Simultaneous assay of sildenafil and desmethylsildenafil in neonatal plasma by ultra-performance liquid chromatography-tandem mass spectrometry

Biomedical Chromatography

Volumn 24, Issue 2, 2010, Pages 180-185

  Witjes, Bregje C ^a,c   Ahsman, Maurice J ^a   Van Der Nagel, Bart C ^a   Tibboel, Dick ^b   Mathot, Ron A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Mass spectrometry; Neonates; Pharmacokinetics; Plasma; Sildenafil; Ultra performance liquid chromatography

Indexed keywords

COLUMN CHROMATOGRAPHY; PHARMACOKINETICS;

LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; NEONATE; PEDIATRIC PATIENTS; PHARMACOKINETIC STUDIES; PULMONARY HYPERTENSION; SAMPLE VOLUME; SILDENAFIL; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION RESULTS;

MASS SPECTROMETRY;

NORSILDENAFIL; SILDENAFIL; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CALIBRATION; DRUG DETERMINATION; DRUG METABOLISM; FEMALE; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; NEWBORN; PULMONARY HYPERTENSION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; VALIDATION PROCESS;

EID: 74849112110     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1268     Document Type: Article

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