Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype

Biochemical Pharmacology

Volumn 82, Issue 9, 2011, Pages 1234-1249

  Piccoli, Elena ^a   Nadai, Matteo ^a   Caretta, Carla Mucignat ^a   Bergonzini, Valeria ^a   Del Vecchio, Claudia ^a   Ha, Huy Riem ^b   Bigler, Laurent ^c   Dal Zoppo, Daniele ^a   Faggin, Elisabetta ^a   Pettenazzo, Andrea ^a   Orlando, Rocco ^a   Salata, Cristiano ^a   Calistri, Arianna ^a   Pal, Giorgio ^a   Baritussio, Aldo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

Amiodarone; Dronedarone; Late endosomes; Niemann Pick C; Phospholipidosis

Indexed keywords

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; AMIODARONE; AMIODARONE ACCUMULATE LYSOBISPHOSPHATIDIC ACID; CHOLESTEROL; DRONEDARONE; ESCRT PROTEIN; GLYCOSPHYNGOLIPID; LIPID; SHIGA TOXIN; SPHINGOMYELIN; TRANSFERRIN; UNCLASSIFIED DRUG;

ARTICLE; CELL MIGRATION; CELL ORGANELLE; CELL SECRETION; CELL STRUCTURE; CELL VACUOLE; ENDOCYTOSIS; ENDOSOME; EXOSOME; HOMEOSTASIS; IN VITRO STUDY; LENTIVIRINAE; NIEMANN PICK DISEASE; NUCLEOTIDE SEQUENCE; PH; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; VIRUS RELEASE;

AMIODARONE; ANDROSTENES; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CELLS, CULTURED; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOSOMES; HUMANS; LYSOPHOSPHOLIPIDS; MOLECULAR STRUCTURE; MONOGLYCERIDES; NIEMANN-PICK DISEASES; NOCODAZOLE;

EID: 80053961518     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.07.090     Document Type: Article

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