Genetic and molecular alterations associated with oral squamous cell cancer (Review)

Oncology Reports

Volumn 22, Issue 6, 2009, Pages 1277-1282

  Pérez sayáns, Mario ^a   Somoza Martín, José Manuel ^a   Barros Angueira, Francisco ^b   Reboiras López, María Dolores ^a   Rey, José Manuel Gándara ^a   García García, Abel ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b Pediatric Nutrition Research Group Health Research Institute of Santiago de Compostela   (Spain)

Author keywords

Methylation; Oncogenes; Oral squamous cell carcinoma; Tumor suppressor genes

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; HLA B35 ANTIGEN; MEMBRANE ANTIGEN; PROTEIN P53; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A;

CARCINOGENESIS; CHROMOSOME ABERRATION; DNA METHYLATION; DNA MICROARRAY; DOWN REGULATION; EPIGENETICS; GENE DELETION; GENE EXPRESSION; HETEROZYGOSITY LOSS; HUMAN; IN SITU HYBRIDIZATION; MOUTH CANCER; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVIEW; SOUTHERN BLOTTING; SQUAMOUS CELL CARCINOMA; UPREGULATION;

CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, TUMOR SUPPRESSOR; HUMANS; INFLAMMATION; MODELS, GENETIC; MOUTH NEOPLASMS; ONCOGENES; PHENOTYPE; SMOKING;

EID: 70449363866     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or_00000565     Document Type: Review

References (64)

1. Jemal A, Siegel R, Ward E, et al: Cancer Statistics. CA Cancer J Clin 58: 71-96, 2008.
2. Boyd NM and Reade PC: Mechanisms of carcinogenesis with particular reference to the oral mucosa. J Oral Pathol 17: 193-201, 1988.
3. Hanahan D and Weinberg RA: The hallmarks of cancer. Cell 100: 57-70, 2000.
4. Duggan DJ, Bittner M, Chen Y, et al: Expression profiling using cDNA microarrays. Nat Genet 21: 10-14, 1999.
5. Rajeevan MS, Vernon SD, Taysavang N, et al: Validation of array-based gene expression profiles by real-time (kinetic) RT-PCR. J Mol Diagn 3: 26-31, 2001.
6. Higuchi R, Fockler C, Dollinger G and Watson R: Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Biotechnology (NY) 11: 1026-1030, 1993.
7. Wittwer CT, Herrmann MG, Moss AA and Rasmussen RP: Continuous fluorescence monitoring of rapid cycle DNA amplification. Biotechniques 22: 130-131, 134-138, 1997.
8. Alevizos I, Mahadevappa M, Zhang X, et al: Oral cancer in vivo gene expression profiling assisted by laser capture microdissection and microarray analysis. Oncogene 20: 6196-6204, 2001.
9. Al Moustafa AE, Alaoui-Jamali MA, Batist G, et al: Identification of genes associated with head and neck carcinogenesis by cDNA microarray comparison between matched primary normal epithelial and squamous carcinoma cells. Oncogene 21: 2634-2640, 2002.
10. Francioso F, Carinci F, Tosi L, et al: Identification of differentially expressed genes in human salivary gland tumors by DNA microarrays. Mol Cancer Ther 1: 533-538, 2002.
11. Hartmann KA, Modlich O, Prisack HB, et al: Gene expression profiling of advanced head and neck squamous cell carcinomas and two squamous cell carcinoma cell lines under radio/chemotherapy using cDNA arrays. Radiother Oncol 63: 309-320, 2002.
12. Zhang X, Liu Y, Gilcrease MZ, Yuan, et al: A lymph node metastatic mouse model reveals alterations of metastasis-related gene expression in metastatic human oral carcinoma sublines selected from a poorly metastatic parental cell line. Cancer 95: 1663-1672, 2002.
13. Mendez E, Cheng C, Farwell DG, et al: Transcriptional expression profiles of oral squamous cell carcinomas. Cancer 95: 1482-1494, 2002.
14. Ibrahim SO, Aarsaether N, Holsve MK, et al: Gene expression profile in oral squamous cell carcinomas and matching normal oral mucosal tissues from black Africans and white Caucasians: the case of the Sudan vs. Norway. Oral Oncol 39: 37-48, 2003.
15. Kuo WP, Hasina R, Ohno-Machado L and Lingen MW: Classification and identification of genes associated with oral cancer based on gene expression profiles. A preliminary study. N Y State Dent J 69: 23-26, 2003.
16. Hwang D, Alevizos I, Schmitt WA, et al: Genomic dissection for characterization of cancerous oral epithelium tissues using transcription profiling. Oral Oncol 39: 259-268, 2003.
17. Nagata M, Fujita H, Ida H, et al: Identification of potential biomarkers of lymph node metastasis in oral squamous cell carcinoma by cDNA microarray analysis. Int J Cancer 106: 683-689, 2003.
18. Brinkman BM and Wong DT: Disease mechanism and biomarkers of oral squamous cell carcinoma. Curr Opin Oncol 18: 228-233, 2006.
19. Ziober AF, Patel KR, Alawi F, et al: Identification of a gene signature for rapid screening of oral squamous cell carcinoma. Clin Cancer Res 12: 5960-5971, 2006.
20. Nguyen ST, Hasegawa S, Tsuda H, et al: Identification of a predictive gene expression signature of cervical lymph node metastasis in oral squamous cell carcinoma. Cancer Sci 98: 740-746, 2007.
21. Martinez I, Wang J, Hobson KF, et al: Identification of differentially expressed genes in HPV-positive and HPV-negative oropharyngeal squamous cell carcinomas. Eur J Cancer 43: 415-432, 2007.
22. Chang JT, Wang HM, Chang KW, et al: Identification of differentially expressed genes in oral squamous cell carcinoma (OSCC): overexpression of NPM, CDK1 and NDRG1 and under-expression of CHES1. Int J Cancer 114: 942-949, 2005.
23. Arora S, Matta A, Shukla NK, et al: Identification of differentially expressed genes in oral squamous cell carcinoma. Mol Carcinog 42: 97-108, 2005.
24. Jeon GA, Lee JS, Patel V, et al: Global gene expression profiles of human head and neck squamous carcinoma cell lines. Int J Cancer 112: 249-258, 2004.
25. Ginos MA, Page GP, Michalowicz BS, et al: Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res 64: 55-63, 2004.
26. Gonzalez HE, Gujrati M, Frederick M, et al: Identification of 9 genes differentially expressed in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 129: 754-759, 2003.
27. Leethanakul C, Knezevic V, Patel V, et al: Gene discovery in oral squamous cell carcinoma through the Head and Neck Cancer Genome Anatomy Project: confirmation by microarray analysis. Oral Oncol 39: 248-258, 2003.
28. Steinau M, Lee DR, Rajeevan MS, et al: Gene expression profile of cervical tissue compared to exfoliated cells: impact on biomarker discovery. BMC Genomics 6: 64, 2005.
29. Choi S and Myers JN: Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy. J Dent Res 87: 14-32, 2008.
30. Somoza-Martin JM, Garcia-Garcia A, Barros-Angueira F, et al: Gene expression profile in oral squamous cell carcinoma: a pilot study. J Oral Maxillofac Surg 63: 786-792, 2005.
31. Yanamoto S, Kawasaki G, Yoshitomi I, et al: Clinicopathologic significance of EpCAM expression in squamous cell carcinoma of the tongue and its possibility as a potential target for tongue cancer gene therapy. Oral Oncol 43: 869-877, 2007.
32. Uzawa N, Akanuma D, Negishi A, et al: Homozygous deletions on the short arm of chromosome 3 in human oral squamous cell carcinomas. Oral Oncol 37: 351-356, 2001.
33. Schwarz S, Bier J, Driemel O, et al: Losses of 3p14 and 9p21 as shown by fluorescence in situ hybridization are early events in tumorigenesis of oral squamous cell carcinoma and already occur in simple keratosis. Cytometry A 73: 305-311, 2008.
34. El-Naggar AK, Hurr K, Batsakis JG, et al: Sequential loss of heterozygosity at microsatellite motifs in preinvasive and invasive head and neck squamous carcinoma. Cancer Res 55: 2656-2659, 1995.
35. Ohta S, Uemura H, Matsui Y, et al: Alterations of p16 and p14ARF genes and their 9p21 locus in oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 107: 81-91, 2009.
36. Gebhart E, Liehr T, Wolff E, et al: Loss of 9p21 is embedded in a complex but consistent pattern of genomic imbalances in oral squamous cell carcinomas. Cytogenet Genome Res 101: 106-112, 2003.
37. Moles MAG, Montoya JAG and Avila IR: Bases moleculares de la cancerización de cavidad oral. Av Odontoestomatol 24: 55-60, 2008.
38. Stephens HA, Vaughan RW, Collins R, et al: Towards a molecular phototyping system for allelic variants of MICA, encoded by polymorphisms in exons 2, 3 and 4 of MHC class I chain-related genes. Tissue Antigens 53: 167-174, 1999.
39. Costa Ade L, de Araujo NS, Pinto Ddos S and de Araujo VC: PCNA/AgNOR and Ki-67/AgNOR double staining in oral squamous cell carcinoma. J Oral Pathol Med 28: 438-441, 1999.
40. Brandt B, Meyer-Staeckling S, Schmidt H, et al: Mechanisms of EGFR gene transcription modulation: relationship to cancer risk and therapy response. Clin Cancer Res 12: 7252-7260, 2006.
41. Silva SD, Perez DE, Alves FA, et al: ErbB2 and fatty acid synthase (FAS) expression in 102 squamous cell carcinomas of the tongue: correlation with clinical outcomes. Oral Oncol 44: 484-490, 2008.
42. Schartinger VH, Kacani L, Andrle J, et al: Pharmacodiagnostic value of the HER family in head and neck squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec 66: 21-26, 2004.
43. Vairaktaris E, Goutzanis L, Kalokerinos G, et al: Diabetes increases both N-ras and ets-1 expression during rat oral oncogenesis resulting in enhanced cell proliferation and metastatic potential. In Vivo 21: 615-621, 2007.
44. Zhou X, Zhang Z, Yang X, et al: Inhibition of cyclin D1 expression by cyclin D1 shRNAs in human oral squamous cell carcinoma cells is associated with increased cisplatin chemo-sensitivity. Int J Cancer 124: 483-489, 2009.
45. Sathyan KM, Nalinakumari KR, Abraham T and Kannan S: CCND1 polymorphisms (A870G and C1722G) modulate its protein expression and survival in oral carcinoma. Oral Oncol 44: 689-697, 2008.
46. Marsit CJ, Black CC, Posner MR and Kelsey KT: A genotype-phenotype examination of cyclin D1 on risk and outcome of squamous cell carcinoma of the head and neck. Clin Cancer Res 14: 2371-2377, 2008.
47. Kozomara RJ, Brankovic-Magic MV, Jovic NR, et al: Prognostic significance of TP53 mutations in oral squamous cell carcinoma with human papilloma virus infection. Int J Biol Markers 22: 252-257, 2007.
48. Kresty LA, Mallery SR, Knobloch TJ, et al: Alterations of p16(INK4a) and p14(ARF) in patients with severe oral epithelial dysplasia. Cancer Res 62: 5295-5300, 2002.
49. Shintani S, Nakahara Y, Mihara M, et al: Inactivation of the p14(ARF), p15(INK4B) and p16(INK4A) genes is a frequent event in human oral squamous cell carcinomas. Oral Oncol 37: 498-504, 2001.
50. Van Heerden WF, Swart TJ, Robson B, et al: FHIT RNA and protein expression in oral squamous cell carcinomas. Anticancer Res 21: 2425-2428, 2001.
51. Van Heerden WF, Swart TJ, van Heerden MB, et al: Immunohistochemical evaluation of Fhit protein expression in oral squamous cell carcinomas. J Oral Pathol Med 28: 433-437, 1999.
52. Teresa DB, Neves KA, Neto CB and Fregonezi PA: Computer-assisted analysis of cell proliferation markers in oral lesions. Acta Histochem 109: 377-387, 2007.
53. Schwartz JL, Gu X, Kittles RA, et al: Experimental oral carcinoma of the tongue and buccal mucosa: possible biologic markers linked to cancers at two anatomic sites. Oral Oncol 36: 225-235, 2000.
54. Otero-Rey EM, Somoza-Martin M, Barros-Angueira F and Garcia-Garcia A: Intracellular pH regulation in oral squamous cell carcinoma is mediated by increased V-ATPase activity via over-expression of the ATP6V1C1 gene. Oral Oncol 44: 193-199, 2008.
55. Imai T, Toyota M, Suzuki H, et al: Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma. Cancer Sci 99: 958-966, 2008.
56. Sudbo J: Novel management of oral cancer: a paradigm of predictive oncology. Clin Med Res 2: 233-242, 2004.
57. Fong D, Spizzo G, Gostner JM, et al: TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity. Mod Pathol 21: 186-191, 2008.
58. Mullis TC, Tang X and Chong KT: Expression of connective tissue growth factor (CTGF/CCN2) in head and neck squamous cell carcinoma. J Clin Pathol 61: 606-610, 2008.
59. Kumar SV, Hurteau GJ and Spivack SD: Validity of messenger RNA expression analyses of human saliva. Clin Cancer Res 12: 5033-5039, 2006.
60. Zhong LP, Zhu HG, Zhang CP, et al: Detection of serum Cyfra 21-1 in patients with primary oral squamous cell carcinoma. Int J Oral Maxillofac Surg 36: 230-234, 2007.
61. Zhong LP, Zhang CP, Zheng JW, et al: Increased Cyfra 21-1 concentration in saliva from primary oral squamous cell carcinoma patients. Arch Oral Biol 52: 1079-1087, 2007.
62. Bahar G, Feinmesser R, Shpitzer T, et al: Salivary analysis in oral cancer patients: DNA and protein oxidation, reactive nitrogen species, and antioxidant profile. Cancer 109: 54-59, 2007.
63. Landesberg R, Woo V, Huang L, et al: The expression of the receptor for glycation endproducts (RAGE) in oral squamous cell carcinomas. Oral Surg Oral Med Oral Patho Oral Radiol Endod 105: 617-624, 2008.
64. Epstein JB, Zhang L and Rosin M: Advances in the diagnosis of oral premalignant and malignant lesions. J Can Dent Assoc 68: 617-621, 2002.