Amiodarone alters late endosomes and inhibits SARS coronavirus infection at a post-endosomal level

American Journal of Respiratory Cell and Molecular Biology

Volumn 39, Issue 2, 2008, Pages 142-149

  Stadler, Konrad ^a,f   Ha, Huy Riem ^b   Ciminale, Vincenzo ^e   Spirli, Carlo ^d,g   Saletti, Giulietta ^a   Schiavon, Marco ^e   Bruttomesso, Daniela ^e   Bigler, Laurent ^c   Follath, Ferenc ^b   Pettenazzo, Andrea ^e   Baritussio, Aldo ^e  

^a NOVARTIS VACCINES AND DIAGNOSTICS   (Italy)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

^e UNIVERSITY OF PADOVA   (Italy)

^f International Vaccine Institute   (South Korea)

^g YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amiodarone; Endocytic pathway; SARS coronavirus

Indexed keywords

2 BUTYL 3 (3',5' DIIODO 4 HYDROXY)BENZOFURAN; AMIODARONE; BENZOFURAN DERIVATIVE; CATHEPSIN L; IODINE 125; TRYPSIN; VIRUS SPIKE PROTEIN;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL MEMBRANE; CELL VACUOLE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BINDING; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG UPTAKE; ENDOCYTOSIS; ENDOSOME; LUNG ALVEOLUS MACROPHAGE; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN DEGRADATION; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRUS ENTRY; VIRUS INFECTIVITY;

AMIODARONE; ANIMALS; ANTIVIRAL AGENTS; CATHEPSINS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; CYSTEINE ENDOPEPTIDASES; CYTOPLASM; ENDOSOMES; HUMANS; IODINE ISOTOPES; MACROPHAGES, ALVEOLAR; MEMBRANE GLYCOPROTEINS; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VACUOLES; VERO CELLS; VIRAL ENVELOPE PROTEINS;

CORONAVIRUS; SARS CORONAVIRUS;

EID: 48649102819     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2007-0217OC     Document Type: Article

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