Particle size and bulk powder flow control by supercritical antisolvent precipitation

Industrial and Engineering Chemistry Research

Volumn 48, Issue 11, 2009, Pages 5302-5309

  Thakur, Ranjit ^a   Hudgins, Auburn E ^a,b   Goncalves, Elisabete ^a   Muhrer, Gerhard ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b Ciba McIntosh   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BATCH PROCESS; BULK DENSITY; BULK POWDERS; CALORIMETRIC TEST; CONTROLLING PARAMETERS; DIFFERENT PORE SIZES; DISSOLUTION PROFILES; DISSOLUTION RATES; FLOWABILITY; GAS ANTISOLVENT; NAKED-EYE; PARTICLE GROWTH; PARTICLE MORPHOLOGIES; PARTICLE SIZE CONTROL; PARTICLE SIZE REDUCTION; POORLY SOLUBLE DRUGS; POORLY WATER-SOLUBLE DRUGS; QUANTITATIVE ANALYSIS; SEM; SILICA PORES; SIZE CONTROL; SUBMICROMETER; SUPERCRITICAL ANTISOLVENT PRECIPITATION; SUPERCRITICAL ANTISOLVENT PROCESS; SUPERCRITICAL FLUID PROCESS; VISUAL INSPECTION;

BATCH DATA PROCESSING; COMPRESSIVE STRENGTH; DISSOLUTION; EFFLUENT TREATMENT; EXPERIMENTS; MICROCRYSTALS; OPTICAL MICROSCOPY; PARTICLE SIZE; POWDERS; SCANNING; SCANNING ELECTRON MICROSCOPY; SILICA; SUPERCRITICAL FLUID EXTRACTION; SUPERCRITICAL FLUIDS; VISUAL COMMUNICATION;

PRECIPITATION (CHEMICAL);

EID: 67650070470     PISSN: 08885885     EISSN: None     Source Type: Journal    
DOI: 10.1021/ie801324q     Document Type: Article

References (26)

1. Feynman, R. There is plenty of room at bottom. Eng. Sci. 1960, XXIII (5).
2. Rasenack, N.; Hartenhauer, H.; Müller, B. W. Microcrystals for dissolution rate enhancement of poorly water soluble drugs. Int. J. Pharm. 2003, 254, 137.145.
3. Johnson, B. K.; Prud'homme, R. K. A process and apparatus for preparing nanoparticles compositions with amphiphilic copolymers and their use. WO 02/078674A1, 2002.
4. Johnson, B. K.; Prud'homme, R. K. Chemical processing and micromixing in confined impinging jets. AIChE J. 2003, 49 (9), 2264-2282.
5. Johnson, B. K.; Prud'homme, R. K. Flash nanoprecipitation of organic actives and block copolymers using a confined impinging jet mixers. Aust. J. Chem. 2003, 56, 1021-1024.
6. Horn, D.; Schmidt, H. W.; Ditter, W.; Hartmann, H.; Lueddecke, E. Verfahren zur Herstellung Von felnverteilten, pulvervörmigen Carotinoidbzw. Retinoidpräparaten. EP 0065 193 B1, 1985.
7. Chen, J. F.; Zhou, M. Y.; Shao, L.; Wang, Y. Y.; Yun, J.; Chew, N. Y. K.; Chan, H. K. Feasibility of preparing nanodrugs by high-gravity reactive precipitation. Int. J. Pharm. 2004, 269 (1), 267-274.
8. Debenedetti, P. G. Supercritical fluids as particle formation media. Supercrit. Fluids 1994, 719-794.
9. York, P. Strategies for particle design using supercritical fluid technologies. PSTT 1999, 2 (11), 430-440.
10. Pasquali, I.; Bettini, R.; Giordano, F. Supercritical fluid technologies: an innovative approach for manipulating the solid-state of pharmaceuticals. Adv. Drug Delivery Rev. 2008, 60 (3), 399-410.
11. Chang, C. J.; Randolph, A. D. Precipitation of microsize organic particles from supercritical fluids. AIChE J. 1989, 35 (11), 1876-1882.
12. Tom, J. W.; Debenedetti, P. G. Precipitation of poly (l-lactic acid) and composite poly (l-lactic acid) -pyrene particles by rapid expansion of supercritical solutions. J. Supercrit. Fluids 1994, 7, 9-29.
13. Turk, M.; Hils, P.; Helfgen, B.; Schaber, K.; Martin, H. J.; Wahl, M. A. Micronization of pharmaceutical substances by the rapid expansion of supercritical solutions (RESS) : a promising method to improve bioavailability of poorly soluble pharmaceutical agents. J. Supercrit. Fluids 2002, 22, 75-84.
14. Franklin, R. K.; Edwards, J. R.; Chemyak, Y.; Gould, R. D.; Henon, F.; Carbonell, R. G. Formation of perfluoropolyether coatings by the rapid expansion of supercritical solutions (RESS) process. Part 2: numerical modeling. Ind. Eng. Chem. Res. 2001, 40, 6127-6137.
15. Turk, M.; Upper, G.; Hils, P. Formation of composite drugpolymer particles by co-precipitation during the rapid expansion of supercritical fluids. J. Supercrit. Fluids 2006, 39 (2), 253-263.
16. Thakur, R.; Gupta, R. B. Formation of Phenytoin nanoparticles using rapid expansion of supercritical solution with solid co-solvent (RESS-SC) process. Int. J. Pharm. 2006, 308, 190-199.
17. Meziani, M. J.; Pathak, P.; Hurezeanu, R.; Thies, M. C. Supercriticl fluid processing technique for nanoscale polymer particles. Angew. Chem., Int. Ed. 2004, 43 (6), 704-707.
18. Dixon, D. J.; Bodmeier, R.; Johnston, K. P. Polymeric materials formed by precipitation with a compressed fluid antisolvent. AIChE J. 1993, 39, 127-139.
19. Thakur, R.; Gupta, R. B. Production of hydrocortisone micro and nano particles using supercritical antisolvent with enhanced mass transfer. Chem. Eng. Commun. 2006, 193 (3), 293-305.
20. Muhrer, G.; Meier, U.; Fusaro, F.; Albano, S.; Mazzotti, M. Use of compressed gas precipitation to enhance the dissolution behavior of a poorly water soluble drug: Generation of drug microparticles and drugpolymer solid dispersions. Int. J. Pharm. 2006, 308 (1-2), 69-83.
21. Reverchon, E.; De Marco, I.; Adami, R.; Caputo, G. Expanded micro-particles by supercritical antisolvent precipitation: Interpretation of results. J. Supercrit. Fluids 2008, 44 (1), 98-108.
22. Jarmer, D. J.; Lengsfeld, C. S.; Anseth, K. S.; Randolph, T. W. Supercritical Fluid Crystallization of Griseofulvin: Crystal Habit Modification with a Selective Growth Inhibitor. J. Pharm. Sci. 2005, 94 (12), 2688-2702.
23. Knoblauch, J.; Zimmermann, I. Thermochemical analysis of the dissolution process of Griseofulvin. Eur. J. Pharm. Biopharm. 2007, 67 (3), 743-751.
24. Metsugi, Y.; Ogawara, K. I.; Higaki, K.; Kimura, T. Intl. J. Pharm. 2008, 352 (1-2), 36-43.
25. Sharma, S.; Sher, P.; Badve, S.; Pawar, A. P. Adsorption of Meloxicam on porous calcium silicate: Characterization and tablet formulation. AAPS PharmSciTech 2005, 6 (4), article 76.
26. 2 antisolvent with enhanced mass transfer. Int. J. Pharm. 2001, 228, 19-31.