Telomerase is involved in IL-7-mediated differential survival of naive and memory CD4+ T cells

Journal of Immunology

Volumn 180, Issue 6, 2008, Pages 3775-3781

  Yang, Yinhua ^a   An, Jie ^a   Weng, Nan Ping ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; INTERLEUKIN 7;

APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIVISION; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MEMORY T LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; ADULT; BIOSYNTHESIS; CELL CULTURE; CELL CYCLE G0 PHASE; CELL DEATH; COMPARATIVE STUDY; CYTOLOGY; ENZYMOLOGY; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; G0 PHASE; HUMANS; IMMUNOLOGIC MEMORY; INTERLEUKIN-7; T-LYMPHOCYTE SUBSETS; TELOMERASE;

EID: 44849104315     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.6.3775     Document Type: Article

References (36)

1. Marrack, P., and J. Kappler. 2004. Control of T cell viability. Annu. Rev. Immunol. 22: 765-787.
2. Bradley, L. M., L. Haynes, and S. L. Swain. 2005. IL-7: maintaining T-cell memory and achieving homeostasis. Trends Immunol. 26: 172-176.
3. Fry, T. J., and C. L. Mackall. 2005. The many faces of IL-7: from lymphopoiesis to peripheral T cell maintenance. J. Immunol. 174: 6571-6576.
4. Jiang, Q., W. Q. Li, F. B. Aiello, R. Mazzucchelli, B. Asefa, A. R. Khaled, and S. K. Durum. 2005. Cell biology of IL-7, a key lymphotrophin. Cytokine Growth Factor Rev. 16: 513-533.
5. Tan, J. T., E. Dudl, E. LeRoy, R. Murray, J. Sprent, K. I. Weinberg, and C. D. Surh. 2001. IL-7 is critical for homeostatic proliferation and survival of naive T cells. Proc. Natl. Acad. Sci. USA 98: 8732-8737.
6. Kieper, W. C., and S. C. Jameson. 1999. Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands. Proc. Natl. Acad. Sci. USA 96: 13306-13311.
7. Seddon, B., P. Tomlinson, and R. Zamoyska. 2003. Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells. Nat. Immunol. 4: 680-686.
8. Li, J., G. Huston, and S. L. Swain. 2003. IL-7 promotes the transition of CD4 effectors to persistent memory cells. J. Exp. Med. 198: 1807-1815.
9. Swainson, L., E. Verhoeyen, F. L. Cosset, and N. Taylor. 2006. IL-7R α gene expression is inversely correlated with cell cycle progression in IL-7-stimulated T lymphocytes. J. Immunol. 176: 6702-6708.
10. Lin, J. X., T. S. Migone, M. Tsang, M. Friedmann, J. A. Weatherbee, L. Zhou, A. Yamauchi, E. T. Bloom, J. Mietz, S. John, et al. 1995. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2: 331-339.
11. Kip1. J. Exp. Med. 203: 573-582.
12. Kim, K., C. K. Lee, T. J. Sayers, K. Muegge, and S. K. Durum. 1998. The trophic action of IL-7 on pro-T cells: inhibition of apoptosis of pro-T1, -T2, and -T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways. J. Immunol. 160: 5735-5741.
13. Khaled, A. R., W. Q. Li, J. Huang, T. J. Fry, A. S. Khaled, C. L. Mackall, K. Muegge, H. A. Young, and S. K. Durum. 2002. Bax deficiency partially corrects interleukin-7 receptor α deficiency. Immunity 17: 561-573.
14. Blackburn, E. H. 2001. Switching and signaling at the telomere. Cell 106: 661-673.
15. Cong, Y. S., W. E. Wright, and J. W. Shay. 2002. Human telomerase and its regulation. Microbiol. Mol. Biol. Rev. 66: 407-425.
16. Weng, N., B. L. Levine, C. H. June, and R. J. Hodes. 1996. Regulated expression of telomerase activity in human T lymphocyte development and activation. J. Exp. Med. 183: 2471-2479.
17. + T cells enables preservation of a naive repertoire. J. Immunol. 161: 5909-5917.
18. + T cells in vitro. J. Immunol. 174: 4019-4024.
19. Rufer, N., M. Migliaccio, J. Antonchuk, R. K. Humphries, E. Roosnek, and P. M. Lansdorp. 2001. Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential. Blood 98: 597-603.
20. Roth, A., H. Yssel, J. Pene, E. A. Chavez, M. Schertzer, P. M. Lansdorp, H. Spits, and R. M. Luiten. 2003. Telomerase levels control the lifespan of human T lymphocytes. Blood 102: 849-857.
21. Fu, W., J. G. Begley, M. W. Killen, and M. P. Mattson. 1999. Anti-apoptotic role of telomerase in pheochromocytoma cells. J. Biol. Chem. 274: 7264-7271.
22. Gorbunova, V., A. Seluanov, and O. M. Pereira-Smith. 2002. Expression of human telomerase (hTERT) does not prevent stress-induced senescence in normal human fibroblasts but protects the cells from stress-induced apoptosis and necrosis. J. Biol. Chem. 277: 38540-38549.
23. Cao, Y., H. Li, S. Deb, and J. P. Liu. 2002. TERT regulates cell survival independent of telomerase enzymatic activity. Oncogene 21: 3130-3138.
24. + helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis. Blood 101: 4512-4519.
25. + T cells. J. Immunol. 166: 7335-7344.
26. + T cell response. Blood 108: 3363-3370.
27. + T cells to interleukin-7 or interleukin-15 stimulates proliferation without differentiation or loss of telomere length. Immunology 119: 243-253.
28. Liu, K., R. J. Hodes, and N. Weng. 2001. Telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but Is associated with hTERT phosphorylation and nuclear translocation. J. Immunol. 166: 4826-4830.
29. Weng, N., B. L. Levine, C. H. June, and R. J. Hodes. 1997. Regulation of telomerase RNA template expression in human T lymphocyte development and activation. J. Immunol. 158: 3215-3220.
30. Viola, A., and A. Lanzavecchia. 1996. T cell activation determined by T cell receptor number and tunable thresholds. Science 273: 104-106.
31. Mandal, M., and R. Kumar. 1997. Bcl-2 modulates telomerase activity. J. Biol. Chem. 272: 14183-14187.
32. Rahman, R., L. Latonen, and K. G. Wiman. 2005. hTERT antagonizes p53-induced apoptosis independently of telomerase activity. Oncogene 24: 1320-1327.
33. Karlseder, J., D. Broccoli, Y. Dai, S. Hardy, and T. de Lange. 1999. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.
34. Lansdorp, P. M., N. P. Verwoerd, F. M. Van de Rijke, V. Dragowska, M. T. Little, R. W. Dirks, A. L. Raap, and H. J. Tanke. 1996. Heterogeneity in telomere length of human chromosomes. Hum. Mol. Genet. 5: 685-691.
35. Hemann, M. T., M. A. Strong, L. Y. Hao, and C. W. Greider. 2001. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107: 67-77.
36. Sarin, K. Y., P. Cheung, D. Gilison, E. Lee, R. I. Tennen, E. Wang, M. K. Artandi, A. E. Oro, and S. E. Artandi. 2005. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 436: 1048-1052.