High-performance liquid chromatographic method with amperometric detection employing boron-doped diamond electrode for the determination of sildenafil, vardenafil and their main metabolites in plasma

Journal of Chromatography A

Volumn 1218, Issue 44, 2011, Pages 7996-8001

  Bartošová, Zdenka ^a   Jirovský, David ^a   Horna, Aleš ^b  

^a PALACKÝ UNIVERSITY   (Czech Republic)

^b TOMAS BATA UNIVERSITY IN ZLIN   (Czech Republic)

Author keywords

Amperometric detection; Boron doped diamond electrode; HPLC; Sildenafil; Vardenafil

Indexed keywords

AMPEROMETRIC DETECTION; BORON-DOPED DIAMOND ELECTRODES; HPLC; SILDENAFIL; VARDENAFIL;

BORON; CHEMICAL DETECTION; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; DIAMONDS; ETHERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUIDS; METABOLISM; METABOLITES; PLASMA (HUMAN); SODIUM;

ELECTROCHEMICAL ELECTRODES;

DRUG METABOLITE; N DESETHYL VARDENAFIL; N DESMETHYL SILDENAFIL; SILDENAFIL; UNCLASSIFIED DRUG; VARDENAFIL;

AMPEROMETRY; ARTICLE; BORON DOPED DIAMOND ELECTRODE; CENTRIFUGATION; CHEMICAL INTERACTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; ELECTROCHEMICAL DETECTION; ELECTRODE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDRODYNAMICS; HYDROGEN BOND; HYDROPHOBICITY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; PH; POTENTIOMETRY; PRIORITY JOURNAL;

BORON; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; DIAMOND; ELECTRODES; HUMANS; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; LINEAR MODELS; PIPERAZINES; PURINES; SENSITIVITY AND SPECIFICITY; SULFONES; TRIAZINES;

EID: 80053941496     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.09.001     Document Type: Article

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