Mechanism of salutary effects of astringinin on rodent hepatic injury following Trauma-Hemorrhage: Akt-Dependent Hemeoxygenase-1 signaling pathways

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Liu, Fu Chao ^a,b   Hwang, Tsong Long ^c   Lau, Ying Tung ^c,d   Yu, Huang Ping ^a,b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHROMIUM MESOPORPHYRIN; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT 1; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT 3; HEME OXYGENASE 1; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; MESOPORPHYRIN; MYELOPEROXIDASE; PICEATANNOL; PROTEIN KINASE B; UNCLASSIFIED DRUG; WORTMANNIN; 3,3',4,5'-TETRAHYDROXYSTILBENE; CXCL1 CHEMOKINE; CXCL1 PROTEIN, RAT; CXCL2 CHEMOKINE; CXCL2 PROTEIN, RAT; PEROXIDASE; STILBENE DERIVATIVE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLEEDING; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLUID RESUSCITATION; INJURY; LIVER DYSFUNCTION; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION; ANIMAL; BLOOD; DRUG EFFECT; ENZYMOLOGY; LIVER; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

RATTUS; RODENTIA;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CHEMOKINE CXCL1; CHEMOKINE CXCL2; HEME OXYGENASE-1; HEMORRHAGE; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; LIVER; MALE; PEROXIDASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; STILBENES; WOUNDS AND INJURIES;

EID: 80053959918     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0025907     Document Type: Article

References (34)

1. Yu HP, Chaudry IH, (2009) The role of estrogen and receptor agonists in maintaining organ function after trauma-hemorrhage. Shock 31: 227-237.
2. Yu HP, Hsu JC, Hwang TL, Yen CH, Lau YT, (2008) Resveratrol attenuates hepatic injury after trauma-hemorrhage via estrogen receptor-related pathway. Shock 30: 324-328.
3. Liu FC, Day YJ, Liao CH, Liou JT, Mao CC, et al. (2009) Hemeoxygenase-1 upregulation is critical for sirtinol-mediated attenuation of lung injury after trauma-hemorrhage in a rodent model. Anesth Analg 108: 1855-1861.
4. Suda K, Takeuchi H, Hagiwara T, Miyasho T, Okamoto M, et al. (2010) Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis. Shock 33: 526-531.
5. Yu HP, Hsieh YC, Suzuki T, Choudhry MA, Schwacha MG, et al. (2007) Mechanism of the nongenomic effects of estrogen on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of the PI-3K/Akt pathway. J Leukoc Biol 82: 774-780.
6. Alten JA, Moran A, Tsimelzon AI, Mastrangelo MA, Hilsenbeck SG, et al. (2008) Prevention of hypovolemic circulatory collapse by IL-6 activated Stat3. PLoS One 3: e1605.
7. Fukao T, Koyasu S, (2003) PI3K and negative regulation of TLR signaling. Trends Immunol 24: 358-363.
8. Williams DL, Ozment-Skelton T, Li C, (2006) Modulation of the phosphoinositide 3-kinase signaling pathway alters host response to sepsis, inflammation, and ischemia/reperfusion injury. Shock 25: 432-439.
9. Cremer TJ, Ravneberg DH, Clay CD, Piper-Hunter MG, Marsh CB, et al. (2009) MiR-155 induction by F. novicida but not the virulent F. tularensis results in SHIP down-regulation and enhanced pro-inflammatory cytokine response. PLoS One 4: e8508.
10. Puri KD, Doggett TA, Douangpanya J, Hou Y, Tino WT, et al. (2004) Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue. Blood 103: 3448-3456.
11. Wymann MP, Sozzani S, Altruda F, Mantovani A, Hirsch E, (2000) Lipids on the move: phosphoinositide 3-kinases in leukocyte function. Immunol Today 21: 260-264.
12. Arcaro A, Wymann MP, (1993) Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses. Biochem J 296 (Pt 2): 297-301.
13. Schabbauer G, Tencati M, Pedersen B, Pawlinski R, Mackman N, (2004) PI3K-Akt pathway suppresses coagulation and inflammation in endotoxemic mice. Arterioscler Thromb Vasc Biol 24: 1963-1969.
14. Cai Z, Semenza GL, (2004) Phosphatidylinositol-3-kinase signaling is required for erythropoietin-mediated acute protection against myocardial ischemia/reperfusion injury. Circulation 109: 2050-2053.
15. Yu HP, Yang SC, Lau YT, Hwang TL, (2010) Role of Akt-dependent up-regulation of hemeoxygenase-1 in resveratrol-mediated attenuation of hepatic injury after trauma hemorrhage. Surgery 148: 103-109.
16. Choi BM, Kim BR, (2008) Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury. Eur J Pharmacol 580: 12-18.
17. Salinas M, Wang J, Rosa de SM, Martin D, Rojo AI, et al. (2004) Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo. FEBS Lett 578: 90-94.
18. Szalay L, Shimizu T, Schwacha MG, Choudhry MA, Rue LW, et al. (2005) Mechanism of salutary effects of estradiol on organ function after trauma-hemorrhage: upregulation of heme oxygenase. Am J Physiol Heart Circ Physiol 289: H92-H98.
19. Szalay L, Shimizu T, Suzuki T, Yu HP, Choudhry MA, et al. (2006) Estradiol improves cardiac and hepatic function after trauma-hemorrhage: role of enhanced heat shock protein expression. Am J Physiol Regul Integr Comp Physiol 290: R812-R818.
20. Shen XD, Ke B, Zhai Y, Gao F, Busuttil RW, et al. (2005) Toll-like receptor and heme oxygenase-1 signaling in hepatic ischemia/reperfusion injury. Am J Transplant 5: 1793-1800.
21. Yu HP, Choudhry MA, Shimizu T, Hsieh YC, Schwacha MG, et al. (2006) Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-beta-dependent HO-1. J Leukoc Biol 79: 277-284.
22. Doucet D, Badami C, Palange D, Bonitz RP, Lu Q, et al. (2010) Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats. PLoS One 5: e9421.
23. Yu HP, Hwang TL, Hsieh PW, Lau YT, (2011) Role of estrogen receptor-dependent upregulation of p38MAPK/hemeoxygenase-1 in resveratrol-mediated attenuation of intestinal injury after trauma-hemorrhage. Shock 35: 517-523.
24. Lee YM, Lim dY, Cho HJ, Seon MR, Kim JK, et al. (2009) Piceatannol, a natural stilbene from grapes, induces G1 cell cycle arrest in androgen-insensitive DU145 human prostate cancer cells via the inhibition of CDK activity. Cancer Lett 285: 166-173.
25. Chen WP, Hung LM, Hsueh CH, Lai LP, Su MJ, (2009) Piceatannol, a derivative of resveratrol, moderately slows I(Na) inactivation and exerts antiarrhythmic action in ischaemia-reperfused rat hearts. Br J Pharmacol 157: 381-391.
26. Kim HJ, Lee KW, Kim MS, Lee HJ, (2008) Piceatannol attenuates hydrogen-peroxide- and peroxynitrite-induced apoptosis of PC12 cells by blocking down-regulation of Bcl-XL and activation of JNK. J Nutr Biochem 19: 459-466.
27. Bastianetto S, Dumont Y, Duranton A, Vercauteren F, Breton L, et al. (2010) Protective action of resveratrol in human skin: possible involvement of specific receptor binding sites. PLoS One 5: e12935.
28. Hung LM, Chen JK, Lee RS, Liang HC, Su MJ, (2001) Beneficial effects of astringinin, a resveratrol analogue, on the ischemia and reperfusion damage in rat heart. Free Radic Biol Med 30: 877-883.
29. Huang YS, Liu FC, Li AH, Lau YT, Yu HP, (2011) Astringinin-mediated attenuation of the hepatic injury following trauma-hemorrhage. Chin J Physiol 54: 183-189.
30. Dorman RB, Bajt ML, Farhood A, Mayes J, Jaeschke H, (2004) Heme oxygenase-1 induction in hepatocytes and non-parenchymal cells protects against liver injury during endotoxemia. Comp Hepatol 3 (Suppl 1): S42.
31. Grochot-Przeczek A, Lach R, Mis J, Skrzypek K, Gozdecka M, et al. (2009) Heme oxygenase-1 accelerates cutaneous wound healing in mice. PLoS One 4: e5803.
32. Yu HP, Shimizu T, Hsieh YC, Suzuki T, Choudhry MA, et al. (2006) Tissue-specific expression of estrogen receptors and their role in the regulation of neutrophil infiltration in various organs following trauma-hemorrhage. J Leukoc Biol 79: 963-970.
33. Shimizu T, Yu HP, Hsieh YC, Choudhry MA, Suzuki T, et al. (2007) Flutamide attenuates pro-inflammatory cytokine production and hepatic injury following trauma-hemorrhage via estrogen receptor-related pathway. Ann Surg 245: 297-304.
34. Yang S, Hu S, Chen J, Choudhry MA, Rue LW, et al. (2009) Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses. J Leukoc Biol 85: 1015-1026.