Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice

Arthritis Research and Therapy

Volumn 13, Issue 5, 2011, Pages

  Hsieh, Ao Ho ^a   Jhou, Yí Jyun ^a   Liang, Chung Ting ^b   Chang, Mingi ^c   Wang, Shih Lien ^a  

^a TZU CHI UNIVERSITY   (Taiwan)

^b ACADEMIA SINICA   (Taiwan)

^c Development Centre for Biotechnology   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; AUTOANTIBODY; CELL NUCLEUS ANTIGEN; CENTRIOLE ANTIBODY; CHROMATIN ANTIBODY; CROSS REACTING ANTIBODY; CYTOMEGALOVIRUS ANTIGEN PP65; DOUBLE STRANDED DNA ANTIBODY; IMMUNOGLOBULIN; MITOTIC SPINDLE TYPE I ANTIBODY; MITOTIC SPINDLE TYPE II ANTIBODY; UNCLASSIFIED DRUG; CYTOMEGALOVIRUS MATRIX PROTEIN 65KDA; MATRIX PROTEIN; PEPTIDE FRAGMENT; PHOSPHOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; BAGG ALBINO MOUSE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC PREDISPOSITION; HUMAN; HUMAN CYTOMEGALOVIRUS; IMMUNIZATION; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; IMMUNOGLOBULIN DEPOSITION; KIDNEY TISSUE; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; PROTEIN INTERACTION; SYSTEMIC LUPUS ERYTHEMATOSUS; TWO HYBRID SYSTEM; ANIMAL; BIOSYNTHESIS; BLOOD; COMPARATIVE STUDY; CYTOMEGALOVIRUS; HELA CELL; IMMUNOLOGY; RANDOMIZATION;

ANIMALS; AUTOANTIBODIES; CYTOMEGALOVIRUS; FEMALE; HELA CELLS; HUMANS; MICE; MICE, INBRED BALB C; PEPTIDE FRAGMENTS; PHOSPHOPROTEINS; RANDOM ALLOCATION; VIRAL MATRIX PROTEINS;

EID: 80053896986     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3481     Document Type: Article

References (38)

1. Poole BD, Scofield RH, Harley JB, James JA: Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus. Autoimmunity 2006, 39:63-70
2. Poole BD, Gross T, Maier S, Harley JB, James JA: Lupus-like autoantibody development in rabbits and mice after immunization with EBNA-1 fragments. J Autoimmun 2008, 31:362-371
3. McClain MT, Heinlen LD, Dennis GJ, Roebuck J, Harley JB, James JA: Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nat Med 2005, 11:85-89
4. Khoshnevis M, Tyring SK: Cytomegalovirus infections. Dermatol Clin 2002, 20:291-299, vii
5. Oldstone MB, Nerenberg M, Southern P, Price J, Lewicki H: Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: role of anti-self (virus) immune response. Cell 1991, 65:319-331
6. Osame K, Takahashi Y, Takasawa H, Watanabe S, Kishimoto M, Yasuda K, Kaburagi Y, Nakanishi K, Kajio H, Noda M: Rapid-onset type 1 diabetes associated with cytomegalovirus infection and islet autoantibody synthesis. Intern Med 2007, 46:873-877
7. Cheng HM, Khairullah NS: Induction of antiphospholipid autoantibody during cytomegalovirus infection. Clin Infect Dis 1997, 25:1493-1494
8. Zhu J: Cytomegalovirus infection induces expression of 60 KD/Ro antigen on human keratinocytes. Lupus 1995, 4:396-406
9. Newkirk MM, van Venrooij WJ, Marshall GS: Autoimmune response to U1 small nuclear ribonucleoprotein (U1 snRNP) associated with cytomegalovirus infection. Arthritis Res 2001, 3:253-258
10. Curtis HA, Singh T, Newkirk MM: Recombinant cytomegalovirus glycoprotein gB (UL55) induces an autoantibody response to the U1-70 kDa small nuclear ribonucleoprotein. Eur J Immunol 1999, 29:3643-3653
11. McLaughlin-Taylor E, Pande H, Forman SJ, Tanamachi B, Li CR, Zaia JA, Greenberg PD, Riddell SR: Identification of the major late human cytomegalovirus matrix protein pp65 as a target antigen for CD8+ virusspecific cytotoxic T lymphocytes. J Med Virol 1994, 43:103-110
12. Tanaka N, Kimura H, Hoshino Y, Nishikawa K, Kojima S, Nishiyama Y, Morishima T: Expression of tegument protein pp65 of human cytomegalovirus (CMV) and its application to the analysis of viralspecific cellular immunity in CMV-infected individuals. Arch Virol 2002, 147:2405-2417
13. Khattab BA, Lindenmaier W, Frank R, Link H: Three T-cell epitopes within the C-terminal 265 amino acids of the matrix protein pp65 of human cytomegalovirus recognized by human lymphocytes. J Med Virol 1997, 52:68-76
14. Kondo E, Akatsuka Y, Kuzushima K, Tsujimura K, Asakura S, Tajima K, Kagami Y, Kodera Y, Tanimoto M, Morishima Y, Takahashi T: Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles. Blood 2004, 103:630-638
15. Chang M, Pan MR, Chen DY, Lan JL: Human cytomegalovirus pp65 lower matrix protein: a humoral immunogen for systemic lupus erythematosus patients and autoantibody accelerator for NZB/W F1 mice. Clin Exp Immunol 2006, 143:167-179
16. Dempsey PW, Allison ME, Akkaraju S, Goodnow CC, Fearon DT: C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 1996, 271:348-350
17. Green TD, Montefiori DC, Ross TM: Enhancement of antibodies to the human immunodeficiency virus type 1 envelope by using the molecular adjuvant C3d. J Virol 2003, 77:2046-2055
18. Yu M, Li da J, Wang XL, Yuan MM, Zhu Y, Yao XY, Li HP: [Molecular adjuvant C3d up-regulates both B7-1 and B7-2 expression on Raji cells]. Fen Zi Xi Bao Sheng Wu Xue Bao 2006, 39:77-82
19. Olmsted JB: Affinity purification of antibodies from diazotized paper blots of heterogeneous protein samples. J Biol Chem 1981, 256:11955-11957
20. Linnik MD, Hu JZ, Heilbrunn KR, Strand V, Hurley FL, Joh T: Relationship between anti-double-stranded DNA antibodies and exacerbation of renal disease in patients with systemic lupus erythematosus. Arthritis Rheum 2005, 52:1129-1137
21. Arbuckle MR, James JA, Kohlhase KF, Rubertone MV, Dennis GJ, Harley JB: Development of anti-dsDNA autoantibodies prior to clinical diagnosis of systemic lupus erythematosus. Scand J Immunol 2001, 54:211-219
22. Arbuckle MR, McClain MT, Rubertone MV, Scofield RH, Dennis GJ, James JA, Harley JB: Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med 2003, 349:1526-1533
23. Bijl M, Dijstelbloem HM, Oost WW, Bootsma H, Derksen RH, Aten J, Limburg PC, Kallenberg CG: IgG subclass distribution of autoantibodies differs between renal and extra-renal relapses in patients with systemic lupus erythematosus. Rheumatology (Oxford) 2002, 41:62-67
24. Hurd ER, Ziff M: Quantitative studies of immunoglobulin deposition in the kidney, glomerular cell proliferation and glomerulosclerosis in NZB/NZW F1 hybrid mice. Clin Exp Immunol 1977, 27:261-268
25. Cui Z, Zhang K, Zhang Z, Liu Y, Zhou Y, Wei H, Zhang XE: Visualization of the dynamic multimerization of human Cytomegalovirus pp65 in punctuate nuclear foci. Virology 2009, 392:169-177
26. Provenzano M, Sais G, Bracci L, Egli A, Anselmi M, Viehl CT, Schaub S, Hirsch HH, Stroncek DF, Marincola FM, Spagnoli GC: A HCMV pp65 polypeptide promotes the expansion of CD4+ and CD8+ T cells across a wide range of HLA specificities. J Cell Mol Med 2009, 13:2131-2147
27. Landini MP, Lazzarotto T, Xu J, Geballe AP, Mocarski ES: Humoral immune response to proteins of human cytomegalovirus latency-associated transcripts. Biol Blood Marrow Transplant 2000, 6:100-108
28. Putterman C, Diamond B: Immunization with a peptide surrogate for double-stranded DNA (dsDNA) induces autoantibody production and renal immunoglobulin deposition. J Exp Med 1998, 188:29-38
29. Sundar K, Jacques S, Gottlieb P, Villars R, Benito ME, Taylor DK, Spatz LA: Expression of the Epstein-Barr virus nuclear antigen-1 (EBNA-1) in the mouse can elicit the production of anti-dsDNA and anti-Sm antibodies. J Autoimmun 2004, 23:127-140
30. Deshmukh US, Kannapell CC, Fu SM: Immune responses to small nuclear ribonucleoproteins: antigen-dependent distinct B cell epitope spreading patterns in mice immunized with recombinant polypeptides of small nuclear ribonucleoproteins. J Immunol 2002, 168:5326-5332
31. Garcia CO, Molina JF, Gutierrez-Urena S, Scopelitis E, Wilson WA, Gharavi AE, Espinoza LR: Autoantibody profile in African-American patients with lupus nephritis. Lupus 1996, 5:602-605
32. Winkler TH, Henschel TA, Kalies I, Baenkler HW, Skvaril F, Kalden JR: Constant isotype pattern of anti-dsDNA antibodies in patients with systemic lupus erythematosus. Clin Exp Immunol 1988, 72:434-439
33. Zhao Z, Weinstein E, Tuzova M, Davidson A, Mundel P, Marambio P, Putterman C: Cross-reactivity of human lupus anti-DNA antibodies with alpha-actinin and nephritogenic potential. Arthritis Rheum 2005, 52:522-530
34. Mendlovic S, Brocke S, Fricke H, Shoenfeld Y, Bakimer R, Mozes E: The genetic regulation of the induction of experimental SLE. Immunology 1990, 69:228-236
35. Andreassen K, Bredholt G, Moens U, Bendiksen S, Kauric G, Rekvig OP: T cell lines specific for polyomavirus T-antigen recognize T-antigen complexed with nucleosomes: a molecular basis for anti-DNA antibody production. Eur J Immunol 1999, 29:2715-2728
36. Schmolke S, Drescher P, Jahn G, Plachter B: Nuclear targeting of the tegument protein pp65 (UL83) of human cytomegalovirus: an unusual bipartite nuclear localization signal functions with other portions of the protein to mediate its efficient nuclear transport. J Virol 1995, 69:1071-1078
37. Dal Monte P, Bessia C, Landini MP, Michelson S: Expression of human cytomegalovirus ppUL83 (pp65) in a stable cell line and its association with metaphase chromosomes. J Gen Virol 1996, 77:2591-2596
38. Maniati E, Potter P, Rogers NJ, Morley BJ: Control of apoptosis in autoimmunity. J Pathol 2008, 214:190-198