메뉴 건너뛰기




Volumn 17, Issue 8, 2011, Pages 771-778

DNA methylation in oral squamous cell carcinoma: Molecular mechanisms and clinical implications

Author keywords

Biomarker; DNA methylation; Oral carcinoma; Therapy

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ANTINEOPLASTIC AGENT; AZACITIDINE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; DEATH ASSOCIATED PROTEIN KINASE; DNA; DNA METHYLATION INHIBITOR; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; FOLIC ACID; METHYL CPG BINDING PROTEIN; METHYL CPG BINDING PROTEIN 2; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MULTIVITAMIN; PROTEIN MLH1; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 80054087837     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/j.1601-0825.2011.01833.x     Document Type: Review
Times cited : (31)

References (83)
  • 1
    • 0011964662 scopus 로고    scopus 로고
    • Tumour class prediction and discovery by microarray-based DNA methylation analysis
    • Adorjan P, Distler J, Lipscher E et al (2002). Tumour class prediction and discovery by microarray-based DNA methylation analysis. Nucleic Acids Res 30: e21.
    • (2002) Nucleic Acids Res , vol.30
    • Adorjan, P.1    Distler, J.2    Lipscher, E.3
  • 2
    • 34147171457 scopus 로고    scopus 로고
    • Human papillomavirus-16 DNA methylation patterns support a causal association of the virus with oral squamous cell carcinomas
    • Balderas-Loaeza A, Anaya-Saavedra G, Ramirez-Amador VA et al (2007). Human papillomavirus-16 DNA methylation patterns support a causal association of the virus with oral squamous cell carcinomas. Int J Cancer 120: 2165-2169.
    • (2007) Int J Cancer , vol.120 , pp. 2165-2169
    • Balderas-Loaeza, A.1    Anaya-Saavedra, G.2    Ramirez-Amador, V.A.3
  • 3
    • 24744453331 scopus 로고    scopus 로고
    • Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger
    • Ballestar E, Esteller M (2005). Methyl-CpG-binding proteins in cancer: blaming the DNA methylation messenger. Biochem Cell Biol 83: 374-384.
    • (2005) Biochem Cell Biol , vol.83 , pp. 374-384
    • Ballestar, E.1    Esteller, M.2
  • 4
    • 0348134871 scopus 로고    scopus 로고
    • Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer
    • Ballestar E, Paz MF, Valle L et al (2003). Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer. EMBO J 22: 6335-6345.
    • (2003) EMBO J , vol.22 , pp. 6335-6345
    • Ballestar, E.1    Paz, M.F.2    Valle, L.3
  • 5
    • 77956392813 scopus 로고    scopus 로고
    • Demethylation treatment restores hic1 expression and impairs aggressiveness of head and neck squamous cell carcinoma
    • Brieger J, Pongsapich W, Mann SA et al (2010). Demethylation treatment restores hic1 expression and impairs aggressiveness of head and neck squamous cell carcinoma. Oral Oncol 46: 678-683.
    • (2010) Oral Oncol , vol.46 , pp. 678-683
    • Brieger, J.1    Pongsapich, W.2    Mann, S.A.3
  • 6
    • 33846841172 scopus 로고    scopus 로고
    • Methylation profile of genes CDKN2A (p14 and p16), DAPK1, CDH1, and ADAM23 in head and neck cancer
    • Calmon MF, Colombo J, Carvalho F et al (2007). Methylation profile of genes CDKN2A (p14 and p16), DAPK1, CDH1, and ADAM23 in head and neck cancer. Cancer Genet Cytogenet 173: 31-37.
    • (2007) Cancer Genet Cytogenet , vol.173 , pp. 31-37
    • Calmon, M.F.1    Colombo, J.2    Carvalho, F.3
  • 7
    • 0037080420 scopus 로고    scopus 로고
    • Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance
    • Chang HW, Chow V, Lam KY, Wei WI, Yuen A (2002). Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance. Cancer 94: 386-392.
    • (2002) Cancer , vol.94 , pp. 386-392
    • Chang, H.W.1    Chow, V.2    Lam, K.Y.3    Wei, W.I.4    Yuen, A.5
  • 8
    • 77957378106 scopus 로고    scopus 로고
    • Diet, epigenetic, and cancer prevention
    • Chen J, Xu X (2010). Diet, epigenetic, and cancer prevention. Adv Genet 71: 237-255.
    • (2010) Adv Genet , vol.71 , pp. 237-255
    • Chen, J.1    Xu, X.2
  • 9
    • 62749188773 scopus 로고    scopus 로고
    • Promoter hypermethylation of mismatch repair genes, hMLH1 and hMSH2 in oral squamous cell carcinoma
    • Czerninski R, Krichevsky S, Ashhab Y, Gazit D, Patel V, Ben-Yehuda D (2009). Promoter hypermethylation of mismatch repair genes, hMLH1 and hMSH2 in oral squamous cell carcinoma. Oral Dis 15: 206-213.
    • (2009) Oral Dis , vol.15 , pp. 206-213
    • Czerninski, R.1    Krichevsky, S.2    Ashhab, Y.3    Gazit, D.4    Patel, V.5    Ben-Yehuda, D.6
  • 10
    • 77954983213 scopus 로고    scopus 로고
    • Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC)
    • Dayyani F, Etzel CJ, Liu M, Ho CH, Lippman SM, Tsao AS (2010). Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC). Head Neck Oncol 2: 15.
    • (2010) Head Neck Oncol , vol.2 , pp. 15
    • Dayyani, F.1    Etzel, C.J.2    Liu, M.3    Ho, C.H.4    Lippman, S.M.5    Tsao, A.S.6
  • 11
    • 62849127213 scopus 로고    scopus 로고
    • Promoter methylation of TIMP3 and CDH1 predicts better outcome in head and neck squamous cell carcinoma treated by radiotherapy only
    • De Schutter H, Geeraerts H, Verbeken E, Nuyts S (2009). Promoter methylation of TIMP3 and CDH1 predicts better outcome in head and neck squamous cell carcinoma treated by radiotherapy only. Oncol Rep 21: 507-513.
    • (2009) Oncol Rep , vol.21 , pp. 507-513
    • De Schutter, H.1    Geeraerts, H.2    Verbeken, E.3    Nuyts, S.4
  • 12
    • 33646872606 scopus 로고    scopus 로고
    • Microsatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer
    • Demokan S, Suoglu Y, Demir D, Gozeler M, Dalay N (2006). Microsatellite instability and methylation of the DNA mismatch repair genes in head and neck cancer. Ann Oncol 17: 995-999.
    • (2006) Ann Oncol , vol.17 , pp. 995-999
    • Demokan, S.1    Suoglu, Y.2    Demir, D.3    Gozeler, M.4    Dalay, N.5
  • 13
    • 79953037668 scopus 로고    scopus 로고
    • Methylation in oral cancer and pre-cancerous lesions (Review)
    • Diez-Perez R, Campo-Trapero J, Cano-Sanchez J et al (2011). Methylation in oral cancer and pre-cancerous lesions (Review). Oncol Rep 25: 1203-1209.
    • (2011) Oncol Rep , vol.25 , pp. 1203-1209
    • Diez-Perez, R.1    Campo-Trapero, J.2    Cano-Sanchez, J.3
  • 14
    • 70649095120 scopus 로고    scopus 로고
    • Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
    • Doi A, Park IH, Wen B et al (2009). Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet 41: 1350-1353.
    • (2009) Nat Genet , vol.41 , pp. 1350-1353
    • Doi, A.1    Park, I.H.2    Wen, B.3
  • 15
    • 0034654669 scopus 로고    scopus 로고
    • MethyLight: a high-throughput assay to measure DNA methylation
    • Eads CA, Danenberg KD, Kawakami K et al (2000). MethyLight: a high-throughput assay to measure DNA methylation. Nucleic Acids Res 28: E32.
    • (2000) Nucleic Acids Res , vol.28
    • Eads, C.A.1    Danenberg, K.D.2    Kawakami, K.3
  • 16
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M (2008). Epigenetics in cancer. N Engl J Med 358: 1148-1159.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 18
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • Frommer M, McDonald LE, Millar DS et al (1992). A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci U S A 89: 1827-1831.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 1827-1831
    • Frommer, M.1    McDonald, L.E.2    Millar, D.S.3
  • 19
    • 0036144883 scopus 로고    scopus 로고
    • Methylation-specific oligonucleotide microarray: a new potential for high-throughput methylation analysis
    • Gitan RS, Shi H, Chen CM, Yan PS, Huang TH (2002). Methylation-specific oligonucleotide microarray: a new potential for high-throughput methylation analysis. Genome Res 12: 158-164.
    • (2002) Genome Res , vol.12 , pp. 158-164
    • Gitan, R.S.1    Shi, H.2    Chen, C.M.3    Yan, P.S.4    Huang, T.H.5
  • 21
    • 0030738231 scopus 로고    scopus 로고
    • Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE)
    • Gonzalgo ML, Jones PA (1997). Rapid quantitation of methylation differences at specific sites using methylation-sensitive single nucleotide primer extension (Ms-SNuPE). Nucleic Acids Res 25: 2529-2531.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2529-2531
    • Gonzalgo, M.L.1    Jones, P.A.2
  • 22
    • 0019875880 scopus 로고
    • Methylation of CpG sequences in eukaryotic DNA
    • Gruenbaum Y, Stein R, Cedar H, Razin A (1981). Methylation of CpG sequences in eukaryotic DNA. FEBS Lett 124: 67-71.
    • (1981) FEBS Lett , vol.124 , pp. 67-71
    • Gruenbaum, Y.1    Stein, R.2    Cedar, H.3    Razin, A.4
  • 23
    • 70350112552 scopus 로고    scopus 로고
    • Global DNA methylation: a common early event in oral cancer cases with exposure to environmental carcinogens or viral agents
    • Guerrero-Preston R, Baez A, Blanco A, Berdasco M, Fraga M, Esteller M (2009). Global DNA methylation: a common early event in oral cancer cases with exposure to environmental carcinogens or viral agents. P R Health Sci J 28: 24-29.
    • (2009) P R Health Sci J , vol.28 , pp. 24-29
    • Guerrero-Preston, R.1    Baez, A.2    Blanco, A.3    Berdasco, M.4    Fraga, M.5    Esteller, M.6
  • 24
    • 29744431723 scopus 로고    scopus 로고
    • Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma
    • Ha PK, Califano JA (2006). Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma. Lancet Oncol 7: 77-82.
    • (2006) Lancet Oncol , vol.7 , pp. 77-82
    • Ha, P.K.1    Califano, J.A.2
  • 25
    • 0037142615 scopus 로고    scopus 로고
    • Patterns of gene promoter methylation in squamous cell cancer of the head and neck
    • Hasegawa M, Nelson HH, Peters E, Ringstrom E, Posner M, Kelsey KT (2002). Patterns of gene promoter methylation in squamous cell cancer of the head and neck. Oncogene 21: 4231-4236.
    • (2002) Oncogene , vol.21 , pp. 4231-4236
    • Hasegawa, M.1    Nelson, H.H.2    Peters, E.3    Ringstrom, E.4    Posner, M.5    Kelsey, K.T.6
  • 26
    • 60549117324 scopus 로고    scopus 로고
    • Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium
    • Hashibe M, Brennan P, Chuang SC et al (2009). Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiol Biomarkers Prev 18: 541-550.
    • (2009) Cancer Epidemiol Biomarkers Prev , vol.18 , pp. 541-550
    • Hashibe, M.1    Brennan, P.2    Chuang, S.C.3
  • 28
    • 51649117107 scopus 로고    scopus 로고
    • Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
    • Hegi ME, Liu L, Herman JG et al (2008). Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J Clin Oncol 26: 4189-4199.
    • (2008) J Clin Oncol , vol.26 , pp. 4189-4199
    • Hegi, M.E.1    Liu, L.2    Herman, J.G.3
  • 30
    • 0036834737 scopus 로고    scopus 로고
    • The correlation between CpG methylation and protein expression of P16 in oral squamous cell carcinomas
    • Huang MJ, Yeh KT, Shih HC et al (2002). The correlation between CpG methylation and protein expression of P16 in oral squamous cell carcinomas. Int J Mol Med 10: 551-554.
    • (2002) Int J Mol Med , vol.10 , pp. 551-554
    • Huang, M.J.1    Yeh, K.T.2    Shih, H.C.3
  • 31
    • 0033047813 scopus 로고    scopus 로고
    • Methylation profiling of CpG islands in human breast cancer cells
    • Huang TH, Perry MR, Laux DE (1999). Methylation profiling of CpG islands in human breast cancer cells. Hum Mol Genet 8: 459-740.
    • (1999) Hum Mol Genet , vol.8 , pp. 459-740
    • Huang, T.H.1    Perry, M.R.2    Laux, D.E.3
  • 32
    • 20444457163 scopus 로고    scopus 로고
    • Promotor hypermethylation of p14ARF is a key alteration for progression of oral squamous cell carcinoma
    • Ishida E, Nakamura M, Ikuta M et al (2005). Promotor hypermethylation of p14ARF is a key alteration for progression of oral squamous cell carcinoma. Oral Oncol 41: 614-622.
    • (2005) Oral Oncol , vol.41 , pp. 614-622
    • Ishida, E.1    Nakamura, M.2    Ikuta, M.3
  • 33
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB (2007). The epigenomics of cancer. Cell 128: 683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 34
    • 0031837109 scopus 로고    scopus 로고
    • Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
    • Jones PL, Veenstra GJ, Wade PA et al (1998). Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19: 187-191.
    • (1998) Nat Genet , vol.19 , pp. 187-191
    • Jones, P.L.1    Veenstra, G.J.2    Wade, P.A.3
  • 36
    • 33748365200 scopus 로고    scopus 로고
    • Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa
    • Kato K, Hara A, Kuno T et al (2006). Aberrant promoter hypermethylation of p16 and MGMT genes in oral squamous cell carcinomas and the surrounding normal mucosa. J Cancer Res Clin Oncol 132: 735-743.
    • (2006) J Cancer Res Clin Oncol , vol.132 , pp. 735-743
    • Kato, K.1    Hara, A.2    Kuno, T.3
  • 38
    • 0348049993 scopus 로고    scopus 로고
    • Concurrent hypermethylation of multiple regulatory genes in chewing tobacco associated oral squamous cell carcinomas and adjacent normal tissues
    • Kulkarni V, Saranath D (2004). Concurrent hypermethylation of multiple regulatory genes in chewing tobacco associated oral squamous cell carcinomas and adjacent normal tissues. Oral Oncol 40: 145-153.
    • (2004) Oral Oncol , vol.40 , pp. 145-153
    • Kulkarni, V.1    Saranath, D.2
  • 39
    • 0036560975 scopus 로고    scopus 로고
    • Promoter hypermethylation: an important epigenetic mechanism for hMLH1 gene inactivation in head and neck squamous cell carcinoma
    • Liu K, Huang H, Mukunyadzi P, Suen JY, Hanna E, Fan CY (2002). Promoter hypermethylation: an important epigenetic mechanism for hMLH1 gene inactivation in head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg 126: 548-553.
    • (2002) Otolaryngol Head Neck Surg , vol.126 , pp. 548-553
    • Liu, K.1    Huang, H.2    Mukunyadzi, P.3    Suen, J.Y.4    Hanna, E.5    Fan, C.Y.6
  • 40
    • 0037287135 scopus 로고    scopus 로고
    • Promoter hypermethylation and inactivation of hMLH1, a DNA mismatch repair gene, in head and neck squamous cell carcinoma
    • Liu K, Zuo C, Luo QK, Suen JY, Hanna E, Fan CY (2003). Promoter hypermethylation and inactivation of hMLH1, a DNA mismatch repair gene, in head and neck squamous cell carcinoma. Diagn Mol Pathol 12: 50-56.
    • (2003) Diagn Mol Pathol , vol.12 , pp. 50-56
    • Liu, K.1    Zuo, C.2    Luo, Q.K.3    Suen, J.Y.4    Hanna, E.5    Fan, C.Y.6
  • 41
    • 33749032436 scopus 로고    scopus 로고
    • A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer
    • Lopez-Serra L, Ballestar E, Fraga MF, Alaminos M, Setien F, Esteller M (2006). A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer. Cancer Res 66: 8342-8346.
    • (2006) Cancer Res , vol.66 , pp. 8342-8346
    • Lopez-Serra, L.1    Ballestar, E.2    Fraga, M.F.3    Alaminos, M.4    Setien, F.5    Esteller, M.6
  • 42
    • 77953293077 scopus 로고    scopus 로고
    • Low prevalence of human papillomavirus in oral cavity carcinomas
    • Machado J, Reis PP, Zhang T et al (2010). Low prevalence of human papillomavirus in oral cavity carcinomas. Head Neck Oncol 2: 6.
    • (2010) Head Neck Oncol , vol.2 , pp. 6
    • Machado, J.1    Reis, P.P.2    Zhang, T.3
  • 43
    • 33750596313 scopus 로고    scopus 로고
    • Epigenetic cancer therapy makes headway
    • Mack GS (2006). Epigenetic cancer therapy makes headway. J Natl Cancer Inst 98: 1443-1444.
    • (2006) J Natl Cancer Inst , vol.98 , pp. 1443-1444
    • Mack, G.S.1
  • 44
    • 79551692337 scopus 로고    scopus 로고
    • Stromal features are predictive of disease mortality in oral cancer patients
    • Marsh D, Suchak K, Moutasim KA et al (2011). Stromal features are predictive of disease mortality in oral cancer patients. J Pathol 223: 470-481.
    • (2011) J Pathol , vol.223 , pp. 470-481
    • Marsh, D.1    Suchak, K.2    Moutasim, K.A.3
  • 45
    • 62349119224 scopus 로고    scopus 로고
    • Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma
    • Marsit CJ, Christensen BC, Houseman EA et al (2009). Epigenetic profiling reveals etiologically distinct patterns of DNA methylation in head and neck squamous cell carcinoma. Carcinogenesis 30: 416-422.
    • (2009) Carcinogenesis , vol.30 , pp. 416-422
    • Marsit, C.J.1    Christensen, B.C.2    Houseman, E.A.3
  • 46
    • 2542584016 scopus 로고    scopus 로고
    • Differential methylation status of tumor-associated genes in head and neck squamous carcinoma: incidence and potential implications
    • Maruya S, Issa JP, Weber RS et al (2004). Differential methylation status of tumor-associated genes in head and neck squamous carcinoma: incidence and potential implications. Clin Cancer Res 10: 3825-3830.
    • (2004) Clin Cancer Res , vol.10 , pp. 3825-3830
    • Maruya, S.1    Issa, J.P.2    Weber, R.S.3
  • 47
    • 23144461860 scopus 로고    scopus 로고
    • Effects of alcohol on folate metabolism: implications for carcinogenesis
    • Mason JB, Choi SW (2005). Effects of alcohol on folate metabolism: implications for carcinogenesis. Alcohol 35: 235-241.
    • (2005) Alcohol , vol.35 , pp. 235-241
    • Mason, J.B.1    Choi, S.W.2
  • 48
    • 77957333258 scopus 로고    scopus 로고
    • Induction of epigenetic alterations by dietary and other environmental factors
    • Mathers JC, Strathdee G, Relton CL (2010). Induction of epigenetic alterations by dietary and other environmental factors. Adv Genet 71: 3-39.
    • (2010) Adv Genet , vol.71 , pp. 3-39
    • Mathers, J.C.1    Strathdee, G.2    Relton, C.L.3
  • 49
    • 49649125042 scopus 로고    scopus 로고
    • Genome-scale DNA methylation maps of pluripotent and differentiated cells
    • Meissner A, Mikkelsen TS, Gu H et al (2008). Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454: 766-770.
    • (2008) Nature , vol.454 , pp. 766-770
    • Meissner, A.1    Mikkelsen, T.S.2    Gu, H.3
  • 50
    • 0035952361 scopus 로고    scopus 로고
    • High frequency of homozygous deletion and methylation of p16(INK4A) gene in oral squamous cell carcinomas
    • Nakahara Y, Shintani S, Mihara M, Ueyama Y, Matsumura T (2001). High frequency of homozygous deletion and methylation of p16(INK4A) gene in oral squamous cell carcinomas. Cancer Lett 163: 221-228.
    • (2001) Cancer Lett , vol.163 , pp. 221-228
    • Nakahara, Y.1    Shintani, S.2    Mihara, M.3    Ueyama, Y.4    Matsumura, T.5
  • 51
    • 0034667383 scopus 로고    scopus 로고
    • Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent
    • Ochs K, Kaina B (2000). Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/3 regulated and Fas/caspase-8 independent. Cancer Res 60: 5815-5824.
    • (2000) Cancer Res , vol.60 , pp. 5815-5824
    • Ochs, K.1    Kaina, B.2
  • 52
    • 0036793885 scopus 로고    scopus 로고
    • Aberrant methylation of multiple genes and clinicopathological features in oral squamous cell carcinoma
    • Ogi K, Toyota M, Ohe-Toyota M et al (2002). Aberrant methylation of multiple genes and clinicopathological features in oral squamous cell carcinoma. Clin Cancer Res 8: 3164-3171.
    • (2002) Clin Cancer Res , vol.8 , pp. 3164-3171
    • Ogi, K.1    Toyota, M.2    Ohe-Toyota, M.3
  • 53
    • 57649230131 scopus 로고    scopus 로고
    • Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma
    • Ohta S, Uemura H, Matsui Y et al (2009). Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107: 81-91.
    • (2009) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.107 , pp. 81-91
    • Ohta, S.1    Uemura, H.2    Matsui, Y.3
  • 55
    • 34547989446 scopus 로고    scopus 로고
    • Decitabine and its role in the treatment of hematopoietic malignancies
    • Plimack ER, Kantarjian HM, Issa JP (2007). Decitabine and its role in the treatment of hematopoietic malignancies. Leuk Lymphoma 48: 1472-1481.
    • (2007) Leuk Lymphoma , vol.48 , pp. 1472-1481
    • Plimack, E.R.1    Kantarjian, H.M.2    Issa, J.P.3
  • 56
    • 11144316623 scopus 로고    scopus 로고
    • Aberrant promoter hypermethylation of multiple genes in head and neck squamous cell carcinoma
    • Puri SK, Si L, Fan CY, Hanna E (2005). Aberrant promoter hypermethylation of multiple genes in head and neck squamous cell carcinoma. Am J Otolaryngol 26: 12-17.
    • (2005) Am J Otolaryngol , vol.26 , pp. 12-17
    • Puri, S.K.1    Si, L.2    Fan, C.Y.3    Hanna, E.4
  • 57
    • 0030823671 scopus 로고    scopus 로고
    • Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene
    • Qian XC, Brent TP (1997). Methylation hot spots in the 5' flanking region denote silencing of the O6-methylguanine-DNA methyltransferase gene. Cancer Res 57: 3672-3677.
    • (1997) Cancer Res , vol.57 , pp. 3672-3677
    • Qian, X.C.1    Brent, T.P.2
  • 58
    • 33947239430 scopus 로고    scopus 로고
    • Tumor-specific methylation in saliva: a promising biomarker for early detection of head and neck cancer recurrence
    • Righini CA, de Fraipont F, Timsit JF et al (2007). Tumor-specific methylation in saliva: a promising biomarker for early detection of head and neck cancer recurrence. Clin Cancer Res 13: 1179-1185.
    • (2007) Clin Cancer Res , vol.13 , pp. 1179-1185
    • Righini, C.A.1    de Fraipont, F.2    Timsit, J.F.3
  • 59
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodriguez-Paredes M, Esteller M (2011). Cancer epigenetics reaches mainstream oncology. Nat Med 17: 330-339.
    • (2011) Nat Med , vol.17 , pp. 330-339
    • Rodriguez-Paredes, M.1    Esteller, M.2
  • 60
    • 0035116695 scopus 로고    scopus 로고
    • Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients
    • Rosas SL, Koch W, da Costa Carvalho MG et al (2001). Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients. Cancer Res 61: 939-942.
    • (2001) Cancer Res , vol.61 , pp. 939-942
    • Rosas, S.L.1    Koch, W.2    da Costa Carvalho, M.G.3
  • 61
    • 77957747958 scopus 로고    scopus 로고
    • Evidence for the relationship between diet and cancer
    • Ross SA (2010). Evidence for the relationship between diet and cancer. Exp Oncol 32: 137-142.
    • (2010) Exp Oncol , vol.32 , pp. 137-142
    • Ross, S.A.1
  • 62
    • 21244447049 scopus 로고    scopus 로고
    • Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies
    • Rudek MA, Zhao M, He P et al (2005). Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies. J Clin Oncol 23: 3906-3911.
    • (2005) J Clin Oncol , vol.23 , pp. 3906-3911
    • Rudek, M.A.1    Zhao, M.2    He, P.3
  • 63
    • 0034652596 scopus 로고    scopus 로고
    • Gene promoter hypermethylation in tumors and serum of head and neck cancer patients
    • Sanchez-Cespedes M, Esteller M, Wu L et al (2000). Gene promoter hypermethylation in tumors and serum of head and neck cancer patients. Cancer Res 60: 892-895.
    • (2000) Cancer Res , vol.60 , pp. 892-895
    • Sanchez-Cespedes, M.1    Esteller, M.2    Wu, L.3
  • 64
    • 0032589204 scopus 로고    scopus 로고
    • Folate and vitamin B12
    • Scott JM (1999). Folate and vitamin B12. Proc Nutr Soc 58: 441-448.
    • (1999) Proc Nutr Soc , vol.58 , pp. 441-448
    • Scott, J.M.1
  • 65
    • 0028319924 scopus 로고
    • Folate/vitamin B12 inter-relationships
    • Scott J, Weir D (1994). Folate/vitamin B12 inter-relationships. Essays Biochem 28: 63-72.
    • (1994) Essays Biochem , vol.28 , pp. 63-72
    • Scott, J.1    Weir, D.2
  • 66
    • 33846938335 scopus 로고    scopus 로고
    • Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype
    • Sengupta S, Chakrabarti S, Roy A, Panda CK, Roychoudhury S (2007). Inactivation of human mutL homolog 1 and mutS homolog 2 genes in head and neck squamous cell carcinoma tumors and leukoplakia samples by promoter hypermethylation and its relation with microsatellite instability phenotype. Cancer 109: 703-712.
    • (2007) Cancer , vol.109 , pp. 703-712
    • Sengupta, S.1    Chakrabarti, S.2    Roy, A.3    Panda, C.K.4    Roychoudhury, S.5
  • 67
    • 0025060989 scopus 로고
    • A quantitative HpaII-PCR assay to measure methylation of DNA from a small number of cells
    • Singer-Sam J, LeBon JM, Tanguay RL, Riggs AD (1990). A quantitative HpaII-PCR assay to measure methylation of DNA from a small number of cells. Nucleic Acids Res 18: 687.
    • (1990) Nucleic Acids Res , vol.18 , pp. 687
    • Singer-Sam, J.1    LeBon, J.M.2    Tanguay, R.L.3    Riggs, A.D.4
  • 69
    • 30544444626 scopus 로고    scopus 로고
    • The epigenetics of oral cancer
    • Shaw R (2006). The epigenetics of oral cancer. Int J Oral Maxillofac Surg 35: 101-108.
    • (2006) Int J Oral Maxillofac Surg , vol.35 , pp. 101-108
    • Shaw, R.1
  • 70
    • 34548671396 scopus 로고    scopus 로고
    • DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage
    • Smith IM, Mydlarz WK, Mithani SK, Califano JA (2007). DNA global hypomethylation in squamous cell head and neck cancer associated with smoking, alcohol consumption and stage. Int J Cancer 121: 1724-1728.
    • (2007) Int J Cancer , vol.121 , pp. 1724-1728
    • Smith, I.M.1    Mydlarz, W.K.2    Mithani, S.K.3    Califano, J.A.4
  • 71
    • 76549092462 scopus 로고    scopus 로고
    • Multivitamins, folate, and green vegetables protect against gene promoter methylation in the aerodigestive tract of smokers
    • Stidley CA, Picchi MA, Leng S et al (2010). Multivitamins, folate, and green vegetables protect against gene promoter methylation in the aerodigestive tract of smokers. Cancer Res 70: 568-574.
    • (2010) Cancer Res , vol.70 , pp. 568-574
    • Stidley, C.A.1    Picchi, M.A.2    Leng, S.3
  • 72
    • 70449592332 scopus 로고    scopus 로고
    • Gene hypermethylation in tumor tissue of advanced oral squamous cell carcinoma patients
    • Supic G, Kozomara R, Brankovic-Magic M, Jovic N, Magic Z (2009). Gene hypermethylation in tumor tissue of advanced oral squamous cell carcinoma patients. Oral Oncol 45: 1051-1057.
    • (2009) Oral Oncol , vol.45 , pp. 1051-1057
    • Supic, G.1    Kozomara, R.2    Brankovic-Magic, M.3    Jovic, N.4    Magic, Z.5
  • 73
    • 43749098985 scopus 로고    scopus 로고
    • DNA methylation landscapes: provocative insights from epigenomics
    • Suzuki MM, Bird A (2008). DNA methylation landscapes: provocative insights from epigenomics. Nat Rev Genet 9: 465-476.
    • (2008) Nat Rev Genet , vol.9 , pp. 465-476
    • Suzuki, M.M.1    Bird, A.2
  • 74
    • 70449516678 scopus 로고    scopus 로고
    • Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation
    • Taioli E, Ragin C, Wang XH et al (2009). Recurrence in oral and pharyngeal cancer is associated with quantitative MGMT promoter methylation. BMC Cancer 9: 354.
    • (2009) BMC Cancer , vol.9 , pp. 354
    • Taioli, E.1    Ragin, C.2    Wang, X.H.3
  • 75
    • 80055062300 scopus 로고    scopus 로고
    • Head and neck squamous cell carcinoma: mismatch repair immunohistochemistry and promoter hypermethylation of hMLH1 gene
    • Tawfik HM, El-Maqsoud NM, Hak BH, El-Sherbiny YM (2011). Head and neck squamous cell carcinoma: mismatch repair immunohistochemistry and promoter hypermethylation of hMLH1 gene. Am J Otolaryngol. DOI.
    • (2011) Am J Otolaryngol
    • Tawfik, H.M.1    El-Maqsoud, N.M.2    Hak, B.H.3    El-Sherbiny, Y.M.4
  • 76
    • 0033563165 scopus 로고    scopus 로고
    • Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification
    • Toyota M, Ho C, Ahuja N et al (1999). Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Cancer Res 59: 2307-2312.
    • (1999) Cancer Res , vol.59 , pp. 2307-2312
    • Toyota, M.1    Ho, C.2    Ahuja, N.3
  • 77
    • 14344252667 scopus 로고    scopus 로고
    • Frequent promoter hypermethylation of RASSF1A and p16INK4a and infrequent allelic loss other than 9p21 in betel-associated oral carcinoma in a Vietnamese non-smoking/non-drinking female population
    • Tran TN, Liu Y, Takagi M, Yamaguchi A, Fujii H (2005). Frequent promoter hypermethylation of RASSF1A and p16INK4a and infrequent allelic loss other than 9p21 in betel-associated oral carcinoma in a Vietnamese non-smoking/non-drinking female population. J Oral Pathol Med 34: 150-156.
    • (2005) J Oral Pathol Med , vol.34 , pp. 150-156
    • Tran, T.N.1    Liu, Y.2    Takagi, M.3    Yamaguchi, A.4    Fujii, H.5
  • 78
    • 0345269743 scopus 로고    scopus 로고
    • Promoter hypermethylation profile of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma
    • Viswanathan M, Tsuchida N, Shanmugam G (2003). Promoter hypermethylation profile of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma. Int J Cancer 105: 41-46.
    • (2003) Int J Cancer , vol.105 , pp. 41-46
    • Viswanathan, M.1    Tsuchida, N.2    Shanmugam, G.3
  • 79
    • 0030825309 scopus 로고    scopus 로고
    • COBRA: a sensitive and quantitative DNA methylation assay
    • Xiong Z, Laird PW (1997). COBRA: a sensitive and quantitative DNA methylation assay. Nucleic Acids Res 25: 2532-2534.
    • (1997) Nucleic Acids Res , vol.25 , pp. 2532-2534
    • Xiong, Z.1    Laird, P.W.2
  • 80
    • 0036875383 scopus 로고    scopus 로고
    • The correlation between CpG methylation on promoter and protein expression of E-cadherin in oral squamous cell carcinoma
    • Yeh KT, Shih MC, Lin TH et al (2002). The correlation between CpG methylation on promoter and protein expression of E-cadherin in oral squamous cell carcinoma. Anticancer Res 22: 3971-3975.
    • (2002) Anticancer Res , vol.22 , pp. 3971-3975
    • Yeh, K.T.1    Shih, M.C.2    Lin, T.H.3
  • 81
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: past, present and future
    • Yoo CB, Jones PA (2006). Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov 5: 37-50.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2
  • 83
    • 70349336146 scopus 로고    scopus 로고
    • Increased microsatellite instability and epigenetic inactivation of the hMLH1 gene in head and neck squamous cell carcinoma
    • Zuo C, Zhang H, Spencer HJ et al (2009). Increased microsatellite instability and epigenetic inactivation of the hMLH1 gene in head and neck squamous cell carcinoma. Otolaryngol Head Neck Surg 141: 484-490.
    • (2009) Otolaryngol Head Neck Surg , vol.141 , pp. 484-490
    • Zuo, C.1    Zhang, H.2    Spencer, H.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.