-
1
-
-
70349443284
-
When mutants gain new powers: News from the mutant p53 field
-
Brosh R, Rotter V. When mutants gain new powers: news from the mutant p53 field. Nat Rev Cancer 2009;9:701-13.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 701-713
-
-
Brosh, R.1
Rotter, V.2
-
2
-
-
0037103914
-
Several regions of p53 are involved in repression of RNA polymerase III transcription
-
DOI 10.1038/sj.onc.1205739
-
Stein T, Crighton D, Warnock LJ, Milner J, White RJ. Several regions of p53 are involved in repression of RNA polymerase III transcription. Oncogene 2002;21:5540-7. (Pubitemid 34983543)
-
(2002)
Oncogene
, vol.21
, Issue.36
, pp. 5540-5547
-
-
Stein, T.1
Crighton, D.2
Warnock, L.J.3
Milner, J.4
White, R.J.5
-
3
-
-
0035496607
-
Rescuing the function of mutant p53
-
Bullock AN, Fersht AR. Rescuing the function of mutant p53. Nat Rev Cancer 2001;1:68-76. (Pubitemid 33741882)
-
(2001)
Nature Reviews Cancer
, vol.1
, Issue.1
, pp. 68-76
-
-
Bullock, A.N.1
Fersht, A.R.2
-
4
-
-
0025894713
-
p53 mutations in human cancers
-
Hollstein M, Sidransky D, Vogelstein B, Harris CC. p53 mutations in human cancers. Science 1991;253:49-53. (Pubitemid 21917115)
-
(1991)
Science
, vol.253
, Issue.5015
, pp. 49-53
-
-
Hollsteln, M.1
Sidransky, D.2
Vogelstein, B.3
Harris, C.C.4
-
5
-
-
33644772215
-
The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer
-
DOI 10.1158/1078-0432.CCR-05-1029
-
Olivier M, Langerød A, Carrieri P, Bergh J, Klaar S, Eyfjord J, et al. The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer. Clin Cancer Res 2006;12:1157-67. (Pubitemid 43342504)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.4
, pp. 1157-1167
-
-
Olivier, M.1
Langerod, A.2
Carrieri, P.3
Bergh, J.4
Klaar, S.5
Eyfjord, J.6
Theillet, C.7
Rodriguez, C.8
Lidereau, R.9
Bieche, I.10
Varley, J.11
Bignon, Y.12
Uhrhammer, N.13
Winqvist, R.14
Jukkola-Vuorinen, A.15
Niederacher, D.16
Kato, S.17
Ishioka, C.18
Hainaut, P.19
Borresen-Dale, A.-L.20
more..
-
6
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
DOI 10.1038/nature05541, PII NATURE05541
-
Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, et al. Restoration of p53 function leads to tumour regression in vivo. Nature 2007;445:661-5. (Pubitemid 46232887)
-
(2007)
Nature
, vol.445
, Issue.7128
, pp. 661-665
-
-
Ventura, A.1
Kirsch, D.G.2
McLaughlin, M.E.3
Tuveson, D.A.4
Grimm, J.5
Lintault, L.6
Newman, J.7
Reczek, E.E.8
Weissleder, R.9
Jacks, T.10
-
8
-
-
77955175360
-
Pharmacological reactivation of mutant p53: From protein structure to the cancer patient
-
Wiman KG. Pharmacological reactivation of mutant p53: from protein structure to the cancer patient. Oncogene 2010;29:4245-52.
-
(2010)
Oncogene
, vol.29
, pp. 4245-4252
-
-
Wiman, K.G.1
-
9
-
-
70350028481
-
An update on gene therapy in China
-
Shi J, Zheng D. An update on gene therapy in China. Curr Opin Mol Ther 2009;11:547-53.
-
(2009)
Curr Opin Mol Ther
, vol.11
, pp. 547-553
-
-
Shi, J.1
Zheng, D.2
-
10
-
-
0037627875
-
Why did p53 gene therapy fail in ovarian cancer?
-
DOI 10.1016/S1470-2045(03)01139-2
-
Zeimet AG, Marth C. Why did p53 gene therapy fail in ovarian cancer? Lancet Oncol 2003;4:415-22. (Pubitemid 36833683)
-
(2003)
Lancet Oncology
, vol.4
, Issue.7
, pp. 415-422
-
-
Zeimet, A.G.1
Marth, C.2
-
11
-
-
41649102468
-
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
-
DOI 10.1073/pnas.0708917105
-
Shangary S, Qin D, McEachern D, Liu M, Miller RS, Qiu S, et al. Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition. Proc Natl Acad Sci U S A 2008;105:3933-8. (Pubitemid 351723502)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.10
, pp. 3933-3938
-
-
Shangary, S.1
Qin, D.2
McEachern, D.3
Liu, M.4
Miller, R.S.5
Qiu, S.6
Nikolovska-Coleska, Z.7
Ding, K.8
Wang, G.9
Chen, J.10
Bernard, D.11
Zhang, J.12
Lu, Y.13
Gu, Q.14
Shah, R.B.15
Pienta, K.J.16
Ling, X.17
Kang, S.18
Guo, M.19
Sun, Y.20
Yang, D.21
Wang, S.22
more..
-
12
-
-
10744221485
-
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
-
DOI 10.1126/science.1092472
-
Vassilev LT, Vu BT, Graves B, Carvajal D, Podlaski F, Filipovic Z, et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 2004;303:844-8. (Pubitemid 38174664)
-
(2004)
Science
, vol.303
, Issue.5659
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
Fotouhi, N.11
Liu, E.A.12
-
13
-
-
11144315535
-
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
-
DOI 10.1038/nm1146
-
Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef LG, Masucci M, et al. Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors. Nat Med 2004;10:1321-8. (Pubitemid 40022713)
-
(2004)
Nature Medicine
, vol.10
, Issue.12
, pp. 1321-1328
-
-
Issaeva, N.1
Bozko, P.2
Enge, M.3
Protopopova, M.4
Verhoef, L.G.G.C.5
Masucci, M.6
Pramanik, A.7
Selivanova, G.8
-
15
-
-
40949141784
-
A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis
-
DOI 10.1038/sj.cdd.4402301, PII 4402301, The biology of Hypoxia-inducible factors
-
Weinmann L, Wischhusen J, Demma MJ, Naumann U, Roth P, Dasmahapatra B, et al. A novel p53 rescue compound inducesp53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis. Cell Death Differ 2008;15:718-29. (Pubitemid 351405077)
-
(2008)
Cell Death and Differentiation
, vol.15
, Issue.4
, pp. 718-729
-
-
Weinmann, L.1
Wischhusen, J.2
Demma, M.J.3
Naumann, U.4
Roth, P.5
DasMahapatra, B.6
Weller, M.7
-
16
-
-
36849084779
-
CP-31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice
-
DOI 10.1172/JCI32481
-
Tang X, Zhu Y, Han L, Kim AL, Kopelovich L, Bickers DR, et al. CP- 31398 restores mutant p53 tumor suppressor function and inhibits UVB-induced skin carcinogenesis in mice. J Clin Invest 2007; 117:3753-64. (Pubitemid 350224086)
-
(2007)
Journal of Clinical Investigation
, vol.117
, Issue.12
, pp. 3753-3764
-
-
Tang, X.1
Zhu, Y.2
Han, L.3
Kim, A.L.4
Kopelovich, L.5
Bickers, D.R.6
Athar, M.7
-
17
-
-
79551544267
-
PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo
-
Bao W, Chen M, Zhao X, Kumar R, Spinnler C, Thullberg M, et al. PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo. Cell Cycle 2011;10:301-7.
-
(2011)
Cell Cycle
, vol.10
, pp. 301-307
-
-
Bao, W.1
Chen, M.2
Zhao, X.3
Kumar, R.4
Spinnler, C.5
Thullberg, M.6
-
18
-
-
79952767541
-
Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells
-
Liu YY, Patwardhan GA, Bhinge K, Gupta V, Gu X, Jazwinski SM. Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells. Cancer Res 2011;71:2276-85.
-
(2011)
Cancer Res
, vol.71
, pp. 2276-2285
-
-
Liu, Y.Y.1
Patwardhan, G.A.2
Bhinge, K.3
Gupta, V.4
Gu, X.5
Jazwinski, S.M.6
-
19
-
-
0031036934
-
Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells
-
Ogretmen B, Safa AR. Expression of the mutated p53 tumor suppressor protein and its molecular and biochemical characterization in multidrug resistant MCF-7/Adr human breast cancer cells. Oncogene 1997;14:499-506. (Pubitemid 27087113)
-
(1997)
Oncogene
, vol.14
, Issue.4
, pp. 499-506
-
-
Ogretmen, B.1
Safa, A.R.2
-
20
-
-
70349129967
-
A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis
-
Patwardhan GA, Zhang QJ, Yin D, Gupta V, Bao J, Senkal CE, et al. A new mixed-backbone oligonucleotide against glucosylceramide synthase sensitizes multidrug-resistant tumors to apoptosis. PLoS ONE 2009;4:e6938.
-
(2009)
PLoS ONE
, vol.4
-
-
Patwardhan, G.A.1
Zhang, Q.J.2
Yin, D.3
Gupta, V.4
Bao, J.5
Senkal, C.E.6
-
21
-
-
78650682926
-
Sphingolipids and expression regulation of genes in cancer
-
Patwardhan GA, Liu YY. Sphingolipids and expression regulation of genes in cancer. Prog Lipid Res 2011;50:104-14.
-
(2011)
Prog Lipid Res
, vol.50
, pp. 104-114
-
-
Patwardhan, G.A.1
Liu, Y.Y.2
-
22
-
-
16044364385
-
Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
-
DOI 10.1016/S0092-8674(00)80091-4
-
Santana P, Peña LA, Haimovitz-Friedman A, Martin S, Green D, McLoughlin M, et al. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis. Cell 1996;86:189-99. (Pubitemid 26286102)
-
(1996)
Cell
, vol.86
, Issue.2
, pp. 189-199
-
-
Santana, P.1
Pena, L.A.2
Haimovitz-Friedman, A.3
Martin, S.4
Green, D.5
McLoughlin, M.6
Cordon-Cardo, C.7
Schuchman, E.H.8
Fuks, Z.9
Kolesnick, R.10
-
23
-
-
0032528176
-
p53-dependent ceramide response to genotoxic stress
-
Dbaibo GS, Pushkareva MY, Rachid RA, Alter N, Smyth MJ, Obeid LM, et al. p53-dependent ceramide response to genotoxic stress. J Clin Invest 1998;102:329-39. (Pubitemid 28335192)
-
(1998)
Journal of Clinical Investigation
, vol.102
, Issue.2
, pp. 329-339
-
-
Dbaibo, G.S.1
Pushkareva, M.Y.2
Rachid, R.A.3
Alter, N.4
Smyth, M.J.5
Obeid, L.M.6
Hannun, Y.A.7
-
24
-
-
38549152194
-
Principles of bioactive lipid signalling: Lessons from sphingolipids
-
DOI 10.1038/nrm2329, PII NRM2329
-
Hannun YA, Obeid LM. Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol 2008;9:139-50. (Pubitemid 351158911)
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, Issue.2
, pp. 139-150
-
-
Hannun, Y.A.1
Obeid, L.M.2
-
25
-
-
33845715579
-
SAP155 Binds to ceramideresponsive RNA cis-element 1 and regulates the alternative 5¢ splice site selection of Bcl-x pre-mRNA
-
Massiello A, Roesser JR, Chalfant CE. SAP155 Binds to ceramideresponsive RNA cis-element 1 and regulates the alternative 5¢ splice site selection of Bcl-x pre-mRNA. FASEB J 2006;20:1680-2.
-
(2006)
FASEB J
, vol.20
, pp. 1680-1682
-
-
Massiello, A.1
Roesser, J.R.2
Chalfant, C.E.3
-
26
-
-
78549234102
-
Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a
-
Shultz JC, Goehe RW, Wijesinghe DS, Murudkar C, Hawkins AJ, Shay JW, et al. Alternative splicing of caspase 9 is modulated by the phosphoinositide 3-kinase/Akt pathway via phosphorylation of SRp30a. Cancer Res 2010;70:9185-96.
-
(2010)
Cancer Res
, vol.70
, pp. 9185-9196
-
-
Shultz, J.C.1
Goehe, R.W.2
Wijesinghe, D.S.3
Murudkar, C.4
Hawkins, A.J.5
Shay, J.W.6
-
27
-
-
77953294709
-
Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling
-
Liu YY, Gupta V, Patwardhan GA, Bhinge K, Zhao Y, Bao J, et al. Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling. Mol Cancer 2010;9:145.
-
(2010)
Mol Cancer
, vol.9
, pp. 145
-
-
Liu, Y.Y.1
Gupta, V.2
Patwardhan, G.A.3
Bhinge, K.4
Zhao, Y.5
Bao, J.6
-
28
-
-
0035079539
-
Ceramide glycosylation potentiates cellular multidrug resistance
-
DOI 10.1096/fj.00-0223com
-
Liu YY, Han TY, Giuliano AE, Cabot MC. Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J 2001;15: 719-30. (Pubitemid 32245990)
-
(2001)
FASEB Journal
, vol.15
, Issue.3
, pp. 719-730
-
-
Liu, Y.-Y.1
Han, T.-Y.2
Giuliano, A.E.3
Cabot, M.C.4
-
29
-
-
12244284610
-
Possible role of ceramide as an indicator of chemoresistance: Decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia
-
Itoh M, Kitano T, Watanabe M, Kondo T, Yabu T, Taguchi Y, et al. Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia. Clin Cancer Res 2003;9:415-23. (Pubitemid 36109759)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.1 I
, pp. 415-423
-
-
Itoh, M.1
Kitano, T.2
Watanabe, M.3
Kondo, T.4
Yabu, T.5
Taguchi, Y.6
Iwai, K.7
Tashima, M.8
Uchiyama, T.9
Okazaki, T.10
-
30
-
-
33744983537
-
Lactoferricin-induced apoptosis in estrogen-nonresponsive MDA-MB-435 breast cancer cells is enhanced by C6 ceramide or tamoxifen
-
Furlong SJ, Mader JS, Hoskin DW. Lactoferricin-induced apoptosis in estrogen-nonresponsive MDA-MB-435 breast cancer cells is enhanced by C6 ceramide or tamoxifen. Oncol Rep 2006;15:1385-90.
-
(2006)
Oncol Rep
, vol.15
, pp. 1385-1390
-
-
Furlong, S.J.1
Mader, J.S.2
Hoskin, D.W.3
|