Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers

International Journal of Radiation Oncology Biology Physics

Volumn 46, Issue 3, 2000, Pages 619-630

  Mohan, Radhe ^a   Wu, Qiuwen ^a   Manning, Matthew ^a   Schmidt Ullrich, Rupert ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Conformal radiotherapy; Fractionation; IMRT

Indexed keywords

ARTICLE; CANCER RADIOTHERAPY; COMPUTER ASSISTED RADIOTHERAPY; DOSIMETRY; HEAD CANCER; HUMAN; NECK CANCER; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION; RADIATION DOSE FRACTIONATION; TARGET ORGAN;

DOSE FRACTIONATION; HEAD AND NECK NEOPLASMS; HUMANS; LYMPH NODES; MODELS, BIOLOGICAL; PARATHYROID NEOPLASMS; PHANTOMS, IMAGING; RADIOBIOLOGY; RELATIVE BIOLOGICAL EFFECTIVENESS;

EID: 0033955922     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(99)00438-1     Document Type: Article

References (13)

1. Withers H.R., Taylor J.M.G., Maciejewski B. The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncolog. 27:1988;131-146.
2. Withers H.R., Peters L.J., Taylor J.M.G., Owen J.B., Morrison W.H., Schultheiss T.E., Keane T., O'Sullivan B., van Dyk J., Gupta N., et al. Local control of carcinoma of the tonsil by radiation therapy An analysis of patterns of fractionation in nine institutions . Int J Radiat Oncol Biol Phys. 33:1995;549-562.
3. Hansen O., Overgaard J., Hansen H.S., Overgaard M., Hoyer M., Jorgensen K.E., Basthold L., Berthelsen A. Importance of overall treatment time for the outcome of radiotherapy of advanced head and neck carcinoma Dependency on tumor differentiation . Radiother Oncol. 43:1997;47-51.
4. Wang C.C. Local control of oropharyngeal carcinoma after two accelerated hyperfractionation radiation therapy schemes. Int J Radiat Oncol Biol Phys. 14:1988;1143-1146.
5. Johnson C.R., Huang D., Khandelwal S., Schmidt-Ullrich R.K. The influence of quantitative tumor measurements on local control in advanced head and neck cancer using concomitant boost accelerated superfractionated irradiation. Int J Radiat Oncol Biol Phys. 32:1995;635-642.
6. Ang K.K., Peters L.J. Concomitant boost radiotherapy in the treatment of head and neck cancers. Semin Radiat Oncol. 2:1992;31-33.
7. Ang K.K., Thames H.D., Peters L.J. Altered fractionation schedules. Perez C.A., Brady L.W. Principles and practice of radiation oncology. 1997;119-142 Lippincott-Raven, Philadelphia.
8. Withers H.R., Peters L.J., Taylor J.M.G., Owen J.B., Morrison W.H., Schultheiss T.E., Keane T., O'Sullivan B., van Dyk J., Gupta N., et al. Late normal tissue sequelae from radiation therapy for carcinoma of the tonsil Patterns of fractionation study of radiobiology . Int J Radiat Oncol Biol Phys. 33:1995;563-568.
9. Maciejewski B., Withers H.R., Taylor J.M.J., Hliniak A. Dose fractionation and regeneration in radiotherapy for cancer of the oral cavity and oropharynx Tumor dose-response and repopulation . Int J Radiat Oncol Biol Phys. 16:1989;831-843.
10. Wu Q, Mohan R. Algorithms and functionality of an IMRT optimization system. Med Phys. Accepted for publication.
11. Wu Q., Schmidt-Ullrich R., Mohan R. The potential for sparing of parotids and escalation of biologically effective dose with intensity-modulated radiation treatments of head and neck cancers A treatment design study . Int J Radiat Oncol Biol Phys. 46:2000;195-205.
12. Niemierko A. Reporting and analyzing dose distributions A concept of equivalent uniform dose . Med Phys. 24:1997;103-110.
13. Ang K.K., Peters L.J., Weber R.S. Concomitant boost radiotherapy schedules in the treatment of carcinoma of the oropharynx and nasopharynx. Int J Radiat Oncol Biol Phys. 19:1990;1339-1345.