Expression of tegument protein pp65 of human cytomegalovirus (CMV) and its application to the analysis of viral-specific cellular immunity in CMV-infected individuals

Archives of Virology

Volumn 147, Issue 12, 2002, Pages 2405-2417

  Tanaka, Naoko ^a,e   Kimura, H ^a   Hoshino, Y ^a   Nishikawa, K ^b   Kojima, S ^a   Nishiyama, Y ^c   Morishima, T ^d  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Nagoya Ekisaikai Hospital   (Japan)

^c Res Inst Dis Mechanism Contr   (Japan)

^d NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e Nagoya Memorial Hospital   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ANTIGENS, VIRAL; BACULOVIRIDAE; BLOOD COMPONENT TRANSFUSION; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DNA, VIRAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENETIC VECTORS; HUMANS; IMMUNOGLOBULIN G; INFANT; INTERFERON TYPE II; MALE; PHOSPHOPROTEINS; RECOMBINANT PROTEINS; VIRAL LOAD; VIRAL MATRIX PROTEINS;

CUCUMBER MOSAIC VIRUS; CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; UNIDENTIFIED BACULOVIRUS;

EID: 0036923159     PISSN: 03048608     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00705-002-0860-0     Document Type: Article

References (28)

1. Altfeld M, Rosenberg ES (2000) The role of CD4(+) T helper cells in the cytotoxic T lymphocyte response to HIV-1. Curr Opin Immunol 12: 375-380
2. Asanuma H, Sharp M, Maecker HT, Maino VC, Arvin AM (2000) Frequencies of memory T cells specific for varicella-zoster virus, herpes simplex virus, and cytomegalovirus by intracellular detection of cytokine expression. J Infect Dis 181: 859-866
3. Avigan D (1999) Dendritic cells: Development, function and potential use for cancer immunotherapy. Blood Rev 13: 51-64
4. Doherty PC, Christensen JP (2000) Accessing complexity: The dynamics of virus-specific T cell responses. Annu Rev Immunol 18: 561-592
5. Endresz VKL, Berencsi K, Kari C, Gyulai Z, Jeney C, Pincus S, Rodeck U, Meric C, Plotkin SA, Gonczol E (1999) Induction of human cytomegalovirus (HCMV) - Glycoprotein B (gB) - Specific neutralizing antibody and phosphoprotein 65 (pp65) - Specific cytotoxic T lymphocyte responses by naked DNA immunization. Vaccine 17: 50-58
6. Jenkins DE, Yasukawa LL, Bergen R, Benike C, Engleman EG, Arvin AM (1999) Comparison of primary sensitization of naive human T cells to varicella-zoster virus peptides by dendritic cells in vitro with responses elicited in vivo by varicella vaccination. J Immunol 162: 560-567
7. Kimura H, Straus SE, Williams RK (1997) Varicella-zoster virus glycoproteins E and I expressed in insect cells form a heterodimer that requires the N-terminal domain of glycoprotein I. Virology 233: 382-391
8. Kimura H, Wang Y, Pesnicak L, Cohen JI, Hooks JJ, Straus SE, Williams RK (1998) Recombinant varicella-zoster virus glycoproteins E and I: immunologic responses and clearance of virus in a guinea pig model of chronic uveitis. J Infect Dis 178: 310-317
9. La Fauci G, Sapienza VJ, Chen CJ, Wisniewski HM, Kim KS (1994) Expression of the human cytomegalovirus 65K tegument phosphoprotein in insect cells by baculovirus vectors. J Gen Virol 75: 189-192
10. Landini MP, Re MC, Mirolo G, Baldassarri B, La Placa M (1985) Human immune response to cytomegalovirus structural polypeptides studied by immunoblotting. J Med Virol 17: 303-311
11. McLaughlin-Taylor E, Pande H, Forman SJ, Tanamachi B, Li CR, Zaia JA, Greenberg PD, Riddell SR (1994) Identification of the major late human cytomegalovirus matrix protein pp65 as a target antigen for CD8+ virus-specific cytotoxic T lymphocytes. J Med Virol 43: 103-110
12. Plachter B, Klages S, Hagelmann S, Britt W, Landini MP, Jahn G (1990) Procaryotic expression of phosphorylated tegument protein pp65 of human cytomegalovirus and application of recombinant peptides for immunoblot analyses. J Clin Microbiol 28: 1229-1235
13. Plotkin SA (1999) Vaccination against cytomegalovirus, the changelingdemon. Pediatr Infect Dis J 18: 313-325
14. Reddehase MJ, Mutter W, Munch K, Buhring HJ, Koszinowski UH (1987) CD8-positive T lymphocytes specific for murine cytomegalovirus immediate-early antigens mediate protective immunity. J Virol 61: 3102-3108
15. Reusser P, Riddell SR, Meyers JD, Greenberg PD (1991) Cytotoxic T-lymphocyte response to cytomegalovirus after human allogeneic bone marrow transplantation: Pattern of recovery and correlation with cytomegalovirus infection and disease. Blood 78: 1373-1380
16. Riddell SR, Rabin M, Geballe AP, Britt WJ, Greenberg PD (1991) Class I MHC-restricted cytotoxic T lymphocyte recognition of cells infected with human cytomegalovirus does not require endogenous viral gene expression. J Immunol 146: 2795-2804
17. Riddell SR, Greenberg PD (2000) T-cell therapy of cytomegalovirus and human immunodeficiency virus infection. J Antimicrob Chemother 45: 35-43
18. Ruger B, Klages S, Walla B, Albrecht J, Fleckenstein B, Tomlinson P, Barrell B (1987) Primary structure and transcription of the genes coding for the two virion phosphoproteins pp65 and pp71 of human cytomegalovirus. J Virol 61: 446-453
19. Soderberg-Naucler C, Nelson JY (1999) Human cytomegalovirus latency and reactivation - A delicate balance between the virus and its host's immune system. Intervirology 42: 314-321
20. Spiegel HM, Ogg GS, DeFalcon E, Sheehy ME, Monard S, Haslett PA, Gillespie G, Donahoe SM, Pollack H, Borkowsky W, McMichael AJ, Nixon DF (2000) Human immunodeficiency virus type 1- and cytomegalovirus-specific cytotoxic T lymphocytes can persist at high frequency for prolonged periods in the absence of circulating peripheral CD4(+) T cells. J Virol 74: 1018-1022
21. Tanaka H, Demeure CE, Rubio M, Delespesse G, Sarfati M (2000) Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors. Role of stimulator/responder ratio. J Exp Med 192: 405-412
22. Tanaka N, Kimura H, Iida K, Saito Y, Tsuge I, Yoshimi A, Matsuyama T, Morishima T (2000) Quantitative analysis of cytomegalovirus load using a real-time PCR assay. J Med Virol 60: 455-462
23. van Zanten J, Harmsen MC, van der Giessen M, van der Bij W, Prop J, de Leij L, The TH (1995) Humoral immune response against human cytomegalovirus (HCMV)-specific proteins after HCMV infection in lung transplantation as detected with recombinant and naturally occurring proteins. Clin Diagn Lab Immun 2: 214-218
24. van Zanten J, Harmsen MC, van der Meer P, van der Bij W, van Son WJ, van der Giessen M, Prop J, de Leij L, The TH (1995) Proliferative T cell responses to four human cytomegalovirus-specific proteins in healthy subjects and solid organ transplant recipients. J Infect Dis 172: 879-882
25. Van-Santiago J, Lule J, Rohrlich P, Jacquier G, Gibert N, Le Roy E, Betbeder D, Davignon JL, Davrinche C (2001) Ex vivo stimulation and expansion of both CD4(+) and CD8(+) T cells from peripheral blood mononuclear cells of human cytomegalovirus-seropositive blood donors by using a soluble recombinant chimeric protein, IE1-pp65. J Virol 75: 7840-7847
26. Waldrop SL, Pitcher CJ, Peterson DM, Maino VC, Picker LJ (1997) Determination of antigen-specific memory/effector CD4+ T cell frequencies by flow cytometry: Evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency. J Clin Invest 99: 1739-1750
27. Walter EA, Greenberg PD, Gilbert MJ, Finch RJ, Watanabe KS, Thomas ED, Riddell SR (1995) Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med 333: 1038-1044
28. Wills MR, Carmichael AJ, Mynard K, Jin X, Weekes MP, Plachter B, Sissons JG (1996) The human cytotoxic T-lymphocyte (CTL) response to cytomegalovirus is dominated by structural protein pp65: frequency, specificity, and T-cell receptor usage of pp65-specific CTL. J Virol 70: 7569-7579