Stress-induced activation of the brainstem Bcl-xL gene expression in rats treated with fluoxetine: Correlations with serotonin metabolism and depressive-like behavior

Neuropharmacology

Volumn 62, Issue 1, 2012, Pages 177-183

  Shishkina, Galina T ^a   Kalinina, Tatyana S ^a   Berezova, Inna V ^a   Dygalo, Nikolay N ^a  

^a INSTITUTE OF CYTOLOGY AND GENETICS   (Russian Federation)

Author keywords

5 HT turnover; 5 HT1A receptor; Bcl xL; Fluoxetine; Stress; TPH2

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; FLUOXETINE; MESSENGER RNA; PROTEIN BAX; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BCL XL GENE; BRAIN STEM; CONFERENCE PAPER; CONTROLLED STUDY; DEPRESSION; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; FORCED SWIMMING TEST; GENE; GENE EXPRESSION; GENE FUNCTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEROTONIN METABOLISM; STRESS; TREATMENT DURATION;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BRAIN STEM; BRAIN-DERIVED NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; FLUOXETINE; GENE EXPRESSION REGULATION; HYDROXYINDOLEACETIC ACID; MALE; RATS; RATS, WISTAR; RECEPTOR, SEROTONIN, 5-HT1A; RNA, MESSENGER; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SEROTONIN UPTAKE INHIBITORS; STATISTICS AS TOPIC; STRESS, PSYCHOLOGICAL; SWIMMING; TRYPTOPHAN HYDROXYLASE;

EID: 80054095410     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2011.06.016     Document Type: Conference Paper

References (72)

1. P.R. Albert, and S. Lemonde 5-HT1A receptors, gene repression, and depression: guilt by association Neuroscientist 10 2004 575 593 (Pubitemid 39546399)
2. C.A. Altar Neurotrophins and depression Trends Pharmacol. Sci. 20 1999 59 61 (Pubitemid 29323957)
3. J. Amat, M.V. Baratta, E. Paul, S.T. Bland, L.R. Watkins, and S.F. Maier Medial prefrontal cortex determines how stressor controllability affects behavior and dorsal raphe nucleus Nat. Neurosci. 8 2005 365 371 (Pubitemid 40300194)
4. C. Anacker, P.A. Zunszain, L.A. Carvalho, and C.M. Pariante The glucocorticoid receptor: pivot of depression and of antidepressant treatment? Psychoneuroendocrinology 36 2011 415 425
5. H. Anisman Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder J. Psychiatry Neurosci. 34 2009 4 20
6. H. Bach-Mizrachi, M.D. Underwood, S.A. Kassir, M.J. Bakalian, E. Sibille, H. Tamir, J.J. Mann, and V. Arango Neuronal tryptophan hydroxylase mRNA expression in the human dorsal and median raphe nuclei: major depression and suicide Neuropsychopharmacology 31 2006 814 824
7. O. Berton, M. Durand, S. Aguerre, P. Mormde, and F. Chaouloff Behavioral, neuroendocrine and serotonergic consequences of single social defeat and repeated fluoxetine pretreatment in the Lewis rat strain Neuroscience 92 1999 327 341 (Pubitemid 29249042)
8. P. Blier, and C. de Montigny Current advances and trends in the treatment of depression Trends Pharmacol. Sci. 15 1994 220 226 (Pubitemid 24210726)
9. L.H. Boise, M. González-García, C.E. Postema, L. Ding, T. Lindsten, L.A. Turka, X. Mao, G. Nuñez, and C.B. Thompson bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death Cell 74 1993 597 608 (Pubitemid 23259741)
10. W.L. Bonkale, G. Turecki, and M.C. Austin Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus Synapse 60 2006 81 85 (Pubitemid 43742959)
11. J.A. Bravo, G. Díaz-Veliz, S. Mora, J.L. Ulloa, V.M. Berthoud, P. Morales, S. Arancibia, and J.L. Fiedler Desipramine prevents stress-induced changes in depressive-like behavior and hippocampal markers of neuroprotection Behav. Pharmacol. 20 2009 273 285
12. J.D. Bremner, M. Narayan, E.R. Anderson, L.H. Staib, H.L. Miller, and D.S. Charney Hippocampal volume reduction in major depression Am. J. Psychiatry 157 2000 115 118
13. Y.C. Chang, S.I. Rapoport, and J.S. Rao Chronic administration of mood stabilizers upregulates BDNF and bcl-2 expression levels in rat frontal cortex Neurochem. Res. 34 2009 536 541
14. F. Chaouloff Serotonin, stress and corticoids J. Psychopharmacol. 14 2000 139 151 (Pubitemid 30389487)
15. S.H. Chiou, S.J. Chen, C.H. Peng, Y.L. Chang, H.H. Ku, W.M. Hsu, L.L. Ho, and C.H. Lee Fluoxetine up-regulates expression of cellular FLICE-inhibitory protein and inhibits LPS-induced apoptosis in hippocampus-derived neural stem cell Biochem. Biophys. Res. Commun. 343 2006 391 400
16. J.F. Cryan, R.J. Valentino, and I. Lucki Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test Neurosci. Biobehav. Rev. 29 2005 547 569 (Pubitemid 40755456)
17. P.L. Delgado, L.H. Price, H.L. Miller, R.M. Salomon, J. Licinio, J.H. Krystal, G.R. Heninger, and D.S. Charney Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression Psychopharmacol. Bull. 27 1991 321 330
18. M.J. Detke, J. Johnson, and I. Lucki Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression Exp. Clin. Psychopharmacol. 5 1997 107 112 (Pubitemid 27239810)
19. S.K. Droste, L. de Groote, H.C. Atkinson, S.L. Lightman, J.M. Reul, and A.C. Linthorst Corticosterone levels in the brain show a distinct ultradian rhythm but a delayed response to forced swim stress Endocrinology 149 2008 3244 3253 (Pubitemid 351919572)
20. J. Du, B. McEwen, and H.K. Manji Glucocorticoid receptors modulate mitochondrial function: a novel mechanism for neuroprotection Commun. Integr. Biol. 2 2009 350 352
21. R.S. Duman, G.R. Heninger, and E.J. Nestler A molecular and cellular theory of depression Arch. Gen. Psychiatry 54 1997 597 606 (Pubitemid 27306570)
22. R.S. Duman, and L.M. Monteggia A neurotrophic model for stress-related mood disorders Biol. Psychiatry 59 2006 1116 1127
23. N.N. Dygalo, G.T. Shishkina, T.S. Kalinina, A.M. Yudina, and E.S. Ovchinnikova Effect of repeated treatment with fluoxetine on tryptophan hydroxylase-2 gene expression in the rat brainstem Pharmacol. Biochem. Behav. 85 2006 220 227 (Pubitemid 44772924)
24. V. Fabre, C. Beaufour, A. Evrard, A. Rioux, N. Hanoun, K.P. Lesch, D.L. Murphy, L. Lanfumey, M. Hamon, and M.P. Martres Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter Eur. J. Neurosci. 12 2000 2299 2310 (Pubitemid 30497028)
25. T. Frodl, A. Schaub, S. Banac, M. Charypar, M. Jäger, P. Kümmler, R. Bottlender, T. Zetzsche, C. Born, G. Leinsinger, M. Reiser, H.J. Möller, and E.M. Meisenzahl Reduced hippocampal volume correlates with executive dysfunctioning in major depression J. Psychiatry Neurosci. 31 2006 316 323
26. R.W. Fuller Serotonin uptake inhibitors: uses in clinical therapy and in laboratory research Prog. Drug Res. 45 1995 167 204
27. K.L. Gardner, M.W. Hale, S. Oldfield, S.L. Lightman, P.M. Plotsky, and C.A. Lowry Adverse experience during early life and adulthood interact to elevate tph2 mRNA expression in serotonergic neurons within the dorsal raphe nucleus Neuroscience 163 2009 991 1001
28. D.M. Gascoyne, R.M. Kypta, and M.M. Vivanco Glucocorticoids inhibit apoptosis during fibrosarcoma development by transcriptionally activating Bcl-xL J. Biol. Chem. 278 2003 18022 18029 (Pubitemid 36799412)
29. M.M. Gonzalez, and G. Aston-Jones Light deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats Proc. Natl. Acad. Sci. USA 105 2008 4898 4903 (Pubitemid 351753843)
30. M. González-García, I. García, L. Ding, S. O'Shea, L.H. Boise, C.B. Thompson, and G. Núñez bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death Proc. Natl. Acad. Sci. USA 92 1995 4304 4308
31. E. Gould, P. Tanapat, B.S. McEwen, G. Flügge, and E. Fuchs Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress Proc. Natl. Acad. Sci. USA 95 1998 3168 3171 (Pubitemid 28135873)
32. F.G. Graeff, F.S. Guimarães, T.G. De Andrade, and J.F. Deakin Role of 5-HT in stress, anxiety, and depression Pharmacol. Biochem. Behav. 54 1996 129 141 (Pubitemid 26146666)
33. B.N. Greenwood, T.E. Foley, H.E. Day, J. Campisi, S.H. Hammack, S. Campeau, S.F. Maier, and M. Fleshner Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons J. Neurosci. 23 2003 2889 2898 (Pubitemid 36418625)
34. T.V. Gurvits, M.E. Shenton, H. Hokama, H. Ohta, N.B. Lasko, M.W. Gilbertson, S.P. Orr, R. Kikinis, F.A. Jolesz, R.W. McCarley, and R.K. Pitman Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder Biol. Psychiatry 40 1996 1091 1099 (Pubitemid 26400873)
35. C. Hammen Stress and depression Annu. Rev. Clin. Psychol. 1 2005 293 319 (Pubitemid 43843953)
36. W. Heydendael, and L. Jacobson Widespread hypothalamic-pituitary- adrenocortical axis-relevant and mood-relevant effects of chronic fluoxetine treatment on glucocorticoid receptor gene expression in mice Eur. J. Neurosci. 31 2010 892 902
37. V.M. Heine, S. Maslam, J. Zareno, M. Joëls, and P.J. Lucassen Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible Eur. J. Neurosci. 19 2004 131 144 (Pubitemid 38122079)
38. S. Hitoshi, N. Maruta, M. Higashi, A. Kumar, N. Kato, and K. Ikenaka Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress J. Neurosci. Res. 85 2007 3574 3585 (Pubitemid 350228703)
39. F. Holsboer The corticosteroid receptor hypothesis of depression Neuropsychopharmacology 23 2000 477 501
40. E. Jonas Bcl-xL regulates synaptic plasticity Mol. Interv. 6 2006 208 222 (Pubitemid 44455203)
41. T.A. Kosten, M.P. Galloway, R.S. Duman, D.S. Russell, and C. D'Sa Repeated unpredictable stress and antidepressants differentially regulate expression of the bcl-2 family of apoptotic genes in rat cortical, hippocampal, and limbic brain structures Neuropsychopharmacology 33 2008 1545 1558 (Pubitemid 351684697)
42. V. Krishnan, and E.J. Nestler The molecular neurobiology of depression Nature 455 2008 894 902
43. M. Lai, J.A. McCormick, K.E. Chapman, P.A. Kelly, J.R. Seckl, and J.L. Yau Differential regulation of corticosteroid receptors by monoamine neurotransmitters and antidepressant drugs in primary hippocampal culture Neuroscience 118 2003 975 984 (Pubitemid 36561186)
44. K.P. Lesch Serotonergic gene expression and depression: implications for developing novel antidepressants J. Affect. Disord. 62 2001 57 76 (Pubitemid 32126612)
45. K.P. Lesch, C.S. Aulakh, B.L. Wolozin, T.J. Tolliver, J.L. Hill, and D.L. Murphy Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants Brain Res. Mol. Brain Res. 17 1993 31 35
46. H. Li, Y. Chen, A.F. Jones, R.H. Sanger, L.P. Collis, R. Flannery, E.C. McNay, T. Yu, R. Schwarzenbacher, B. Bossy, E. Bossy-Wetzel, M.V. Bennett, M. Pypaert, J.A. Hickman, P.J. Smith, J.M. Hardwick, and E.A. Jonas Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons Proc. Natl. Acad. Sci. USA 105 2008 2169 2174 (Pubitemid 351439483)
47. C.A. Lowry Functional subsets of serotonergic neurones: implications for control of the hypothalamic-pituitary-adrenal axis J. Neuroendocrinol. 14 2002 911 923 (Pubitemid 35378709)
48. L. MacGillivray, L.M. Lagrou, K.B. Reynolds, P.I. Rosebush, and M.F. Mazurek Role of serotonin transporter inhibition in the regulation of tryptophan hydroxylase in brainstem raphe nuclei: time course and regional specificity Neuroscience 171 2010 407 420
49. J.E. Malberg, A.J. Eisch, E.J. Nestler, and R.S. Duman Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus J. Neurosci. 20 2000 9104 9110 (Pubitemid 32042912)
50. H.K. Manji, and R.S. Duman Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics Psychopharmacol. Bull. 35 2001 5 49
51. J.G. McEuen, S.G. Beck, and T.L. Bale Failure to mount adaptive responses to stress results in dysregulation and cell death in the midbrain raphe J. Neurosci. 28 2008 8169 8177
52. B.S. McEwen Physiology and neurobiology of stress and adaptation: central role of the brain Physiol. Rev. 87 2007 873 904 (Pubitemid 47086281)
53. D.P. McKernan, T.G. Dinan, and J.F. Cryan "Killing the Blues": a role for cellular suicide (apoptosis) in depression and the antidepressant response? Prog. Neurobiol. 88 2009 246 263
54. J.F. Neumaier, D.C. Root, and M.W. Hamblin Chronic fluoxetine reduces serotonin transporter mRNA and 5-HT1B mRNA in a sequential manner in the rat dorsal raphe nucleus Neuropsychopharmacology 15 1996 515 522 (Pubitemid 26389875)
55. U. Nudel, R. Zakut, M. Shani, S. Neuman, Z. Levy, and D. Yaffe The nucleotide sequence of the rat cytoplasmic beta-actin gene Nucleic Acids Res. 11 1983 1759 1771
56. J.M. Oliva, L. Urigüen, S. Pérez-Rial, and J. Manzanares Time course of opioid and cannabinoid gene transcription alterations induced by repeated administration with fluoxetine in the rat brain Neuropharmacology 49 2005 618 626 (Pubitemid 41208283)
57. K.S. Panickar, D. Nonner, and J.N. Barrett Overexpression of Bcl-xL protects septal neurons from prolonged hypoglycemia and from acute ischemia-like stress Neuroscience 135 2005 73 80 (Pubitemid 41219739)
58. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates fourth ed 1998 Academic Press London
59. D. Popa, J. Cerdan, C. Repérant, B.P. Guiard, J.P. Guilloux, D.J. David, and A.M. Gardier A longitudinal study of 5-HT outflow during chronic fluoxetine treatment using a new technique of chronic microdialysis in a highly emotional mouse strain Eur. J. Pharmacol. 628 2010 83 90
60. R.D. Porsolt, G. Anton, N. Blavet, and M. Jalfre Behavioural despair in rats: a new model sensitive to antidepressant treatments Eur. J. Pharmacol. 47 1978 379 391
61. J.M. Reul, and E.R. de Kloet Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation Endocrinology 117 1985 2505 2511 (Pubitemid 16194083)
62. J.W. Richardson-Jones, C.P. Craige, B.P. Guiard, A. Stephen, K.L. Metzger, H.F. Kung, A.M. Gardier, A. Dranovsky, D.J. David, S.G. Beck, R. Hen, and E.D. Leonardo 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants Neuron 65 2010 40 52
63. L. Santarelli, M. Saxe, C. Gross, A. Surget, F. Battaglia, S. Dulawa, N. Weisstaub, J. Lee, R. Duman, O. Arancio, C. Belzung, and R. Hen Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants Science 301 2003 805 809 (Pubitemid 36962615)
64. Y.I. Sheline, M. Sanghavi, M.A. Mintun, and M.H. Gado Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression J. Neurosci. 19 1999 5034 5043 (Pubitemid 29270138)
65. G.T. Shishkina, T.S. Kalinina, I.V. Berezova, V.V. Bulygina, and N.N. Dygalo Resistance to the development of stress-induced behavioral despair in the forced swim test associated with elevated hippocampal Bcl-xL expression Behav. Brain Res. 213 2010 218 224
66. G.T. Shishkina, T.S. Kalinina, and N.N. Dygalo Serotonergic changes produced by repeated exposure to forced swimming: correlation with behavior Ann. N. Y. Acad. Sci. 1148 2008 148 153
67. G.T. Shishkina, T.S. Kalinina, and N.N. Dygalo Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect Neuroscience 150 2007 404 412 (Pubitemid 350198715)
68. D. Tardito, J. Perez, E. Tiraboschi, L. Musazzi, G. Racagni, and M. Popoli Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview Pharmacol. Rev. 58 2006 115 134
69. R.J. Valentino, I. Lucki, and E. Van Bockstaele Corticotropin-releasing factor in the dorsal raphe nucleus: linking stress coping and addiction Brain Res. 1314 2010 29 37
70. L.R. Viegas, G.P. Vicent, J.L. Barañao, M. Beato, and A. Pecci Steroid hormones induce bcl-X gene expression through direct activation of distal promoter P4 J. Biol. Chem. 279 2004 9831 9839 (Pubitemid 38372581)
71. J.L. Yau, C. Hibberd, J. Noble, and J.R. Seckl The effect of chronic fluoxetine treatment on brain corticosteroid receptor mRNA expression and spatial memory in young and aged rats Brain Res. Mol. Brain Res. 106 2002 117 123 (Pubitemid 35223284)
72. R. Yehuda, and J. LeDoux Response variation following trauma: a translational neuroscience approach to understanding PTSD Neuron 56 2007 19 32 (Pubitemid 47484180)