Determination of the activity of CD134 (OX-40) and CD137 (4-1BB) adhesive nolecules by means of flow cytometry in patients with colorectal cancer metastases to the liver

Polski Przeglad Chirurgiczny/ Polish Journal of Surgery

Volumn 83, Issue 8, 2011, Pages 424-429

  Cepowicz, Dariusz ^a   Zarȩba, Konrad ^a   Gryko, Mariusz ^a   Stasiak Bermuta, Anna ^a   Kȩdra, Bogusław ^a  

^a MEDICAL UNIVERSITY OF BIALYSTOK   (Poland)

Author keywords

adhesive molecules; CD134; CD137; colorectal carcinoma; flow cytometry; liver metastases

Indexed keywords

CD134 ANTIGEN; CD137 ANTIGEN; CD137 LIGAND; TUMOR MARKER;

ARTICLE; BLOOD; CHEMISTRY; COLORECTAL TUMOR; FEMALE; FLOW CYTOMETRY; HUMAN; LIVER TUMOR; MALE; METASTASIS; MIDDLE AGED; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD;

4-1BB LIGAND; ANTIGENS, CD137; COLORECTAL NEOPLASMS; FEMALE; FLOW CYTOMETRY; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; RECEPTORS, OX40; TUMOR MARKERS, BIOLOGICAL;

EID: 80053931847     PISSN: 0032373X     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10035-011-0066-9     Document Type: Article

References (18)

1. Chen S-H, Pham-Nguyen KB, Marinet O et al.: Rejection of disseminated metastases of colon carcinoma by synergism of IL-12 gene therapy and 4-1BB costimulation. Molecular Therapy 2000; 2(1): 39-46.
2. Mazollini G, Murillo O, Atorrasagasti C et al.: Immunotherapy and immunoescape in colorectal cancer. World J Gastroenterol 2007; 13(44): 5822-31.
3. Petty JK, He K, Corless CL et al.: Survival in human colorectal cancer correlates with expression of the T-cell costimulatory molecule OX-40 (CD134). Am J Surg 2002; 183: 512-18.
4. Tebutt NC, Cattell E, Midgley R et al.: Systemic treatment of colorectal cancer. Eur J Cancer 2002; 38: 1000-15.
5. Mayer-Kuckuk P, Banerjee D, Kemeny et al.: Molecular therapies of colorectal cancer metastatic to the liver. Molecular Therapy 2002; 5(5): 492-500.
6. Cragg MS, French RR, Glennie MJ: Signaling antibodies in cancer therapy. Cancer 1999; 11: 541-47.
7. Vonderheide RH, June CH: A translational bridge to cancer immunotherapy: exploiting costimulation and target antigens for active and passive T cells immunotherapy. Immunol Res 2003; 27: 341-56.
8. Weinberg AD, Rivera M-M, Prell R et al.: Engagement of the OX-40 receptor in vivo enhances antitumor immunity. J Immunology 2000; 164: 2160-69.
9. Marinet O, Ermekova V, Qiao JQ et al.: Immunomodulatory gene therapy with interleukin 12 and 4-1BB ligand: long-term remission of liver metastases in mouse model. Journal of the National Cancer Institute 2000; 92(11): 931-36.
10. Croft M: Costimulation of T cells by OX-40, 4-1BB, and CD27. Cytokine Growth Factor Rec 2003; 14: 265-73.
11. Pan P-Y, Zang Y, Weber K et al.: OX40 ligation enhances primary and memory cytotoxic L lymphocyte responses in an immunotherapy for hepatic colon metastases. Molecular Therapy 2002; 6(4): 528-36.
12. Tirapu I, Arina A, Mazollini G et al.: Improving efficacy of interleukin-12-transfected dendritic cells injected into murine colon cancer with colon cancer with anti-CD-137 monoclonal antibodies and alloantigens. Int J Cancer 2004;110: 51-60.
13. Dimberg J, Hugander A, Wagsater D: Expression of CD137 and CD137 ligand in colorectal cancer patients. Oncology Reports 2006; 15: 1197-1200.
14. Zhang N, Sadun RE, Arias RS et al.: Targeted and untargeted CD137L fusion proteins for the immunotherapy of experimental solid tumors. Clinical Cancer Research 2007,; 13: 2758-67.
15. Cepowicz D, Stasiak-Barmuta A, Zalewski B et al.: Assessment expresion of the adhesion molecules, CD134 and CD137, In patients with colorectal cancer by flow cytometry. Annales Academiae Medicae Bialostocensis 2004; 49 (suppl 1): 34-36.
16. Ballestrero A, Boy D, Moran E et al.: Immunotherapy with dendritic cells for cancer. Advanced Drug Delivery Reviews 2008; 60: 173-83.
17. Mocellin S, Nitti D: Therapeutics targeting tumor immune escape: towards the development of new generation anticancer vaccines. Medicinal Research Reviews 2008; 28(3): 413-44.
18. Sanz L, Blanco B, Alvarez-Vallina L: Antibodies and gene therapy: teaching old 'magic bullets' new trics. Trends in immunology 2004; 25(2): 85-91.