The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease

Journal of Gastroenterology

Volumn 45, Issue 10, 2010, Pages 1014-1021

  Ban, Hiromistu ^a   Andoh, Akira ^b   Imaeda, Hirotsugu ^a   Kobori, Ayako ^a   Bamba, Shigeki ^a   Tsujikawa, Tomoyuki ^a   Sasaki, Masaya ^a   Saito, Yasuharu ^a   Fujiyama, Yoshihide ^a  

^a SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^b NONE

Author keywords

6 Mercaptopurine; Azathioprine; IBD; MRP4

Indexed keywords

AMINOSALICYLIC ACID; AZATHIOPRINE; MERCAPTOPURINE; MULTIDRUG RESISTANCE PROTEIN 4;

ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DRUG SENSITIVITY; DRUG WITHDRAWAL; ENTERITIS; EXON; FEMALE; GENE FREQUENCY; GENE SEQUENCE; GENETIC ASSOCIATION; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; JAPANESE; LEUKOCYTE COUNT; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS;

6-MERCAPTOPURINE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AZATHIOPRINE; COLITIS, ULCERATIVE; CROHN DISEASE; EXONS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; JAPAN; MALE; MIDDLE AGED; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; YOUNG ADULT;

EID: 78249243846     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-010-0248-y     Document Type: Article

References (30)

1. DJ Adler BI Korelitz 1990 The therapeutic efficacy of 6-mercaptopurine in refractory ulcerative colitis Am J Gastroenterol 85 717 722 1:STN:280:DyaK3c3ot1aitA%3D%3D 1972315
2. Sandborn W, Sutherland L, Pearson D, May G, Modigliani R, Prantera C. Azathioprine or 6-mercaptopurine for inducing remission of Crohn's disease. Cochrane Database Syst Rev. 2000:CD000545.
3. T Hibi H Ogata 2006 Novel pathophysiological concepts of inflammatory bowel disease J Gastroenterol 41 10 16 10.1007/s00535-005-1744-3 16501852
4. RB Gearry ML Barclay MJ Burt JA Collett BA Chapman 2004 Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease Pharmacoepidemiol Drug Saf 13 563 567 1:CAS:528:DC%2BD2cXotVKjsr4%3D 10.1002/pds.926 15317038 (Pubitemid 39214035)
5. JM Van Dieren BE Hansen EJ Kuipers EE Nieuwenhuis CJ Van der Woude 2007 Meta-analysis: Inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease Aliment Pharmacol Ther 26 643 652 10.1111/j.1365-2036.2007.03412.x 17697198 (Pubitemid 47246201)
6. JP Gisbert F Gomollon 2008 Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: a review Am J Gastroenterol 103 1783 1800 10.1111/j.1572-0241.2008.01848.x 18557712
7. N Takatsu T Matsui Y Murakami H Ishihara T Hisabe T Nagahama, et al. 2009 Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease J Gastroenterol Hepatol 24 1258 1264 1:CAS:528:DC%2BD1MXht1WqtL%2FO 10.1111/j.1440-1746.2009.05917.x 19682195
8. CW Lees AK Maan B Hansoti J Satsangi ID Arnott 2008 Tolerability and safety of mercaptopurine in azathioprine-intolerant patients with inflammatory bowel disease Aliment Pharmacol Ther 27 220 227 1:CAS:528:DC%2BD1cXitFKmt74%3D 10.1111/j.1365-2036.2007.03570.x 17988235
9. JW Winter D Gaffney D Shapiro RJ Spooner AM Marinaki JD Sanderson, et al. 2007 Assessment of thiopurine methyltransferase enzyme activity is superior to genotype in predicting myelosuppression following azathioprine therapy in patients with inflammatory bowel disease Aliment Pharmacol Ther 25 1069 1077 1:CAS:528:DC%2BD2sXmsFars7s%3D 10.1111/j.1365-2036.2007.03301.x 17439508 (Pubitemid 46587697)
10. GR Lichtenstein MT Sbreu R Cohen W Tremaine 2006 American Gastroenterological Association Institute technical review on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease Rev Gastroenterol Mex 71 351 401 17140062
11. T Hibi M Naganuma T Kitahora F Kinjyo T Shimoyama 2003 Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis J Gastroenterol 38 740 746 1:CAS:528:DC%2BD3sXntlShurg%3D 10.1007/s00535-003-1139-2 14505127 (Pubitemid 37161337)
12. LJ Derijks LP Gilissen LG Engels LP Bos PJ Bus JJ Lohman, et al. 2006 Pharmacokinetics of 6-thioguanine in patients with inflammatory bowel disease Ther Drug Monit 28 45 50 1:CAS:528:DC%2BD28XkvFKntw%3D%3D 10.1097/01.ftd. 0000179839.71138.6d 16418693 (Pubitemid 44391693)
13. S Haglund J Taipalensuu C Peterson S Almer 2008 IMPDH activity in thiopurine-treated patients with inflammatory bowel disease-relation to TPMT activity and metabolite concentrations Br J Clin Pharmacol 65 1 69 77 1:CAS:528:DC%2BD1cXhslyktL8%3D 10.1111/j.1365-2125.2007.02985.x 17662091 (Pubitemid 350265173)
14. M Hiratsuka T Inoue F Omori Y Agatsuma M Mizugaki 2000 Genetic analysis of thiopurine methyltransferase polymorphism in a Japanese population Mutat Res 448 91 95 1:CAS:528:DC%2BD3cXit1aqsr8%3D 10751626
15. H Ban A Andoh A Tanaka T Tsujikawa M Sasaki Y Saito, et al. 2008 Analysis of thiopurine S-methyltransferase genotypes in Japanese patients with inflammatory bowel disease Intern Med 47 1645 1648 10.2169/internalmedicine.47. 1268 18827410
16. K Uchiyama M Nakamura T Kubota T Yamane K Fujise H Tajiri 2009 Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment J Gastroenterol 44 197 203 1:CAS:528:DC%2BD1MXhvVyqtLs%3D 10.1007/s00535-008-2307-1 19214663
17. M Kurzawski K Dziewanowski A Lener M Drozdzik 2009 TPMT but not ITPA gene polymorphism influences the risk of azathioprine intolerance in renal transplant recipients Eur J Clin Pharmacol 65 533 540 1:CAS:528: DC%2BD1MXkvV2jtrc%3D 10.1007/s00228-009-0630-y 19229528
18. D Allorge R Hamdan F Broly C Libersa JF Colombel 2005 ITPA genotyping test does not improve detection of Crohn's disease patients at risk of azathioprine/6-mercaptopurine induced myelosuppression Gut 54 565 1:STN:280:DC%2BD2M7ltleluw%3D%3D 10.1136/gut.2004.055947 15753546
19. Z Zelinkova LJ Derijks PC Stokkers EW Vogels AH van Kampen WL Curvers, et al. 2006 Inosine triphosphate pyrophosphatase and thiopurine S-methyltransferase genotypes relationship to azathioprine-induced myelosuppression Clin Gastroenterol Hepatol 4 44 49 1:CAS:528: DC%2BD28XhvVSqsLo%3D 10.1016/j.cgh.2005.10.019 16431304 (Pubitemid 43129523)
20. PR Wielinga G Reid EE Challa I van der Heijden L van Deemter M de Haas, et al. 2002 Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells Mol Pharmacol 62 1321 1331 1:CAS:528:DC%2BD38XptVyls7w%3D 10.1124/mol.62.6.1321 12435799 (Pubitemid 35407456)
21. P Krishnamurthy M Schwab K Takenaka D Nachagari J Morgan M Leslie, et al. 2008 Transporter-mediated protection against thiopurine-induced hematopoietic toxicity Cancer Res 68 4983 4989 1:CAS:528:DC%2BD1cXnvFOqtr0%3D 10.1158/0008-5472.CAN-07-6790 18593894
22. XX Peng Z Shi VL Damaraju XC Huang GD Kruh HC Wu, et al. 2008 Up-regulation of MRP4 and down-regulation of influx transporters in human leukemic cells with acquired resistance to 6-mercaptopurine Leuk Res 32 799 809 1:CAS:528:DC%2BD1cXjtVegsbk%3D 10.1016/j.leukres.2007.09.015 17996297 (Pubitemid 351323936)
23. P Borst R Evers M Kool J Wijnholds 2000 A family of drug transporters: the multidrug resistance-associated proteins J Natl Cancer Inst 92 1295 1302 1:CAS:528:DC%2BD3cXmtlektr8%3D 10.1093/jnci/92.16.1295 10944550
24. O Turriziani N Gianotti F Falasca A Boni AR Vestri A Zoccoli, et al. 2008 Expression levels of MDR1, MRP1, MRP4, and MRP5 in peripheral blood mononuclear cells from HIV infected patients failing antiretroviral therapy J Med Virol 80 766 771 1:CAS:528:DC%2BD1cXltFCku7k%3D 10.1002/jmv.21152 18360888 (Pubitemid 351500021)
25. L Oevermann J Scheitz K Starke K Kock T Kiefer G Dolken, et al. 2009 Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs Int J Cancer 124 2303 2311 1:CAS:528:DC%2BD1MXltFaqsbY%3D 10.1002/ijc.24207 19142964
26. ZS Chen K Lee GD Kruh 2001 Transport of cyclic nucleotides and estradiol 17-beta-d-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine J Biol Chem 276 33747 33754 1:CAS:528:DC%2BD3MXmslyltr8%3D 10.1074/jbc.M104833200 11447229
27. CR Yates EY Krynetski T Loennechen MY Fessing HL Tai CH Pui, et al. 1997 Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance Ann Intern Med 126 608 614 1:CAS:528:DyaK2sXivFehur8%3D 9103127
28. AM Marinaki A Ansari JA Duley M Arenas S Sumi CM Lewis, et al. 2004 Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase) Pharmacogenetics 14 181 187 1:CAS:528:DC%2BD2cXjt1Kjsrc%3D 10.1097/00008571- 200403000-00006 15167706 (Pubitemid 38373112)
29. MG Pike CL Franklin DC Mays JJ Lipsky PW Lowry WJ Sandborn 2001 Improved methods for determining the concentration of 6-thioguanine nucleotides and 6-methylmercaptopurine nucleotides in blood J Chromatogr B Biomed Sci Appl 757 1 9 1:CAS:528:DC%2BD3MXjtFCkurk%3D 10.1016/S0378-4347(00)00513-2 11419732 (Pubitemid 32424452)
30. A Andoh T Tsujikawa H Ban T Hashimoto S Bamba A Ogawa, et al. 2008 Monitoring 6-thioguanine nucleotide concentrations in Japanese patients with inflammatory bowel disease J Gastroenterol Hepatol 23 1373 1377 1:CAS:528:DC%2BD1cXht1Cls7nM 10.1111/j.1440-1746.2008.05419.x 18662197