Blockade of toll-like receptor 2 expression and membrane translocation in rat corneal epithelial cells by glucocorticoid (TobraDex) after penetrating keratoplasty

Cornea

Volumn 30, Issue 11, 2011, Pages 1253-1259

  Bai, Lang ^a   Lu, Xiao He ^b   Sun, Feng Yang ^a   Zhong, Yan Yan ^b   Yu, Jian ^a   Tang, Ming Fang ^a   Zhang, Jing ^b  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

allograft; cornea; glucocorticoid; rejection; Toll like receptor 2

Indexed keywords

DEXAMETHASONE PLUS TOBRAMYCIN; MESSENGER RNA; TOLL LIKE RECEPTOR 2;

ALLOGRAFT; ALLOTRANSPLANTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGGREGATION; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA NEOVASCULARIZATION; CORNEA TRANSPLANTATION; DRUG EFFECT; EPITHELIUM CELL; GRAFT REJECTION; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; ISOGRAFT; NONHUMAN; PENETRATING KERATOPLASTY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; RECEPTOR BLOCKING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; DEXAMETHASONE; DRUG COMBINATIONS; EPITHELIUM, CORNEAL; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; GRAFT REJECTION; IMMUNOHISTOCHEMISTRY; KERATOPLASTY, PENETRATING; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TOBRAMYCIN; TOLL-LIKE RECEPTOR 2; TRANSPLANTATION, HOMOLOGOUS;

EID: 80053627023     PISSN: 02773740     EISSN: 15364798     Source Type: Journal    
DOI: 10.1097/ICO.0b013e318213f389     Document Type: Article

References (22)

1. Tesar BM, Goldstein DR. Toll-like receptors and their role in transplantation. Front Biosci. 2007;12:4221-4238.
2. Lien E, Sellati TJ, Yoshimura A, et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem. 1999;274:33419-33425. (Pubitemid 129511647)
3. Frasnelli ME, Tarussio D, Chobaz-Péclat V, et al. TLR2 modulates inflammation in zymosan-induced arthritis in mice. Arthritis Res Ther. 2005;7:370-379.
4. Saint Andre A, Blackwell NM, Hall LR, et al. The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness. Science. 2002; 295:1892-1895. (Pubitemid 34214126)
5. Hise AG, Gillette-Ferguson I, Pearlman E. Immunopathogenesis of Onchocerca volvulus keratitis (river blindness): A novel role for TLR4 and endosymbiotic Wolbachia bacteria. J Endotoxin Res. 2003;9:390-394. (Pubitemid 38035604)
6. Zhang J, Xu K, Ambati B, et al. Toll-like receptor 5-mediated corneal epithelial inflammatory responses to Pseudomonas aeruginosa flagellin. Invest Ophthalmol Vis Sci. 2003;44:4247-4254. (Pubitemid 37186258)
7. Gao JL, Wu XY. Aspergillus fumigatus activate human corneal epithelial cells via Toll-like receptor 2 and 4. Zhonghua Yan Ke Za Zhi. 2006;42: 628-633.
8. Alegre ML, Goldstein DR, Chong AS. Toll-like receptor signaling in transplantation. Curr Opin Organ Transplant. 2008;13:358-365.
9. Goldstein DR. Toll like receptors and acute allograft rejection. Transpl Immunol. 2006;17:11-15. (Pubitemid 44828796)
10. Obhrai J, Goldstein DR. The role of toll-like receptors in solid organ transplantation. Transplantation. 2006;81:497-502.
11. Goldstein DR, Tesar BM, Akira S, et al. Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J Clin Invest. 2003;111:1571-1578. (Pubitemid 38063290)
12. Bai L, Lu XH, Yu J, et al. Study on effect of TLRs in rejection reaction after penetrating keratoplasty. Chin Ophthalmic Res. 2010;28:491-495.
13. Bai L, Lu XH, Dang ST, et al. Role of dendritic cells in graft rejection after penetrating keratoplasty. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27: 72-74.
14. Bai L, Lu XH, Zhou J, et al. Immunohistochemical study of in situ CD86 expression in rejected rat corneal graft after penetrating keratoplasty. Di Yi Jun Yi Da Xue Xue Bao. 2004;24:533-535.
15. Holland EJ, Chan CC, Wetzig RP, et al. Clinical and immunohistologic studies of corneal rejection in the rat penetrating keratoplasty model. Cornea. 1991;10:374-380.
16. Liu Q, Wu J, Wang XM, et al. Expression of 5 muscarinic receptor subtypes in the scleral tissue of immature guinea pigs. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27:1327-1330.
17. Xia D, Sanders A, Shah M, et al. Real-time polymerase chain reaction analysis reveals an evolution of cytokine mRNA production in allograft acceptor mice. Transplantation. 2001;72:907-914. (Pubitemid 32879866)
18. Dong C, Zhu S, Wang T, et al. Upregulation of PAI-1 is mediated through TGF-beta/Smad pathway in transplant arteriopathy. J Heart Lung Transplant. 2002;21:999-1008. (Pubitemid 35291149)
19. Niederkorn JY. Immune mechanisms of corneal allograft rejection. Curr Eye Res. 2007;32:1005-1016. (Pubitemid 351412293)
20. Yamagami S. Treatment strategy for rejection-free corneal transplantation- transition from full-thickness corneal transplantation to corneal endothelium transplantation. Nippon Ganka Gakkai Zasshi. 2008;112:266-278.
21. Williams KA, Coster DJ. The immunobiology of corneal transplantation. Transplantation. 2007;84:806-813. (Pubitemid 351338939)
22. Goldstein DR, Palmer SM. Role of Toll-like receptor-driven innate immunity in thoracic organ transplantation. J Heart Lung Transplant. 2005;24:1721-1729. (Pubitemid 41643834)