Liquid chromatography/tandem mass spectrometry method for the simultaneous determination of vardenafil and its major metabolite, N-desethylvardenafil, in human plasma: Application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 1-2, 2009, Pages 95-100

  Ku, Hei Young ^a   Shon, Ji Hong ^a,b   Liu, Kwang Hyeon ^a   Shin, Jae Gook ^a,b   Bae, Soo Kyung ^a,b  

^a Inje University College of Medicine   (South Korea)

^b Inje University College of Medicine   (South Korea)

Author keywords

Human plasma; LC MS MS; N desethylvardenafil; Vardenafil

Indexed keywords

ACETONITRILE; AMMONIUM COMPOUNDS; ELECTROSPRAY IONIZATION; ESTERS; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONIZATION OF LIQUIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES; PHARMACOKINETICS; PHASE SEPARATION; PLASMA (HUMAN); RATE CONSTANTS; SOLVENT EXTRACTION; SPECTROMETERS; SPECTROMETRY;

AMMONIUM ACETATES; ANALYTES; CHROMATOGRAPHIC SEPARATIONS; COEFFICIENT OF VARIATIONS; CONCENTRATION RANGES; ETHYL ACETATES; HUMAN PLASMA; HUMAN PLASMAS; INTERNAL STANDARDS; ISOCRATIC MOBILE PHASE; LC-MS/MS; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRIES; LIQUID EXTRACTIONS; LOWER LIMIT OF QUANTIFICATIONS; MONITORING MODES; N-DESETHYLVARDENAFIL; ORAL ADMINISTRATIONS; PHARMACOKINETIC STUDIES; POSITIVE ELECTROSPRAY IONIZATIONS; RUN TIMES; SIMULTANEOUS DETERMINATIONS; VARDENAFIL;

PLASMAS;

ACETIC ACID ETHYL ESTER; ACETONITRILE; AMMONIUM ACETATE; DEETHYLVARDENAFIL; DRUG METABOLITE; UNCLASSIFIED DRUG; VARDENAFIL;

ACCURACY; ADULT; ARTICLE; CONCENTRATION RESPONSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; ELECTROSPRAY; FLOW RATE; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; NORMAL HUMAN; PH; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REACTION ANALYSIS; STANDARD; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

CHROMATOGRAPHY, LIQUID; HUMANS; IMIDAZOLES; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; REFERENCE STANDARDS; SENSITIVITY AND SPECIFICITY; SULFONES; TANDEM MASS SPECTROMETRY; TRIAZINES;

EID: 57549098769     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2008.11.015     Document Type: Article

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