The influence of sex hormones on coagulation and inflammation in the trauma patient

Shock

Volumn 29, Issue 3, 2008, Pages 334-341

  Gee, Arvin C ^a   Sawai, Rebecca S ^a   Differding, Jerome ^a   Muller, Patrick ^a   Underwood, Samantha ^a   Schreiber, Martin A ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Estrogen; Hypercoagulable state; Progesterone; Sex; Testosterone; Trauma

Indexed keywords

ESTRADIOL; FIBRIN; FIBRINOGEN; INTERLEUKIN 6; INTERLEUKIN 8; PROGESTERONE; SEX HORMONE; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; BLOOD CLOTTING; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FIBRIN DEPOSITION; HORMONE BLOOD LEVEL; HORMONE RELEASE; HOSPITAL ADMISSION; HUMAN; INFLAMMATION; INJURY; INJURY SCALE; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PARTIAL THROMBOPLASTIN TIME; PROGNOSIS; PROTEIN BLOOD LEVEL; SCORING SYSTEM; SEX DIFFERENCE; THROMBOPLASTIN TIME;

ADULT; BLOOD COAGULATION; COHORT STUDIES; CYTOKINES; ESTRADIOL; FEMALE; GONADAL STEROID HORMONES; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; PARTIAL THROMBOPLASTIN TIME; PROGESTERONE; PROSPECTIVE STUDIES; SEVERITY OF ILLNESS INDEX; SEX CHARACTERISTICS; TESTOSTERONE; THROMBELASTOGRAPHY; WOUNDS AND INJURIES;

EID: 39449089221     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/SHK.0b013e3181506ee5     Document Type: Article

References (37)

1. Choudhry MA, Schwacha MG, Hubbard WJ, Kerby JD, Rue LW, Bland KI, Chaudry IH: Gender differences in acute response to trauma-hemorrhage. Shock 24(Suppl 1):101-106, 2005.
2. Peng R, Chang C, Gilmore D, Bongard F: Epidemiology of immediate and early trauma deaths at an urban Level I trauma center. Am Surg 64:950-954, 1998.
3. Frink M, Pape HC, van Griensven M, Krettek C, Chaudry IH, Hildebrand F: Influence of sex and age on MODS and cytokines after multiple injuries. Shock 27:151-156, 2007.
4. George RL, McGwin G Jr, Metzger J, Chaudry IH, Rue LW III: The association between gender and mortality among trauma patients as modified by age. J Trauma 54:464-471, 2003.
5. George RL, McGwin G Jr, Windham ST, Melton SM, Metzger J, Chaudry IH, Rue LW III: Age-related gender differential in outcome after blunt or penetrating trauma. Shock 19:28-32, 2003.
6. Mostafa G, Huynh T, Sing RF, Miles WS, Norton HJ, Thomason MH: Gender-related outcomes in trauma. J Trauma 53:430-434, 2002. discussion 434-435.
7. Napolitano LM, Greco ME, Rodriguez A, Kufera JA, West RS, Scalea TM: Gender differences in adverse outcomes after blunt trauma. J Trauma 50:274-280, 2001.
8. Wohltmann CD, Franklin GA, Boaz PW, Luchette FA, Kearney PA, Richardson JD, Spain DA: A multicenter evaluation of whether gender dimorphism affects survival after trauma. Am J Surg 181:297-300, 2001.
9. Gorton HJ, Warren ER, Simpson NA, Lyons GR, Columb MO: Thromboelastography identifies sex-related differences in coagulation. Anesth Analg 91:1279-1281, 2000.
10. Harnett MJ, Bhavani-Shankar K, Datta S, Tsen LC: In vitro fertilization-induced alterations in coagulation and fibrinolysis as measured by thromboelastography. Anesth Analg 95:1063-1066, 2002, table of contents.
11. Koh KK, Mincemoyer R, Bui MN, Csako G, Pucino F, Guetta V, Waclawiw M, Cannon RO III: Effects of hormone-replacement therapy on fibrinolysis in postmenopausal women. N Engl J Med 336:683-690, 1997.
12. Walsh BW, Kuller LH, Wild RA, Paul S, Farmer M, Lawrence JB, Shah AS, Anderson PW: Effects of raloxifene on serum lipids and coagulation factors in healthy postmenopausal women. JAMA 279:1445-1451, 1998.
13. Schreiber MA, Differding J, Thorborg P, Mayberry JC, Mullins RJ: Hypercoagulability is most prevalent early after injury and in female patients. J Trauma 58:475-480, 2005. discussion 480-481.
14. Schroder J, Kahlke V, Staubach KH, Zabel P, Stuber F: Gender differences in human sepsis. Arch Surg 133:1200-1205, 1998.
15. Bayir H, Marion DW, Puccio AM, Wisniewski SR, Janesko KL, Clark RS, Kochanek PM: Marked gender effect on lipid peroxidation after severe traumatic brain injury in adult patients. J Neurotrauma 21:1-8, 2004.
16. Ananthakrishnan P, Cohen DB, Xu DZ, Lu Q, Feketeova E, Deitch EA: Sex hormones modulate distant organ injury in both a trauma/hemorrhagic shock model and a burn model. Surgery 137:56-65, 2005.
17. Jarrar D, Wang P, Cioffi WG, Bland KI, Chaudry IH: The female reproductive cycle is an important variable in the response to trauma-hemorrhage. Am J Physiol Heart Circ Physiol 279:H1015-H1021, 2000.
18. Kovacs EJ, Faunce DE, Messingham KA: Ethanol and burn injury: estrogen modulation of immunity. Alcohol 33:209-216, 2004.
19. Krausz MM, Bashenko Y, Hirsh M: Improved survival in uncontrolled hemorrhagic shock induced by massive splenic injury in the proestrus phase of the reproductive cycle in the female rat. Shock 20:444-448, 2003.
20. Salooja N, Perry DJ: Thrombelastography. Blood Coagul Fibrinolysis 12: 327-337, 2001.
21. Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R: The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 149:818-824, 1994.
22. Ciesla DJ, Moore EE, Johnson JL, Sauaia A, Cothren CC, Moore JB, Burch JM: Multiple organ dysfunction during resuscitation is not postinjury multiple organ failure. Arch Surg 139:590-594, 2004. discussion 594-595.
23. Katzenellenbogen BS: Mechanisms of action and cross-talk between estrogen receptor and progesterone receptor pathways. J Soc Gynecol Investig 7:S33-S37, 2000.
24. Prasad RN, Koh S, Ratnam SS: Effects of three types of combined O.C. pills on blood coagulation, fibrinolysis and platelet function. Contraception 39:369-383, 1989.
25. Sharma SK, Philip J, Wiley J: Thromboelastographic changes in healthy parturients and postpartum women. Anesth Analg 85:94-98, 1997.
26. Majetschak M, Christensen B, Obertacke U, Waydhas C, Schindler AE, Nast-Kolb D, Schade FU: Sex differences in posttraumatic cytokine release of endotoxin-stimulated whole blood: relationship to the development of severe sepsis. J Trauma 48:832-839, 2000. discussion 839-840.
27. Pfeilschifter J, Koditz R, Pfohl M, Schatz H: Changes in proinflammatory cytokine activity after menopause. Endocr Rev 23:90-119, 2002.
28. Janele D, Lang T, Capellino S, Cutolo M, Da Silva JA, Straub RH: Effects of testosterone, 17beta-estradiol, and downstream estrogens on cytokine secretion from human leukocytes in the presence and absence of cortisol. Ann N Y Acad Sci 1069:168-182, 2006.
29. Katzenellenbogen BS, Katzenellenbogen JA: Estrogen receptor transcription and transactivation: estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer. Breast Cancer Res 2:335-344, 2000.
30. Katzenellenbogen BS, Montano MM, Ediger TR, Sun J, Ekena K, Lazennec G, Martini PG, McInerney EM, Delage-Mourroux R, Weis K, et al.: Estrogen receptors: selective ligands, partners, and distinctive pharmacology. Recent Prog Horm Res 55:163-193, 2000. discussion 194-195.
31. Jakacka M, Ito M, Weiss J, Chien PY, Gehm BD, Jameson JL: Estrogen receptor binding to DNA is not required for its activity through the nonclassical AP1 pathway. J Biol Chem 276:13615-13621, 2001.
32. Srivastava S, Weitzmann MN, Cenci S, Ross FP, Adler S, Pacifici R: Estrogen decreases TNF gene expression by blocking JNK activity and the resulting production of c-Jun and JunD. J Clin Invest 104:503-513, 1999.
33. Gee AC, Carlson KE, Martini PG, Katzenellenbogen BS, Katzenellenbogen JA: Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor. Mol Endocrinol 13:1912-1923, 1999.
34. Christeff N, Benassayag C, Carli-Vielle C, Carli A, Nunez EA: Elevated oestrogen and reduced testosterone levels in the serum of male septic shock patients. J Steroid Biochem 29:435-440, 1988.
35. Moss M, Mannino DM: Race and gender differences in acute respiratory distress syndrome deaths in the United States: an analysis of multiple-cause mortality data (1979-1996). Crit Care Med 30:1679-1685, 2002.
36. Tsai BM, Wang M, Pitcher JM, Kher A, Brown JW, Meldrum DR: Endothelium-dependent pulmonary artery vasorelaxation is dysfunctional in males but not females after acute lung injury. Surgery 138:78-84, 2005.
37. Scheingraber S, Dobbert D, Schmiedel P, Seliger E, Dralle H: Gender-specific differences in sex hormones and cytokines in patients undergoing major abdominal surgery. Surg Today 35:846-854, 2005.