Water extract of Aralia elata prevents cataractogenesis in vitro and in vivo

Journal of Ethnopharmacology

Volumn 101, Issue 1-3, 2005, Pages 49-54

  Chung, Young Shin ^a   Choi, Yun Hee ^b   Lee, Seok Jong ^a   Choi, Sun A ^a   Lee, Jang Ha ^a   Kim, Harriet ^b   Hong, Eun Kyung ^a  

^a Medvill Central Research Laboratory   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Aldose reductase inhibitor; Anticataract; Antioxidant; Aralia elata; Diabetes; Diabetic animal; Lens culture

Indexed keywords

ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; ANTIOXIDANT; ARALIA ELATA EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG; WATER; XYLOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARALIA ELATA; ARTICLE; CATARACT; CATARACTOGENESIS; CHEMOPROPHYLAXIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DOSE TIME EFFECT RELATION; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; ENZYME INHIBITION; HOMOGENATE; IC 50; IN VITRO STUDY; IN VIVO STUDY; LENS; MALE; MEDICINAL PLANT; NONHUMAN; RAT; STREPTOZOCIN DIABETES; TISSUE CULTURE; TREATMENT OUTCOME;

ALDEHYDE REDUCTASE; ANIMALS; ANTIOXIDANTS; ARALIA; CATARACT; DIABETES MELLITUS, EXPERIMENTAL; MALE; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; STREPTOZOCIN;

ANIMALIA; ARALIA; ARALIA ELATA;

EID: 24044499486     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2005.03.020     Document Type: Article

References (30)

1. AAALAC Guide for the Care and Use of Laboratory Animals by Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, USA 1996 National Academy Press Washington, DC
2. D.K. Ahn Illustrated Book of Korean Medicinal Herbs 1998 Kyo-Hak Publishing Seoul p. 720
3. E. Altomare, I. Grattagliano, and G. Vendemaile Oxidative protein damage in human diabetic eye: evidence of a retinal participation European Journal of Clinical Investigation 27 1997 141 147
4. J.W. Birks Chemiluminescence and photochemical reaction detection Chromatography 1989 VCH Publisher pp. 10-13
5. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Analytical Biochemistry 72 1976 248 254
6. D. Chand, H. EL-Aguizy, R.D. Richards, and S.D. Varma Sugar cataracts in vitro: implication of oxidative stress and aldose reductase I Experimental Eye Research 35 1982 491 497
7. S.S. Chung, E.C. Ho, K.S. Lam, and S.K. Chung Contribution of polyol pathway to diabetes-induced oxidative stress Journal of American Society for Nephrology 14 2003 S233 S236
8. Y.S. Chung, S.J. Lee, S. Choi, J. Lee, J.C. Ryu, and E.K. Hong Genotoxicity study of Aralia elata extract in bacterial and mammalian cell system Environmental Mutagens and Carcinogens 22 2002 319 323
9. L.T. Chylack Jr., H.F. Henriquez III, H.-M. Cheng, and W.H. Tung Efficacy of alrestatin, an aldose reductase inhibitor in human diabetic and non-diabetic lenses Ophthalmology 86 1979 1579 1585
10. M. Collier, and M. Small The role of the polyol pathway in diabetes meliitus British Journal of Hospital Medicine 45 1991 38 40
11. B. Das, and S.K. Srivastava Purification and properties of aldose reductase and aldehyde reductase II from human erythrocyte Archives of Biochemistry and Biophysics 238 1985 670 679
12. N. Halder, S. Joshi, and S.K. Gupta Lens aldose reductase inhibiting potential of some indigenous plants Journal of Ethnopharmacology 86 2003 113 116
13. S. Hayman, and J.H. Kinoshita Isolation and properties of lens aldose reductase Journal of Biological Chemistry 240 1956 877 882
14. O.K. Kim, E.B. Lee, and S.S. Kang Antihyperglycemic constituent of Aralia elata root bark(II) Korean Journal of Pharmacognosy 24 1993 219 222
15. S.J. Kim, Y.Y. Kim, K.H. Ko, E.K. Hong, Y.B. Han, B. Kang, and H. Kim Butanol extract of 1:1 mixture of Phellodendron cortex and Aralia cortex stimulates PI3-kinase and ERK2 with increase of glycogen levels in HepG2 cells Phytotherapy Research 12 1998 1 6
16. H. Kuang, H. Sun, N. Zhang, Y. Okada, and T. Okuyama Two new saponins, congmuyenosides A and B, from the leaves of Aralia elata collected in Heilongjiang, China Chemical and Pharmaceutical Bulletin 44 1996 2183 2185
17. M. Kubo, H. Matsuda, K. Tokuoka, Y. Kobayashi, S. Ma, and T. Tanaka Studies of anti-cataract drugs from natural sources. I. Effects of a methanolic extract and alkaloidal components from Corydalis tuber on in vitro aldose reductase activity Biology and Pharmacology Bulletin 17 1994 458 459
18. M. Kubo, H. Matsuda, M. Fukuda, and Y. Akagi Cataract formation through the polyol pathway is associated with free radical production Experimental Eye Research 68 1999 457 464
19. Y. Lee, K. Harrit, H.S. Choi, B.H. Kang, Y.B. Han, and S.J. Kim Effects of water extract of 1:1 mixture of Phellodendron cortex and Aralia cortex on polyol pathway and oxidative damage in lenses of diabetic rats Phytotherapy Research 13 1999 555 560
20. H. Nakai, Y. Fujii, K. Kobashi, and K. Homura Aldose reductase inhibitors: flavonoids, alkaloids, acetophenones, benzophenones, and spirohydantoins of chroman Archives of Biochemistry and Biophysics 239 1985 491 496
21. H. Obazawa, L.O. Merola, and J.H. Kinoshita The effects of xylose on the isolated lens Investigative Ophthalmology 13 1974 204 209
22. W.M. Ross, M.O. Creighton, and G. Bendemaile Modelling cortical cataractogenesis. VI. Induction by glucose in vitro or in diabetic rats: prevention and reversal by glutathione Experimental Eye Research 37 1983 559 573
23. A. Spector, G. Wang, and R. Wang The prevention of cataract by oxidative stress in cultured rat lenses. II. Early effects of photochemical stress and recovery Experimental Eye Research 57 1993 656 667
24. D.R. Tomlinson, E.J. Stwvwns, and I.T. Diemel Aldose reductase inhibitors and their potental for the treatment of diabetes complications Trends in Pharmacological Science 15 1994 292 298
25. S.J. Tumminia, C. Qin, J.S. Zigler, and P. Russel The integrity of mammalian lenses in organ cultrue Experimental Eye Research 58 1994 367 374
26. S.D. Varma, and J.H. Kinoshoita Inhibition of lens aldose reductase by flavonoids - their possible role in the prevention of diabetic cataracts Biochemical Pharmacology 25 1976 2505 2513
27. S.D. Varma, and R.D. Richard Etiology of cataracts in diabetics International Ophtalmology Clinics 24 1984 93 110
28. M. Yoshikawa, T. Murakami, E. Harada, N. Murakami, J. Yamahara, and H. Matsuda Bioactive saponins and glycosides. VII. On the hypoglycemic principles from the root cortex of Aralia elata Seem.: structure related hypoglycemic activity of oleanolic acid oligoglycoside Chemical and Pharmaceutical Bulletin 44 1996 1923-1927
29. M. Yoshikawa, S. Yoshizumi, T. Ueno, H. Matsuda, T. Murakami, J. Yamahara, and N. Murakami Medicinal foodstuffs. I. Hypoglycemic constituents from a garnish foodstuff "Taranome," the young shoot of Aralia elata Seem.: elatoside G, H, I, J, and K Chemical and Pharmaceutical Bulletin 43 1995 1878 1882
30. D.S. Zatechka Jr., P.F. Kador, S. Garcia-Castineiras, and M.F. Lou Diabetes can alter the signal transduction pathways in the lens of rats Diabetes 52 2003 1014 1022