Drug-Induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by Focal Activity

Circulation: Arrhythmia and Electrophysiology

Volumn 4, Issue 4, 2011, Pages 566-576

  Boulaksil, Mohamed ^a,b   Jungschleger, Jerome G ^c   Antoons, Gudrun ^a,e   Houtman, Marien J C ^a   De Boer, Teun P ^a   Wilders, Ronald ^f   Beekman, Jet D ^a   Maessen, Jos G ^c   Van Der Hulst, Ferenc F ^a,d   Van Der Heyden, Marcel A G ^a   Van Veen, Toon A B ^a   Van Rijen, Harold V M ^a   De Bakker, Jacques M T ^a,b,f   Vos, Marc A ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c Interuniversity Cardiology Institute of the Netherlands ^*  (Netherlands)

^d MAASTRICHT UNIVERSITY   (Netherlands)

^e UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^f ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Conduction; Ion channels; Long QT syndrome; Mechanisms of arrhythmia; Torsade de pointes

Indexed keywords

COLLAGEN; CONNEXIN 43; IBUTILIDE; ANTIARRHYTHMIC AGENT; SODIUM CHANNEL; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATRIOVENTRICULAR BLOCK; CELL ISOLATION; CELL SIZE; COMPUTER SIMULATION; CONTROLLED STUDY; ELECTROGRAPHY; EXPERIMENTAL DOG; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART MUSCLE REFRACTORY PERIOD; HEART RIGHT VENTRICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINUS NODE CONDUCTION VELOCITY; SODIUM CURRENT; TORSADE DES POINTES; ANIMAL; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DOG; HEART FUNCTION TEST; HEART LEFT VENTRICLE FUNCTION; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE; HYPERTROPHY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; REFRACTORY PERIOD;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; ATRIOVENTRICULAR BLOCK; COLLAGEN; CONNEXIN 43; DISEASE MODELS, ANIMAL; DOGS; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; HEART VENTRICLES; HYPERTROPHY; REFRACTORY PERIOD, ELECTROPHYSIOLOGICAL; SODIUM CHANNELS; SULFONAMIDES; TORSADES DE POINTES; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR DYSFUNCTION, RIGHT;

EID: 80054015760     PISSN: 19413149     EISSN: 19413084     Source Type: Journal    
DOI: 10.1161/CIRCEP.110.958991     Document Type: Article

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