Exercise-induced dehydration with and without environmental heat stress results in increased oxidative stress

Applied Physiology, Nutrition and Metabolism

Volumn 36, Issue 5, 2011, Pages 698-706

  Hillman, Angela ^a   Vince, Rebecca ^b   Taylor, Lee ^b   Mcnaughton, Lars ^c   Mitchell, Nigel ^d   Siegler, Jason ^e  

^a UNIVERSITY OF HULL   (United Kingdom)

^b UNIVERSITY OF BEDFORDSHIRE   (United Kingdom)

^c BOND UNIVERSITY   (Australia)

^d National Cycling Centre   (United Kingdom)

^e UNIVERSITY OF WESTERN SYDNEY   (Australia)

Author keywords

Cycling exercise; Glutathione; Heat shock protein; Reactive oxygen species

Indexed keywords

GLUTATHIONE; HEAT SHOCK PROTEIN 72;

ADULT; ARTICLE; ATHLETE; ATHLETIC PERFORMANCE; BICYCLE; BLOOD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEHYDRATION; EXERCISE; EXERCISE TEST; FLUID THERAPY; HEAT INJURY; HOSPITALIZATION; HUMAN; LYMPHOCYTE; MALE; METABOLISM; MONOCYTE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PHYSIOLOGICAL STRESS; RANDOMIZED CONTROLLED TRIAL;

ADULT; ATHLETES; ATHLETIC PERFORMANCE; BICYCLING; DEHYDRATION; EXERCISE; EXERCISE TEST; FLUID THERAPY; GLUTATHIONE; HEAT STRESS DISORDERS; HSP72 HEAT-SHOCK PROTEINS; HUMANS; LYMPHOCYTES; MALE; MONOCYTES; OXIDATION-REDUCTION; OXIDATIVE STRESS; PHYSICAL EXERTION; SEVERITY OF ILLNESS INDEX; STRESS, PHYSIOLOGICAL;

EID: 80054031036     PISSN: 17155312     EISSN: 17155320     Source Type: Journal    
DOI: 10.1139/h11-080     Document Type: Article

References (48)

1. Abbiss, C.R., Quod, M.J., Levin, G., Martin, D.T., and Laursen, P.B. 2009. Accuracy of the Velotron ergometer and SRM power meter. Int. J. Sports Med. 30(2): 107-112. doi:10.1055/s-0028-1103285. PMID:19177315.
2. Alessio, H.M. 1993. Exercise-induced oxidative stress. Med. Sci. Sports Exerc. 25(2): 218-224. PMID:8383786.
3. Byrne, C., Twist, C., and Eston, R. 2004. Neuromuscular function after exercise-induced muscle damage: theoretical and applied implications. Sports Med. 34(1): 49-69. doi:10.2165/00007256-200434010-00005. PMID:14715039.
4. Cairo, G., Bardella, L., Schiaffonati, L., and Bernelli-Zazzera, A. 1985. Synthesis of heat shock proteins in rat liver after ischemia and hyperthermia. Hepatology, 5(3): 357-361. doi:10.1002/hep. 1840050303. PMID:2581879.
5. Cheng, B., Kuipers, H., Snyder, A.C., Keizer, H.A., Jeukendrup, A., and Hesselink, M. 1992. A new approach for the determination of ventilatory and lactate thresholds. Int. J. Sports Med. 13(7): 518-522. doi:10.1055/s-2007-1021309. PMID:1459746.
6. Cheuvront, S.N., Kenefick, R.W., Montain, S.J., and Sawka, M.N. 2010. Mechanisms of aerobic performance impairment with heat stress and dehydration. J. Appl. Physiol. 109(6): 1989-1995. doi:10.1152/japplphysiol.00367.2010. PMID:20689090.
7. Dill, D.B., and Costill, D.L. 1974. Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J. Appl. Physiol. 37(2): 247-248. PMID:4850854.
8. Falone, S., Mirabilio, A., Pennelli, A., Cacchio, M., Di Baldassarre, A., Gallina, S., et al. 2010. Differential impact of acute bout of exercise on redox- and oxidative damage-related profiles between untrained subjects and amateur runners. Physiol. Res. 59(6): 953-961. PMID:20533869.
9. Fehrenbach, E., Niess, A.M., Schlotz, E., Passek, F., Dickhuth, H.H., and Northoff, H. 2000a. Transcriptional and translational regulation of heat shock proteins in leukocytes of endurance runners. J. Appl. Physiol. 89(2): 704-710. PMID:10926657.
10. Fehrenbach, E., Passek, F., Niess, A.M., Pohla, H., Weinstock, C., Dickhuth, H.H., and Northoff, H. 2000b. HSP expression in human leukocytes is modulated by endurance exercise. Med. Sci. Sports Exerc. 32(3): 592-600. doi:10.1097/00005768-200003000-00007. PMID:10731000.
11. Fehrenbach, E., Niess, A.M., Passek, F., Sorichter, S., Schwirtz, A., Berg, A., et al. 2003a. Influence of different types of exercise on the expression of haem oxygenase-1 in leukocytes. J. Sports Sci. 21(5): 383-389. doi:10.1080/0264041031000071164. PMID: 12800860.
12. Fehrenbach, E., Veith, R., Schmid, M., Dickhuth, H.H., Northoff, H., and Niess, A.M. 2003b. Inverse response of leukocyte heat shock proteins and DNA damage to exercise and heat. Free Radic. Res. 37(9): 975-982. doi:10.1080/10715760310001595748. PMID: 14670005.
13. Ferncheckentityá P., Guillcheckentityé M.I., Gomar, F., and Alcaraz, M.J. 2003. Expression of heme oxygenase-1 and regulation by cytokines in human osteoarthritic chondrocytes. Biochem. Pharmacol. 66(10): 2049-2052. doi:10.1016/S0006-2952(03)00543-4. PMID:14599563.
14. Fisher-Wellman, K., and Bloomer, R.J. 2009. Acute exercise and oxidative stress: a 30 year history. Dyn. Med. 8(1): 1. doi:10.1186/1476-5918-8-1. PMID:19144121.
15. Flanagan, S.W., Ryan, A.J., Gisolfi, C.V., and Moseley, P.L. 1995. Tissue-specific HSP70 response in animals undergoing heat stress. Am. J. Physiol. 268(1 Pt 2): R28-R32. PMID:7840333.
16. Gohil, K., Viguie, C., Stanley, W.C., Brooks, G.A., and Packer, L. 1988. Blood glutathione oxidation during human exercise. J. Appl. Physiol. 64(1): 115-119. PMID:3356628.
17. Goto, C., Higashi, Y., Kimura, M., Noma, K., Hara, K., Nakagawa, K., et al. 2003. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation, 108(5): 530-535. doi:10.1161/01.CIR.0000080893.55729. 28. PMID:12874192.
18. Hcheckentityä D., Lang, F., Bauers, K., and Gerok, W. 1990. Control of hepatic nitrogen metabolism and glutathione release by cell volume regulatory mechanisms. Eur. J. Biochem. 193(3): 891-898. doi:10.1111/j.1432-1033.1990.tb19414.x. PMID:2249700.
19. Kalmar, B., and Greensmith, L. 2009. Induction of heat shock proteins for protection against oxidative stress. Adv. Drug Deliv. Rev. 61(4): 310-318. doi:10.1016/j.addr.2009.02.003. PMID: 19248813.
20. Knez, W.L., Jenkins, D.G., and Coombes, J.S. 2007. Oxidative stress in half and full Ironman triathletes. Med. Sci. Sports Exerc. 39(2): 283-288. doi:10.1249/01.mss.0000246999.09718.0c. PMID: 17277592.
21. Kurz, A.K., Schliess, F., and Hcheckentityä D. 1998. Osmotic regulation of the heat shock response in primary rat hepatocytes. Hepatology, 28(3): 774-781.doi:10.1002/hep.510280326. PMID: 9731572.
22. Laitano, O., Kalsi, K.K., Pook, M., Oliveira, A.R., and Gonzalez-Alonso, J. 2010. Separate and combined effects of heat stress and exercise on circulatory markers of oxidative stress in euhydrated humans. Eur. J. Appl. Physiol. 110(5): 953-960. doi:10.1007/s00421-010-1577-5. PMID:20658249.
23. Lovell, R., Madden, L., Carroll, S., and McNaughton, L. 2007. The time-profile of the PBMC HSP70 response to in vitro heat shock appears temperature-dependent. Amino Acids, 33(1): 137-144. doi:10.1007/s00726-006-0400-4. PMID:16988908.
24. Markovitch, D., Tyrrell, R.M., and Thompson, D. 2007. The effect of prior exercise on ex vivo induction of heme oxygenase-1 in human lymphocytes. Free Radic. Res. 41(10): 1125-1134. doi:10.1080/10715760701589230. PMID:17886034.
25. Martins, E.A., and Meneghini, R. 1994. Cellular DNA damage by hydrogen peroxide is attenuated by hypotonicity. Biochem. J. 299 (Pt 1): 137-140. PMID:8166631.
26. Mattson, M.P. 2006. Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders. Antioxid. Redox Signal. 8(11-12): 1997-2006. doi:10.1089/ars.2006.8.1997. PMID:17034345.
27. McAnulty, S.R., McAnulty, L., Pascoe, D.D., Gropper, S.S., Keith, R.E., Morrow, J.D., and Gladden, L.B. 2005. Hyperthermia increases exercise-induced oxidative stress. Int. J. Sports Med. 26 (3): 188-192. doi:10.1055/s-2004-820990. PMID:15776334.
28. Mena, P., Maynar, M., Gutierrez, J.M., Maynar, J., Timon, J., and Campillo, J.E. 1991. Erythrocyte free radical scavenger enzymes in bicycle professional racers. Adaptation to training. Int. J. Sports Med. 12(6): 563-566. doi:10.1055/s-2007-1024734. PMID: 1797698.
29. Miyazaki, H., Oh-ishi, S., Ookawara, T., Kizaki, T., Toshinai, K., Ha, S., et al. 2001. Strenuous endurance training in humans reduces oxidative stress following exhausting exercise. Eur. J. Appl. Physiol. 84(1-2): 1-6. doi:10.1007/s004210000342. PMID: 11394236.
30. Mobley, J.L., Leininger, M., Madore, S., Baginski, T.J., and Renkiewicz, R. 2007. Genetic evidence of a functional monocyte dichotomy. Inflammation, 30(6): 189-197. doi:10.1007/s10753-007-9036-0. PMID:17587162.
31. Montain, S.J., and Coyle, E.F. 1992. Influence of graded dehydration on hyperthermia and cardiovascular drift during exercise. J. Appl. Physiol. 73(4): 1340-1350. PMID:1447078.
32. Morillas-Ruiz, J., Zafrilla, P., Almar, M., Cuevas, M.J., Lopez, F.J., Abellan, P., et al. 2005. The effects of an antioxidant-supplemented beverage on exercise-induced oxidative stress: results from a placebo-controlled double-blind study in cyclists. Eur. J. Appl. Physiol. 95(5-6): 543-549. doi:10.1007/s00421-005-0017-4.PMID:16132121.
33. Morton, J.P., Maclaren, D.P., Cable, N.T., Campbell, I.T., Evans, L., Bongers, T., et al. 2007. Elevated core and muscle temperature to levels comparable to exercise do not increase heat shock protein content of skeletal muscle of physically active men. Acta Physiol. (Oxf.), 190(4): 319-327. doi:10.1111/j.1748-1716.2007.01711.x. PMID:17488245.
34. Niess, A.M., Hartmann, A., Grunert-Fuchs, M., Poch, B., and Speit, G. 1996. DNA damage after exhaustive treadmill running in trained and untrained men. Int. J. Sports Med. 17(6): 397-403. doi:10.1055/s-2007-972868. PMID:8884412.
35. Niess, A.M., Passek, F., Lorenz, I., Schneider, E.M., Dickhuth, H.H., Northoff, H., and Fehrenbach, E. 1999. Expression of the antioxidant stress protein heme oxygenase-1 (HO-1) in human leukocytes. Free Radic. Biol. Med. 26(1-2): 184-192. doi:10.1016/S0891-5849(98)00192-0. PMID:9890653.
36. Oehler, R., Pusch, E., Zellner, M., Dungel, P., Hergovics, N., Homoncik, M., et al. 2001. Cell type-specific variations in the induction of hsp70 in human leukocytes by feverlike whole body hyperthermia. Cell Stress Chaperones, 6(4): 306-315. doi:10. 1379/1466-1268(2001)0060306:CTSVIT2.0.CO;2. PMID: 11795467.
37. Ohtsuka, Y., Yabunaka, N., Fujisawa, H., Watanabe, I., and Agishi, Y. 1994. Effect of thermal stress on glutathione metabolism in human erythrocytes. Eur. J. Appl. Physiol. Occup. Physiol. 68(1): 87-91. doi:10.1007/BF00599247. PMID:8162928.
38. Paik, I.Y., Jeong, M.H., Jin, H.E., Kim, Y.I., Suh, A.R., Cho, S.Y., et al. 2009. Fluid replacement following dehydration reduces oxidative stress during recovery. Biochem. Biophys. Res. Commun. 383(1): 103-107. doi:10.1016/j.bbrc.2009.03.135. PMID: 19344695.
39. Powers, S.K., and Jackson, M.J. 2008. Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol. Rev. 88(4): 1243-1276. doi:10.1152/physrev.00031. 2007. PMID:18923182.
40. Reid, M.B. 2001. Invited Review: redox modulation of skeletal muscle contraction: what we know and what we don't. J. Appl. Physiol. 90(2): 724-731. PMID:11160074.
41. Saha, N., Stoll, B., Lang, F., and Haussinger, D. 1992. Effect of anisotonic cell-volume modulation on glutathione-S-conjugate release, t-butylhydroperoxide metabolism and the pentose-phosphate shunt in perfused rat liver. Eur. J. Biochem. 209(1): 437-444. doi:10.1111/j.1432-1033.1992.tb17307.x. PMID:1396717.
42. Sandstrcheckentityö M.E., Madden, L.A., Taylor, L., Siegler, J.C., Lovell, R.J., Midgley, A., and McNaughton, L. 2009. Variation in basal heat shock protein 70 is correlated to core temperature in human subjects. Amino Acids, 37(2): 279-284. doi:10.1007/s00726-008-0144-4. PMID:18665435.
43. Sawka, M.N., Burke, L.M., Eichner, E.R., Maughan, R.J., Montain, S.J., and Stachenfeld, N.S.American College of Sports Medicine. 2007. American College of Sports Medicine position stand. Exercise and fluid replacement. Med. Sci. Sports Exerc. 39(2): 377-390. PMID:17277604.
44. Schliess, F., and Haussinger, D. 2002. The cellular hydration state: a critical determinant for cell death and survival. Biol. Chem. 383(3-4): 577-583. doi:10.1515/BC.2002.059.PMID:12033446.
45. Speit, G., Dennog, C., Eichhorn, U., Rothfuss, A., and Kaina, B. 2000. Induction of heme oxygenase-1 and adaptive protection against the induction of DNA damage after hyperbaric oxygen treatment. Carcinogenesis, 21(10): 1795-1799. doi:10.1093/carcin/21.10.1795. PMID:11023535.
46. Sporer, B.C., and McKenzie, D.C. 2007. Reproducibility of a laboratory based 20-km time trial evaluation in competitive cyclists using the Velotron Pro ergometer. Int. J. Sports Med. 28(11): 940-944. doi:10.1055/s-2007-964977. PMID:17497571.
47. Thompson, D., Basu-Modak, S., Gordon, M., Poore, S., Markovitch, D., and Tyrrell, R.M. 2005. Exercise-induced expression of heme oxygenase-1 in human lymphocytes. Free Radic. Res. 39(1): 63-69. doi:10.1080/10715760400022327. PMID:15875813.
48. Viguie, C.A., Frei, B., Shigenaga, M.K., Ames, B.N., Packer, L., and Brooks, G.A. 1993. Antioxidant status and indexes of oxidative stress during consecutive days of exercise. J. Appl. Physiol. 75(2): 566-572. PMID:7693646.