based frst-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised Phase 3 MRC COIN trial. Lancet 377(9783), 2103-2114 (2011).
    • (2011) Lancet , vol.377 , Issue.9783 , pp. 2103-2114
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.G.3
  • 36
    • 78049341541 scopus 로고    scopus 로고
    • Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab
    • De Roock W, Jonker DJ, Di Nicolantonio F et al. Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab. JAMA 304(16), 1812-1820 (2010).
    • (2010) JAMA , vol.304 , Issue.16 , pp. 1812-1820
    • De Roock, W.1    Jonker, D.J.2    Di Nicolantonio, F.3
  • 37
    • 79960892233 scopus 로고    scopus 로고
    • Infuence of KRAS G13D mutations on outcome in patients with metastatic colorectal cancer (mCRC) treated with frst-line chemotherapy with or without cetuximab
    • Abstract 3511
    • Tejpar S, Bokemeyer C, Celik I et al. Infuence of KRAS G13D mutations on outcome in patients with metastatic colorectal cancer (mCRC) treated with frst-line chemotherapy with or without cetuximab. J. Clin. Oncol. 29(Suppl.) (2011) (Abstract 3511).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.SUPPL.
    • Tejpar, S.1    Bokemeyer, C.2    Celik, I.3
  • 38
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the effcacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • De Roock W, Claes B, Bernasconi D et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the effcacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol. 11(8), 753-762 (2010).
    • (2010) Lancet Oncol. , vol.11 , Issue.8 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3
  • 39
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Di Nicolantonio F, Martini M, Molinari F A et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J. Clin. Oncol. 26(35), 5705-5712 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.35 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.A.3
  • 40
    • 62449302407 scopus 로고    scopus 로고
    • PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
    • Sartore-Bianchi A, Martini M, Molinari F et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res. 69(5), 1851-1857 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.5 , pp. 1851-1857
    • Sartore-Bianchi, A.1    Martini, M.2    Molinari, F.3
  • 41
    • 80054746341 scopus 로고    scopus 로고
    • BRAF, PIK3CA and KRAS mutations and loss of PTEN expression impair response to EGFR targeted therapies in metastatic colorectal cancer
    • Di Nicolantonio F, Sartore-Bianchi A, Molinari F et al. BRAF, PIK3CA and KRAS mutations and loss of PTEN expression impair response to EGFR targeted therapies in metastatic colorectal cancer. Am. Assoc. Cancer Res. 68, 1953 (2009).
    • (2009) Am. Assoc. Cancer Res. , vol.68 , pp. 1953
    • Di Nicolantonio, F.1    Sartore-Bianchi, A.2    Molinari, F.3
  • 42
    • 80054773779 scopus 로고    scopus 로고
    • Evaluation of BRAF mutation as a powerful prognostic factor in advanced and recurrent colorectal cancer
    • CA USA 21-22 January
    • Yokota T, Ura T, Shibata D et al. Evaluation of BRAF mutation as a powerful prognostic factor in advanced and recurrent colorectal cancer. Presented at: Gastrointestinal Cancers Symposium. CA, USA, 21-22 January 2011.
    • (2011) Presented At: Gastrointestinal Cancers Symposium
    • Yokota, T.1    Ura, T.2    Shibata, D.3
  • 43
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fuorouracil, and leucovorin as frst-line treatment for metastatic colorectal cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E, Kohne CH, Lang I et al. Cetuximab plus irinotecan, fuorouracil, and leucovorin as frst-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J. Clin. Oncol. 29(15), 2011-2019 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.15 , pp. 2011-2019
    • Van Cutsem, E.1    Kohne, C.H.2    Lang, I.3
  • 44
    • 80054751260 scopus 로고    scopus 로고
    • Mutant KRAS and BRAF gene expression profles in colorectal cancer: Results of the translational study on the PETACC 3-EORTC 40993-SAKK
    • Abstract 3505 trial
    • Tejpar S, Popovici V, Delorenzi M et al. Mutant KRAS and BRAF gene expression profles in colorectal cancer: results of the translational study on the PETACC 3-EORTC 40993-SAKK 60-00 trial. J. Clin. Oncol. 28(15 Suppl.) (2010) (Abstract 3505).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.15 SUPPL. , pp. 60-00
    • Tejpar, S.1    Popovici, V.2    Delorenzi, M.3
  • 45
    • 43049101029 scopus 로고    scopus 로고
    • Dual-specifcity MAP kinase phosphatases (MKPs) and cancer
    • Keyse SM. Dual-specifcity MAP kinase phosphatases (MKPs) and cancer. Cancer Metastasis Rev. 27(2), 253-261 (2008).
    • (2008) Cancer Metastasis Rev. , vol.27 , Issue.2 , pp. 253-261
    • Keyse, S.M.1
  • 46
    • 80054765444 scopus 로고    scopus 로고
    • DUSP expression as a predictor of outcome after cetuximab treatment in Kras wild type and mutant colorectal tumors
    • San Francisco, CA, USA 17-19 January
    • De Roock SF, Biesmans B, Jacobs B et al. DUSP expression as a predictor of outcome after cetuximab treatment in Kras wild type and mutant colorectal tumors. Presented at: Gastrointestinal Cancers Symposium. San Francisco, CA, USA, 17-19 January 2009.
    • (2009) Presented At: Gastrointestinal Cancers Symposium
    • De Roock, S.F.1    Biesmans, B.2    Jacobs, B.3
  • 47
    • 68149165771 scopus 로고    scopus 로고
    • Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer
    • Souglakos J, Philips J, Wang R et al. Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br. J. Cancer 101(3), 465-472 (2009).
    • (2009) Br. J. Cancer , vol.101 , Issue.3 , pp. 465-472
    • Souglakos, J.1    Philips, J.2    Wang, R.3
  • 48
    • 79951958340 scopus 로고    scopus 로고
    • A robust immunohistochemical assay for detecting PTEN expression in human tumors
    • Sangale Z, Prass C, Carlson A et al. A robust immunohistochemical assay for detecting PTEN expression in human tumors. Appl. Immunohistochem. Mol. Morphol. 19(2), 173-183 (2010).
    • (2010) Appl. Immunohistochem. Mol. Morphol. , vol.19 , Issue.2 , pp. 173-183
    • Sangale, Z.1    Prass, C.2    Carlson, A.3
  • 49
    • 32544444419 scopus 로고    scopus 로고
    • The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: Influence of tumor site, type of mutation, and adjuvant treatment
    • DOI 10.1200/JCO.2005.00.471
    • Russo A, Bazan V, Iacopetta B et al. The TP53 colorectal cancer international collaborative study on the prognostic and predictive signifcance of p53 mutation: infuence of tumor site, type of mutation, and adjuvant treatment. J. Clin. Oncol. 23(30), 7518-7528 (2005). (Pubitemid 46291815)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.30 , pp. 7518-7528
    • Russo, A.1    Bazan, V.2    Iacopetta, B.3    Kerr, D.4    Soussi, T.5    Gebbia, N.6
  • 50
    • 80054754946 scopus 로고    scopus 로고
    • TP53 mutations in irinotecan-refractory KRAS wt-BRAF wt metastatic colorectal cancer patients treated with cetuximab-based chemotherapy
    • Abstract 426
    • Di Fiore F, Blanchard F, Oden-Gangloff A et al. TP53 mutations in irinotecan-refractory KRAS wt-BRAF wt metastatic colorectal cancer patients treated with cetuximab-based chemotherapy. J. Clin. Oncol. 29(Suppl. 4) (2011) (Abstract 426).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.SUPPL. 4
    • Di Fiore, F.1    Blanchard, F.2    Oden-Gangloff, A.3
  • 52
    • 78651081207 scopus 로고    scopus 로고
    • Safety and effcacy of panitumumab therapy after progression with cetuximab: Experience at two institutions
    • Saif M W, Kaley K, Chu E et al. Safety and effcacy of panitumumab therapy after progression with cetuximab: experience at two institutions. Clin. Colorectal Cancer 5(5), 315-318 (2008).
    • (2008) Clin. Colorectal Cancer , vol.5 , Issue.5 , pp. 315-318
    • Saif, M.W.1    Kaley, K.2    Chu, E.3
  • 53
    • 33748861663 scopus 로고    scopus 로고
    • Mechanisms of resistance to small molecule kinase inhibition in the treatment of solid tumors
    • DOI 10.1038/labinvest.3700466, PII 3700466
    • Rubin BP, Duensing A. Mechanisms of resistance to small molecule kinase inhibition in the treatment of solid tumors. Lab. Ivest. J. Tech. Methods Pathol. 86(10), 981-986 (2006). (Pubitemid 44423063)
    • (2006) Laboratory Investigation , vol.86 , Issue.10 , pp. 981-986
    • Rubin, B.P.1    Duensing, A.2
  • 54
    • 79951772042 scopus 로고    scopus 로고
    • MDR1 polymorphism role in patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancer
    • Paule B, Castagne V, Picard V et al. MDR1 polymorphism role in patients treated with cetuximab and irinotecan in irinotecan refractory colorectal cancer. Med. Oncol. 27(4), 1066-1072 (2011).
    • (2011) Med. Oncol. , vol.27 , Issue.4 , pp. 1066-1072
    • Paule, B.1    Castagne, V.2    Picard, V.3
  • 58
    • 1642587778 scopus 로고    scopus 로고
    • HIP1: Trafficking roles and regulation of tumorigenesis
    • DOI 10.1016/j.molmed.2004.02.003, PII S1471491404000516
    • Hyun TS, Ross TS. HIP1: traffcking roles and regulation of tumorigenesis. Trends Mol. Med. 10(4), 194-199 (2004). (Pubitemid 38410978)
    • (2004) Trends in Molecular Medicine , vol.10 , Issue.4 , pp. 194-199
    • Hyun, T.S.1    Ross, T.S.2
  • 59
    • 70350743119 scopus 로고    scopus 로고
    • Mammary-derived growth inhibitor alters traffc of EGFR and induces a novel form of cetuximab resistance
    • Nevo J, Mattila E, Pellinen T et al. Mammary-derived growth inhibitor alters traffc of EGFR and induces a novel form of cetuximab resistance. Clin. Cancer Res. 15(21), 6570-6581 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.21 , pp. 6570-6581
    • Nevo, J.1    Mattila, E.2    Pellinen, T.3
  • 61
    • 67649472398 scopus 로고    scopus 로고
    • Novel anticancer targets: Revisiting ERBB2 and discovering ERBB3
    • Baselga J, Swain SM. Novel anticancer targets: revisiting ERBB2 and discovering ERBB3. Nature Rev. 9(7), 463-475 (2009).
    • (2009) Nature Rev. , vol.9 , Issue.7 , pp. 463-475
    • Baselga, J.1    Swain, S.M.2
  • 62
    • 70349199083 scopus 로고    scopus 로고
    • Tumor-specifc apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium
    • Lee D, Yu M, Lee E et al. Tumor-specifc apoptosis caused by deletion of the ERBB3 pseudo-kinase in mouse intestinal epithelium. J. Clin. Invest. 119(9), 2702-2713 (2009).
    • (2009) J. Clin. Invest. , vol.119 , Issue.9 , pp. 2702-2713
    • Lee, D.1    Yu, M.2    Lee, E.3
  • 63
    • 33846552656 scopus 로고    scopus 로고
    • Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
    • DOI 10.1038/nature05474, PII NATURE05474
    • Sergina NV, Rausch M, Wang D et al. Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 445(7126), 437-441 (2007). (Pubitemid 46160912)
    • (2007) Nature , vol.445 , Issue.7126 , pp. 437-441
    • Sergina, N.V.1    Rausch, M.2    Wang, D.3    Blair, J.4    Hann, B.5    Shokat, K.M.6    Moasser, M.M.7
  • 64
    • 79952607191 scopus 로고    scopus 로고
    • The role of HER-3 expression in the prediction of clinical outcome for advanced colorectal cancer patients receiving irinotecan and cetuximab
    • Scartozzi M, Mandolesi A, Giampieri R et al. The role of HER-3 expression in the prediction of clinical outcome for advanced colorectal cancer patients receiving irinotecan and cetuximab. Oncologist 16(1), 53-60 (2011).
    • (2011) Oncologist , vol.16 , Issue.1 , pp. 53-60
    • Scartozzi, M.1    Mandolesi, A.2    Giampieri, R.3
  • 65
    • 33645552165 scopus 로고    scopus 로고
    • Prognostic signifcance of HER3 and HER4 protein expression in colorectal adenocarcinomas
    • Kountourakis P, Pavlakis K, Psyrri A et al. Prognostic signifcance of HER3 and HER4 protein expression in colorectal adenocarcinomas. BMC Cancer 6, 46 (2006).
    • (2006) BMC Cancer , vol.6 , pp. 46
    • Kountourakis, P.1    Pavlakis, K.2    Psyrri, A.3
  • 67
    • 70350653741 scopus 로고    scopus 로고
    • Nuclear EGFR contributes to acquired resistance to cetuximab
    • Li C, Iida M, Dunn EF, Ghia AJ et al. Nuclear EGFR contributes to acquired resistance to cetuximab. Oncogene 28(43), 3801-3813 (2009).
    • (2009) Oncogene , vol.28 , Issue.43 , pp. 3801-3813
    • Li, C.1    Iida, M.2    Dunn, E.F.3    Ghia, A.J.4
  • 68
    • 77955386542 scopus 로고    scopus 로고
    • Prognostic value of mucin 4 expression in colorectal adenocarcinomas
    • Shanmugam C, Jhala NC, Katkoori VR et al. Prognostic value of mucin 4 expression in colorectal adenocarcinomas. Cancer 116(15), 3577-3586 (2010).
    • (2010) Cancer , vol.116 , Issue.15 , pp. 3577-3586
    • Shanmugam, C.1    Jhala, N.C.2    Katkoori, V.R.3
  • 69
    • 0037142184 scopus 로고    scopus 로고
    • Rat MUC4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistance
    • DOI 10.1002/ijc.10410
    • Price-Schiavi SA, Jepson S, Li P et al. Rat Muc4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistance. Int. J. Cancer 99(6), 783-791 (2002). (Pubitemid 34575694)
    • (2002) International Journal of Cancer , vol.99 , Issue.6 , pp. 783-791
    • Price-Schiavi, S.A.1    Jepson, S.2    Li, P.3    Arango, M.4    Rudland, P.S.5    Yee, L.6    Carraway, K.L.7
  • 70
    • 0037110602 scopus 로고    scopus 로고
    • Overexpression of the insulin-like growth factor I receptor in human colon carcinomas
    • DOI 10.1002/cncr.10945
    • Weber MM, Fottner C, Liu SB et al. Overexpression of the insulin-like growth factor I receptor in human colon carcinomas. Cancer 95(10), 2086-2095 (2002). (Pubitemid 35253369)
    • (2002) Cancer , vol.95 , Issue.10 , pp. 2086-2095
    • Weber, M.M.1    Fottner, C.2    Liu, S.B.3    Jung, M.C.4    Engelhardt, D.5    Baretton, G.B.6
  • 71
    • 54249117292 scopus 로고    scopus 로고
    • Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors
    • Buck E, Eyzaguirre A, Rosenfeld-Franklin M et al. Feedback mechanisms promote cooperativity for small molecule inhibitors of epidermal and insulin-like growth factor receptors. Cancer Res. 68(20), 8322-8332 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.20 , pp. 8322-8332
    • Buck, E.1    Eyzaguirre, A.2    Rosenfeld-Franklin, M.3
  • 74
    • 62449205665 scopus 로고    scopus 로고
    • Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition
    • Dallas NA, Xia L, Fan F et al. Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition. Cancer Res. 69(5), 1951-1957 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.5 , pp. 1951-1957
    • Dallas, N.A.1    Xia, L.2    Fan, F.3
  • 75
    • 63349086603 scopus 로고    scopus 로고
    • Cetuximab-mediated cellular cytotoxicity is inhibited by HLA-E membrane expression in colon cancer cells
    • Levy EM, Sycz G, Arriaga JM et al. Cetuximab-mediated cellular cytotoxicity is inhibited by HLA-E membrane expression in colon cancer cells. Innate Immunity 15(2), 91-100 (2009).
    • (2009) Innate Immunity , vol.15 , Issue.2 , pp. 91-100
    • Levy, E.M.1    Sycz, G.2    Arriaga, J.M.3
  • 76
    • 77951744287 scopus 로고    scopus 로고
    • New strategies in head and neck cancer: Understanding resistance to epidermal growth factor receptor inhibitors
    • Chen LF, Cohen EE, Grandis JR. New strategies in head and neck cancer: understanding resistance to epidermal growth factor receptor inhibitors. Clin. Cancer Res. 16(9), 2489-2495 (2011).
    • (2011) Clin. Cancer Res. , vol.16 , Issue.9 , pp. 2489-2495
    • Chen, L.F.1    Cohen, E.E.2    Grandis, J.R.3
  • 77
    • 84862807556 scopus 로고    scopus 로고
    • An international consortium study in chemorefractory metastatic colorectal cancer patients to assess the impact of FCGR polymorphisms on cetuximab effcacy
    • Abstract 3528
    • Geva R. An international consortium study in chemorefractory metastatic colorectal cancer patients to assess the impact of FCGR polymorphisms on cetuximab effcacy. J. Clin. Oncol. 29(Suppl.) (2011) (Abstract 3528).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.SUPPL.
    • Geva, R.1
  • 78
    • 55849126233 scopus 로고    scopus 로고
    • Signal integration: A framework for understanding the effcacy of therapeutics targeting the human EGFR family
    • Shepard HM, Brdlik CM, Schreiber H. Signal integration: a framework for understanding the effcacy of therapeutics targeting the human EGFR family. J. Clin. Invest. 118(11), 3574-3581 (2008).
    • (2008) J. Clin. Invest. , vol.118 , Issue.11 , pp. 3574-3581
    • Shepard, H.M.1    Brdlik, C.M.2    Schreiber, H.3
  • 79
    • 73549120610 scopus 로고    scopus 로고
    • High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886)
    • Meng J, Peng H, Dai B et al. High level of AKT activity is associated with resistance to MEK inhibitor AZD6244 (ARRY-142886). Cancer Biol. Ther. 8(21), 2073-2080 (2009).
    • (2009) Cancer Biol. Ther. , vol.8 , Issue.21 , pp. 2073-2080
    • Meng, J.1    Peng, H.2    Dai, B.3
  • 81
    • 77954217891 scopus 로고    scopus 로고
    • Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to geftinib in HCC827 NSCLC cells
    • Kim SM, Kim JS, Kim JH et al. Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to geftinib in HCC827 NSCLC cells. Cancer Lett. 296(2), 150-159 (2010).
    • (2010) Cancer Lett. , vol.296 , Issue.2 , pp. 150-159
    • Kim, S.M.1    Kim, J.S.2    Kim, J.H.3
  • 82
    • 79959640290 scopus 로고    scopus 로고
    • The Ras signaling pathway mediates cetuximab resistance in nasopharyngeal carcinoma
    • Zuo Q, Shi M, Chen J et al. The Ras signaling pathway mediates cetuximab resistance in nasopharyngeal carcinoma. Biomed. Pharmacother. 65(3), 168-174 (2011).
    • (2011) Biomed. Pharmacother. , vol.65 , Issue.3 , pp. 168-174
    • Zuo, Q.1    Shi, M.2    Chen, J.3
  • 84
    • 80054718129 scopus 로고    scopus 로고
    • A Phase II trial of lapatinib and capecitabine for patients with refractory advanced colorectal adenocarcinoma
    • Abstract e14092
    • Frank DJ, Brooks W, Kim et al. A Phase II trial of lapatinib and capecitabine for patients with refractory advanced colorectal adenocarcinoma. J. Clin. Oncol. 28(Suppl.) (2010) (Abstract e14092).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.SUPPL.
    • Frank, D.J.1    Kim, B.W.2
  • 85
    • 54049086648 scopus 로고    scopus 로고
    • HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924
    • Haluska P, Carboni JM, TenEyck C et al. HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924. Mol. Cancer Ther. 7(9), 2589-2598 (2008).
    • (2008) Mol. Cancer Ther. , vol.7 , Issue.9 , pp. 2589-2598
    • Haluska, P.1    Carboni, J.M.2    Teneyck, C.3
  • 86
    • 58249101005 scopus 로고    scopus 로고
    • The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors
    • Huang F, Greer A, Hurlburt W et al. The mechanisms of differential sensitivity to an insulin-like growth factor-1 receptor inhibitor (BMS-536924) and rationale for combining with EGFR/HER2 inhibitors. Cancer Res. 69(1), 161-170 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.1 , pp. 161-170
    • Huang, F.1    Greer, A.2    Hurlburt, W.3
  • 87
    • 66449091211 scopus 로고    scopus 로고
    • Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis
    • Kaulfuss S, Burfeind P, Gaedcke J et al. Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis. Mol. Cancer Ther. 8(4), 821-833 (2009).
    • (2009) Mol. Cancer Ther. , vol.8 , Issue.4 , pp. 821-833
    • Kaulfuss, S.1    Burfeind, P.2    Gaedcke, J.3
  • 88
    • 77957962308 scopus 로고    scopus 로고
    • Randomized, Phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with or without cetuximab, in patients with cetuximab-or panitumumab-refractory metastatic colorectal cancer
    • Reidy DL, Vakiani E, Fakih MG et al. Randomized, Phase II study of the insulin-like growth factor-1 receptor inhibitor IMC-A12, with or without cetuximab, in patients with cetuximab-or panitumumab-refractory metastatic colorectal cancer. J. Clin. Oncol. 28(27), 4240-4246 (2011).
    • (2011) J. Clin. Oncol. , vol.28 , Issue.27 , pp. 4240-4246
    • Reidy, D.L.1    Vakiani, E.2    Fakih, M.G.3
  • 89
    • 80054746340 scopus 로고    scopus 로고
    • A randomized, Phase Ib/II trial of rilotumumab (AMG 102; Ril) or ganitumab (AMG 479; Gan) with panitumumab (pmab) versus pmab alone in patients (pts) with wild-type (WT) KRAS metastatic colorectal cancer (mCRC): Primary and biomarker analyses
    • Abstract 3500
    • Eng C. A randomized, Phase Ib/II trial of rilotumumab (AMG 102; ril) or ganitumab (AMG 479; gan) with panitumumab (pmab) versus pmab alone in patients (pts) with wild-type (WT) KRAS metastatic colorectal cancer (mCRC): primary and biomarker analyses. J. Clin. Oncol. 29(Suppl.) (2011) (Abstract 3500).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.SUPPL.
    • Eng, C.1
  • 90
    • 0035394833 scopus 로고    scopus 로고
    • Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: A role for altered tumor angiogenesis
    • Viloria-Petit A, Crombet T, Jothy S et al. Acquired resistance to the antitumor effect of epidermal growth factor receptor-blocking antibodies in vivo: a role for altered tumor angiogenesis. Cancer Res. 61(13), 5090-5101 (2001). (Pubitemid 32681540)
    • (2001) Cancer Research , vol.61 , Issue.13 , pp. 5090-5101
    • Viloria-Petit, A.1    Crombet, T.2    Jothy, S.3    Hicklin, D.4    Bohlen, P.5    Schlaeppi, J.M.6    Rak, J.7    Kerbel, R.S.8
  • 91
  • 92
    • 59949102930 scopus 로고    scopus 로고
    • A randomized Phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht JR, Mitchell E, Chidiac T et al. A randomized Phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J. Clin. Oncol. 27(5), 672-680 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.5 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 93
    • 49149109102 scopus 로고    scopus 로고
    • Randomized Phase III study of capecitabine, oxaliplatin, and bevacizumab with or without cetuximab in advanced colorectal cancer (ACC), the CAIRO2 study of the Dutch Colorectal Cancer Group (DCCG)
    • Abstract LBA4011
    • Punt C, Tol,J, Rodenburg, CJ et al. Randomized Phase III study of capecitabine, oxaliplatin, and bevacizumab with or without cetuximab in advanced colorectal cancer (ACC), the CAIRO2 study of the Dutch Colorectal Cancer Group (DCCG). J. Clin. Oncol. 26(Suppl.) (2008) (Abstract LBA4011).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.SUPPL.
    • Punt, C.1    Tol, J.2    Rodenburg, C.J.3
  • 94
    • 59749091477 scopus 로고    scopus 로고
    • Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer
    • Tol J, Koopman M, Cats A et al. Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer. N. Engl. J. Med. 360(6), 563-572 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , Issue.6 , pp. 563-572
    • Tol, J.1    Koopman, M.2    Cats, A.3
  • 95
    • 78149274146 scopus 로고    scopus 로고
    • EGFR antibodies in colorectal cancer: Where do they belong? J
    • Grothey A. EGFR antibodies in colorectal cancer: where do they belong? J. Clin. Oncol. 28(31), 4668-4670 (2010).
    • (2010) Clin. Oncol. , vol.28 , Issue.31 , pp. 4668-4670
    • Grothey, A.1
  • 96
    • 80054737917 scopus 로고    scopus 로고
    • Dasatinib (D) in previously treated metastatic colorectal cancer (mCRC) patients: A Phase II trial of the University of Chicago Phase II consortium
    • CA, USA, 21-22 January
    • Sharma M, Kozloff M. Modi SS et al. Dasatinib (D) in previously treated metastatic colorectal cancer (mCRC) patients: a Phase II trial of the University of Chicago Phase II consortium. Presented at: Gastrointestinal Cancers Symposium. CA, USA, 21-22 January 2011.
    • (2011) Presented At: Gastrointestinal Cancers Symposium
    • Sharma, M.1    Kozloff, M.2    Modi, S.S.3
  • 97
    • 77954692090 scopus 로고    scopus 로고
    • Phase IB study of the Src inhibitor dasatinib with FOLFOX and cetuximab in metastatic colorectal cancer
    • (Abstract 3536
    • Lieu CH, Wolff RA, Eng C et al. Phase IB study of the Src inhibitor dasatinib with FOLFOX and cetuximab in metastatic colorectal cancer. J. Clin. Oncol. 28(Suppl. 15) (2010) (Abstract 3536).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.SUPPL. 15
    • Lieu, C.H.1    Wolff, R.A.2    Eng, C.3
  • 98
    • 80054762297 scopus 로고    scopus 로고
    • Phase i study of dasatinib in combination with capecitabine, oxaliplatin, and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer
    • (Abstract 513
    • Strickler J. Phase I study of dasatinib in combination with capecitabine, oxaliplatin, and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer. J. Clin. Oncol. 29(Suppl. 4) (2011) (Abstract 513).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.SUPPL. 4
    • Strickler, J.1
  • 99
    • 77954296394 scopus 로고    scopus 로고
    • 4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors
    • She QB, Halilovic E, Ye Q et al. 4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors. Cancer Cell 18(1), 39-51 (2011).
    • (2011) Cancer Cell , vol.18 , Issue.1 , pp. 39-51
    • She, Q.B.1    Halilovic, E.2    Ye, Q.3
  • 100
    • 78651458656 scopus 로고    scopus 로고
    • AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity
    • Chandarlapaty S, Sawai A, Scaltriti M et al. AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. Cancer Cell 19(1), 58-71 (2011).
    • (2011) Cancer Cell , vol.19 , Issue.1 , pp. 58-71
    • Chandarlapaty, S.1    Sawai, A.2    Scaltriti, M.3
  • 101
    • 79957917078 scopus 로고    scopus 로고
    • PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer
    • Serra V, Scaltriti M, Prudkin L et al. PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer. Oncogene 30(22), 2547-2557 (2011).
    • (2011) Oncogene , vol.30 , Issue.22 , pp. 2547-2557
    • Serra, V.1    Scaltriti, M.2    Prudkin, L.3
  • 102
    • 77954034976 scopus 로고    scopus 로고
    • Downregulation of EGFR by a novel multivalent nanobody-liposome platform
    • Oliveira S, Schiffelers RM, van der Veeken J et al. Downregulation of EGFR by a novel multivalent nanobody-liposome platform. J. Control Release 145(2), 165-175 (2011).
    • (2011) J. Control Release , vol.145 , Issue.2 , pp. 165-175
    • Oliveira, S.1    Schiffelers, R.M.2    Van Der Veeken, J.3
  • 103
    • 65849378710 scopus 로고    scopus 로고
    • Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics
    • Cragg MS, Harris C, Strasser A et al. Unleashing the power of inhibitors of oncogenic kinases through BH3 mimetics. Nat. Rev. 9(5), 321-326 (2009).
    • (2009) Nat. Rev. , vol.9 , Issue.5 , pp. 321-326
    • Cragg, M.S.1    Harris, C.2    Strasser, A.3
  • 104
    • 35648953299 scopus 로고    scopus 로고
    • Geftinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics
    • discussion 1690
    • Cragg MS, Kuroda J, Puthalakath H et al. Geftinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics. PLoS Med. 4(10), 1681-1689; discussion 1690 (2007).
    • (2007) PLoS Med. , vol.4 , Issue.10 , pp. 1681-1689
    • Cragg, M.S.1    Kuroda, J.2    Puthalakath, H.3


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