Long-lived inflammatory signaling in irradiated bone marrow is genome dependent

Cancer Research

Volumn 71, Issue 20, 2011, Pages 6485-6491

  Lorimore, Sally A ^a   Mukherjee, Debayan ^a   Robinson, Joanne I ^a   Chrystal, Jennifer A ^a   Wright, Eric G ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; CYTOKINE; FAS LIGAND; MITOGEN ACTIVATED PROTEIN KINASE; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; BYSTANDER EFFECT; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; COCULTURE; COLONY FORMING CELL; CONTROLLED STUDY; CYTOGENETICS; GENOTYPE; IONIZING RADIATION; LETHALITY; MALE; METAPHASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; SIGNAL TRANSDUCTION;

ANIMALS; BONE MARROW; BYSTANDER EFFECT; CHROMOSOMAL INSTABILITY; CYCLOOXYGENASE 2; CYTOKINES; INFLAMMATION; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; SIGNAL TRANSDUCTION;

EID: 80054023439     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-11-1926     Document Type: Article

References (43)

1. UNSCEAR. UNSCEAR 2006 Report to the general assembly, Vol. I: Effects of ionising radiation. New York: United Nations; 2008.
2. Nadeau JH. Modifier genes in mice and humans. Nat Rev Genet 2001;2:165-74. (Pubitemid 33674015)
3. Ewart-Toland A, Balmain A. The genetics of cancer susceptibility: from mouse to man. Toxicol Pathol 2004;32Suppl 1:26-30. (Pubitemid 38437564)
4. Barcellos-Hoff MH, Nguyen DH. Radiation carcinogenesis in context: how do irradiated tissues become tumors?Health Phys 2009;97:446-57.
5. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010;140:883-99.
6. Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science 331:1565-70.
7. Little JB. Genomic instability and bystander effects: a historical perspective. Oncogene 2003;22:6978-87. (Pubitemid 37386665)
8. Lorimore SA, Coates PJ, Wright EG. Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation. Oncogene 2003;22:7058-69. (Pubitemid 37386675)
9. Morgan WF. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiat Res 2003;159:567-80. (Pubitemid 36539236)
10. Morgan WF. Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiat Res 2003;159:581-96. (Pubitemid 36539237)
11. Mothersill C, Seymour C. Radiation-induced bystander effects: past history and future directions. Radiat Res 2001;155:759-67. (Pubitemid 32494601)
12. Mothersill C, Seymour CB. Radiation-induced bystander effects-implications for cancer. Nat Rev Cancer 2004;4:158-64.
13. Lorimore SA, McIlrath JM, Coates PJ, Wright EG. Chromosomal instability in unirradiated hemopoietic cells resulting from a delayed in vivo bystander effect of gamma radiation. Cancer Res 2005;65:5668-73. (Pubitemid 40911168)
14. Wright EG, Coates PJ. Untargeted effects of ionizing radiation: implications for radiation pathology. Mutat Res 2006;597:119-32.
15. Wright EG. Ionizing radiation and leukaemia: more questions than answers. Hematol Oncol 2005;23:119-26. (Pubitemid 43061889)
16. Rithidech KN, Cronkite EP, Bond VP. Advantages of the CBA mouse in leukemogenesis research. Blood Cells Mol Dis 1999;25:38-45. (Pubitemid 29205489)
17. Lorimore SA, Pragnell IB, Eckmann L, Wright EG. Synergistic interactions allow colony formation in vitro by murine haemopoietic stem cells. Leuk Res 1990;14:481-9. (Pubitemid 20175219)
18. Kadhim MA, Pocock DA, Lorimore SA, Wright EG. An improved micro-method for obtaining chromosome preparations from individual haemopoietic colonies. Br J Haematol 1999;105:673-5. (Pubitemid 29277024)
19. Wright EG, Lorimore SA. The production of factors regulating the proliferation of haemopoietic spleen colony-forming cells by bone marrow macrophages. Cell Tissue Kinet 1987;20:191-203.
20. Coates PJ, Lorimore SA, Lindsay KJ, Wright EG. Tissue-specific p53 responses to ionizing radiation and their genetic modification: the key to tissue-specific tumour susceptibility?J Pathol 2003;201:377-88. (Pubitemid 37408258)
21. Krammer PH. CD95(APO-1/Fas)-mediated apoptosis: live and let die. Adv Immunol 1999;71:163-210. (Pubitemid 30227734)
22. Peter MEBudd RC, Desbarats J, Hedrick SM, Hueber AO, Newell MK, et al. The CD95 receptor: apoptosis revisited. Cell 2007;129:447-50.
23. Holler N, Zaru R, Micheau O, Thome M, Attinger A, Valitutti S, et al. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 2000;1:489-95.
24. Dupont PJ, Warrens AN. Fas ligand exerts its pro-inflammatory effects via neutrophil recruitment but not activation. Immunology 2007;120:133-9. (Pubitemid 44950478)
25. Fehsel K, Kolb-Bachofen V, Kolb H. Analysis of TNF alpha-induced DNA strand breaks at the single cell level. Am J Pathol 1991;139:251-4.
26. Schulze-Osthoff K, Beyaert R, Vandevoorde V, Haegeman G, Fiers W. Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. Embo J 1993;12:3095-104. (Pubitemid 23232740)
27. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S. MAPK pathways in radiation responses. Oncogene 2003;22:5885-96. (Pubitemid 37176709)
28. Au PY, Yeh WC. Physiological roles and mechanisms of signaling by TRAF2 and TRAF5. Adv Exp Med Biol 2007;597:32-47.
29. Lorimore SA, Chrystal JA, Robinson JI, Coates PJ, Wright EG. Chromosomal instability in unirradiated hemaopoietic cells induced by macrophages exposed in vivo to ionizing radiation. Cancer Res 2008;68:8122-6.
30. Hei TK, Zhou H, Ivanov VN, Hong M, Lieberman HB, Brenner DJ, et al. Mechanism of radiation-induced bystander effects: a unifying model. J Pharm Pharmacol 2008;60:943-50.
31. Gilroy DW, Colville-Nash PR. New insights into the role of COX 2 in inflammation. J Mol Med 2000;78:121-9. (Pubitemid 30337493)
32. Nathan C. Points of control in inflammation. Nature 2002;420:846-52. (Pubitemid 36019637)
33. Shishodia S, Koul D, Aggarwal BB. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. J Immunol 2004;173:2011-22. (Pubitemid 38971638)
34. Fiers W. Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level. FEBS Lett 1991;285:199-212.
35. Emerit I. Clastogenic factors: detection and assay. Methods Enzymol 1990;186:555-64. (Pubitemid 20279998)
36. Lorimore SA, Coates PJ, Scobie GE, Milne G, Wright EG. Inflammatory-type responses after exposure to ionizing radiation in vivo: a mechanism for radiation-induced bystander effects? Oncogene 2001;20:7085-95. (Pubitemid 33052200)
37. Spitz DR, Azzam EI, Jian Li J, Gius D. Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: A unifying concept in stress response biology. Cancer Metastasis Rev 2004;23:311-22. (Pubitemid 38881814)
38. Kodama K, Mabuchi K, Shigematsu I. A long-term cohort study of the atomic-bomb survivors. J Epidemiol 1996;6:S95-105.
39. Shimizu Y, Pierce DA, Preston DL, Mabuchi K. Studies of the mortality of atomic bomb survivors. Report 12, part II. Noncancer mortality: 1950-1990. Radiat Res 1999;152:374-89. (Pubitemid 29463615)
40. Neriishi K, Nakashima E, Delongchamp RR. Persistent subclinical inflammation among A-bomb survivors. Int J Radiat Biol 2001;77:475-82. (Pubitemid 32281128)
41. Hayashi T, Kusunoki Y, Hakoda M, Morishita Y, Kubo Y, Maki M, et al. Radiation dose-dependent increases in inflammatory response markers in A-bomb survivors. Int J Radiat Biol 2003;79:129-36. (Pubitemid 36183071)
42. Medzhitov R. Origin and physiological roles of inflammation. Nature 2008;454:428-35.
43. Schaue D, McBride WH. Links between innate immunity and normal tissue radiobiology. Radiat Res 2010;173:406-17.