Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease

Journal of Biological Chemistry

Volumn 285, Issue 34, 2010, Pages 26279-26288

  Strauss, Katrin ^a,b   Goebel, Cornelia ^c   Runz, Heiko ^d   Möbius, Wiebke ^a   Weiss, Sievert ^a   Feussner, Ivo ^c   Simons, Mikael ^a,b   Schneider, Anja ^a,b  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR CHOLESTEROL; CELLULAR MECHANISMS; CHOLESTEROL ACCUMULATION; EXOSOMES; FREE CHOLESTEROLS; LYSOSOMAL STORAGE DISORDER; NEURODEGENERATION; NIEMANN-PICK TYPE C; NIEMANN-PICK TYPE C1 DISEASE; SPHINGOLIPIDS; UP-REGULATION; WILD TYPES;

CELL CULTURE; PHYSIOLOGY;

CHOLESTEROL;

3BETA (2 DIETHYLAMINOETHOXY)ANDROST 5 EN 17 ONE; CHOLESTEROL; FLOTILLIN; MEMBRANE PROTEIN; PROTEIN NPC1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL SECRETION; CHOLESTEROL METABOLISM; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENDOSOME; EXOSOME; FIBROBLAST; HOMEOSTASIS; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NIEMANN PICK DISEASE; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANDROSTENES; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CELLS, CULTURED; CHOLESTEROL; EXOSOMES; FIBROBLASTS; HOMEOSTASIS; HUMANS; LYSOSOMES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; NIEMANN-PICK DISEASES; OLIGODENDROGLIA;

EID: 77956193128     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.134775     Document Type: Article

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