Gender and acute respiratory distress syndrome in critically injured adults: A prospective study

Journal of Trauma - Injury, Infection and Critical Care

Volumn 71, Issue 4, 2011, Pages 878-885

  Heffernan, Daithi S ^a   Dossett, Lesly A ^a   Lightfoot, Michelle A ^a   Fremont, Richard D ^b   Ware, Lorraine B ^b   Sawyer, Robert G ^c   May, Addison K ^b  

^a BROWN UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

ARDS; Critical illness; Gender; Sex hormones; Trauma

Indexed keywords

ESTRADIOL; TESTOSTERONE;

ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGE; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DEATH; FEMALE; GENDER; HOSPITAL ADMISSION; HUMAN; INJURY; INJURY SEVERITY; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; REVIEW; SEX DIFFERENCE;

ADULT; APACHE; ESTRADIOL; FEMALE; HUMANS; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RESPIRATORY DISTRESS SYNDROME, ADULT; SEX FACTORS; TESTOSTERONE; TRAUMA CENTERS; WOUNDS AND INJURIES;

EID: 80054036177     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e31822c0d31     Document Type: Review

References (30)

1. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet. 1967;2:319-323.
2. Awad SS. State-of-the-art therapy for severe sepsis and multisystem organ dysfunction. Am J Surg. 2003;186:23S-30S.
3. Lee CC, Marill KA, Carter WA, Crupi RS. A current concept of trauma-induced multiorgan failure. Ann Emerg Med. 2001;38:170-176. (Pubitemid 32702284)
4. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ. Multiple organ dysfunction score: A reliable descriptor of a complex clinical outcome. Crit Care Med. 1995;23:1638-1652.
5. Angele MK, Wichmann MW, Ayala A, Cioffi WG, Chaudry IH. Testosterone receptor blockage after hemorrhage in males. Restoration of the depressed immune functions and improves survival following subsequent sepsis. Arch Surg. 1997;132:1207-1214. (Pubitemid 27486050)
6. Knöferl MW, Angele MK, Diodato MD, et al. Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis. Ann Surg. 2002;235:105-112. (Pubitemid 34062406)
7. Schneider CP, Nickel EA, Samy TS, et al. The aromatase inhibitor 4-hydroxyandrostenedione, restores immune responses following trauma-hemorrhage in males and decreases mortality from subsequent sepsis. Shock. 2000;14:347-353.
8. Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH. Mechanism of immunosuppression in males following traumahemorrhage. Critical role of testosterone. Arch Surg. 1996;131: 1186-1191; discussion 1191-1192.
9. Wichmann MW, Inthorn D, Andress HJ, Schildberg FW. Incidence and mortality of severe sepsis in surgical intensive care patients: The influence of patient gender on disease process and outcome. Intensive Care Med. 2000;26:167-172. (Pubitemid 30186590)
10. Zellweger R, Wichmann MW, Ayala A, Stein S, DeMaso CM, Chaudry IH. Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males. Crit Care Med. 1997;25:106-110. (Pubitemid 27015048)
11. Wichmann MW, Angele MK, Ayala A, Cioffi WG, Chaudry IH. Flutaminde: A novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock. Shock. 1997;8: 242-248. (Pubitemid 127654333)
12. Angstwurm MW, Gaertner R, Schopohl J. Outcome in elderly patients with severe infection is influenced by sex hormones but not gender. Crit Care Med. 2005;12:2786-2793. (Pubitemid 41816413)
13. Bowles BJ, Roth B, Demetriades D. Sexual diamorphism in trauma? A retrospective evaluation of outcome. Injury. 2003;34:27-31. (Pubitemid 36071402)
14. Crabtree TD, Pelletier SJ, Gleason TG, Pruett TL, Sawyer RG. Genderdependent differences in outcome after the treatment of infection in hospitalized patients. JAMA. 1999;282:2143-2148.
15. Croce MA, Fabian TC, Malhotra AK, Bee TK, Miller PR. Does gender difference influence outcome? J Trauma. 2002;53:889-894. (Pubitemid 35334783)
16. Gannon CJ, Pasquale M, Tracy JK, McCarter RJ, Napolitano LM. Male gender is associated with increased risk for postinjury pneumonia. Shock. 2004;21:410-414.
17. Napolitano LM, Greco ME, Rodriguez A, Kufera JA, West RS, Scalea TM. Gender differences in adverse outcomes after blunt trauma. J Trauma. 2001;50:274-280. (Pubitemid 32230148)
18. Schröder J, Kahlke V, Staubach KH, Zabel P, Stüber F. Gender differences in human sepsis. Arch Surg. 1998;133:1200-1205. (Pubitemid 28516271)
19. Valentin A, Jordan B, Lang T, Hiesmayr M, Metnitz PG. Gender-related differences in intensive care: A multiple-center cohort study of therapeutic interventions and outcomes in critically ill patients. Crit Care Med. 2003;31:1901-1907. (Pubitemid 36900742)
20. May AK, Dossett LA, Norris PR, et al. Estradiol is assoicated with mortality in critically ill trauma and surgical patients. Crit Care Med. 2008;36:62-68.
21. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med. 2000;342:1334-1349. (Pubitemid 30408719)
22. Homo-Delarche F, Fitzpatrick F, Christeff N, Nunez EA, Bach JF, Dardenne M. Sex steroids, glucocorticoids, stress and autoimmunity. J Steroid Biochem Mol Biol. 1991;40:619-637.
23. Yokoyama Y, Kuebler JF, Matsutani T, Schwacha MG, Bland KI, Chaudry IH. Mechanism of the salutary effects of 17beta-estradiol following trauma-hemorrhage: Direct downregulation of Kupffer cell proinflammatory cytoine production. Cytokine. 2003;21:91-97. (Pubitemid 36369395)
24. Melgert BN, Ray A, Hylkema MN, Timens W, Postma DS. Are there reasons why adult asthma is more common in females? Curr Allergy Asthma Rep. 2007;7:143-150. (Pubitemid 46736336)
25. Watson L, Turk F, James P, Holgate ST. Factors associated with mortality after an asthma admission: A national United Kingdom database analysis. Respir Med. 2007;101:1659-1664. (Pubitemid 46947879)
26. Tsai CL, Clark S, Cydulka RK, Rowe BH, Camargo CA Jr. Factors associated with hospital admission among emergency department patients with chronic obstructive pulmonary disease exacerbation. Acad Emerg Med. 2007;14:6-14. (Pubitemid 46001754)
27. Kovacs EJ, Messingham KA, Gregory MS. Estrogen regulation of immune responses after injury. Mol Cell Endocrinol. 2002;193:129-135. (Pubitemid 34823617)
28. Fourrier F, Jallot A, Leclerc L, et al. Sex steroid hormones in circulatory shock, sepsis syndrome and septic shock. Circ Shock. 1994;43:171-178.
29. Gee AC, Sawai RS, Differding J, Muller P, Underwood S, Schreiber MA. The influence of sex hormones on coagulation and inflammation in the trauma patient. Shock. 2008;29:334-341. (Pubitemid 351271704)
30. Miller PR, Croce MA, Kilgo PD, Scott J, Fabian TC. Acute respiratory distress syndrome in blunt trauma: Identification of independent risk factors. Am Surg. 2002;68:845-850; discussion 850-851. (Pubitemid 44897026)