The antitumor effects of araloside a extracted from the root bark of Aralia elata on human kidney cancer cell lines

African Journal of Pharmacy and Pharmacology

Volumn 5, Issue 4, 2011, Pages 462-467

  Yu, Liu ^a   Jinfeng, Liu ^b   Zhenhong, Liu ^a   Yanju, Liu ^a   Mingna, Liu ^b   Jing, Jiang ^b   Wanhai, Xu ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Antitumor; Araloside A; Bax bcl 2

Indexed keywords

ARALIA ELATA EXTRACT; ARALOSIDE A; MESSENGER RNA; PLANT EXTRACT; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARALIA; ARALIA ELATA; ARTICLE; CANCER CELL CULTURE; CELL COUNT; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INCUBATION TIME; KIDNEY CANCER; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION;

EID: 80054002132     PISSN: None     EISSN: 19960816     Source Type: Journal    
DOI: 10.5897/AJPP10.317     Document Type: Article

References (19)

1. Arash K (2010). Protective effect of quercetin against necrosis and apoptosis induced by experimental ischemia and reperfusion in rat liver. Afr. J. Pharm. Pharmacol., 4(1): 22-26.
2. Chung CK, Jung ME (2003). Ethanol fraction of Aralia elata Seemann enhances antioxidant activity and lowers serum lipids in rats when administered with benzo(a)pyrene. Biol. Pharm. Bull., 26(10): 1502-1504.
3. Chung YS, Choi YH, Lee SJ, Choi SA, Lee JH, Kim H, Hong EK (2005). Water extract of Aralia elata prevents cataractogenesis in vitro and in vivo. J. Ethnopharmacol. 101(1-3): 49-54.
4. Hu WC, Wang MH (2009). Antioxidant activity of Aralia elata seeds fractions. horticulture, environment, and biotechnol., 50(3): 253-257.
5. Johnston JB, Daeninck P, Verburg L, Lee K, Williams G, Israels LG, Mowat MR, Begleiter A (1997). P53, MDM-2, BAX and BCL-2 and drug resistance in chronic lymphocytic leukemia. Leuk. Lymphoma. 26(5-6): 435-449.
6. Jung-Hynes B, Nihal M, Zhong W, Ahmad N (2009). Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J. Biol. Chem., 284(6): 3823-3832.
7. Kim GH, Jeong CS, Lee JH (2009). Inhibitory effects of Aralia elata extract fractions on the biosynthesis of inflammatory mediators. FASEB. J., p. 899
8. Konturek PC, Konturek SJ, Sulekova Z, Meixner H, Bielanski W, Starzynska T, Karczewska E, Marlicz K, Stachura J, Hahn EG (2001). Expression of hepatocyte growth factor, transforming growth factor alpha, apoptosis related proteins Bax and Bcl-2, and gastrin in human gastric cancer. Aliment Pharmacol. Ther., 15(7): 989-999.
9. Lee EB, Kim OJ, Kang SS, Jeong C (2005). Araloside A, an antiulcer constituent from the root bark of Aralia elata. Biol. Pharm. Bull., 28(3): 523-526.
10. Lee YM, Kim H, Hong EK, Kang BH, Kim SJ (2000). Water extract of 1:1 mixture of Phellodendron cortex and Aralia cortex has inhibitory effects on oxidative stress in kidney of diabetic rats. J. Ethnopharmacol., 73(3): 429-436.
11. Li L, Chang B (2009). Research on the preventive effect of Aralia elata on the impairment of renal function following overtraining in rats. J. Beijing. Sport Univ., 4: 64-67.
12. Ljungberg B, Hanbury DC, Kuczyk MA, Merseburger AS, Mulders PF, Patard JJ, Sinescu IC (2007). Renal cellcarcinoma guideline. Eur. Urol., 51: 1502-1510.
13. Saito S, Ebashi J, Sumita S, Furumoto T, Nagamura Y, Nishida K, Isiguro I (1993). Comparison of cytoprotective effects of saponins isolated from leaves of Aralia elata Seem. (Araliaceae) with synthesized bisdesmosides of oleanoic acid and hederagenin on carbon tetrachloride-induced hepatic injury. Chem. Pharm. Bull. (Tokyo), 41(8): 1395-1401.
14. Sim JS, Zhao HL, Li DW, Cho SY, Jeong CS, Lee EB, Kim YS (2005). Effects of saponins from the root bark of Aralia elata on the transport of chondroitin sulfate in Caco-2 cell monolayers and rats. Biol. Pharm. Bull., 28(6): 1043-1048.
15. Xi S, Zhou G, Zhang X, Zhang W, Cai L, Zhao C (2009). Protective effect of total aralosides of Aralia elata (Miq) Seem (TASAES) against diabetic cardiomyopathy in rats during the early stage, and possible mechanisms. Exp. Mol. Med., 41(8):538-547.
16. Yang Y, An J, Weng NP (2008). Telomerase is involved in IL-7-mediated differential survival of naive and memory CD4+ T cells. J. Immunol., 180(6): 3775-3781.
17. Yogev-Falach M, Bar-Am O, Amit T, Weinreb O, Youdim MB (2006). A multifunctional, neuroprotective drug, ladostigil (TV3326), regulates holo-APP translation and processing. FASEB. J., 20(12): 2177-2179
18. Yoshikawa M, Murakami T, Harada E, Murakami N, Yamahara J, Matsuda H (1996). Bioactive saponins and glycosides. VII. On the hypoglycemic principles from the root cortex of Aralia elata Seem: structure related hypoglycemic activity of oleanolic acid oligoglycoside. Chem. Pharm. Bull. (Tokyo), 44(10): 1923-1927.
19. Zhang M, Liu G, Tang S, Song S, Yamashita K, Manabe M, Kodama H (2006). Effect of five triterpenoid compounds from the buds of Aralia elata on stimulus- induced superoxide generation, tyrosyl phosphorylation and translocation of cytosolic compounds to the cell membrane in human neutrophils. Planta Med., 72(13): 1216-1222.