Down-regulation of 20-HETE synthesis and signaling inhibits renal adenocarcinoma cell proliferation and tumor growth

Anticancer Research

Volumn 29, Issue 10, 2009, Pages 3819-3824

  Alexanian, Anna ^a   Rufanova, Victoriya A ^a   Miller, Bradley ^a   Flasch, Averia ^a   Roman, Richard J ^a   Sorokin, Andrey ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

20 hydroxyeicosatetraenoic acid; CYP4A; Eicosanoids; Renal adenocarcinoma; Xenograft model

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; CYTOCHROME P450 4A; FATTY ACID SYNTHASE INHIBITOR; HET 0016; HORMONE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; WIT 002;

ARACHIDONIC ACID METABOLISM; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL COUNT; CELL PROLIFERATION; CLEAR CELL CARCINOMA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; FATTY ACID SYNTHESIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; KIDNEY CARCINOMA; KIDNEY PROXIMAL TUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUMOR VOLUME;

AMIDINES; ANIMALS; ARACHIDONIC ACID; CARCINOMA, RENAL CELL; CELL GROWTH PROCESSES; CYTOCHROME P-450 ENZYME SYSTEM; DOWN-REGULATION; HUMANS; HYDROXYEICOSATETRAENOIC ACIDS; KIDNEY NEOPLASMS; MICE; MICE, NUDE; RNA, MESSENGER; TNF-RELATED APOPTOSIS-INDUCING LIGAND; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 71949116212     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. Chao C, Goluszko E, Lee YT, Kolokoltsov AA, Davey RA, Uchida T, Townsend CM Jr and Hellmich MR: Constitutively active CCK2 receptor splice variant increases Src-dependent HIF-1 alpha expression and tumor growth. Oncogene 26: 1013-1019, 2007. (Pubitemid 46272212)
2. Griffith TS, Brunner T, Fletcher SM, Green DR and Ferguson TA: Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270: 1189-1192, 1995.
3. Griffith TS, Fialkov JM, Scott DL, Azuhata T, Williams RD, Wall NR, Altieri DC and Sandler AD: Induction and regulation of tumor necrosis factor-related apoptosis-inducing ligand/Apo-2 ligand-mediated apoptosis in renal cell carcinoma. Cancer Res 62: 3093-3099, 2002. (Pubitemid 34602400)
4. Guo AM, Sheng J, Scicli GM, Arbab AS, Lehman NL, Edwrads PA, Falck JR, Roman RJ and Scicli AG: Expression of CYP4A1 in U251 Human Glioma Cell Induces Hyperproliferative Phenotype in vitro and Rapidly Growing Tumors in vivo. J Pharmacol Exp Ther 2008.
5. Guo M, Roman RJ, Falck JR, Edwards PA and Scicli AG: Human U251 glioma cell proliferation is suppressed by HET0016 [N-hydroxy-N′-(4-butyl-2- methylphenyl)formamidine], a selective inhibitor of CYP4A. J Pharmacol Exp Ther 315: 526-533, 2005.
6. Guo M, Roman RJ, Fenstermacher JD, Brown SL, Falck JR, Arbab AS, Edwards PA and Scicli AG: 9L Gliosarcoma cell proliferation and tumor growth in rats are suppressed by N-hydroxy-N′-(4-butyl-2-methylphenol) formamidine (HET0016), a selective inhibitor of CYP4A. J Pharmacol Exp Ther 317: 97-108, 2006.
7. Matsuyama M, Yoshimura R, Mitsuhashi M, Tsuchida K, Takemoto Y, Kawahito Y, Sano H and Nakatani T: 5-Lipoxygenase inhibitors attenuate growth of human renal cell carcinoma and induce apoptosis through arachidonic acid pathway. Oncol Rep 14: 73-79, 2005.
8. McGiff JC and Carroll MA: Cytochrome P450-dependent arachidonate metabolites, renal function and blood pressure regulation. Adv Prostaglandin Thromboxane Leukot Res 21B: 675-682, 1991.
9. Miyata N and Roman RJ: Role of 20-hydroxyeicosatetraenoic acid (20-HETE) in vascular system. J Smooth Muscle Res 41: 175-193, 2005.
10. Park F, Sweeney WE, Jia G, Roman RJ and Avner ED: 20-HETE mediates proliferation of renal epithelial cells in polycystic kidney disease. J Am Soc Nephrol 208: 1929-1939, 2008.
11. Ramakers C, Ruijter JM, Deprez RH and Moorman AF: Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data. Neurosci Lett 339: 62-66, 2003.
12. Sachdeva K: Renal Cell Carcinoma. eMedicine from WebMD. 1-7-2008. Ref Type: Electronic Citation.
13. Simpson AE: The cytochrome P450 4 (CYP4) family. Gen Pharmacol 28: 351-359, 1997.
14. Sorokin A: Eicosanoids and resistance of cancer cells to chemotherapeutic agents. In: Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy. Bonavida B. (ed.). Humana Press, pp. 133-156, 2008.
15. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, and Speleman F: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 3: RESEARCH0034, 2002.
16. Weiss RH and Lin PY: Kidney cancer: identification of novel targets for therapy. Kidney Int 69: 224-232, 2006.
17. Yoshimura R, Matsuyama M, Kawahito Y, Takemoto Y, Tsuchida K, Kuratsukuri K, Segawa Y, Shinnka T, Sano H and Nakatani T: The effects of cyclooxygenase-2 inhibitors on urological cancer cells. Int J Mol Med 13: 789-793, 2004.