Interplay of formulation and process methodology on the extent of nifedipine molecular dispersion in polymers

International Journal of Pharmaceutics

Volumn 420, Issue 1, 2011, Pages 59-67

  Huang, Jingjun ^a,b   Li, Ying ^a,c   Wigent, Rodney J ^a   Malick, Waseem A ^b   Sandhu, Harpreet K ^b   Singhal, Dharmendra ^b   Shah, Navnit H ^b  

^a UNIVERSITY OF THE SCIENCES   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Amorphous solid dispersion; Drug polymer interactions; Formulation; Molecular dispersibility; Process technology

Indexed keywords

ETHYL CELLULOSE; EUDRAGIT; NIFEDIPINE; POLYMER;

ARTICLE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; EVAPORATION; GLASS TRANSITION TEMPERATURE; INFRARED SPECTROSCOPY; PHASE SEPARATION; PRECIPITATION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS TECHNOLOGY; THERMODYNAMICS; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CELLULOSE; CHEMICAL PRECIPITATION; CHEMISTRY, PHARMACEUTICAL; CRYSTALLOGRAPHY, X-RAY; DRUG CARRIERS; DRUG COMPOUNDING; KINETICS; NIFEDIPINE; POLYMERS; POWDER DIFFRACTION; SOLUBILITY; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TECHNOLOGY, PHARMACEUTICAL; TRANSITION TEMPERATURE;

EID: 80054690161     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.08.021     Document Type: Article

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