메뉴 건너뛰기




Volumn 17, Issue 8, 2011, Pages 794-800

Hypermethylation of RUNX3 but not WIF1 gene and its association with stage and nodal status of tongue cancers

Author keywords

DNA methylation; Nodal and tumor stage; Oral squamous cell carcinoma; RUNX3; Tongue carcinoma; WIF1

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RUNX3; UNCLASSIFIED DRUG; WNT INHIBITORY FACTOR 1;

EID: 80054082401     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/j.1601-0825.2011.01838.x     Document Type: Article
Times cited : (21)

References (47)
  • 1
    • 60749086521 scopus 로고    scopus 로고
    • Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers
    • Ahlquist T, Lind G, Costa V et al (2008). Gene methylation profiles of normal mucosa, and benign and malignant colorectal tumors identify early onset markers. Mol Cancer 7: 94-99.
    • (2008) Mol Cancer , vol.7 , pp. 94-99
    • Ahlquist, T.1    Lind, G.2    Costa, V.3
  • 2
    • 33745634864 scopus 로고    scopus 로고
    • Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer
    • Ai L, Tao Q, Zhong S et al (2006). Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer. Carcinogenesis 27: 1341-1348.
    • (2006) Carcinogenesis , vol.27 , pp. 1341-1348
    • Ai, L.1    Tao, Q.2    Zhong, S.3
  • 3
    • 69349084287 scopus 로고    scopus 로고
    • Methylation of p16 CpG island associated with malignant progression of oral epithelial dysplasia: a prospective cohort study
    • Cao J, Zhou J, Gao Y et al (2009). Methylation of p16 CpG island associated with malignant progression of oral epithelial dysplasia: a prospective cohort study. Clin Cancer Res 15: 5178-5183.
    • (2009) Clin Cancer Res , vol.15 , pp. 5178-5183
    • Cao, J.1    Zhou, J.2    Gao, Y.3
  • 4
    • 34250310905 scopus 로고    scopus 로고
    • The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas
    • Chan S, Cui Y, van Hasselt A et al (2007). The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas. Lab Invest 87: 644-650.
    • (2007) Lab Invest , vol.87 , pp. 644-650
    • Chan, S.1    Cui, Y.2    van Hasselt, A.3
  • 5
    • 77950151788 scopus 로고    scopus 로고
    • Hypermethylation downregulates Runx3 gene expression and its restoration suppresses gastric epithelial cell growth by inducing p27 and caspase3 in human gastric cancer
    • Chen W, Gao N, Shen Y, Cen J (2010). Hypermethylation downregulates Runx3 gene expression and its restoration suppresses gastric epithelial cell growth by inducing p27 and caspase3 in human gastric cancer. J Gastroenterol Hepatol 25: 823-831.
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 823-831
    • Chen, W.1    Gao, N.2    Shen, Y.3    Cen, J.4
  • 6
    • 36949027736 scopus 로고    scopus 로고
    • Epigenetic alteration of the Wnt inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett's esophagus
    • Clément G, Guilleret I, He B et al (2008). Epigenetic alteration of the Wnt inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett's esophagus. Cancer Sci 99: 46-53.
    • (2008) Cancer Sci , vol.99 , pp. 46-53
    • Clément, G.1    Guilleret, I.2    He, B.3
  • 7
    • 63549104387 scopus 로고    scopus 로고
    • Frequent inactivation of RUNX3 by promoter hypermethylation and protein mislocalization in oral squamous cell carcinomas
    • Gao F, Huang C, Lin M et al (2009). Frequent inactivation of RUNX3 by promoter hypermethylation and protein mislocalization in oral squamous cell carcinomas. J Cancer Res Clin Oncol 135: 739-747.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 739-747
    • Gao, F.1    Huang, C.2    Lin, M.3
  • 8
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman J, Baylin S (2003). Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 349: 2042-2054.
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.1    Baylin, S.2
  • 9
    • 0029843950 scopus 로고    scopus 로고
    • Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands
    • Herman J, Graff J, Myohanen S et al (1996). Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93: 9821-9826.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9821-9826
    • Herman, J.1    Graff, J.2    Myohanen, S.3
  • 10
    • 24744470103 scopus 로고    scopus 로고
    • RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization
    • Ito K, Liu Q, Salto-Tellez M et al (2005). RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. Cancer Res 65: 7743-7750.
    • (2005) Cancer Res , vol.65 , pp. 7743-7750
    • Ito, K.1    Liu, Q.2    Salto-Tellez, M.3
  • 11
    • 50649086570 scopus 로고    scopus 로고
    • RUNX3 attenuates b-catenin/T cell factors in intestinal tumorigenesis
    • Ito K, Lim A, Salto-Tellez M et al (2008). RUNX3 attenuates b-catenin/T cell factors in intestinal tumorigenesis. Cancer Cell 14: 226-237.
    • (2008) Cancer Cell , vol.14 , pp. 226-237
    • Ito, K.1    Lim, A.2    Salto-Tellez, M.3
  • 12
    • 27744568076 scopus 로고    scopus 로고
    • Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma
    • Iwai S, Katagiri W, Kong C et al (2005). Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma. J Cancer Res Clin Oncol 13: 773-782.
    • (2005) J Cancer Res Clin Oncol , vol.13 , pp. 773-782
    • Iwai, S.1    Katagiri, W.2    Kong, C.3
  • 13
    • 27144524894 scopus 로고    scopus 로고
    • RUNX3 inactivation by point mutations and aberrant DNA methylation in bladder tumors
    • Kim W, Kim E, Jeong P et al (2005). RUNX3 inactivation by point mutations and aberrant DNA methylation in bladder tumors. Cancer Res 65: 9347-9354.
    • (2005) Cancer Res , vol.65 , pp. 9347-9354
    • Kim, W.1    Kim, E.2    Jeong, P.3
  • 14
    • 79251614031 scopus 로고    scopus 로고
    • Oncogenic role of RUNX3 in head and neck cancer
    • Kudo Y, Tsunematsu T, Takata T (2011). Oncogenic role of RUNX3 in head and neck cancer. J Cell Biochem 112: 387-393.
    • (2011) J Cell Biochem , vol.112 , pp. 387-393
    • Kudo, Y.1    Tsunematsu, T.2    Takata, T.3
  • 15
    • 33746121227 scopus 로고    scopus 로고
    • RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer
    • Lau Q, Raja E, Salto-Tellez M et al (2006). RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Cancer Res 66: 6512-6520.
    • (2006) Cancer Res , vol.66 , pp. 6512-6520
    • Lau, Q.1    Raja, E.2    Salto-Tellez, M.3
  • 16
    • 70349656779 scopus 로고    scopus 로고
    • Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer
    • Lee B, Lee E, Jung E et al (2009). Aberrant methylation of APC, MGMT, RASSF2A, and Wif-1 genes in plasma as a biomarker for early detection of colorectal cancer. Clin Cancer Res 15: 6185-6191.
    • (2009) Clin Cancer Res , vol.15 , pp. 6185-6191
    • Lee, B.1    Lee, E.2    Jung, E.3
  • 17
    • 47249111724 scopus 로고    scopus 로고
    • Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung
    • Licchesi J, Westra W, Hooker C et al (2008). Epigenetic alteration of Wnt pathway antagonists in progressive glandular neoplasia of the lung. Carcinogenesis 29: 895-904.
    • (2008) Carcinogenesis , vol.29 , pp. 895-904
    • Licchesi, J.1    Westra, W.2    Hooker, C.3
  • 18
    • 31444455766 scopus 로고    scopus 로고
    • Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines
    • Lin YC, You L, Xu Z et al (2006). Wnt signaling activation and WIF-1 silencing in nasopharyngeal cancer cell lines. Biochem Biophys Res Commun 341: 635-640.
    • (2006) Biochem Biophys Res Commun , vol.341 , pp. 635-640
    • Lin, Y.C.1    You, L.2    Xu, Z.3
  • 19
    • 0035013507 scopus 로고    scopus 로고
    • A possible role for the WNT-1 pathway in oral carcinogenesis
    • Lo Muzio L (2001). A possible role for the WNT-1 pathway in oral carcinogenesis. Crit Rev Oral Biol Med 12: 152-165.
    • (2001) Crit Rev Oral Biol Med , vol.12 , pp. 152-165
    • Lo Muzio, L.1
  • 20
    • 36849052340 scopus 로고    scopus 로고
    • Promoter hypermethylation of the RUNX3 gene in esophageal squamous cell carcinoma
    • Long C, Yin B, Lu Q et al (2007). Promoter hypermethylation of the RUNX3 gene in esophageal squamous cell carcinoma. Cancer Invest 25: 685-690.
    • (2007) Cancer Invest , vol.25 , pp. 685-690
    • Long, C.1    Yin, B.2    Lu, Q.3
  • 21
    • 70350044048 scopus 로고    scopus 로고
    • Towards targeted epigenetic therapy of cancer
    • Magic Z, Supic G, Brankovic-Magic M (2009). Towards targeted epigenetic therapy of cancer. J BUON 14(Suppl 1): S79-S88.
    • (2009) J BUON , vol.14 , Issue.SUPPL. 1
    • Magic, Z.1    Supic, G.2    Brankovic-Magic, M.3
  • 22
    • 3142679453 scopus 로고    scopus 로고
    • Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer
    • Mazieres J, He B, You L et al (2004). Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Cancer Res 64: 4717-4720.
    • (2004) Cancer Res , vol.64 , pp. 4717-4720
    • Mazieres, J.1    He, B.2    You, L.3
  • 23
    • 0034326238 scopus 로고    scopus 로고
    • Predicting lung cancer by detecting aberrant promoter methylation in sputum
    • Palmisano W, Divine K, Saccomanno G et al (2000). Predicting lung cancer by detecting aberrant promoter methylation in sputum. Cancer Res 60: 5954-5958.
    • (2000) Cancer Res , vol.60 , pp. 5954-5958
    • Palmisano, W.1    Divine, K.2    Saccomanno, G.3
  • 24
    • 77957374553 scopus 로고    scopus 로고
    • WNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors
    • Pannone G, Bufo P, Santoro A et al (2010). WNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors. Oncol Rep 24: 1035-1041.
    • (2010) Oncol Rep , vol.24 , pp. 1035-1041
    • Pannone, G.1    Bufo, P.2    Santoro, A.3
  • 25
    • 78651313568 scopus 로고    scopus 로고
    • Promoter CpG island hypermethylation during breast cancer progression
    • Park S, Kwon H, Lee H et al (2011). Promoter CpG island hypermethylation during breast cancer progression. Virchows Arch 458: 73-84.
    • (2011) Virchows Arch , vol.458 , pp. 73-84
    • Park, S.1    Kwon, H.2    Lee, H.3
  • 26
    • 4444323767 scopus 로고    scopus 로고
    • Cloning and characterization of the promoter of human Wnt inhibitory factor-1
    • Reguart N, He B, Xu Z et al (2004). Cloning and characterization of the promoter of human Wnt inhibitory factor-1. Biochem Biophys Res Commun 323: 229-234.
    • (2004) Biochem Biophys Res Commun , vol.323 , pp. 229-234
    • Reguart, N.1    He, B.2    Xu, Z.3
  • 27
    • 0037179894 scopus 로고    scopus 로고
    • Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas
    • Rhee C, Sen M, Lu D et al (2002). Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene 21: 6598-6605.
    • (2002) Oncogene , vol.21 , pp. 6598-6605
    • Rhee, C.1    Sen, M.2    Lu, D.3
  • 28
    • 80054070012 scopus 로고    scopus 로고
    • Cell alterations and molecular mechanisms in oral carcinogenesis
    • Romana PG (2010) Cell alterations and molecular mechanisms in oral carcinogenesis. Int J Oral Maxillofac Surg doi:.
    • (2010) Int J Oral Maxillofac Surg
    • Romana, P.G.1
  • 30
    • 33845513110 scopus 로고    scopus 로고
    • RUNX3 protein is overexpressed in human basal cell carcinomas
    • Salto-Tellez M, Peh BK, Ito K et al (2006). RUNX3 protein is overexpressed in human basal cell carcinomas. Oncogene 25: 7646-7649.
    • (2006) Oncogene , vol.25 , pp. 7646-7649
    • Salto-Tellez, M.1    Peh, B.K.2    Ito, K.3
  • 31
    • 21244467485 scopus 로고    scopus 로고
    • Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk
    • Schulmann K, Sterian A, Berki A et al (2005). Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk. Oncogene 24: 4138-4148.
    • (2005) Oncogene , vol.24 , pp. 4138-4148
    • Schulmann, K.1    Sterian, A.2    Berki, A.3
  • 32
    • 68949221111 scopus 로고    scopus 로고
    • Oral squamous cell carcinoma: overview of current understanding of aetiopathogenesis and clinical implications
    • Scully C, Bagan J (2009). Oral squamous cell carcinoma: overview of current understanding of aetiopathogenesis and clinical implications. Oral Dis 15: 388-399.
    • (2009) Oral Dis , vol.15 , pp. 388-399
    • Scully, C.1    Bagan, J.2
  • 33
    • 30544444626 scopus 로고    scopus 로고
    • The epigenetics of oral cancer
    • Shaw R (2006). The epigenetics of oral cancer. Int J Oral Maxillofac Surg 35: 101-108.
    • (2006) Int J Oral Maxillofac Surg , vol.35 , pp. 101-108
    • Shaw, R.1
  • 34
    • 35748966123 scopus 로고    scopus 로고
    • Quantitative methylation analysis of resection margins and lymph nodes in oral squamous cell carcinoma
    • Shaw R, Hall G, Woolgar J et al (2007). Quantitative methylation analysis of resection margins and lymph nodes in oral squamous cell carcinoma. Br J Oral Maxillofac Surg 45: 617-622.
    • (2007) Br J Oral Maxillofac Surg , vol.45 , pp. 617-622
    • Shaw, R.1    Hall, G.2    Woolgar, J.3
  • 35
    • 77957376763 scopus 로고    scopus 로고
    • p16(INK4A) promoter hypermethylation is associated with invasiveness and prognosis of oral squamous cell carcinoma in an age-dependent manner
    • Su P, Huang W, Wu H, Wu C, Liu T, Kao S (2010). p16(INK4A) promoter hypermethylation is associated with invasiveness and prognosis of oral squamous cell carcinoma in an age-dependent manner. Oral Oncol 46: 734-739.
    • (2010) Oral Oncol , vol.46 , pp. 734-739
    • Su, P.1    Huang, W.2    Wu, H.3    Wu, C.4    Liu, T.5    Kao, S.6
  • 36
    • 70349175538 scopus 로고    scopus 로고
    • Molecular pathology of RUNX3 in human carcinogenesis
    • Subramaniam M, Chan J, Yeoh K et al (2009). Molecular pathology of RUNX3 in human carcinogenesis. Biochim Biophys Acta 1796: 315-331.
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 315-331
    • Subramaniam, M.1    Chan, J.2    Yeoh, K.3
  • 37
    • 70449592332 scopus 로고    scopus 로고
    • Gene hypermethylation in tumor tissue of advanced oral squamous cell carcinoma patients
    • Supic G, Kozomara R, Brankovic-Magic M, Jovic N, Magic Z (2009). Gene hypermethylation in tumor tissue of advanced oral squamous cell carcinoma patients. Oral Oncol 45: 1051-1057.
    • (2009) Oral Oncol , vol.45 , pp. 1051-1057
    • Supic, G.1    Kozomara, R.2    Brankovic-Magic, M.3    Jovic, N.4    Magic, Z.5
  • 38
    • 78650979029 scopus 로고    scopus 로고
    • Interaction between the MTHFR C677T polymorphism and alcohol - impact on oral cancer risk and multiple DNA methylation of tumor-related genes
    • Supic G, Jovic N, Kozomara R, Zeljic K, Magic Z (2011). Interaction between the MTHFR C677T polymorphism and alcohol - impact on oral cancer risk and multiple DNA methylation of tumor-related genes. J Dent Res 90: 65-70.
    • (2011) J Dent Res , vol.90 , pp. 65-70
    • Supic, G.1    Jovic, N.2    Kozomara, R.3    Zeljic, K.4    Magic, Z.5
  • 39
    • 33846013934 scopus 로고    scopus 로고
    • Analyses of promoter hypermethylation for RUNX3 and other tumor suppressor genes in nasopharyngeal carcinoma
    • Tan SH, Ida H, Goh BC, Hsieh W, Loh M, Ito Y (2006). Analyses of promoter hypermethylation for RUNX3 and other tumor suppressor genes in nasopharyngeal carcinoma. Anticancer Res 26: 4287-4292.
    • (2006) Anticancer Res , vol.26 , pp. 4287-4292
    • Tan, S.H.1    Ida, H.2    Goh, B.C.3    Hsieh, W.4    Loh, M.5    Ito, Y.6
  • 40
    • 33846481932 scopus 로고    scopus 로고
    • Runt-related transcription factor 3 expression in human oral squamous cell carcinomas; implication for tumor progression and prognosis
    • Tanji Y, Osaki M, Nagahama Y, Kodani I, Ryoke K, Ito H (2007). Runt-related transcription factor 3 expression in human oral squamous cell carcinomas; implication for tumor progression and prognosis. Oral Oncol 43: 88-94.
    • (2007) Oral Oncol , vol.43 , pp. 88-94
    • Tanji, Y.1    Osaki, M.2    Nagahama, Y.3    Kodani, I.4    Ryoke, K.5    Ito, H.6
  • 41
    • 3843072194 scopus 로고    scopus 로고
    • RUNX3 inhibits cell proliferation and induces apoptosis by reinstating transforming growth factor beta responsiveness in esophageal adenocarcinoma cells
    • Torquati A, O'rear L, Longobardi L, Spagnoli A, Richards W, Daniel B (2004). RUNX3 inhibits cell proliferation and induces apoptosis by reinstating transforming growth factor beta responsiveness in esophageal adenocarcinoma cells. Surgery 136: 310-316.
    • (2004) Surgery , vol.136 , pp. 310-316
    • Torquati, A.1    O'rear, L.2    Longobardi, L.3    Spagnoli, A.4    Richards, W.5    Daniel, B.6
  • 42
    • 67651240362 scopus 로고    scopus 로고
    • RUNX3 has an oncogenic role in head and neck cancer
    • Tsunematsu T, Kudo Y, Iizuka S et al (2009). RUNX3 has an oncogenic role in head and neck cancer. PLoS ONE 4: 1-12.
    • (2009) PLoS ONE , vol.4 , pp. 1-12
    • Tsunematsu, T.1    Kudo, Y.2    Iizuka, S.3
  • 43
    • 31544468969 scopus 로고    scopus 로고
    • Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway
    • Urakami S, Shiina H, Enokida H et al (2006). Epigenetic inactivation of Wnt inhibitory factor-1 plays an important role in bladder cancer through aberrant canonical Wnt/beta-catenin signaling pathway. Clin Cancer Res 12: 383-391.
    • (2006) Clin Cancer Res , vol.12 , pp. 383-391
    • Urakami, S.1    Shiina, H.2    Enokida, H.3
  • 44
    • 0033866818 scopus 로고    scopus 로고
    • Molecular pathogenesis of oral squamous carcinoma
    • Williams HK (2000). Molecular pathogenesis of oral squamous carcinoma. Mol Pathol 53: 165-172.
    • (2000) Mol Pathol , vol.53 , pp. 165-172
    • Williams, H.K.1
  • 45
    • 0141995804 scopus 로고    scopus 로고
    • WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer
    • Wissmann C, Wild PJ, Kaiser S et al (2003). WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. J Pathol 201: 204-212.
    • (2003) J Pathol , vol.201 , pp. 204-212
    • Wissmann, C.1    Wild, P.J.2    Kaiser, S.3
  • 46
    • 34548513807 scopus 로고    scopus 로고
    • Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers
    • Yanagawa N, Tamura G, Oizumi H et al (2007). Promoter hypermethylation of RASSF1A and RUNX3 genes as an independent prognostic prediction marker in surgically resected non-small cell lung cancers. Lung Cancer 58: 131.
    • (2007) Lung Cancer , vol.58 , pp. 131
    • Yanagawa, N.1    Tamura, G.2    Oizumi, H.3
  • 47
    • 30944433183 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling inhibits death receptor-mediated apoptosis and promotes invasive growth of HNSCC
    • Yang F, Zeng Q, Yu G, Li S, Wang C (2006). Wnt/beta-catenin signaling inhibits death receptor-mediated apoptosis and promotes invasive growth of HNSCC. Cell Signal 18: 679-687.
    • (2006) Cell Signal , vol.18 , pp. 679-687
    • Yang, F.1    Zeng, Q.2    Yu, G.3    Li, S.4    Wang, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.