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Volumn 13, Issue 8 B, 2009, Pages 2131-2147

A HCMV pp65 polypeptide promotes the expansion of CD4+ and CD8+ T cells across a wide range of HLA specificities

Author keywords

Immunotherapy; Peptide cross presentation; Vaccine

Indexed keywords

CYTOMEGALOVIRUS MATRIX PROTEIN 65KDA; HLA ANTIGEN; MATRIX PROTEIN; PHOSPHOPROTEIN; PRIMER DNA;

EID: 72949083318     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00531.x     Document Type: Article
Times cited : (9)

References (54)
  • 1
    • 84862859311 scopus 로고    scopus 로고
    • Cytomegalovirus and polyomavirus BK posttransplant
    • Egli A, Binggeli S, Bodaghi S, et al. Cytomegalovirus and polyomavirus BK posttransplant. Nephrol Dial Transplant. 2007 22 : viii72 82.
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 72-82
    • Egli, A.1    Binggeli, S.2    Bodaghi, S.3
  • 2
    • 34249907536 scopus 로고    scopus 로고
    • Cytomegalovirus (CMV) IE1- and pp65-specific CD8+ T cell responses broaden over time after primary CMV infection in infants
    • Gibson L, Dooley S, Trzmielina S, et al. Cytomegalovirus (CMV) IE1- and pp65-specific CD8+ T cell responses broaden over time after primary CMV infection in infants. J Infect Dis. 2007 195 : 1789 1798.
    • (2007) J Infect Dis. , vol.195 , pp. 1789-1798
    • Gibson, L.1    Dooley, S.2    Trzmielina, S.3
  • 3
    • 33847031357 scopus 로고    scopus 로고
    • Longitudinal assessment of cytomegalovirus (CMV)-specific immune responses in liver transplant recipients at high risk for late CMV disease
    • La Rosa C, Limaye AP, Krishnan A, et al. Longitudinal assessment of cytomegalovirus (CMV)-specific immune responses in liver transplant recipients at high risk for late CMV disease. J Infect Dis. 2007 195 : 633 644.
    • (2007) J Infect Dis. , vol.195 , pp. 633-644
    • La Rosa, C.1    Limaye, A.P.2    Krishnan, A.3
  • 4
    • 0035437133 scopus 로고    scopus 로고
    • Isolation and expansion of cytomegalovirus-specific cytotoxic T lymphocytes to clinical scale from a single blood draw using dendritic cells and HLA-tetramers
    • Szmania S, Galloway A, Bruorton M, et al. Isolation and expansion of cytomegalovirus-specific cytotoxic T lymphocytes to clinical scale from a single blood draw using dendritic cells and HLA-tetramers. Blood. 2001 98 : 505 512.
    • (2001) Blood , vol.98 , pp. 505-512
    • Szmania, S.1    Galloway, A.2    Bruorton, M.3
  • 5
    • 24344489044 scopus 로고    scopus 로고
    • Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
    • Sylwester AW, Mitchell BL, Edgar JB, et al. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med. 2005 202 : 673 685.
    • (2005) J Exp Med. , vol.202 , pp. 673-685
    • Sylwester, A.W.1    Mitchell, B.L.2    Edgar, J.B.3
  • 6
    • 2542503295 scopus 로고    scopus 로고
    • Progress made towards the development of a CMV peptide vaccine
    • Paston SJ, Dodi IA, Madrigal JA. Progress made towards the development of a CMV peptide vaccine. Hum Immun. 2004 65 : 544 549.
    • (2004) Hum Immun. , vol.65 , pp. 544-549
    • Paston, S.J.1    Dodi, I.A.2    Madrigal, J.A.3
  • 7
    • 33845875194 scopus 로고    scopus 로고
    • Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation
    • Casazza JP, Betts MR, Price DA, et al. Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation. J Exp Med. 2006 203 : 2865 2877.
    • (2006) J Exp Med. , vol.203 , pp. 2865-2877
    • Casazza, J.P.1    Betts, M.R.2    Price, D.A.3
  • 8
    • 35348891071 scopus 로고    scopus 로고
    • Functional characterization of BK virus-specific CD4+ T cells with cytotoxic potential in seropositive adults
    • Zhou W, Sharma M, Martinez J, et al. Functional characterization of BK virus-specific CD4+ T cells with cytotoxic potential in seropositive adults. Viral Immunol. 2007 20 : 379 388.
    • (2007) Viral Immunol. , vol.20 , pp. 379-388
    • Zhou, W.1    Sharma, M.2    Martinez, J.3
  • 9
    • 12144291649 scopus 로고    scopus 로고
    • Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection
    • Zaunders JJ, Dyer WB, Wang B, et al. Identification of circulating antigen-specific CD4+ T lymphocytes with a CCR5+, cytotoxic phenotype in an HIV-1 long-term nonprogressor and in CMV infection. Blood. 2004 103 : 2238 2247.
    • (2004) Blood , vol.103 , pp. 2238-2247
    • Zaunders, J.J.1    Dyer, W.B.2    Wang, B.3
  • 10
    • 0036624737 scopus 로고    scopus 로고
    • Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy
    • Einsele H, Roosnek E, Rufer N, et al. Infusion of cytomegalovirus (CMV)-specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood. 2002 99 : 3916 3922.
    • (2002) Blood , vol.99 , pp. 3916-3922
    • Einsele, H.1    Roosnek, E.2    Rufer, N.3
  • 11
    • 0038784382 scopus 로고    scopus 로고
    • Primary immune responses to human CMV: A critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease
    • Gamadia LE, Remmerswaal EB, Weel JF, et al. Primary immune responses to human CMV: a critical role for IFN-gamma-producing CD4+ T cells in protection against CMV disease. Blood. 2003 101 : 2686 2692.
    • (2003) Blood , vol.101 , pp. 2686-2692
    • Gamadia, L.E.1    Remmerswaal, E.B.2    Weel, J.F.3
  • 12
    • 38849166751 scopus 로고    scopus 로고
    • Induction of EBV-latent membrane protein 1-specific MHC class II-restricted T-cell responses against natural killer lymphoma cells
    • Kobayashi H, Nagato T, Takahara M, et al. Induction of EBV-latent membrane protein 1-specific MHC class II-restricted T-cell responses against natural killer lymphoma cells. Cancer Res. 2008 68 : 901 908.
    • (2008) Cancer Res. , vol.68 , pp. 901-908
    • Kobayashi, H.1    Nagato, T.2    Takahara, M.3
  • 13
    • 34249664529 scopus 로고    scopus 로고
    • The impact of HLA-B micropolymorphism outside primary peptide anchor pockets on the CTL response to CMV
    • Burrows JM, Wynn KK, Tynan FE, et al. The impact of HLA-B micropolymorphism outside primary peptide anchor pockets on the CTL response to CMV. Eur J Immunol. 2007 37 : 946 953.
    • (2007) Eur J Immunol. , vol.37 , pp. 946-953
    • Burrows, J.M.1    Wynn, K.K.2    Tynan, F.E.3
  • 14
    • 34247159208 scopus 로고    scopus 로고
    • CMV pp65 and IE-1 T cell epitopes recognized by healthy subjects
    • Slezak SL, Bettinotti M, Selleri S, et al. CMV pp65 and IE-1 T cell epitopes recognized by healthy subjects. J Transl Med. 2007 5 : 17.
    • (2007) J Transl Med. , vol.5 , pp. 17
    • Slezak, S.L.1    Bettinotti, M.2    Selleri, S.3
  • 15
    • 34247572039 scopus 로고    scopus 로고
    • Comprehensive epitope mapping of the Epstein-Barr virus latent membrane protein-2 in normal, non tumor-bearing individuals
    • Provenzano M, Selleri S, Jin P, et al. Comprehensive epitope mapping of the Epstein-Barr virus latent membrane protein-2 in normal, non tumor-bearing individuals. Cancer Immunol Immunother. 2007 56 : 1047 1063.
    • (2007) Cancer Immunol Immunother. , vol.56 , pp. 1047-1063
    • Provenzano, M.1    Selleri, S.2    Jin, P.3
  • 16
    • 9644259300 scopus 로고    scopus 로고
    • Human cytomegalovirus: Clinical aspects, immune regulation, and emerging treatments
    • Gandhi MK, Khanna R. Human cytomegalovirus: clinical aspects, immune regulation, and emerging treatments. Lancet Infect Dis. 2004 4 : 725 738.
    • (2004) Lancet Infect Dis. , vol.4 , pp. 725-738
    • Gandhi, M.K.1    Khanna, R.2
  • 17
    • 33644884175 scopus 로고    scopus 로고
    • Identification of HLA-A33-restricted CMV pp65 epitopes as common targets for CD8(+) CMV-specific cytotoxic T lymphocytes
    • Lim JB, Provenzano M, Kwon OH, et al. Identification of HLA-A33-restricted CMV pp65 epitopes as common targets for CD8(+) CMV-specific cytotoxic T lymphocytes. Exp Hematol. 2006 34 : 296 307.
    • (2006) Exp Hematol. , vol.34 , pp. 296-307
    • Lim, J.B.1    Provenzano, M.2    Kwon, O.H.3
  • 18
    • 27344445458 scopus 로고    scopus 로고
    • Analysis of memory T lymphocyte activity following stimulation with overlapping HLA-A*2402, A*0101 and Cw*0402 restricted CMV pp65 peptides
    • Ghei M, Stroncek DF, Provenzano M. Analysis of memory T lymphocyte activity following stimulation with overlapping HLA-A*2402, A*0101 and Cw*0402 restricted CMV pp65 peptides. J Transl Med. 2005 3 : 23.
    • (2005) J Transl Med. , vol.3 , pp. 23
    • Ghei, M.1    Stroncek, D.F.2    Provenzano, M.3
  • 19
    • 0035129970 scopus 로고    scopus 로고
    • Quantification of human cytomegalovirus DNA by real-time PCR
    • Gault E, Michel Y, Dehee A, et al. Quantification of human cytomegalovirus DNA by real-time PCR. J Clin Microbiol. 2001 39 : 772 775.
    • (2001) J Clin Microbiol. , vol.39 , pp. 772-775
    • Gault, E.1    Michel, Y.2    Dehee, A.3
  • 20
    • 45949083381 scopus 로고    scopus 로고
    • Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients
    • Egli A, Binet I, Binggeli S, et al. Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients. J Transl Med. 2008 6 : 29.
    • (2008) J Transl Med. , vol.6 , pp. 29
    • Egli, A.1    Binet, I.2    Binggeli, S.3
  • 21
    • 13644266455 scopus 로고    scopus 로고
    • Dendritic-cell infection by human cytomegalovirus is restricted to strains carrying functional UL131-128 genes and mediates efficient viral antigen presentation to CD8+ T cells
    • Gerna G, Percivalle E, Lilleri D, et al. Dendritic-cell infection by human cytomegalovirus is restricted to strains carrying functional UL131-128 genes and mediates efficient viral antigen presentation to CD8+ T cells. J Gen Virol. 2005 86 : 275 284.
    • (2005) J Gen Virol. , vol.86 , pp. 275-284
    • Gerna, G.1    Percivalle, E.2    Lilleri, D.3
  • 22
    • 0035990387 scopus 로고    scopus 로고
    • Identification of immune dominant cytomegalovirus epitopes using quantitative real-time polymerase chain reactions to measure interferon-gamma production by peptide-stimulated peripheral blood mononuclear cells
    • Provenzano M, Mocellin S, Bettinotti M, et al. Identification of immune dominant cytomegalovirus epitopes using quantitative real-time polymerase chain reactions to measure interferon-gamma production by peptide-stimulated peripheral blood mononuclear cells. J Immunother. 2002 25 : 342 351.
    • (2002) J Immunother. , vol.25 , pp. 342-351
    • Provenzano, M.1    Mocellin, S.2    Bettinotti, M.3
  • 23
    • 0142043427 scopus 로고    scopus 로고
    • Use of quantitative real-time PCR to determine immune cell density and cytokine gene profile in the tumor microenvironment
    • Mocellin S, Provenzano M, Rossi CR, et al. Use of quantitative real-time PCR to determine immune cell density and cytokine gene profile in the tumor microenvironment. J Immunol Methods. 2003 280 : 1 11.
    • (2003) J Immunol Methods. , vol.280 , pp. 1-11
    • Mocellin, S.1    Provenzano, M.2    Rossi, C.R.3
  • 24
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods San Diego, Calif. 2001 25 : 402 408.
    • (2001) Methods San Diego, Calif. , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 25
    • 0036173941 scopus 로고    scopus 로고
    • Visualization and quantification of T cell-mediated cytotoxicity using cell-permeable fluorogenic caspase substrates
    • Liu L, Chahroudi A, Silvestri G, et al. Visualization and quantification of T cell-mediated cytotoxicity using cell-permeable fluorogenic caspase substrates. Nat Med. 2002 8 : 185 189.
    • (2002) Nat Med. , vol.8 , pp. 185-189
    • Liu, L.1    Chahroudi, A.2    Silvestri, G.3
  • 26
    • 33845217989 scopus 로고    scopus 로고
    • Characterization of highly frequent epitope-specific CD45RA+/CCR7+/- T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*0201+ BKV-seropositive donors
    • Provenzano M, Bracci L, Wyler S, et al. Characterization of highly frequent epitope-specific CD45RA+/CCR7+/- T lymphocyte responses against p53-binding domains of the human polyomavirus BK large tumor antigen in HLA-A*0201+ BKV-seropositive donors. J Transl Med. 2006 4 : 47.
    • (2006) J Transl Med. , vol.4 , pp. 47
    • Provenzano, M.1    Bracci, L.2    Wyler, S.3
  • 27
    • 0020601431 scopus 로고
    • Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing
    • Shimonkevitz R, Kappler J, Marrack P, et al. Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing. J Exp Med. 1983 158 : 303 316.
    • (1983) J Exp Med. , vol.158 , pp. 303-316
    • Shimonkevitz, R.1    Kappler, J.2    Marrack, P.3
  • 28
    • 0030928128 scopus 로고    scopus 로고
    • Development of a candidate HLA A*0201 restricted peptide-based vaccine against human cytomegalovirus infection
    • Diamond DJ, York J, Sun JY, et al. Development of a candidate HLA A*0201 restricted peptide-based vaccine against human cytomegalovirus infection. Blood. 1997 90 : 1751 1767.
    • (1997) Blood , vol.90 , pp. 1751-1767
    • Diamond, D.J.1    York, J.2    Sun, J.Y.3
  • 29
    • 0026317416 scopus 로고
    • The minimum peptide epitope from the influenza virus matrix protein. Extra and intracellular loading of HLA-A2
    • Bednarek MA, Sauma SY, Gammon MC, et al. The minimum peptide epitope from the influenza virus matrix protein. Extra and intracellular loading of HLA-A2. J Immunol. 1991 147 : 4047 4053.
    • (1991) J Immunol. , vol.147 , pp. 4047-4053
    • Bednarek, M.A.1    Sauma, S.Y.2    Gammon, M.C.3
  • 30
    • 16644387582 scopus 로고    scopus 로고
    • Major contribution of codominant CD8 and CD4 T cell epitopes to the human cytomegalovirus-specific T cell repertoire
    • Nastke MD, Herrgen L, Walter S, et al. Major contribution of codominant CD8 and CD4 T cell epitopes to the human cytomegalovirus-specific T cell repertoire. Cell Mol Life Sci. 2005 62 : 77 86.
    • (2005) Cell Mol Life Sci. , vol.62 , pp. 77-86
    • Nastke, M.D.1    Herrgen, L.2    Walter, S.3
  • 31
    • 0035885950 scopus 로고    scopus 로고
    • Efficient identification of HLA-A*2402-restricted cytomegalovirus-specific CD8(+) T-cell epitopes by a computer algorithm and an enzyme-linked immunospot assay
    • Kuzushima K, Hayashi N, Kimura H, et al. Efficient identification of HLA-A*2402-restricted cytomegalovirus-specific CD8(+) T-cell epitopes by a computer algorithm and an enzyme-linked immunospot assay. Blood. 2001 98 : 1872 1881.
    • (2001) Blood , vol.98 , pp. 1872-1881
    • Kuzushima, K.1    Hayashi, N.2    Kimura, H.3
  • 32
    • 13244275187 scopus 로고    scopus 로고
    • Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues
    • Mora JR, Cheng G, Picarella D, et al. Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues. J Exp Med. 2005 201 : 303 316.
    • (2005) J Exp Med. , vol.201 , pp. 303-316
    • Mora, J.R.1    Cheng, G.2    Picarella, D.3
  • 33
    • 20844437647 scopus 로고    scopus 로고
    • Simultaneous quantification of human cytomegalovirus (HCMV)-specific CD4+ and CD8+ T cells by a novel method using monocyte-derived HCMV-infected immature dendritic cells
    • Lozza L, Lilleri D, Percivalle E, et al. Simultaneous quantification of human cytomegalovirus (HCMV)-specific CD4+ and CD8+ T cells by a novel method using monocyte-derived HCMV-infected immature dendritic cells. Eur J Immunol. 2005 35 : 1795 1804.
    • (2005) Eur J Immunol. , vol.35 , pp. 1795-1804
    • Lozza, L.1    Lilleri, D.2    Percivalle, E.3
  • 34
    • 0032910554 scopus 로고    scopus 로고
    • Peripheral blood CD14(+) cells from healthy subjects carry a circular conformation of latent cytomegalovirus genome
    • Bolovan-Fritts CA, Mocarski ES, Wiedeman JA. Peripheral blood CD14(+) cells from healthy subjects carry a circular conformation of latent cytomegalovirus genome. Blood. 1999 93 : 394 398.
    • (1999) Blood , vol.93 , pp. 394-398
    • Bolovan-Fritts, C.A.1    Mocarski, E.S.2    Wiedeman, J.A.3
  • 35
    • 29544450845 scopus 로고    scopus 로고
    • Progress in cytomegalovirus vaccine development
    • Schleiss M. Progress in cytomegalovirus vaccine development. Herpes. 2005 12 : 66 75.
    • (2005) Herpes. , vol.12 , pp. 66-75
    • Schleiss, M.1
  • 36
    • 30644480151 scopus 로고    scopus 로고
    • Human cytomegalovirus vaccine: Time to look for alternative options
    • Khanna R, Diamond DJ. Human cytomegalovirus vaccine: time to look for alternative options. Trends Mol Med. 2006 12 : 26 33.
    • (2006) Trends Mol Med. , vol.12 , pp. 26-33
    • Khanna, R.1    Diamond, D.J.2
  • 37
    • 0035675871 scopus 로고    scopus 로고
    • Peptide-based immunotherapy of autoimmunity: A path of puzzles, paradoxes and possibilities
    • Anderton SM. Peptide-based immunotherapy of autoimmunity: a path of puzzles, paradoxes and possibilities. Immunology. 2001 104 : 367 376.
    • (2001) Immunology. , vol.104 , pp. 367-376
    • Anderton, S.M.1
  • 38
    • 33748980437 scopus 로고    scopus 로고
    • MHC-peptide specificity and T-cell epitope mapping: Where immunotherapy starts
    • Provenzano M, Panelli MC, Mocellin S, et al. MHC-peptide specificity and T-cell epitope mapping: where immunotherapy starts. Trends Mol Med. 2006 12 : 465 472.
    • (2006) Trends Mol Med. , vol.12 , pp. 465-472
    • Provenzano, M.1    Panelli, M.C.2    Mocellin, S.3
  • 39
    • 0035176638 scopus 로고    scopus 로고
    • Negative selection during the peripheral immune response to antigen
    • Anderton SM, Radu CG, Lowrey PA, et al. Negative selection during the peripheral immune response to antigen. J Exp Med. 2001 193 : 1 11.
    • (2001) J Exp Med. , vol.193 , pp. 1-11
    • Anderton, S.M.1    Radu, C.G.2    Lowrey, P.A.3
  • 40
    • 0028052724 scopus 로고
    • Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains
    • Parker KC, Bednarek MA, Coligan JE. Scheme for ranking potential HLA-A2 binding peptides based on independent binding of individual peptide side-chains. J Immunol. 1994 152 : 163 175.
    • (1994) J Immunol. , vol.152 , pp. 163-175
    • Parker, K.C.1    Bednarek, M.A.2    Coligan, J.E.3
  • 41
    • 0033388725 scopus 로고    scopus 로고
    • SYFPEITHI: Database for MHC ligands and peptide motifs
    • Rammensee H, Bachmann J, Emmerich NP, et al. SYFPEITHI: database for MHC ligands and peptide motifs. Immunogenetics. 1999 50 : 213 219.
    • (1999) Immunogenetics , vol.50 , pp. 213-219
    • Rammensee, H.1    Bachmann, J.2    Emmerich, N.P.3
  • 42
    • 33750080168 scopus 로고    scopus 로고
    • Identification of key peptide-specific CD4+ T cell responses to human cytomegalovirus: Implications for tracking antiviral populations
    • Harcourt GC, Scriba TJ, Semmo N, et al. Identification of key peptide-specific CD4+ T cell responses to human cytomegalovirus: implications for tracking antiviral populations. Clin Exp Immunol. 2006 146 : 203 210.
    • (2006) Clin Exp Immunol. , vol.146 , pp. 203-210
    • Harcourt, G.C.1    Scriba, T.J.2    Semmo, N.3
  • 43
    • 15944424571 scopus 로고    scopus 로고
    • Generation of CMV-specific T lymphocytes using protein-spanning pools of pp65-derived overlapping pentadecapeptides for adoptive immunotherapy
    • Trivedi D, Williams RY, O'Reilly RJ, et al. Generation of CMV-specific T lymphocytes using protein-spanning pools of pp65-derived overlapping pentadecapeptides for adoptive immunotherapy. Blood. 2005 105 : 2793 2801.
    • (2005) Blood , vol.105 , pp. 2793-2801
    • Trivedi, D.1    Williams, R.Y.2    O'Reilly, R.J.3
  • 44
    • 29044449200 scopus 로고    scopus 로고
    • Direct ex vivo detection of HLA-DR3-restricted cytomegalovirus- and Mycobacterium tuberculosis-specific CD4+ T cells
    • Bronke C, Palmer NM, Westerlaken GH, et al. Direct ex vivo detection of HLA-DR3-restricted cytomegalovirus- and Mycobacterium tuberculosis-specific CD4+ T cells. Hum Immun. 2005 66 : 950 961.
    • (2005) Hum Immun. , vol.66 , pp. 950-961
    • Bronke, C.1    Palmer, N.M.2    Westerlaken, G.H.3
  • 45
    • 9144241614 scopus 로고    scopus 로고
    • Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles
    • Kondo E, Akatsuka Y, Kuzushima K, et al. Identification of novel CTL epitopes of CMV-pp65 presented by a variety of HLA alleles. Blood. 2004 103 : 630 638.
    • (2004) Blood , vol.103 , pp. 630-638
    • Kondo, E.1    Akatsuka, Y.2    Kuzushima, K.3
  • 46
    • 0034305809 scopus 로고    scopus 로고
    • Kinetics of dendritic cell activation: Impact on priming of TH1, TH2 and nonpolarized T cells
    • Langenkamp A, Messi M, Lanzavecchia A, et al. Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol. 2000 1 : 311 316.
    • (2000) Nat Immunol. , vol.1 , pp. 311-316
    • Langenkamp, A.1    Messi, M.2    Lanzavecchia, A.3
  • 47
    • 33751169354 scopus 로고    scopus 로고
    • Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection
    • van Leeuwen EM, Remmerswaal EB, Heemskerk MH, et al. Strong selection of virus-specific cytotoxic CD4+ T-cell clones during primary human cytomegalovirus infection. Blood. 2006 108 : 3121 3127.
    • (2006) Blood , vol.108 , pp. 3121-3127
    • Van Leeuwen, E.M.1    Remmerswaal, E.B.2    Heemskerk, M.H.3
  • 48
    • 0034142024 scopus 로고    scopus 로고
    • Multispecific CD4+ T cell response to a single 12-mer epitope of the immunodominant heat-shock protein 60 of Yersinia enterocolitica in Yersinia-triggered reactive arthritis: Overlap with the B27-restricted CD8 epitope, functional properties, and epitope presentation by multiple DR alleles
    • Mertz AK, Wu P, Sturniolo T, et al. Multispecific CD4+ T cell response to a single 12-mer epitope of the immunodominant heat-shock protein 60 of Yersinia enterocolitica in Yersinia-triggered reactive arthritis: overlap with the B27-restricted CD8 epitope, functional properties, and epitope presentation by multiple DR alleles. J Immunol. 2000 164 : 1529 1537.
    • (2000) J Immunol. , vol.164 , pp. 1529-1537
    • Mertz, A.K.1    Wu, P.2    Sturniolo, T.3
  • 49
    • 3042722360 scopus 로고    scopus 로고
    • Identification of an antigenic peptide derived from the cancer-testis antigen NY-ESO-1 binding to a broad range of HLA-DR subtypes
    • Neumann F, Wagner C, Kubuschok B, et al. Identification of an antigenic peptide derived from the cancer-testis antigen NY-ESO-1 binding to a broad range of HLA-DR subtypes. Cancer Immunol Immunother. 2004 53 : 589 599.
    • (2004) Cancer Immunol Immunother. , vol.53 , pp. 589-599
    • Neumann, F.1    Wagner, C.2    Kubuschok, B.3
  • 50
    • 0024796883 scopus 로고
    • Universally immunogenic T cell epitopes: Promiscuous binding to human MHC class II and promiscuous recognition by T cells
    • Panina-Bordignon P, Tan A, Termijtelen A, et al. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur J Immunol. 1989 19 : 2237 2242.
    • (1989) Eur J Immunol. , vol.19 , pp. 2237-2242
    • Panina-Bordignon, P.1    Tan, A.2    Termijtelen, A.3
  • 51
    • 0036141435 scopus 로고    scopus 로고
    • NY-ESO-1 119-143 is a promiscuous major histocompatibility complex class II T-helper epitope recognized by Th1- and Th2-type tumor-reactive CD4+ T cells
    • Zarour HM, Maillere B, Brusic V, et al. NY-ESO-1 119-143 is a promiscuous major histocompatibility complex class II T-helper epitope recognized by Th1- and Th2-type tumor-reactive CD4+ T cells. Cancer Res. 2002 62 : 213 218.
    • (2002) Cancer Res. , vol.62 , pp. 213-218
    • Zarour, H.M.1    Maillere, B.2    Brusic, V.3
  • 52
    • 39149137814 scopus 로고    scopus 로고
    • Heterologous prime-boost immunotherapy of melanoma patients with Influenza virosomes, and recombinant Vaccinia virus encoding 5 melanoma epitopes and 3 co-stimulatory molecules. A multi-centre phase I/II open labeled clinical trial
    • Adamina M, Weber WP, Rosenthal R, et al. Heterologous prime-boost immunotherapy of melanoma patients with Influenza virosomes, and recombinant Vaccinia virus encoding 5 melanoma epitopes and 3 co-stimulatory molecules. A multi-centre phase I/II open labeled clinical trial. Contemp Clin Trials. 2008 29 : 165 181.
    • (2008) Contemp Clin Trials. , vol.29 , pp. 165-181
    • Adamina, M.1    Weber, W.P.2    Rosenthal, R.3
  • 53
    • 27744509733 scopus 로고    scopus 로고
    • Efficient induction of tumoricidal cytotoxic T lymphocytes by HLA-A0201 restricted, melanoma associated, L(27)Melan-A/MART-1(26-35) peptide encapsulated into virosomes in vitro
    • Schumacher R, Amacker M, Neuhaus D, et al. Efficient induction of tumoricidal cytotoxic T lymphocytes by HLA-A0201 restricted, melanoma associated, L(27)Melan-A/MART-1(26-35) peptide encapsulated into virosomes in vitro. Vaccine. 2005 23 : 5572 5582.
    • (2005) Vaccine. , vol.23 , pp. 5572-5582
    • Schumacher, R.1    Amacker, M.2    Neuhaus, D.3
  • 54
    • 10744226368 scopus 로고    scopus 로고
    • Phase I/II clinical trial of a nonreplicative vaccinia virus expressing multiple HLA-A0201-restricted tumor-associated epitopes and costimulatory molecules in metastatic melanoma patients
    • Zajac P, Oertli D, Marti W, et al. Phase I/II clinical trial of a nonreplicative vaccinia virus expressing multiple HLA-A0201-restricted tumor-associated epitopes and costimulatory molecules in metastatic melanoma patients. Hum Gene Ther. 2003 14 : 1497 1510.
    • (2003) Hum Gene Ther. , vol.14 , pp. 1497-1510
    • Zajac, P.1    Oertli, D.2    Marti, W.3


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