Flutamide: A novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock

Shock

Volumn 8, Issue 4, 1997, Pages 242-248

  Wichmann, Matthias W ^a,b   Angele, Martin K ^a   Ayala, Alfred ^a   Cioffi, William G ^a   Chaudry, Irshad H ^a  

^a BROWN UNIVERSITY   (United States)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; FLUTAMIDE; INTERLEUKIN 1; INTERLEUKIN 2; INTERLEUKIN 3; TESTOSTERONE;

ANIMAL; ARTICLE; BLOOD; BODY WEIGHT; C3H MOUSE; CELLULAR IMMUNITY; CYTOLOGY; DRUG EFFECT; HEMORRHAGIC SHOCK; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MALE; METABOLISM; MOUSE; PERITONEUM MACROPHAGE; SOFT TISSUE INJURY; SPLEEN; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BODY WEIGHT; CORTICOSTERONE; FLUTAMIDE; IMMUNITY, CELLULAR; INJECTIONS, SUBCUTANEOUS; INTERLEUKIN-1; INTERLEUKIN-2; INTERLEUKIN-3; LYMPHOCYTE ACTIVATION; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C3H; SHOCK, HEMORRHAGIC; SOFT TISSUE INJURIES; SPLEEN; TESTOSTERONE;

EID: 0031255106     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-199710000-00002     Document Type: Article

References (28)

1. Kemp CJ, Drinkwater NR: Genetic variation in liver tumor susceptibility, plasma testosterone levels, and androgen receptor binding in six inbred strains of mice. Cancer Res 49:5044-5047, 1989.
2. Schuurs AHWM, Verheul HAM: Effects of gender and sex steroids on the immune response. J Steroid Biochem 35:157-172, 1990.
3. Wichmann MW, Zellweger R, DeMaso CM, Ayala A, Chaudry IH: Mechanisms of immunosuppression in males following trauma-hemorrhage: Critical role of testosterone. Arch Surg 131:1186-1192, 1996.
4. Olsen NJ, Watson MB, Henderson GS, Kovacs WJ: Androgen deprivation induces phenotypic and functional changes in the thymus of adult male mice. Endocrinology 129:2471-2476, 1991.
5. Homo-Delarche F, Fitzpatrick F, Christeff N, Nunez EA, Bach JF, Dardenne M: Sex steroids, glucocorticoids, stress and autoimmunity. J Steroid Biochem Molec Biol 40:619-637, 1991.
6. Luster MI, Pfeifer RW, Tucker AN: Influence of sex hormones on immunoregulation with specific reference to natural and environmental estrogens. In Thomas, J. A. Korach, K. S. and McLachlan, J. A. (eds): Endocrine Toxicology, New York: Raven Press, 1985, pp 67-83.
7. Viselli SM, Stanziale S, Shults K, Kovacs WJ, Olsen NJ: Castration alters peripheral immune function in normal male mice. Immunology 84:337-342, 1995.
8. Roubinian JR, Talal N, Greenspan JS, Goodman JR, Siiteri PK: Delayed androgen treatment prolongs survival in murine lupus. J Clin Invest 63:902-911, 1979.
9. I mice treated with the testosterone-blocking drug flutamide. J Lab Clin Med 124:401-407, 1994.
10. Chaudry IH, Ayala A: Immunological Aspects of Hemorrhage. Austin, TX: R. G. Landes Company, 1992, pp 1-132.
11. Swain SL, Weinberg AD, English M, Huston G: IL-4 directs the development of Th2-like helper effectors. J Immmol 145:3796-3806, 1990.
12. Zellweger R, Ayala A, DeMaso CM, Chaudry IH: Trauma-hemorrhage causes prolonged depression in cellular immunity. Shock 4:149-153, 1995.
13. Chaudry IH, Ayala A, Ertel W, Stephan RN: Hemorrhage and resuscitation: Immunological aspects. Am J Physiol 259:R663-R678, 1990.
14. Stephan RN, Kupper TS, Geha AS, Baue AS, Chaudry IH: Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis. Arch Surg 122:62-68, 1987.
15. Ayala A, Lehman DL, Herdon CD, Chaudry IH: Mechanism of enhanced susceptibility to sepsis following hemorrhage: Interleukin (IL)-10 suppres-sion of T-cell response is mediated by eicosanoid induced IL-4 release. Arch Surg 129:1172-1178, 1994.
16. Ayala A, Perrin MM, Wagner MA, Chaudry IH: Enhanced susceptibility to sepsis following simple hemorrhage: Depression of Fc and C3b receptor mediated phagocytosis. Arch Surg 125:70-75, 1990.
17. Ihle JN, Keller J, Greenberger JS, Henderson L, Yetter RA, Morse HC: Phenotypic characteristics of cell lines requiring IL-3 for growth. J Immunol 129:1377-1383, 1982.
18. Meldrum DR, Ayala A, Perrin MM, Ertel W, Chaudry IH: Diltiazem restores IL-2, IL-3, IL-6 and IFN-gamma synthesis and decreases susceptibility to sepsis following hemorrhage. J Surg Res 51:158-164, 1991.
19. Mizel SB: Production and quantitation of lymphocyte-activating factor (interleukin 1). In Herscowitz HB, Holden HT, Bellanti JA, Ghaffar A (eds): Manual of Macrophage Methodology, New York: Marcel Dekker, Inc., 1981, pp 407-441.
20. Ertel W, Morrison MH, Ayala A, Chaudry IH: Chloroquine attenuates hemorrhagic shock induced suppression of Kupffer cell antigen presentation and MHC class II antigen expression through blockade of tumor necrosis factor and prostaglandin release. Blood 78:1781-1788, 1991.
21. Sheridan PJ: Can a single androgen receptor fill the bill? Mol Cell Endocrinonl 76:C39-C45, 1991.
22. Pierpaoli W, Kopp HG, Blanchi E: Interdependence of thymic and neu-roendocrine functions in ontogeny. Clin Exp Immunol 24:501-506, 1976.
23. Neri R, Florance K, Koziol P, Van Cleave S: A biological profile of a nonsteroidal antiandrogen, SCH 13521 (4′-nitro-3′-trifluoromethylisobutyranilide). Endocrinology 91:427-437, 1972.
24. Zellweger R, Zhu X, Wichmann MW, Ayala A, DeMaso CM, Chaudry IH: Prolactin administration following hemorrhagic shock improves macrophage cytokine release capacity and decreases mortality from subsequent sepsis. J Immunol 157:5748-5754, 1996.
25. Zellweger R, Wichmann MW, Ayala A, Stein S, DeMaso CM, Chaudry IH: Females in proestrus state maintain splenic immune functions and tolerate sepsis better than males. Crit Care Med 25:106-110, 1997.
26. Ertel W, Morrison MH, Ayala A, Chaudry IH: Chloroquine attenuates hemorrhagic shock-induced immunosuppression and decreases susceptibility to sepsis. Arch Surg 127:70-76, 1992.
27. Benten WPM, Wunderlich F, Mossmann H: Testosterone-induced suppression of self-healing Plasmodium chabaudi malaria: An effect not mediated by androgen receptors? Endocrinology 135:407-413, 1992.
28. Angele MK, Wichmann MW, Ayala A, Cioffi WG, Chaudry IH: Testosterone receptor blockade after hemorrhage in males: Restoration of the depressed immune functions and improved survival following subsequent sepsis. Arch Surg 1997. In press.