Volumetric modulated arc therapy: A review of current literature and clinical use in practice

British Journal of Radiology

Volumn 84, Issue 1007, 2011, Pages 967-996

  Teoh, May ^a   Clark, C H ^a,b   Wood, K ^a   Whitaker, S ^a   Nisbet, A ^a  

^a ROYAL SURREY COUNTY HOSPITAL   (United Kingdom)

^b NATIONAL PHYSICAL LABORATORY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ABDOMINAL CANCER; ACOUSTIC NEURINOMA; ANUS CANCER; BRACHYTHERAPY; BRAIN METASTASIS; BREAST CANCER; CANCER RADIOTHERAPY; CANCER SIZE; CLINICAL PRACTICE; DERMATITIS; DUODENUM CANCER; DYSPHAGIA; ESOPHAGUS CANCER; GAMMA KNIFE RADIOSURGERY; GLIOMA; HODGKIN DISEASE; HUMAN; HYPOPHARYNX CANCER; HYPOPHYSIS ADENOMA; INTENSITY MODULATED RADIATION THERAPY; INTERMETHOD COMPARISON; INTRACRANIAL TUMOR; KIDNEY CANCER; LARYNX CANCER; LIVER CANCER; LUNG NON SMALL CELL CANCER; MALIGNANT MESOTHELIOMA; MEDICAL LITERATURE; MENINGIOMA; MOUTH CANCER; MUCOSA INFLAMMATION; NASOPHARYNX CANCER; NOSE CANCER; OROPHARYNX CANCER; OVARY CANCER; PANCREAS CANCER; PARANASAL SINUS CANCER; PAROTID GLAND CANCER; PEDIATRICS; PLEURA MESOTHELIOMA; POSITRON EMISSION TOMOGRAPHY; PROSTATE CANCER; RADIATION DOSE; RECTUM CANCER; RETROPERITONEAL TUMOR; REVIEW; SMALL INTESTINE CANCER; SPINE METASTASIS; STEREOTACTIC BODY RADIATION THERAPY; STOMACH CANCER; SYSTEMATIC REVIEW; THORAX TUMOR; TUMOR LOCALIZATION; UTERINE CERVIX CANCER; VOLUMETRIC MODULATED ARC THERAPY; XEROSTOMIA;

BREAST NEOPLASMS; CENTRAL NERVOUS SYSTEM NEOPLASMS; DIGESTIVE SYSTEM NEOPLASMS; FEMALE; GENITAL NEOPLASMS, FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; MALE; NEOPLASMS; PROSTATIC NEOPLASMS; RADIOTHERAPY DOSAGE; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, INTENSITY-MODULATED; THORACIC NEOPLASMS;

EID: 80054717095     PISSN: 00071285     EISSN: None     Source Type: Journal    
DOI: 10.1259/bjr/22373346     Document Type: Review

References (159)

1. Newbold K, Partridge M, Cook G, Sohaib SA, Charles- Edwards E, Rhys-Evans P, et al. Advanced imaging applied to radiotherapy planning in head and neck cancer: a clinical review. Br J Radiol 2006;79:554-61. (Pubitemid 44083389)
2. Thwaites DI, Tuohy JB. Back to the future: the history and development of the clinical linear accelerator. Phys Med Biol 2006;51:R343-62. (Pubitemid 43958623)
3. Sternick ES (ed). The theory and practice of intensity modulated radiation therapy. Madison WI: Advanced Medical Publishing 1997.
4. Webb S. Intensity-modulated radiation therapy. Bristol: Institute of Physics Publishing 2000.
5. Webb S. Advances in treatment with intensity-modulated conformal radiotherapy. Tumori 1998;84:112-26. (Pubitemid 28232636)
6. Veldeman L, Madani I, Hulstaert F, De Meerleer G, Mareel M, De Neve W. Evidence behind the use of intensity-modulated radiotherapy: a systematic review of comparative clinical studies. Lancet Oncol 2008;9:367-75. (Pubitemid 351411653)
7. Staffurth J. Radiotherapy Development Board. A review of the clinical evidence for intensity-modulated radiotherapy. Clin Oncol 2010;22:643-57.
8. Guerrero Urbano MT, Nutting CM. Clinical use of intensity-modulated radiotherapy: part I. Br J Radiol 2004; 77:88-96. (Pubitemid 38313219)
9. Guerrero Urbano MT, Nutting CM. Clinical use of intensity-modulated radiotherapy: part II. Br J Radiol 2004;77:177-82. (Pubitemid 38404782)
10. Wu Q, Mohan R, Morris M, Lauve A, Schmidt-Ullrich R. Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas: I - dosimetric results. Int J Radiat Oncol Biol Phys 2003;56:573-85. (Pubitemid 36546258)
11. Mohan R, Wu Q, Manning M, Schmidt-Ullrich R. Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers. Int J Radiat Oncol Biol Phys 2000;46:619-30. (Pubitemid 30100639)
12. Saw CB, Ayyangar KM, Zhen W, Yoe-Sein M, Pillai S, Enke CA. Clinical implementation of intensity-modulated radiation therapy. Med Dosim 2002;27:161-9. (Pubitemid 34553479)
13. McNair HA, Adams EJ, Clark CH, Miles EA, Nutting CM. Implementation of IMRT in the radiotherapy department. Br J Radiol 2003;76:859-6.
14. Miles EA, Clark CH, Guerrero Urbano MT, Bidmead M, Dearnaley DP, Harrington KJ, et al. The impact of introducing intensity modulated radiotherapy into routine clinical practice. Radiother Oncol 2005;77:241-6. (Pubitemid 41785331)
15. Intensity Modulated Radiation Therapy Collaborative Working Group. Intensity-modulated radiotherapy: current status and issues of interest. Int J Radiat Oncol Biol Phys 2001;51:880-914.
16. Wang JZ, Li XA, D'Souza WD, Stewart RD. Impact of prolonged fraction delivery times on tumour control: a note of caution for intensity-modulated radiation therapy (IMRT). Int J Radiat Oncol Biol Phys 2003;57:543-52. (Pubitemid 37040952)
17. Withers HR, Taylor JM, Maciejewski B. The hazard of accelerated tumour clonogen repopulation during radiotherapy. Acta Oncol 1988;27:131-46.
18. Bese NS, Hendry J, Jeremic B. Effects of prolongation of overall treatment time due to unplanned interruptions during radiotherapy of different tumour sites and practical methods for compensation. Int J Radiat Oncol Biol Phys 2007;68:654-61. (Pubitemid 46818766)
19. Adams EJ, Convery DJ, CosgroveVP, McNair HA, Staffurth JN, Vaarkamp J, et al. Clinical implementation of dynamic and step-and-shoot IMRT to treat prostate cancer with high risk of pelvic lymph node involvement. Radiother Oncol 2004;70:1-10. (Pubitemid 38177156)
20. Longobardi B, De Martin E, Fiorino C, Dell'oca I, Broggi S, Cattaneo GM, et al. Comparing 3DCRT and inversely optimized IMRT planning for head and neck cancer: equivalence between step-and-shoot and sliding window techniques. Radiother Oncol 2005;77:18-56.
21. Hall EJ, Wuu CS. Radiation-induced second cancers: the impact of 3D-CRT and IMRT. Int J Radiat Oncol Biol Phys 2003;56:83-8. (Pubitemid 36403679)
22. Verellen D, Vanhavere F. Risk assessment of radiation-induced malignancies based on whole-body equivalent dose estimates for IMRT treatment in the head and neck region. Radiother Oncol 1999;53:199-203.
23. Ruben JD, Davis S, Evans C, Jones P, Gagliardi F, Harnes M, Hunter A. The effect of intensity-modulated radiotherapy on radiation-induced second malignancies. Int J Radiat Oncol Biol Phys 2008;70:1530-6.
24. Gershkevitsh E, Clark CH, Staffurth J, Dearnaley DP, Trott KR. Dose to bone marrow using IMRT techniques in prostate cancer patients. Strahlenther Onkol 2005;181:172-8.
25. Palma DA, Verbakel WF, Otto K, Senan S. New developments in arc radiation therapy: a review. Cancer Treat Rev 2010;36:393-9.
26. Yu CX, Li XA, Ma L, Chen D, Naqvi S, Shepard D, et al. Clinical implementation of intensity-modulated arc therapy. Int J Radiat Oncol Biol Phys 2002;53:453-63. (Pubitemid 34522111)
27. Fenwick JD, Tome WA, Soisson ET, Mehta MP, Rock Mackie T. Tomotherapy and other innovative IMRT delivery systems. Semin Radiat Oncol 2006;16:199-208. (Pubitemid 44436960)
28. Verellen D, De Ridder M, Storme G. A (short) history of image-guided radiotherapy. Radiother Oncol 2008;86: 4-13.
29. Verellen D, Ridder MD, Linthout N, Tournel K, Soete G, Storme G. Innovations in image-guided radiotherapy. Nat Rev Cancer 2007;7:949-60. (Pubitemid 350165868)
30. Mackie TR, Holmes T, Swerdloff S, Reckwerdt P, Deasy JO, Yang J et al. Tomotherapy: a new concept for the delivery of dynamic conformal radiotherapy. Med Phys 1993;20:1709-19. (Pubitemid 24001191)
31. Welsh JS, Patel RR, Ritter MA, Harari PM, Mackie TR, Mehta MP. Helical tomotherapy: an innovative technology and approach to radiation therapy. Technol Cancer Res Treat 2002;1(4):311-6. (Pubitemid 36554413)
32. Mackie TR. History of tomotherapy. Phys Med Biol 2006; 51:R427-53. (Pubitemid 43958627)
33. Beavis AW. Is tomotherapy the future of IMRT? Br J Radiol 2004;77:285-95. (Pubitemid 38579112)
34. Sheng K, Molloy JA, Larner JM, Read PW. A dosimetric comparison of non-coplanar IMRT versus helical tomotherapy for nasal cavity and paranasal sinus cancer. Radiother Oncol 2007;82:174-8. (Pubitemid 46275139)
35. Joseph KJ, Syme A, Small C, Warkentin H, Quon H, Ghosh S, et al. A treatment planning study comparing helical tomotherapy with intensity-modulated radiotherapy for the treatment of anal cancer. Radiother Oncol 2010;94:60-6.
36. Van Vulpen M, Field C, Raajmakers CP, Parliament MB, Terhaard CH, Mackenzie MA, et al. Comparing step-andshoot IMRT with dynamic helical tomotherapy IMRT plans for head-and-neck cancer. Int J Radiat Oncol Biol Phys 2005;62:1535-9. (Pubitemid 40982080)
37. Mavroidis P, Shi C, Plataniotis GA, Delichas MG, Costa Ferreira B, Rodriguez S, et al. Comparison of the helical tomotherapy against the multileaf collimator-based intensity- modulated radiotherapy and 3D conformal radiation modalities in lung cancer radiotherapy. Br J Radiol 2011;84:161-72.
38. Lee TF, Fang FM, Chao PJ, Su TJ, Wang LK, Leung SW. Dosimetric comparisons of helical tomotherapy and stepand- shoot intensity-modulated radiotherapy in nasopharyngeal carcinoma. Radiother Oncol 2008;89:89-96.
39. Sterzing F, Sroka-Perez G, Schubert K, Münter MW, Thieke C, Huber P et al. Evaluating target coverage and normal tissue sparing in the adjuvant radiotherapy of malignant pleural mesothelioma: helical tomotherapy compared with step-and-shoot IMRT. Radiother Oncol 2008;86:251-7.
40. Marnitz S, Lukarski D, Kohler C, Wlodarczyk W, Ebert A, Budach V, et al. Helical tomotherapy versus conventional intensity-modulated radiation therapy for primary chemoradiation in cervical cancer patients: an intraindividual comparison. Int J Radiat Oncol Biol Phys 2011;81:424-30.
41. Otto K. Volumetric modulated arc therapy: IMRT in a single gantry arc. Med Phys 2008;35:310-7.
42. Yu CX. Intensity-modulated arc therapy with dynamic multileaf collimation: an alternative to tomotherapy. Phys Med Biol 1995;40:1435-49.
43. Yu CX, Tang G. Intensity-modulated arc therapy: principles, technologies and clinical implementation. Phys Med Biol 2011;56:R31-R54.
44. Dearnaley DP, Sydes MR, Graham JD, Aird EG, Bottomley D, Cowan RA, et al. RT01 collaborators. Escalated-dose versus standard-dose conformal radiotherapy in prostate cancer: first results from the MRC RT01 randomised controlled trial. Lancet Oncol 2007;8:475-87. (Pubitemid 46805903)
45. Zelefsky MJ, Fuks Z, Hunt M, Yamada Y, Marion C, Ling CC, et al. High-dose intensity modulated radiation therapy for prostate cancer: early toxicity and biochemical outcome in 772 patients. Int J Radiat Oncol Biol Phys 2002;53:1111-6. (Pubitemid 34787844)
46. Zelefsky MJ, Levin EJ, Hunt M, Yamada Y, Shippy AM, Jackson A, et al. Incidence of late rectal and urinary toxicities after three-dimensional conformal radiotherapy and intensity-modulated radiotherapy for localized prostate cancer. Int J Radiat Oncol Biol Phys 2008;70:1124-9. (Pubitemid 351296130)
47. De Meerleer GO, Fonteyne VH, Vakaet L, Villeirs GM, Denoyette L, Verbaeys A, et al. Intensity-modulated radiation therapy for prostate cancer: late morbidity and results on biochemical control. Radiother Oncol 2007;82: 160-6.
48. Zelefsky MJ, Yamada Y, Fuks Z, Zhang Z, Hunt M, Cahlon O, et al. Long-term results of conformal radiotherapy for prostate cancer: impact of dose escalation on biochemical tumor control and distant metastases-free survival outcomes. Int J Radiat Oncol Biol Phys 2008;71:1028-33.
49. Kupelian PA, Reddy CA, Carlson TP, Altsman KA, Willoughby TR. Preliminary observations on biochemical relapse-free survival rates after short-course intensity-modulated radiotherapy (70 Gy at 2.5 Gy/fraction) for localized prostate cancer. Int J Radiat Oncol Biol Phys 2002;53:904-12. (Pubitemid 34722635)
50. De Meerleer GO, Vakaet LA, De Gersem WR, De Wagter C, De Naeyer B, De Neve W. Radiotherapy of prostate cancer with or without intensity modulated beams: a planning comparison. Int J Radiat Oncol Biol Phys 2000;47:639-48. (Pubitemid 30317481)
51. Palma D, Vollans E, James K, Nakano S, Moiseenko V, Shaffer R, et al. Volumetric modulated arc therapy for delivery of prostate radiotherapy: comparison with intensity-modulated radiotherapy and three-dimensional conformal radiotherapy. Int J Radiat Oncol Biol Phys 2008;72:996-1001.
52. Zhang P, Happersett L, Hunt M, Jackson A, Zelefsky M, Mageras G. Volumetric modulated arc therapy: planning and evaluation for prostate cancer cases. Int J Radiat Oncol Biol Phys 2010;76:1456-62.
53. Kjaer-Kristoffersen F, Ohlhues L, Medin J, Korreman S. RapidArc volumetric modulated therapy planning for prostate cancer patients. Acta Oncol 2009;48:227-32.
54. Hardcastle N, Tome WA, Foo K, Miller A, Carolan M, Metcalfe P. Comparison of prostate IMRT and VMAT biologically optimised treatment plans. Med Dosim 2011;36:292-8.
55. Ost P, Speleers B, De Meerleer G, De Neve W, Fonteyne V, Villeirs G, et al. Volumetric arc therapy and intensity-modulated radiotherapy for primary prostate radiotherapy with simultaneous integrated boost to intraprostatic lesion with 6 and 18 MV: a planning comparison study. Int J Radiat Oncol Biol Phys 2011;79:920-6.
56. Weber DC, Wang H, Cozzi L, Dipasquale G, Khan HG, Ratib O, et al. RapidArc, intensity modulated photon and proton techniques for recurrent prostate cancer in previously irradiated patients: a treatment planning comparison study. Radiat Oncol 2009;4:34.
57. Kopp RW, Duff M, Catalfamo F, Shah D, Rajecki M, Ahmad K. VMAT vs 7-field IMRT: Assessing the dosimetric parameters of prostate cancer treatment with a 292-patient sample. Med Dosim 2011;4:[Epub ahead of print]
58. Yoo S, Wu QJ, Lee WR, Yin FF. Radiotherapy treatment plans with RapidArc for prostate cancer involving seminal vesicles and lymph nodes. Int J Radiat Oncol Biol Phys 2010;76:935-42.
59. Wolff D, Stieler F, Welzel G, Lorenz F, Abo-Madyan Y, Mai S, et al. Volumetric modulated arc therapy (VMAT) vs. serial tomotherapy, step-and-shoot IMRT and 3D-conformal RT for treatment of prostate cancer. Radiother Oncol 2009;93:226-33.
60. Tsai CL, Wu JK, Chao HL, Tsai YC, Cheng JC. Treatment and dosimetric advantages between VMAT, IMRT, and helical tomotherapy in prostate cancer. Med Dosim 2011;36:264-71.
61. Rao M, Yang W, Chen F, Sheng K, Ye J, Mehta V et al. Comparison of Elekta VMAT with helical tomotherapy and fixed field IMRT: plan quality, delivery efficiency and accuracy. Med Phys 2010;37:1350-9.
62. Shaffer R, Morris WJ, Moiseenko V, Welsh M, Crumley C, Nakano S, et al. Volumetric modulated arc therapy and conventional intensity-modulated radiotherapy for simultaneous maximal intraprostatic boost: a planning comparison study. Clin Oncol 2009;21:401-7.
63. Alvarez Moret J, Koelbl O, Bogner L. Quasi-IMAT technique and secondary cancer risk in prostate cancer. Strahlenther Onkol 2009;185:248-53.
64. Crijns W, Budiharto T, Defraene G, Verstraete J, Depuydt T, Haustermans K, et al. IMRT-based optimization approaches for volumetric modulated single arc radiotherapy planning. Radiother Oncol 2010;95:149-52.
65. Miles EF, Lee WR. Hypofractionation for prostate cancer: a critical review. Semin Radiat Oncol 2008;18:41-7. (Pubitemid 350235955)
66. Ritter M. Rationale, conduct, and outcome using hypofractionated radiotherapy in prostate cancer. Semin Radiat Oncol 2008;18:249-56.
67. Yeoh EE, Botten RJ, Butters J, Di Matteo AC, Holloway RH, Fowler J. Hypofractionated versus conventionally fractionated radiotherapy for prostate carcinoma: final results of phase iii randomized Trial. Int J Radiat Oncol Biol Phys 2010;7:[Epub ahead of print]
68. Rene N, Faria S, Cury F, David M, Duclos M, Shenouda G. et al. Hypofractionated radiotherapy for favorable risk prostate cancer. Int J Radiat Oncol Biol Phys 2010; 77:805-10.
69. Pesce GA, Clivio A, Cozzi L, Nicolini G, Richetti A, Salati E, et al. Early clinical experience of radiotherapy of prostate cancer with volumetric modulated arc therapy. Radiat Oncol 2010;5:54.
70. Mundt AJ, Lujan AE, Rotmensch J, Waggoner SE, Yamada SD, Fleming G, et al. Intensity-modulated whole pelvic radiotherapy in women with gynecologic malignancies. Int J Radiat Oncol Biol Phys 2002;52:1330-7. (Pubitemid 34296492)
71. Portelance L, Chao KS, Grigsby PW, Bennet H, Low D. Intensity-modulated radiation therapy (IMRT) reduces small bowel, rectum, and bladder doses in patients with cervical cancer receiving pelvic and para-aortic irradiation. Int J Radiat Oncol Biol Phys 2001;51:261-6. (Pubitemid 32758886)
72. Meyer JJ, Willett CG, Czito BG. Emerging role of intensity-modulated radiation therapy in anorectal cancer. Expert Rev Anticancer Ther 2008;8:585-93. (Pubitemid 351818353)
73. Pepek JM, Willett CG, Wu QJ, Yoo S, Clough RW, Czito BG. Intensity-modulated radiation therapy for anal malignancies: a preliminary toxicity and disease outcomes analysis. Int J Radiat Oncol Biol Phys 2010;78:1413-9.
74. Guerrero Urbano MT, Henrys AJ, Adams EJ, Norman AR, Bedford JL, Harrington KJ, et al. Intensity-modulated radiotherapy in patients with locally advanced rectal cancer reduces volume of bowel treated to high dose levels. Int J Radiat Oncol Biol Phys 2006;65:907-16. (Pubitemid 43795830)
75. Clivio A, Fogliata A, Franzetti-Pellanda A, Nicolini G, Vanetti E, Wyttenbach R, et al. Volumetric-modulated arc radiotherapy for carcinomas of the anal canal: A treatment planning comparison with fixed field IMRT. Radiother Oncol 2009;92:118-24.
76. Vieillot S, Azria D, Lemanski C, Moscardo CL, Gourgou S, Dubois JB, et al. Plan comparison of volumetric-modulated arc therapy (RapidArc) and conventional intensity-modulated radiation therapy (IMRT) in anal canal cancer. Radiat Oncol 2010;5:92.
77. Stieler F, Wolff D, Lohr F, Steil V, Abo-Madyan Y, Lorenz F, et al. A fast radiotherapy paradigm for anal cancer with volumetric modulated arc therapy (VMAT). Radiat Oncol 2009;4:48.
78. Duthoy W, De Gersem W, Vergote K, Boterberg T, Derie C, Smeets P, et al. Clinical implementation of intensity-modulated arc therapy (IMAT) for rectal cancer. Int J Radiat Oncol Biol Phys 2004;60:794-806. (Pubitemid 39311759)
79. Richetti A, Fogliata A, Clivio A, Nicolini G, Pesce G, Salati E, et al. Neo-adjuvant chemo-radiation of rectal cancer with volumetric modulated arc therapy: summary of technical and dosimetric features and early clinical experience. Radiat Oncol 2010;5:14.
80. Duthoy W, De Gersem W, Vergote K, Coghe M, Boterberg T, De Deene Y, et al. Whole abdominopelvic radiotherapy (WAPRT) using intensity-modulated arc therapy (IMAT): first clinical experience. Int J Radiat Oncol Biol Phys 2003;57:1019-32. (Pubitemid 37324120)
81. Wong E, D'Souza DP, Chen JZ, Lock M, Rodrigues G, Coad T, et al. Intensity-modulated arc therapy for treatment of high-risk endometrial malignancies. Int J Radiat Oncol Biol Phys 2005;61:830-41. (Pubitemid 40247979)
82. Cozzi L, Dinshaw KA, Shrivastava SK, Mahantshetty U, Engineer R, Deshpande DD, et al. A treatment planning study comparing volumetric arc modulation with RapidArc and fixed field IMRT for cervix uteri radiotherapy. Radiother Oncol 2008;89:180-91.
83. Tinger A, Waldron T, Peluso N, Katin MJ, Dosoretz DE, Blitzer PH, et al. Effective palliative radiation therapy in advanced and recurrent ovarian carcinoma. Int J Radiat Oncol Biol Phys 2001;51:1256-63. (Pubitemid 33116319)
84. Hepp R, Baeza MR, Olfos P, Suarez E. Adjuvant whole abdominal radiotherapy in epithelial cancer of the ovary. Int J Radiat Oncol Biol Phys 2002;53:360-5. (Pubitemid 34522102)
85. Hamilton CA, Cheung MK, Osann K, Balzer B, Berman ML, Husain A, et al. The effect of adjuvant chemotherapy versus whole abdominopelvic radiation on the survival of patients with advanced stage uterine papillary serous carcinoma. Gynecol Oncol 2006;103:679-83. (Pubitemid 44602186)
86. Hong L, Alektiar K, Chui C, LoSasso T, Hunt M, Spirou S, et al. IMRT of large fields: whole-abdomen irradiation. Int J Radiat Oncol Biol Phys 2002;54:278-89.
87. Mahantshetty U, Jamema S, Engineer R, Deshpande D, Sarin R, Fogliata A et al. Whole abdomen radiation therapy in ovarian cancers: a comparison between fixed beam and volumetric arc based intensity modulation. Radiat Oncol 2010;5:106.
88. Matsuzak MM, Yan D, Grills I, Martinez A. Clinical applications of volumetric modulated arc therapy. Int J Radiat Oncol Biol Phys 2010;77:608-16.
89. Nutting CM, Morden JP, Harrington KJ, Urbano TG, Bhide SA, Clark C, et al. on behalf of the PARSPORT trial management group. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol 2011;12:127-136.
90. Wu Q, Mohan R, Morris M, Lauve A, Schmidt-Ullrich R. Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas: I - dosimetric results. Int J Radiat Oncol Biol Phys 2003;56:573-85. (Pubitemid 36546258)
91. Verbakel WF, Cuijpers JP, Hoffmans D, Bieker M, Slotman BJ, Senan S. Volumetric intensity-modulated arc therapy vs. conventional IMRT in head-and-neck cancer: a comparative planning and dosimetric study. Int J Radiat Oncol Biol Phys 2009;74:252-9.
92. Vanetti E, Clivio A, Nicolini G, Fogliata A, Ghosh-Laskar S, Agarwal JP, et al. Volumetric modulated arc radiotherapy for carcinomas of the oro-pharynx, hypo-pharynx and larynx: a treatment planning comparison with fixed field IMRT. Radiother Oncol 2009;92:111-7.
93. Johnston M, Clifford S, Bromley R, Back M, Oliver L, Eade T. Volumetric-modulated arc therapy in head and neck radiotherapy: A planning comparison using simultaneous integrated boost for nasopharynx and oropharynx carcinoma. Clin Oncol (R Coll Radiol) 2011;23:503-11.
94. Guckenberger M, Richter A, Krieger T, Wilbert J, Baier K, Flentje M. Is a single arc sufficient in volumetric-modulated arc therapy (VMAT) for complex-shaped target volumes? Radiother Oncol 2009;93:259-65.
95. Bertelsen A, Hansen CR, Johansen J, Brink C. Single arc volumetric modulated arc therapy of head and neck cancer. Radiother Oncol 2010;95:142-8.
96. Alvarez-Moret J, Pohl F, Koelbl O, Dobler B. Evaluation of volumetric modulated arc therapy (VMAT) with Oncentra MasterPlan for the treatment of head and neck cancer. Radiat Oncol 2010;5:110.
97. Eisbruch A, Ten Haken RK, Kim HM, Marsh LH, Ship JA. Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer. Int J Radiat Oncol Biol Phys 1999;45:577-87. (Pubitemid 29462636)
98. Blanco AI, Chao KS, El Naqa I, Franklin GE, Zakarian K, Vicic M, et al. Dose-volume modeling of salivary function in patients with head-and-neck cancer receiving radiotherapy. Int J Radiat Oncol Biol Phys 2005;62:1055-69. (Pubitemid 40884418)
99. van Luijk P, Faber H, Schippers JM, Brandenburg S, Langendijk JA, Meertens H, et al. Bath and shower effects in the rat parotid gland explain increased relative risk of parotid gland dysfunction after intensity-modulated radiotherapy. Int J Radiat Oncol Biol Phys 2009;74:1002-5.
100. Clemente S, Wu B, Sanguineti G, Fusco V, Ricchetti F, Wong J, et al. SmartArc-based volumetric modulated arc therapy for oropharyngeal cancer: a dosimetric comparison with both intensity-modulated radiation therapy and helical tomotherapy. Int J Radiat Oncol Biol Phys 2011;80:1248-55.
101. Scorsetti M, Fogliata A, Castiglioni S, Bressi C, Bignardi M, Navarria P, et al. Early clinical experience with volumetric modulated arc therapy in head and neck cancer patients. Radiat Oncol 2010;5:93.
102. Pigott K, Dische S, Saunders MI. Where exactly does failure occur after radiation in head and neck cancer? Radiother Oncol 1995;37:17-9.
103. Chao KS, Ozyigit G, Tran BN, Cengiz M, Dempsey JF, Low DA. Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer. Int J Radiat Oncol Biol Phys 2003;55:312-21. (Pubitemid 36069088)
104. Bussels B, Maes A, Hermans R, Nuyts S, Weltens C, Van den Bogaert W. Recurrences after conformal parotidsparing radiotherapy for head and neck cancer. Radiother Oncol 2004;72:119-27. (Pubitemid 39024587)
105. Guerrero Urbano MT, Clark CH, Hansen VN, Adams EJ, A'Hern R, Miles EA et al. A phase I study of doseescalated chemoradiation with accelerated intensity modulated radiotherapy in locally advanced head and neck cancer. Radiother Oncol 2007;85:36-41. (Pubitemid 47570062)
106. Lauve A, Morris M, Schmidt-Ullrich R, Wu Q, Mohan R, Abayomi O, et al. Simultaneous integrated boost intensity- modulated radiotherapy for locally advanced headand- neck squamous cell carcinomas: II-clinical results. Int J Radiat Oncol Biol Phys 2004;60:374-87. (Pubitemid 39233454)
107. Madani I, Duthoy W, Derie C, De Gersem W, Botergerg T, Saerens M, et al. Positron emission tomography-guided, focal-dose escalation using intensity-modulated radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys 2007;68:126-35. (Pubitemid 46589860)
108. Korreman SS, Ulrich S, Bowen S, Deveau M, Bentzen SM, Jeraj R. Feasibility of dose painting using volumetric modulated arc optimization and delivery. Acta Oncol 2010;49:964-71.
109. Murshed H, Liu HH, Liao Z, Barker JL, Wang X, Tucker SL, et al. Dose and volume reduction for normal lung using intensity-modulated radiotherapy for advancedstage non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2004;58:1258-67. (Pubitemid 38314812)
110. Chapet O, Khodri M, Jalade P, N'guyen D, Flandin I, D'hombres A, et al. Potential benefits of using non coplanar field and intensity modulated radiation therapy to preserve the heart in irradiation of lung tumors in the middle and lower lobes. Radiother Oncol 2006; 80:333-40. (Pubitemid 44397200)
111. Keall P. 4-dimensional computed tomography imaging and treatment planning. Semin Radiat Oncol 2004;14:81-90. (Pubitemid 38168957)
112. McNair HA, Brock J, Symonds-Tayler JR, Ashley S, Eagle S, Evans PM, et al. Feasibility of the use of the Active Breathing Co ordinator (ABC) in patients receiving radical radiotherapy for non-small cell lung cancer (NSCLC). Radiother Oncol 2009;93:424-9.
113. Suh Y, Weiss E, Zhong H, Fatyga M, Siebers JV, Keall PJ. A deliverable four-dimensional intensity-modulated radiation therapy-planning method for dynamic multileaf collimator tumor tracking delivery. Int J Radiat Oncol Biol Phys 2008;71:1526-36. (Pubitemid 351978172)
114. Hoogeman MS, Nuyttens JJ, Levendag PC, Heijmen BJ. Time dependence of intrafraction patient motion assessed by repeat stereoscopic imaging. Int J Radiat Oncol Biol Phys 2008;70:609-18.
115. Zimmerman J, Korreman S, Persson G, Cattell H, Svatos M, Sawant A, et al. DMLC motion tracking of moving targets for intensity modulated arc therapy treatment: a feasibility study. Acta Oncol 2009;48:245-50.
116. Lagerwaard FJ, Haasbeek CJ, Smit EF, Slotman BJ, Senan S. Outcomes of risk-adapted fractionated stereotactic radiotherapy for stage I non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2008;70:685-92.
117. Xia T, Li H, Sun Q, Wang Y, Fan N, Yu Y, et al. Promising clinical outcome of stereotactic body radiation therapy for patients with inoperable Stage I/II non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2006;66:117-25. (Pubitemid 44175645)
118. Videtic GM, Stephans K, Reddy C, Gajdos S, Kolar M, Clouser E, et al. Intensity-modulated radiotherapy-based stereotactic body radiotherapy for medically inoperable early-stage lung cancer: excellent local control. Int J Radiat Oncol Biol Phys 2010;77:344-9.
119. Baisden JM, Romney DA, Reish AG, Cai J, Sheng K, Jones DR, et al. Dose as a function of lung volume and planned treatment volume in helical tomotherapy intensity-modulated radiation therapy-based stereotactic body radiation therapy for small lung tumors. Int J Radiat Oncol Biol Phys 2007;68:1229-37. (Pubitemid 47048586)
120. McGrath SD, Matuszak MM, Yan D, Kestin LL, Martinez AA, Grills IS. Volumetric modulated arc therapy for delivery of hypofractionated stereotactic lung radiotherapy: A dosimetric and treatment efficiency analysis. Radiother Oncol 2010;95:153-7.
121. Ong CL, Verbakel WF, Cuijpers JP, Slotman BJ, Lagerwaard FJ, Senan S. Stereotactic radiotherapy for peripheral lung tumors: a comparison of volumetric modulated arc therapy with 3 other delivery techniques. Radiother Oncol 2010;97:437-42.
122. Holt A, van Vliet-Vroegindeweij C, Mans A, Belderbos JS, Damen EM. Volumetric-modulated arc therapy for stereotactic body radiotherapy of lung tumors: a comparison with intensity-modulated radiotherapy techniques. Int J Radiat Oncol Biol Phys 2011;5:[Epub ahead of print]
123. Brock J, Bedford J, Nioutsikou E, Partridge M, Ashley S, McNair H, et al. Optimising stereotactic body radiotherapy for non-small cell lung cancer with volumetric intensity-modulated arc therapy - a planning study. Clin Oncol 2011;9:[Epub ahead of print]
124. Bedford JL, Nordmark Hansen V, McNair HA, Aitken AH, Brock JE, Warrington AP, et al. Treatment of lung cancer using volumetric modulated arc therapy and image guidance: a case study. Acta Oncol 2008;47:1438-43.
125. Scorsetti M, Navarria P, Mancosu P, Alongi F, Castiglioni S, Cavina R, et al. Large volume unresectable locally advanced non-small cell lung cancer: acute toxicity and initial outcome results with rapid arc. Radiat Oncol 2010;5:94.
126. Palma DA, Senan S, Haasbeek CJ, Verbakel WF, Vincent A, Lagerwaard F. Radiological and clinical pneumonitis after stereotactic lung radiotherapy: a matched analysis of three-dimensional conformal and volumetric-modulated arc therapy techniques. Int J Radiat Oncol Biol Phys 2011;80:506-13.
127. de Perrot M, Feld R, Cho BC, Bezjak A, Anraku M, Burkes R, et al. Trimodality therapy with induction chemotherapy followed by extrapleural pneumonectomy and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma. J Clin Oncol 2009;27:1413-8.
128. Scorsetti M, Bignardi M, Clivio A, Cozzi L, Fogliata A, Lattuada P, et al. Volumetric modulation arc radiotherapy compared with static gantry intensity-modulated radiotherapy for malignant pleural mesothelioma tumor: a feasibility study. Int J Radiat Oncol Biol Phys 2010;77:942-9.
129. Fogliata A, Clivio A, Nicolini G, Vanetti E, Cozzi L. Intensity modulation with photons for benign intracranial tumours: a planning comparison of volumetric single arc, helical arc and fixed gantry techniques. Radiother Oncol 2008;89:254-62.
130. Lagerwaard FJ, Meijer OW, van der Hoorn EA, Verbakel WF, Slotman BJ, Senan S. Volumetric modulated arc radiotherapy for vestibular schwannomas. Int J Radiat Oncol Biol Phys 2009;74:610-5.
131. MacDonald SM, Ahmad S, Kachris S, Vogds BJ, DeRouen M, Gittleman AE, et al. Intensity modulated radiation therapy versus three-dimensional conformal radiation therapy for the treatment of high grade glioma: a dosimetric comparison. J Appl Clin Med Phys 2007;8:47-60.
132. Wagner D, Christiansen H, Wolff H, Vorwerk H. Radiotherapy of malignant gliomas: comparison of volumetric single arc technique (RapidArc), dynamic intensity- modulated technique and 3D conformal technique. Radiother Oncol 2009;93:593-6.
133. Shaffer R, Nichol AM, Vollans E, Fong M, Nakano S, Moiseenko V, et al. A comparison of volumetric modulated arc therapy and conventional intensity-modulated radiotherapy for frontal and temporal high-grade gliomas. Int J Radiat Oncol Biol Phys 2010;76:1177-84.
134. Andrews DW, Scott CB, Sperduto PW, Flanders AE, Gaspar LE, Schell MC, et al. Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial. Lancet 2004;363: 1665-72. (Pubitemid 38670323)
135. Lagerwaard FJ, van der Hoorn EA, Verbakel WF, Haasbeek CJ, Slotman BJ, Senan S. Whole-brain radiotherapy with simultaneous integrated boost to multiple brain metastases using volumetric modulated arc therapy. Int J Radiat Oncol Biol Phys 2009;75:253-9.
136. Ma Y, Li M, Yin Y, Kong L, Sun X, Lin X, et al. Hypofractionated stereotactic radiotherapy for brain metastases: a dosimetric and treatment
137. Clark GM, Popple RA, Young PE, Fiveash JB. Feasibility of single-isocenter volumetric modulated arc radiosurgery for treatment of multiple brain metastases. Int J Radiat Oncol Biol Phys 2010;76:296-302.
138. Hsu F, Carolan H, Nichol A, Cao F, Nuraney N, Lee R, et al. Whole brain radiotherapy with hippocampal avoidance and simultaneous integrated boost for 1-3 brain metastases: a feasibility study using volumetric modulated arc therapy. Int J Radiat Oncol Biol Phys 2010;76:1480-5.
139. Wu QJ, Yoo S, Kirkpatrick JP, Thongphiew D, Yin FF. Volumetric arc intensity-modulated therapy for spine body radiotherapy: comparison with static intensity-modulated treatment. Int J Radiat Oncol Biol Phys 2009; 75:1596-604.
140. Kuijper IT, Dahele M, Senan S, Verbakel WF. Volumetric modulated arc therapy versus conventional intensity modulated radiation therapy for stereotactic spine radiotherapy: a planning study and early clinical data. Radiother Oncol 2010;94:224-8.
141. Mancosu P, Navarria P, Bignardi M, Cozzi L, Fogliata A, Lattuada P, et al. Re-irradiation of metastatic spinal cord compression: a feasibility study by volumetric-modulated arc radiotherapy for in-field recurrence creating a dosimetric hole on the central canal. Radiother Oncol 2010;94:67-70.
142. Qiu JJ, Chang Z, Wu QJ, Yoo S, Horton J, Yin FF. Impact of volumetric modulated arc therapy technique on treatment with partial breast irradiation. Int J Radiat Oncol Biol Phys 2010;78:288-96.
143. Popescu CC, Olivotto IA, Beckham WA, Ansbacher W, Zavgorodni S, Shaffer R, et al. Volumetric modulated arc therapy improves dosimetry and reduces treatment time compared to conventional intensity-modulated radiotherapy for locoregional radiotherapy of left-sided breast cancer and internal mammary nodes. Int J Radiat Oncol Biol Phys 2010;76:287-95.
144. Johansen S, Cozzi L, Olsen DR. A planning comparison of dose patterns in organs at risk and predicted risk for radiation induced malignancy in the contralateral breast following radiation therapy of primary breast using conventional, IMRT and volumetric modulated arc treatment techniques. Acta Oncol 2009;48:495-503.
145. Nicolini G, Clivio A, Fogliata A, Vanetti E, Cozzi L. Simultaneous integrated boost radiotherapy for bilateral breast: a treatment planning and dosimetric comparison for volumetric modulated arc and fixed field intensity modulated therapy. Radiat Oncol 2009;4:27.
146. Clarke M, Collins R, Darby S, Davies C, Elphinstone P, Evans E, et al. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. Lancet 2005;366:2087-106. (Pubitemid 41797643)
147. Donovan EM, Ciurlionis L, Fairfoul J, James H, Mayles H, Manktelow S, et al. planning with intensity-modulated radiotherapy and tomotherapy to modulate dose across breast to reflect recurrence risk (IMPORT high trial). Int J Radiat Oncol Biol Phys 2011;75:1064-72.
148. Weber DC, Peguret N, Dipasquale G, Cozzi L. Involved-node and involved-field volumetric modulated arc vs. fixed beam intensity-modulated radiotherapy for female patients with early-stage supra-diaphragmatic Hodgkin lymphoma: a comparative planning study. Int J Radiat Oncol Biol Phys 2009;75:1578-86.
149. W, Lagerwaard F, Verbakel W, Slotman B, Senan S. Volumetric modulated arc therapy for advanced pancreatic cancer. Strahlenther Onkol 2010;186:382-7.
150. Llacer-Moscardo C, Quenet F, Azria D, Fenoglietto P. Feasibility study of volumetric modulated arc therapy for the treatment of retroperitoneal sarcomas. Radiat Oncol 2010;5:83.
151. Benthuysen LV, Hales L, Podgorsak MB. Volumetric modulated arc therapy vs IMRT for the treatment of distal oesophageal cancer. Med Dosim 2011;4:[Epub ahead of print]
152. Hawkins MA, Bedford JL, Warrington AP, Tait DM. Volumetric modulated arc therapy planning for distal oesophageal malignancies. Br J Radiol 2011;22:[Epub ahead of print]
153. Bignardi M, Navarria P, Mancosu P, Cozzi L, Fogliata A, Tozzi A, et al. Critical appraisal of volumetric modulated arc therapy in stereotactic body radiation therapy for metastases to abdominal lymph nodes. Int J Radiat Oncol Biol Phys 2009;75:1570-7.
154. Scorsetti M, Bignardi M, Alongi F, Fogliata A, Mancosu P, Navarria P, et al. Stereotactic body radiation therapy for abdominal targets using volumetric intensity modulated arc therapy with RapidArc: Feasibility and clinical preliminary results. Acta Oncol 2011;50:528-38.
155. Fogliata A, Bergstrom S, Cafaro I, Clivio A, Cozzi L, Dipasquale G, et al. Cranio-spinal irradiation with volumetric modulated arc therapy: A multi-institutional treatment experience. Radiother Oncol 2011;99:79-85.
156. Lee YK, Brooks CJ, Bedford JL, Warrington AP, Saran FH. Development and evaluation of multiple isocentric volumetric modulated arc therapy technique for craniospinal axis radiotherapy planning. Int J Radiat Oncol Biol Phys 2011;22:[Epub ahead of print]
157. Shaffer R, Vollans E, Vellani R, Welsh M, Moiseenko V, Goddard K. A radiotherapy planning study of RapidArc, intensity modulated radiotherapy, three-dimensional conformal radiotherapy, and parallel opposed beams in the treatment of pediatric retroperitoneal tumors. Pediatr Blood Cancer 2011;56:16-23.
158. Fogliata A, Cozzi L, Clivio A, Ibatici A, Mancosu P, Navarria P, et al. Preclinical assessment of volumetric modulated arc therapy for total marrow irradiation. Int J Radiat Oncol Biol Phys 2011;80:628-36.
159. Aydogan B, Yeginer M, Kavak GO, Fan J, Radosevich JA, Gwe-Ya K. Total marrow irradiation with RapidArc volumetric arc therapy. Int J Radiat Oncol Biol Phys 2011;81:592-9.