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Volumn 18, Issue 6, 2011, Pages 438-445

Diagnosis of well-differentiated hepatocellular lesions: Role of immunohistochemistry and other ancillary techniques

Author keywords

FISH; focal nodular hyperplasia; hepatocellular adenoma; hepatocellular carcinoma; high grade dysplastic nodule; immunohistochemistry

Indexed keywords

AMYLOID; AMYLOID PROTEIN; BETA CATENIN; C REACTIVE PROTEIN; CARCINOEMBRYONIC ANTIGEN; CD34 ANTIGEN; CLUSTERIN; CYCLASE ASSOCIATED PROTEIN 2; CYTOKERATIN 7; ESTROGEN RECEPTOR; GLUTAMATE AMMONIA LIGASE; GLYPICAN 3; HEAT SHOCK PROTEIN 70; INTERLEUKIN 6 RECEPTOR; PROTEIN; RETICULIN; SERUM AMYLOID ASSOCIATED PROTEIN; SOMATOMEDIN B; UNCLASSIFIED DRUG;

EID: 80054694374     PISSN: 10724109     EISSN: 15334031     Source Type: Journal    
DOI: 10.1097/PAP.0b013e318234abb4     Document Type: Review
Times cited : (65)

References (64)
  • 1
    • 0032171504 scopus 로고    scopus 로고
    • Angioarchitecture and blood circulation in focal nodular hyperplasia of the liver
    • DOI 10.1016/S0168-8278(98)80067-6
    • Fukukura Y, Nakashima O, Kusaba A, et al. Angioarchitecture and blood circulation in focal nodular hyperplasia of the liver. J Hepatol. 1998;29:470-475. (Pubitemid 28396666)
    • (1998) Journal of Hepatology , vol.29 , Issue.3 , pp. 470-475
    • Fukukura, Y.1    Nakashima, O.2    Kusaba, A.3    Kage, M.4    Kojiro, M.5
  • 2
    • 0030801180 scopus 로고    scopus 로고
    • Evidence for the polyclonal nature of focal nodular hyperplasia of the liver by the study of X-chromosome inactivation
    • Paradis V, Laurent A, Flejou JF, et al. Evidence for the polyclonal nature of focal nodular hyperplasia of the liver by the study of X-chromosome inactivation. Hepatology. 1997;26:891-895. (Pubitemid 27413654)
    • (1997) Hepatology , vol.26 , Issue.4 , pp. 891-895
    • Paradis, V.1    Laurent, A.2    Flejou, J.-F.3    Vidaud, M.4    Bedossa, P.5
  • 3
    • 0022393813 scopus 로고
    • On the pathogenesis of focal nodular hyperplasia of the liver
    • DOI 10.1002/hep.1840050622
    • Wanless IR, Mawdsley C, Adams R. On the pathogenesis of focal nodular hyperplasia of the liver. Hepatology. 1985;5:1194-1200. (Pubitemid 16222291)
    • (1985) Hepatology , vol.5 , Issue.6 , pp. 1194-1200
    • Wanless, I.R.1    Mawdsley, C.2    Adams, R.3
  • 4
    • 0033858424 scopus 로고    scopus 로고
    • CT and MR imaging findings in focal nodular hyperplasia of the liver: Radiologicpathologic correlation
    • Mortele KJ, Praet M, Van VH, et al. CT and MR imaging findings in focal nodular hyperplasia of the liver: radiologicpathologic correlation. AJR Am J Roentgenol. 2000;175:687-692.
    • (2000) AJR Am J Roentgenol. , vol.175 , pp. 687-692
    • Mortele, K.J.1    Praet, M.2    Van, V.H.3
  • 8
    • 0029829651 scopus 로고    scopus 로고
    • Hepatic sinusoidal fibrosis induced by cholesterol and stilbestrol in the rabbit: 1. Morphology and inhibition of fibrogenesis by dipyridamole
    • DOI 10.1053/jhep.1996.v24.pm0008855188
    • Wanless IR, Belgiorno J, Huet PM. Hepatic sinusoidal fibrosis induced by cholesterol and stilbestrol in the rabbit. 1: morphology and inhibition of fibrogenesis by dipyridamole. Hepatology. 1996;24:855-864. (Pubitemid 26334285)
    • (1996) Hepatology , vol.24 , Issue.4 , pp. 855-864
    • Wanless, I.R.1    Belgiorno, J.2    Huet, P.-M.3
  • 10
    • 33947139689 scopus 로고    scopus 로고
    • Hepatocellular expression of glutamine synthetase: An indicator of morphogen actions as master regulators of zonation in adult liver
    • DOI 10.1016/j.proghi.2006.12.001, PII S0079633606000702
    • Gebhardt R, Baldysiak-Figiel A, Krugel V, et al. Hepatocellular expression of glutamine synthetase: an indicator of morphogen actions as master regulators of zonation in adult liver. Prog Histochem Cytochem. 2007;41:201-266. (Pubitemid 46412421)
    • (2007) Progress in Histochemistry and Cytochemistry , vol.41 , Issue.4 , pp. 201-266
    • Gebhardt, R.1    Baldysiak-Figiel, A.2    Krugel, V.3    Ueberham, E.4    Gaunitz, F.5
  • 11
    • 59849121912 scopus 로고    scopus 로고
    • Overexpression of glutamine synthetase in focal nodular hyperplasia: A novel easy diagnostic tool in surgical pathology
    • Bioulac-Sage P, Laumonier H, Rullier A, et al. Overexpression of glutamine synthetase in focal nodular hyperplasia: a novel easy diagnostic tool in surgical pathology. Liver Int. 2009;29:459-465.
    • (2009) Liver Int. , vol.29 , pp. 459-465
    • Bioulac-Sage, P.1    Laumonier, H.2    Rullier, A.3
  • 12
    • 80054682377 scopus 로고    scopus 로고
    • Diagnostic utility and limitations of glutamine synthetase and serum amyloid associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and telangiectatic hepatic adenoma (abstract)
    • Joseph NM, Jain D, Wu T, et al. Diagnostic utility and limitations of glutamine synthetase and serum amyloid associated protein immunohistochemistry in the distinction of focal nodular hyperplasia and telangiectatic hepatic adenoma (abstract). Mod Path. 2011;24:364A.
    • (2011) Mod Path. , vol.24
    • Joseph, N.M.1    Jain, D.2    Wu, T.3
  • 13
    • 50649106432 scopus 로고    scopus 로고
    • How to classify a benign liver cell tumor in 2008?
    • Paradis V. How to classify a benign liver cell tumor in 2008? Gastroenterol Clin Biol. 2008;32:294-295.
    • (2008) Gastroenterol Clin Biol. , vol.32 , pp. 294-295
    • Paradis, V.1
  • 14
    • 64049116606 scopus 로고    scopus 로고
    • Diagnostic use of cytokeratins, CD34, and neuronal cell adhesion molecule staining in focal nodular hyperplasia and hepatic adenoma
    • Ahmad I, Iyer A, Marginean CE, et al. Diagnostic use of cytokeratins, CD34, and neuronal cell adhesion molecule staining in focal nodular hyperplasia and hepatic adenoma. Hum Pathol. 2009;40:726-734.
    • (2009) Hum Pathol. , vol.40 , pp. 726-734
    • Ahmad, I.1    Iyer, A.2    Marginean, C.E.3
  • 15
    • 48949107360 scopus 로고    scopus 로고
    • Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance
    • Iyer A, Robert ME, Bifulco CB, et al. Different cytokeratin and neuronal cell adhesion molecule staining patterns in focal nodular hyperplasia and hepatic adenoma and their significance. Hum Pathol. 2008;39:1370-1377.
    • (2008) Hum Pathol. , vol.39 , pp. 1370-1377
    • Iyer, A.1    Robert, M.E.2    Bifulco, C.B.3
  • 16
    • 68749096287 scopus 로고    scopus 로고
    • Chromosomal abnormalities determined by comparative genomic hybridization are helpful in the diagnosis of atypical hepatocellular neoplasms
    • Kakar S, Chen X, Ho C, et al. Chromosomal abnormalities determined by comparative genomic hybridization are helpful in the diagnosis of atypical hepatocellular neoplasms. Histopathology. 2009;55:197-205.
    • (2009) Histopathology. , vol.55 , pp. 197-205
    • Kakar, S.1    Chen, X.2    Ho, C.3
  • 19
    • 22244464888 scopus 로고    scopus 로고
    • Glypican-3 and alphafetoprotein as diagnostic tests for hepatocellular carcinoma
    • DOI 10.2165/00066982-200408040-00002
    • Filmus J, Capurro M. Glypican-3 and alphafetoprotein as diagnostic tests for hepatocellular carcinoma. Mol Diagn. 2004;8:207-212. (Pubitemid 40994223)
    • (2004) Molecular Diagnosis , vol.8 , Issue.4 , pp. 207-212
    • Filmus, J.1    Capurro, M.2
  • 20
    • 79952116112 scopus 로고    scopus 로고
    • Assessment of serum GPC3 as a tumor marker for hepatocellular carcinoma and malignant melanoma
    • Komori H, Beppu T, Baba H, et al. Assessment of serum GPC3 as a tumor marker for hepatocellular carcinoma and malignant melanoma. Nihon Rinsho. 2010;68(Suppl 7):833-836.
    • (2010) Nihon Rinsho. , vol.68 , Issue.7 SUPPL. , pp. 833-836
    • Komori, H.1    Beppu, T.2    Baba, H.3
  • 21
    • 69849103763 scopus 로고    scopus 로고
    • Glypican-3 protein expression in primary and metastatic melanoma: A combined immunohistochemistry and immunocytochemistry study
    • Kandil D, Leiman G, Allegretta M, et al. Glypican-3 protein expression in primary and metastatic melanoma: a combined immunohistochemistry and immunocytochemistry study. Cancer. 2009;117:271-278.
    • (2009) Cancer. , vol.117 , pp. 271-278
    • Kandil, D.1    Leiman, G.2    Allegretta, M.3
  • 22
    • 17644401029 scopus 로고    scopus 로고
    • Usefulness of the novel oncofetal antigen glypican-3 for diagnosis of hepatocellular carcinoma and melanoma
    • DOI 10.2165/00063030-200519020-00001
    • Nakatsura T, Nishimura Y. Usefulness of the novel oncofetal antigen glypican-3 for diagnosis of hepatocellular carcinoma and melanoma. Bio Drugs. 2005;19:71-77. (Pubitemid 40559473)
    • (2005) BioDrugs , vol.19 , Issue.2 , pp. 71-77
    • Nakatsura, T.1    Nishimura, Y.2
  • 24
    • 48649084091 scopus 로고    scopus 로고
    • Expression of glypican 3 in ovarian and extragonadal germ cell tumors
    • Zynger DL, Everton MJ, Dimov ND, et al. Expression of glypican 3 in ovarian and extragonadal germ cell tumors. Am J Clin Pathol. 2008;130:224-230.
    • (2008) Am J Clin Pathol. , vol.130 , pp. 224-230
    • Zynger, D.L.1    Everton, M.J.2    Dimov, N.D.3
  • 26
    • 48749100170 scopus 로고    scopus 로고
    • Utility and limitations of glypican-3 expression for the diagnosis of hepatocellular carcinoma at both ends of the differentiation spectrum
    • Shafizadeh N, Ferrell LD, Kakar S. Utility and limitations of glypican-3 expression for the diagnosis of hepatocellular carcinoma at both ends of the differentiation spectrum. Mod Pathol. 2008;21:1011-1018.
    • (2008) Mod Pathol. , vol.21 , pp. 1011-1018
    • Shafizadeh, N.1    Ferrell, L.D.2    Kakar, S.3
  • 30
    • 0037330804 scopus 로고    scopus 로고
    • Hep Par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 Tumors tested using tissue microarrays and conventional tissue sections
    • DOI 10.1097/01.MP.0000052103.13730.20
    • Fan Z, van de Rijn M, Montgomery K, et al. Hep par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 tumors tested using tissue microarrays and conventional tissue sections. Mod Pathol. 2003;16:137-144. (Pubitemid 36245745)
    • (2003) Modern Pathology , vol.16 , Issue.2 , pp. 137-144
    • Fan, Z.1    Van De Rijn, M.2    Montgomery, K.3    Rouse, R.V.4
  • 31
    • 77955154380 scopus 로고    scopus 로고
    • Arginase-1: A new immunohistochemical marker of hepatocytes and hepatocellular neoplasms
    • Yan BC, Gong C, Song J, et al. Arginase-1: a new immunohistochemical marker of hepatocytes and hepatocellular neoplasms. Am J Surg Pathol. 2010;34:1147-1154.
    • (2010) Am J Surg Pathol. , vol.34 , pp. 1147-1154
    • Yan, B.C.1    Gong, C.2    Song, J.3
  • 33
    • 33645223878 scopus 로고    scopus 로고
    • Genotypephenotype correlation in hepatocellular adenoma: New classification and relationship with HCC
    • Zucman-Rossi J, Jeannot E, Nhieu JT, et al. Genotypephenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology. 2006;43:515-524.
    • (2006) Hepatology. , vol.43 , pp. 515-524
    • Zucman-Rossi, J.1    Jeannot, E.2    Nhieu, J.T.3
  • 34
    • 58149326854 scopus 로고    scopus 로고
    • Frequent inframe somatic deletions activate gp130 in inflammatory hepatocellular tumours
    • Rebouissou S, Amessou M, Couchy G, et al. Frequent inframe somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature. 2009;457:200-204.
    • (2009) Nature. , vol.457 , pp. 200-204
    • Rebouissou, S.1    Amessou, M.2    Couchy, G.3
  • 36
    • 0032761853 scopus 로고    scopus 로고
    • Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection
    • Huang H, Fujii H, Sankila A, et al. Beta-catenin mutations are frequent in human hepatocellular carcinomas associated with hepatitis C virus infection. Am J Pathol. 1999;155:1795-1801.
    • (1999) Am J Pathol. , vol.155 , pp. 1795-1801
    • Huang, H.1    Fujii, H.2    Sankila, A.3
  • 37
    • 80054683561 scopus 로고    scopus 로고
    • Immunohistochemical classification of hepatic adenomas and atypical hepatocellular neoplasms: Correlation with clinicopathologic characteristics and chromosomal abnormalities (abstract)
    • Evason K, Grenert JP, Ferrell L, et al. Immunohistochemical classification of hepatic adenomas and atypical hepatocellular neoplasms: correlation with clinicopathologic characteristics and chromosomal abnormalities (abstract). Mod Path. 2010;23:354A.
    • (2010) Mod Path. , vol.23
    • Evason, K.1    Grenert, J.P.2    Ferrell, L.3
  • 38
    • 0026451313 scopus 로고
    • An immunohistochemical study of the blood vessels within primary hepatocellular tumours
    • Dhillon AP, Colombari R, Savage K, et al. An immunohistochemical study of the blood vessels within primary hepatocellular tumours. Liver. 1992;12:311-318.
    • (1992) Liver. , vol.12 , pp. 311-318
    • Dhillon, A.P.1    Colombari, R.2    Savage, K.3
  • 41
    • 33749359258 scopus 로고    scopus 로고
    • A Tumor Progression Model for Hepatocellular Carcinoma: Bioinformatic Analysis of Genomic Data
    • DOI 10.1053/j.gastro.2006.08.014, PII S0016508506017537
    • Poon TC, Wong N, Lai PB, et al. A tumor progression model for hepatocellular carcinoma: bioinformatic analysis of genomic data. Gastroenterology. 2006;131:1262-1270. (Pubitemid 44515104)
    • (2006) Gastroenterology , vol.131 , Issue.4 , pp. 1262-1270
    • Poon, T.C.W.1    Wong, N.2    Lai, P.B.S.3    Rattray, M.4    Johnson, P.J.5    Sung, J.J.Y.6
  • 42
    • 0031936144 scopus 로고    scopus 로고
    • Expression of proliferation associated antigens and detection of numerical chromosome aberrations in primary human liver tumours: Relevance to tumour characteristics and prognosis
    • Nolte M, Werner M, Nasarek A, et al. Expression of proliferation associated antigens and detection of numerical chromosome aberrations in primary human liver tumours: relevance to tumour characteristics and prognosis. J Clin Pathol. 1998;51:47-51. (Pubitemid 28122586)
    • (1998) Journal of Clinical Pathology , vol.51 , Issue.1 , pp. 47-51
    • Nolte, M.1    Werner, M.2    Nasarek, A.3    Bektas, H.4    Von Wasielewski, R.5    Klempnauer, J.6    Georgii, A.7
  • 44
    • 0035071967 scopus 로고    scopus 로고
    • Differentiation of liver cell adenomas from well-differentiated hepatocellular carcinomas by comparative genomic hybridization
    • DOI 10.1002/path.825
    • Wilkens L, Bredt M, Flemming P, et al. Differentiation of liver cell adenomas from well-differentiated hepatocellular carcinomas by comparative genomic hybridization. J Pathol. 2001;193:476-482. (Pubitemid 32266816)
    • (2001) Journal of Pathology , vol.193 , Issue.4 , pp. 476-482
    • Wilkens, L.1    Bredt, M.2    Flemming, P.3    Becker, T.4    Klempnauer, J.5    Kreipe, H.H.6
  • 46
    • 33644789090 scopus 로고    scopus 로고
    • Identification of a unique gene expression signature that differentiates hepatocellular adenoma from well-differentiated hepatocellular carcinoma
    • Chen ZM, Crone KG, Watson MA, et al. Identification of a unique gene expression signature that differentiates hepatocellular adenoma from well-differentiated hepatocellular carcinoma. Am J Surg Pathol. 2005;29:1600-1608.
    • (2005) Am J Surg Pathol. , vol.29 , pp. 1600-1608
    • Chen, Z.M.1    Crone, K.G.2    Watson, M.A.3
  • 47
    • 79952231921 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma: An update
    • Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology. 2011;53:1020-1022.
    • (2011) Hepatology. , vol.53 , pp. 1020-1022
    • Bruix, J.1    Sherman, M.2
  • 48
    • 28844480321 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma
    • DOI 10.1002/hep.20933
    • Bruix J, Sherman M. Management of hepatocellular carcinoma. Hepatology. 2005;42:1208-1236. (Pubitemid 43112690)
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 1208-1236
    • Bruix, J.1    Sherman, M.2
  • 50
    • 21344434090 scopus 로고    scopus 로고
    • Diagnosis of small hepatocellular carcinoma
    • DOI 10.1002/hep.20790
    • Sherman M. Diagnosis of small hepatocellular carcinoma. Hepatology. 2005;42:14-16. (Pubitemid 40911304)
    • (2005) Hepatology , vol.42 , Issue.1 , pp. 14-16
    • Sherman, M.1
  • 51
    • 61949171989 scopus 로고    scopus 로고
    • Pathologic diagnosis of early hepatocellular carcinoma: A report of the international consensus group for hepatocellular neoplasia
    • International Consensus Group for Hepatocellular Neoplasia
    • International Consensus Group for Hepatocellular Neoplasia. Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia. Hepatology. 2009;49:658-64.
    • (2009) Hepatology. , vol.49 , pp. 658-664
  • 52
    • 61949462471 scopus 로고    scopus 로고
    • East-west pathology agreement on precancerous liver lesions and early hepatocellular carcinoma
    • Desmet VJ. East-West pathology agreement on precancerous liver lesions and early hepatocellular carcinoma. Hepatology. 2009;49:355-357.
    • (2009) Hepatology. , vol.49 , pp. 355-357
    • Desmet, V.J.1
  • 53
    • 61749083279 scopus 로고    scopus 로고
    • Hepatocellular dysplastic nodules
    • Roncalli M, Borzio M, Di TL. Hepatocellular dysplastic nodules. Hepatol Res. 2007;37(Suppl 2):S125-S134.
    • (2007) Hepatol Res. , vol.37 , Issue.2 SUPPL.
    • Roncalli, M.1    Borzio, M.2    Di, T.L.3
  • 54
    • 0029155354 scopus 로고
    • Terminology of nodular hepatocellular lesions. International working party
    • Wanless IR. Terminology of nodular hepatocellular lesions. International Working Party. Hepatology. 1995;22:983-993.
    • (1995) Hepatology. , vol.22 , pp. 983-993
    • Wanless, I.R.1
  • 57
    • 0037223571 scopus 로고    scopus 로고
    • Expression profiling in multistage hepatocarcinogenesis: Identification of HSP70 as a molecular marker of early hepatocellular carcinoma
    • DOI 10.1053/jhep.2003.50022
    • Chuma M, Sakamoto M, Yamazaki K, et al. Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma. Hepatology. 2003;37:198-207. (Pubitemid 36042161)
    • (2003) Hepatology , vol.37 , Issue.1 , pp. 198-207
    • Chuma, M.1    Sakamoto, M.2    Yamazaki, K.3    Ohta, T.4    Ohki, M.5    Asaka, M.6    Hirohashi, S.7
  • 59
    • 61749103943 scopus 로고    scopus 로고
    • The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma
    • Di Tommaso L, Destro A, Seok JY, et al. The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma. J Hepatol. 2009;50:746-754.
    • (2009) J Hepatol. , vol.50 , pp. 746-754
    • Di Tommaso, L.1    Destro, A.2    Seok, J.Y.3
  • 61
    • 44949120637 scopus 로고    scopus 로고
    • Candidate molecular markers for histological diagnosis of early hepatocellular carcinoma
    • DOI 10.1159/000122603
    • Sakamoto M, Mori T, Masugi Y, et al. Candidate molecular markers for histological diagnosis of early hepatocellular carcinoma. Intervirology. 2008;51(Suppl 1):42-45. (Pubitemid 351821841)
    • (2008) Intervirology , vol.51 , Issue.SUPPL. 1 , pp. 42-45
    • Sakamoto, M.1    Mori, T.2    Masugi, Y.3    Effendi, K.4    Rie, I.5    Du, W.6
  • 62
    • 38149004217 scopus 로고    scopus 로고
    • Glypican-3 expression in benign liver tissue with active hepatitis C: Implications for the diagnosis of hepatocellular carcinoma
    • Abdul-Al HM, Makhlouf HR, Wang G, et al. Glypican-3 expression in benign liver tissue with active hepatitis C: implications for the diagnosis of hepatocellular carcinoma. Hum Pathol. 2008;39:209-212.
    • (2008) Hum Pathol. , vol.39 , pp. 209-212
    • Abdul-Al, H.M.1    Makhlouf, H.R.2    Wang, G.3


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