Patterns of skin and soft tissue metastases from breast cancer according to subtypes: Relationship between egfr overexpression and skin manifestations

Oncology

Volumn 81, Issue 1, 2011, Pages 55-62

  Kong, Jee Hyun ^a   Park, Yeon Hee ^a   Kim, Jung A ^a   Kim, Jeong Hoon ^a   Yun, Jina ^a   Sun, Jong Mu ^a   Won, Young Woong ^a   Lee, Soohyeon ^a   Kim, Seung Tae ^a   Cho, Eun Yoon ^a   Ahn, Jin Seok ^a   Im, Young Hyuck ^a  

^a Sungkyunkwan University   (South Korea)

Author keywords

Breast cancer; Hormonal receptor; Human epidermal growth factor receptor 2; Skin changes; Soft tissue infiltration

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; LAPATINIB; PROGESTERONE RECEPTOR; TRASTUZUMAB;

ADULT; AGED; BRAIN METASTASIS; BREAST BIOPSY; BREAST CANCER; BREAST CARCINOMA; CANCER CHEMOTHERAPY; CANCER INFILTRATION; CANCER PATIENT; CANCER RADIOTHERAPY; CLINICAL FEATURE; COHORT ANALYSIS; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISTANT METASTASIS; ERYTHEMA; FEMALE; FOLLOW UP; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG METASTASIS; MAJOR CLINICAL STUDY; MASTECTOMY; MEDICAL RECORD REVIEW; NUCLEAR MAGNETIC RESONANCE IMAGING; OVERALL SURVIVAL; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECURRENT CANCER; RETROSPECTIVE STUDY; REVIEW; SKIN DEFECT; SKIN METASTASIS; SOFT TISSUE METASTASIS; TELANGIECTASIA; VISCERAL METASTASIS;

ADULT; AGED; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; FEMALE; HUMANS; LYMPHATIC METASTASIS; MEDICAL RECORDS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; RETROSPECTIVE STUDIES; SKIN NEOPLASMS; SOFT TISSUE NEOPLASMS; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 80053643861     PISSN: 00302414     EISSN: 14230232     Source Type: Journal    
DOI: 10.1159/000331417     Document Type: Review

References (23)

1. Hu SC, Chen GS, Wu CS, Chai CY, Chen WT, Lan CC: Rates of cutaneous metastases from different internal malignancies: Experience from a Taiwanese medical center. J Am Acad Dermatol 2009; 60: 379-387.
2. Krathen RA, Orengo IF, Rosen T: Cutaneous metastasis: A meta-analysis of data. South Med J 2003; 96: 164-167. (Pubitemid 36268589)
3. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, Fluge O, Pergamenschikov A, Williams C, Zhu SX, Lonning PE, Borresen-Dale AL, Brown PO, Botstein D: Molecular portraits of human breast tumours. Nature 2000; 406: 747-752.
4. Rouzier R, Perou CM, Symmans WF, Ibrahim N, Cristofanilli M, Anderson K, Hess KR, Stec J, Ayers M, Wagner P, Morandi P, Fan C, Rabiul I, Ross JS, Hortobagyi GN, Pusztai L: Breast cancer molecular subtypes respond differently to preoperative chemotherapy. Clin Cancer Res 2005; 11: 5678-5685. (Pubitemid 41170290)
5. Chiang AC, Massague J: Molecular basis of metastasis. N Engl J Med 2008; 359: 2814-2823.
6. Braverman AS: Cutaneous metastases from breast cancer. South Med J 2009; 102: 343-344.
7. Fernandez-Flores A: Cutaneous metastases: A study of 78 biopsies from 69 patients. Am J Dermatopathol 2010; 32: 222-239.
8. Guth U, Huang DJ, Schotzau A, Dirnhofer S, Wight E, Singer G: Breast cancer with noninflammatory skin involvement: Current data on an underreported entity and its problematic classification. Breast 2010; 19: 59-64.
9. Marneros AG, Blanco F, Husain S, Silvers DN, Grossman ME: Classification of cutaneous intravascular breast cancer metastases based on immunolabeling for blood and lymph vessels. J Am Acad Dermatol 2009; 60: 633-638.
10. Nashan D, Muller ML, Braun-Falco M, Reichenberger S, Szeimies RM, Bruckner- Tuderman L: Cutaneous metastases of visceral tumours: A review. J Cancer Res Clin Oncol 2009; 135: 1-14.
11. Prat A, Perou CM: Deconstructing the molecular portraits of breast cancer. Mol Oncol 2011; 5: 5-23.
12. Park SY, Lee HE, Li H, Shipitsin M, Gelman R, Polyak K: Heterogeneity for stem cell-related markers according to tumor subtype and histologic stage in breast cancer. Clin Cancer Res 2010; 16: 876-887.
13. Asselin-Labat ML, Shackleton M, Stingl J, Vaillant F, Forrest NC, Eaves CJ, Visvader JE, Lindeman GJ: Steroid hormone receptor status of mouse mammary stem cells. J Natl Cancer Inst 2006; 98: 1011-1014. (Pubitemid 44288166)
14. Gupta GP, Nguyen DX, Chiang AC, Bos PD, Kim JY, Nadal C, Gomis RR, Manova-Todorova K, Massague J: Mediators of vascular remodelling co-opted for sequential steps in lung metastasis. Nature 2007; 446: 765-770. (Pubitemid 46582040)
15. Egeblad M, Werb Z: New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer 2002; 2: 161-174. (Pubitemid 37328786)
16. Padua D, Zhang XH, Wang Q, Nadal C, Gerald WL, Gomis RR, Massague J: Tgfbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 2008; 133: 66-77. (Pubitemid 351442989)
17. Saharinen J, Hyytiainen M, Taipale J, Keski- Oja J: Latent transforming growth factor-beta binding proteins (LTBPs) - structural extracellular matrix proteins for targeting TGF-beta action. Cytokine Growth Factor Rev 1999; 10: 99-117. (Pubitemid 29446375)
18. Adams JC: Roles of fascin in cell adhesion and motility. Curr Opin Cell Biol 2004; 16: 590-596. (Pubitemid 39201245)
19. Bos PD, Zhang XH, Nadal C, Shu W, Gomis RR, Nguyen DX, Minn AJ, van de Vijver MJ, Gerald WL, Foekens JA, Massague J: Genes that mediate breast cancer metastasis to the brain. Nature 2009; 459: 1005-1009.
20. Bhargava R, Gerald WL, Li AR, Pan Q, Lal P, Ladanyi M, Chen B: EGFR gene amplification in breast cancer: Correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations. Mod Pathol 2005; 18: 1027-1033. (Pubitemid 41224492)
21. Tsutsui S, Ohno S, Murakami S, Hachitanda Y, Oda S: Prognostic value of epidermal growth factor receptor (EGFR) and its relationship to the estrogen receptor status in 1029 patients with breast cancer. Breast Cancer Res Treat 2002; 71: 67-75. (Pubitemid 34121818)
22. Uhm JE, Park YH, Yi SY, Cho EY, Choi YL, Lee SJ, Park MJ, Lee SH, Jun HJ, Ahn JS, Kang WK, Park K, Im YH: Treatment outcomes and clinicopathologic characteristics of triple-negative breast cancer patients who received platinum-containing chemotherapy. Int J Cancer 2009; 124: 1457-1462.
23. Hadzisejdic I, Mustac E, Jonjic N, Petkovic M, Grahovac B: Nuclear EGFR in ductal invasive breast cancer: Correlation with cyclin- D1 and prognosis. Mod Pathol 2010; 23: 392-403.