Increased tryptophan hydroxylase immunoreactivity in the dorsal raphe nucleus of alcohol-dependent, depressed suicide subjects is restricted to the dorsal subnucleus

Synapse

Volumn 60, Issue 1, 2006, Pages 81-85

  Bonkale, Willy L ^a,d   Turecki, Gustavo ^b   Austin, Mark C ^c  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

^d CTVHCS   (United States)

Author keywords

Alcohol dependence; Brainstem; Human; Immunoautoradiography; Mood disorders; Postmortem

Indexed keywords

ALCOHOL; TRYPTOPHAN HYDROXYLASE;

ADULT; ALCOHOLISM; ARTICLE; AUTOPSY; AUTORADIOGRAPHY; BRAIN STEM; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DORSAL RAPHE NUCLEUS; HUMAN; IMMUNOREACTIVITY; MAJOR DEPRESSION; MENTAL DISEASE; MOOD DISORDER; NEUROTRANSMISSION; PRIORITY JOURNAL; SUICIDE;

ADULT; ALCOHOLISM; AUTORADIOGRAPHY; DEPRESSION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; RAPHE NUCLEI; SUICIDE; TRYPTOPHAN HYDROXYLASE;

EID: 33646684688     PISSN: 08874476     EISSN: 10982396     Source Type: Journal    
DOI: 10.1002/syn.20278     Document Type: Article

References (19)

1. American Psychiatry Association. 1994. DSM-IV: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. Washington, DC: American Psychiatric Press.
2. Baker KG, Halliday GM, Tork I. 1990. Cytoarchitecture of the human dorsal raphe nucleus. J Comp Neurol 301:147-161.
3. Baker KG, Halliday GM, Kril JJ, Harper C. 1996. Chronic alcoholics without Wernicke-Korsakoff syndrome or cirrhosis do not lose serotonergic neurons in the dorsal raphe nucleus. Alcohol Clin Exp Res 20:61-66.
4. Bonkale WL, Murdock S, Janosky J, Austin MC. 2004. Normal levels of tryptophan hydroxylase immunoreactivity in the dorsal raphe of depressed suicide victims. J Neurochem 88:958-964.
5. Casu MA, Pisu C, Lobina C, Pani L. 2004. Immunocytochemical study of the forebrain serotonergic innervation in Sardinian alcohol-preferring rats. Psychopharmacology 172:341-351.
6. Fils-Aime ML, Eckardt MJ, George DT, Brown GL, Mefibrd I, Linnoila M. 1996. Early-onset alcoholics have lower cerebrospinal fluid 5- hydroxyindoleacetic acid levels than late-onset alcoholics. Arch Gen Psychiatry 53:211-216.
7. Haan EA, Jennings IG, Cuello AC, Nakata H, Fujisawa H, Chow CW, Kushinsky R, Brittingham J, Cotton RGH. 1987. Identification of serotonergic neurons in human brain by a monoclonal antibody binding to all three aromatic amino acid hydroxylases. Brain Res 426:19-27.
8. Halliday G, Ellis J, Heard R, Caine D, Harper C. 1993. Brainstem serotonergic neurons in chronic alcoholics with and without the memory impairment of Korsakoff's psychosis. J Neuropath Exp Neurol 52:567-579.
9. Heinz A, Ragan P, Jones DW, Hommer D, Williams W, Knable MB, Gorey JG, Doty L, Geyer C, Lee KS, Coppola R, Weinberger DR, Linnoila M. 1998. Reduced central serotonin transporters in alcoholism. Am J Psychiatry 155:1544-1549.
10. Jacobs BL, Azmitia EC. 1992. Structure and function of the brain serotonin system. Physiol Rev 72:165-229.
11. Jang MH, Shin MC, Lee TH, Kim YP, Jung SB, Shin DH, Kim H, Kim SS, Kim EH, Kim CJ. 2002. Alcohol and nicotine administration inhibits serotonin synthesis and tryptophan hydroxylase expression in dorsal and median raphe of young rats. Neurosci Lett 329:141-144.
12. Kim C, Lesage A, Seguin M, Chawky N, Vanier C, Lipp O, Turecki G. 2003. Patterns of co-morbidity in male suicide completers. Psychol Med 33:1299-1309.
13. Lalovic A, Turecki G. 2002. Meta-analysis of the association between tryptophan hydroxylase and suicidal behavior. Am J Med Genet 114:533-540.
14. Mantere T, Tupala E, Hall H, Särkioja T, Räsänen P, Bergström K, Callaway J, Tiihonen J. 2002. Serotonin transporter distribution and density in the cerebral cortex of alcoholic and nonalcoholic comparison subjects: a whole-hemisphere autoradiography study. Am J Psychiatry 159:599-606.
15. Nielsen DA, Virkkunen M, Lappalainen J, Eggert M, Brown GL, Long JC, Goldman D, Linnoila M. 1998. A Tryptophan hydroxylase gene marker for suicidality and alcoholism. Arch Gen Psychiatry 55:593-602.
16. Spitzer RL, Williams JB, Gibbon M, First MB. 1992. The structured clinical interview for DSM-III-R (SCID). I. History, rationale, and description. Arch Gen Psychiatry 49:624-629.
17. Szabo Z, Owonikoko T, Peyrot M, Varga J, Mathews WB, Ravert HT, Dannals RF, Wand G. 2004. Positron emission tomography imaging of the serotonin transporter in subjects with a history of alcoholism. Biol Psychiatry 55:766-771.
18. Underwood MD, Mann JJ, Arango V. 2004. Serotonergic and noradrenergic neurobiology of alcoholic suicide. Alcohol Clin Exp Res 28:57S-69S.
19. Walther DJ, Peter JU, Bashammakh S, Hortnagl H, Voits M, Fink H, Bader M. 2003. Synthesis of serotonin by a second tryptophan hydroxylase isoform. Science 299:76.