Toll-like receptors and their role in transplantation

Frontiers in Bioscience

Volumn 12, Issue 11, 2007, Pages 4221-4238

  Tesar, Bethany M ^a   Goldstein, Daniel R ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Allograft; Innate immunity; Ischemia; Mouse; MyD88; Regulatory T cell; Rejection; Reperfusion; Review; Tolerance; Toll like receptor; Transplantation; Xenograft

Indexed keywords

ANIMALIA;

TOLL LIKE RECEPTOR;

ADAPTATION; ANIMAL; HISTOCOMPATIBILITY; HUMAN; METABOLISM; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; TRANSPLANTATION;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; HUMANS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS; TRANSPLANTATION; TRANSPLANTATION IMMUNOLOGY;

EID: 34347222876     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/2382     Document Type: Article

References (66)

1. Hoebe, K., E. Janssen & B. Beutler: The interface between innate and adaptive immunity. Nat Immunol, 5, 971-974 (2004) (Pubitemid 41057712)
2. Medzhitov, R.: Toll-like receptors and innate immunity. Nature Rev Immunol, 1, 135-45 (2001) (Pubitemid 33741967)
3. Akira S & Takeda K: Toll-like receptor signalling. Nat Rev Immunol., 4, 499-511 (2004) (Pubitemid 38931765)
4. Hoebe K, Janssen E & B. B.: The interface between innate and adaptive immunity. Nat Immunol., 5, 971-4 (2004) (Pubitemid 41057712)
5. Staros, E. B.: Innate Immunity: New Approaches to Understanding its Clinical Indicate. Am J Clin Pathol, 123, 8 (2005)
6. Goldstein, D. R.: Toll like receptors and other links between innate and acquired alloimmunity. Curr Opin Immunol, 16, 538-544 (2004) (Pubitemid 39165878)
7. Modlin, R. L., H. D. Brightbill & P. J. Godowski: The Toll of Innate Immunity on Microbial Pathogens. N Engl J Med, 340, 1834-1835 (1999) (Pubitemid 29266411)
8. Beutler, B., Z. Jiang, P. Georgel, K. Crozat, B. Croker, S. Rutschmann, X. Du & K. Hoebe: GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large. Annual Review of Immunology, 24, 353-389 (2006)
9. Ishii, K. J. & S. Akira: TLR Ignores Methylated RNA? Immunity, 23, 111-113 (2005) (Pubitemid 41169280)
10. Krieg, A. M.: Now I know my CpGs. Trends in Microbiology, 9, 249-252 (2001) (Pubitemid 32522795)
11. Haziot, A., E. Ferrero, F. Kontgen, N. Hijiya, S. Yamamoto, J. Silver, C. L. Stewart & S. M. Goyert: Resistance to Endotoxin Shock and Reduced Dissemination of Gram-Negative Bacteria in CD14-Deficient Mice. Immunity, 4, 407-414 (1996) (Pubitemid 26174055)
12. Xu, Y., X. Tao, B. Shen, T. Horng, R. Medzhitov, J. L. Manley & L. Tong: Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature, 408, 111-115 (2000)
13. Huang, Q., D. Liu, P. Majewski, L. C. Schulte, J. M. Korn, R. A. Young, E. S. Lander & N. Hacohen: The plasticity of dendritic cell responses to pathogens and their components. Science, 294, 870-5 (2001) (Pubitemid 33032108)
14. Akira, S.: Mammalian Toll-like receptors. Curr Opin Immunol, 15, 5-11 (2003) (Pubitemid 35454185)
15. Zarember, K. A. & P. J. Godowski: Tissue expression of human Toll-like receptors and differential regulation of Toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol, 168, 554-61 (2002) (Pubitemid 34049553)
16. Zhai, Y., X.-d. Shen, R. O'Connell, F. Gao, C. Lassman, R. W. Busuttil, G. Cheng & J. W. Kupiec-Weglinski: Cutting Edge: TLR4 Activation Mediates Liver Ischemia/Reperfusion Inflammatory Response via IFN Regulatory Factor 3-Dependent MyD88-Independent Pathway. J Immunol, 173, 7115-7119 (2004) (Pubitemid 39628144)
17. Chong, A. J., A. Shimamoto, C. R. Hampton, H. Takayama, D. J. Spring, C. L. Rothnie, M. Yada, T. H. Pohlman & E. D. Verrier: Toll-like Receptor 4 Mediates Ischemia/Reperfusion Injury of the Heart. The Journal of Thoracic and Cardiovascular Surgery, 128, 170-179 (2004) (Pubitemid 38969797)
18. Wang, L., X. JB., H. Wu, J. Zhang, J. Zhang, Y. Tian & C. Wang: The relationship between activation of TLR4 and partial hepatic ischemia/reperfusion injury in mice. Hepatobiliary Pancreatic Diseases International, 5, 101-104 (2006)
19. Leemans, J. C., G. Stokman, N. Claessen, K. M. Rouschop, G. J. D. Teske, C. J. Kirschning, S. Akira, T. van der Poll, J. J. Weening & S. Florquin: Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J. Clin. Invest., 115, 2894-2903 (2005) (Pubitemid 41434417)
20. Kim, B. S., S. W. Lim, C. Li, J. S. Kim, B. K. Sun, K. O. Ahn, S. W. Han, J. Kim, C. W. Yang & Ischemia-Reperfusin Injury Acitvates Innate Immunity in Rat Kidneys. Transplantation, 79, 1370-1377 (2005) (Pubitemid 40740256)
21. Boyd, J. H., S. Mathur, Y. Wang, R. M. Bateman & K. R. Walley: Toll-like receptor stimulation in cardiomyoctes decreases contractility and initiates an NF-[kappa]B dependent inflammatory response. Cardiovascular Research, 72, 384-393 (2006) (Pubitemid 44665856)
22. Gelman, A. E., D. F. LaRosa, J. Zhang, P. T. Walsh, Y. Choi, J. O. Sunyer & L. A. Turka: The Adaptor Molecule MyD88 Activates PI-3 Kinase Signaling in CD4+ T Cells and Enables CpG Oligodeoxynucleotide-Mediated Costimulation. Immunity, 25, (2006)
23. Caramalho, I., T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury & J. Demengeot: Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide. J. Exp. Med., 197, 403-411 (2003) (Pubitemid 36278597)
24. Gelman, A. E., J. Zhang, Y. Choi & L. A. Turka: Toll-Like Receptor Ligands Directly Promote Activated CD4+ T Cell Survival. J Immunol, 172, 6065-6073 (2004) (Pubitemid 38621208)
25. Crellin, N. K., R. V. Garcia, O. Hadisfar, S. E. Allan, T. S. Steiner & M. K. Levings: Human CD4+ T Cells Express TLR5 and Its Ligand Flagellin Enhances the Suppressive Capacity and Expression of FOXP3 in CD4+CD25+ T Regulatory Cells. J Immunol, 175, 8051-8059 (2005) (Pubitemid 41798367)
26. Sylvia Bendigs, U. S. G. B. L. H. W. K. H.: CpG-oligodeoxynucleotides co-stimulate primary T cells in the absence of antigen-presenting cells. European Journal of Immunology, 29, 1209-1218 (1999)
27. Caron, G., D. Duluc, I. Fremaux, P. Jeannin, C. David, H. Gascan & Y. Delneste: Direct Stimulation of Human T Cells via TLR5 and TLR7/8: Flagellin and R-848 Up-Regulate Proliferation and IFN-{gamma} Production by Memory CD4+ T Cells. J Immunol, 175, 1551-1557 (2005) (Pubitemid 41023056)
28. Miggin, S. M. & L. A. J. O'Neill: New insights into the regulation of TLR signaling. J Leukoc Biol, 80, 220-226 (2006) (Pubitemid 44835495)
29. Pasare, C. & R. Medzhitov: Toll Pathway-Dependent Blockade of CD4+CD25+ T Cell-Mediated Suppression by Dendritic Cells. Science, 299, 1033-1036 (2003) (Pubitemid 36222922)
30. Chen, L., T. Wang, P. Zhou, L. Ma, D. Yin, J. Shen, L. Molinero, T. Nozaki, T. Phillips, S. Uematsu, S. Akira, C. Wang, R. Fairchild, M. Alegre & A. Chong: TLR engagment prevents transplantation tolerance. Amer J. Trans, 6, (2006)
31. Yamamoto, M., S. Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Sanjo, O. Takeuchi, M. Sugiyama, M. Okabe, K. Takeda & S. Akira: Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway. Science, 301, 640-643 (2003) (Pubitemid 36927946)
32. Goldstein, D. R., T. B. M., S. Akira & F. G. Lakkis: Critical Role of Toll-Like Receptor Signal Adaptor Protein MyD88 in Acute Allograft Rejection. Journal of Clinical Investigation, 111, (2003)
33. Andrade, C. F., T. K. Waddell, S. Keshavjee & M. Liu: Innate Immunity and Organ Transplantation: The Potential Role of Toll-like Receptors. American Journal of Transplantation, 5, 969-975 (2005) (Pubitemid 40571244)
34. Tesar, B., D. Jiang, J. Liang, S. Palmer, P. Noble & G. DR: The role of hyaluronan degradation products as innate alloimmune agonists. AJT, 6, 2622-2635 (2006) (Pubitemid 44571682)
35. Samstein B, Johnson GB & P. JL.: Toll-like receptor-4 and allograft responses. Transplantation., 15, 475-7 (2004) (Pubitemid 38209758)
36. Gaston, J. S.: Heat shock proteins and innate immunity.[comment]. Clinical & Experimental Immunology, 127, 1-3 (2002) (Pubitemid 34155450)
37. Palmer, S. M., L. H. Burch, R. D. Davis, W. F. Herczyk, D. N. Howell, N. L. Reinsmoen & D. A. Schwartz: The Role of Innate Immunity in Acute Allograft Rejection after Lung Transplantation. Am. J. Respir. Crit. Care Med. 200303-447OC (2003)
38. Pockley, A. G.: Heat shock proteins, anti-heat shock protein reactivity and allograft rejection. Transplantation, 71, 1503-7 (2001) (Pubitemid 32574143)
39. Rizzo, M., Y. G. Alevy, S. Sundaresan, J. Lynch, E. P. Trulock, J. D. Cooper, G. A. Patterson & T. Mohanakumar: Increased expression of HDJ-2 (heat shock protein 40) and heat shock protein 70 in biopsy specimens of transplanted human lungs. J Heart Lung Transp, 17, 241-9 (1998) (Pubitemid 28175861)
40. Mehta, N. K., M. Carroll, D. E. Sykes, Z. Tan, J. Bergsland, J. Canty, Jr., J. N. Bhayana, E. L. Hoover & T. A. Salerno: Heat shock protein 70 expression in native and heterotopically transplanted rat hearts. J. Surg Res., 70, 151-5 (1997) (Pubitemid 27315199)
41. Tesar, B. M. & D. R. Goldstein: Acute Allograft Rejection Occurs Independently of Inducible HSP-70. Transplantation, In Press, (2007)
42. Obhrai, J. & D. R. Goldstein: The Role of Toll-like Receptors in Solid Organ Transplantation. [Editorial]. Transplantation, 81,: 497-502 (2006)
43. Palmer, S. M., L. H. Burch, A. J. Trindade, R. D. Davis, W. F. Herczyk, N. L. Reinsmoen & D. A. Schwartz: Innate Immunity Influences Long-term Outcomes after Human Lung Transplant. Am. J. Respir. Crit. Care Med., 171, 780-785 (2005) (Pubitemid 40471150)
44. Methe, H., E. Zimmer, C. Grimm, M. a. Nabauer & J. Koglin: Evidence for a Role of Toll-Like Receptor 4 in Development of Chronic Allograft Rejection after Cardiac Transplantation. Transplantation, 78, 1324 (2004)
45. Kiechl, S., E. Lorenz, M. Reindl, C. J. Wiedermann, F. Oberhollenzer, E. Bonora, J. Willeit & D. A. Schwartz: Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med, 347, 185-92 (2002) (Pubitemid 34764822)
46. Ducloux, D., M. Deschamps, M. Yannaraki, C. Ferrand, J. Bamoulid, P. Saas, A. Kazory, J.-M. Chalopin & P. Tiberghien: Relevance of Toll-like receptor-4 polymorphisms in renal transplantation. Kidney International, 67, 2454-2461 (2005) (Pubitemid 41623410)
47. Smith, C., H. Pilgrim & D. Steinmuller: The survival of skin allografts and xenografts in germ-free mice. Transplantation, 13, 38-41 (1972)
48. Oyama, J.-i., C. Blais, Jr, X. Liu, M. Pu, L. Kobzik, R. A. Kelly & T. Bourcier: Reduced Myocardial Ischemia-Reperfusion Injury in Toll-Like Receptor 4-Deficient Mice. Circulation, 109, 784-789 (2004) (Pubitemid 38222900)
49. Shimamoto, A., A. J. Chong, M. Yada, S. Shomura, H. Takayama, A. J. Fleisig, M. L. Agnew, C. R. Hampton, C. L. Rothnie, D. J. Spring, T. H. Pohlman, H. Shimpo & E. D. Verrier: Inhibition of Toll-like Receptor 4 With Eritoran Attenuates Myocardial Ischemia-Reperfusion Injury. Circulation, 114, I-270-274 (2006) (Pubitemid 44297162)
50. Wu HS, Zhang JX, Wang L, Tian Y, Wang H & R. O.: Toll-like receptor 4 involvement in hepatic ischemia/reperfusion injury in mice. Hepatobiliary Pancreat Dis Int. 2004 May;, 3, 250-3 (2004) (Pubitemid 38660160)
51. Tsoulfas, G., Y. Takahashi, R. W. Ganster, G. Yagnik, Z. Guo, J. J. Fung, N. Murase & D. A. Geller: Activation of the lipopolysaccharide signaling pathway in hepatic transplantation preservation injury. Transplantation, 74, 7-13 (2002) (Pubitemid 34779204)
52. Peng, Y., J. Gong, C. Liu, X. Li, L. Gan & S. Li: Expression of toll-like receptor 4 and MD-2 gene and protein in Kupffer cells after ischemia-reperfusion in rat liver graft. World Journal of Gastronterology, 10, 2890-2893 (2004) (Pubitemid 39303013)
53. Zhang, J., H. Wu, H. Wang, J. Zhang, Y. Wang & Q. Zheng: Protection against hepatic ischemia/reperfusion injury via downregulaton of toll-like receptor 2 expression by inhibition of Kupffer cell function. World Journal of Gastronterology, 11, 4423-4426 (2005) (Pubitemid 41093966)
54. Sutmuller, R. P. M., M. H. den Brok, M. Kramer, E. J. Bennink, L. W. J. Toonen, B.-J. Kullberg, L. A. Joosten, S. Akira, M. G. Netea & G. J. Adema: Toll-like receptor 2 controls expansion and function of regulatory T cells. J. Clin. Invest., 116, 485-494 (2006) (Pubitemid 43228366)
55. Liu, H., M. Komai-Koma, D. Xu & F. Y. Liew: Tolllike receptor 2 signaling modulates the functions of CD4+CD25+ regulatory T cells. PNAS 103, 7048-7053 (2006)
56. Walker, W. E. & D. R. Goldstein: Toll-like receptor pathways and innate responses to allografts. Current Opinions in Organ Transplantation (2007)
57. Adams, A. B., M. A. Williams, T. R. Jones, N. Shirasugi, M. M. Durham, S. M. Kaech, E. J. Wherry, T. Onami, J. G. Lanier, K. E. Kokko, T. C. Pearson, R. Ahmed & C. P. Larsen: Heterologous immunity provides a potent barrier to transplantation tolerance. J. Clin. Invest., 111, 1887-1895 (2003) (Pubitemid 38057733)
58. Goldstein, D. R., B. M. Tesar, S. Akira & F. G. Lakkis: Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J. Clin. Invest., 111, 1571-1578 (2003) (Pubitemid 38063290)
59. McKay D, Shigeoka A, Rubinstein M, Surh C & J. Sprent: Simultaneous deletion of MyD88 and Trif delays major histocompatibility and minor antigen mismatch allograft rejection. Euro J. Immunol, 36, 1994-2002 (2006) (Pubitemid 44251746)
60. Tesar, B. M., J. Zhang, Q. Li & D. R. Goldstein: TH1 Immune Responses to Fully MHC Mismatched Allografts are Diminished in the Absence of MyD88, a Toll Like Receptor Signal Adaptor Protein. Am J Transplant 2004:, 4, 1429-1439 (2004) (Pubitemid 39159057)
61. Walker, W. E., I. W. Nasr, G. Camirand, B. M. Tesar, C. J. Booth & D. R. Goldstein: Absence of Innate MyD88 Signaling Promotes Inducible Allograft Acceptance. J Immunol, 177, 5307-5316 (2006) (Pubitemid 44527603)
62. Thornley, T. B., M. A. Brehm, T. G. Markees, L. D. Shultz, J. P. Mordes, R. M. Welsh, A. A. Rossini & D. L. Greiner: TLR Agonists Abrogate Costimulation Blockade-Induced Prolongation of Skin Allografts. J Immunol, 176, 1561-1570 (2006) (Pubitemid 43134300)
63. Rakoff-Nahoum, S., J. Paglino, F. Eslami-Varzaneh, S. Edberg & R. Medzhitov: Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis. Cell, 118, 229 (2004)
64. Schmidt, P., H. Krook, M. Goto & O. Korsgren: MyD88-dependent toll-like receptor signalling is not a requirement for fetal islet xenograft rejection in mice. Xenotransplantation, 11, 347-352 (2004) (Pubitemid 38868560)
65. Tesar, B. M., G. Chalasani, L. Smith-Diggs, F. K. Baddoura, F. G. Lakkis & D. R. Goldstein: Direct antigen presentation by a xenograft induces immunity independently of secondary lymphoid organs. Journal of Immunology, 173, (2004)
66. Lakkis, F. G., A. Arakelov, B. T. Konieczny & Y. Inoue: Immunologic 'ignorance' of vascularized organ transplants in the absence of secondary lymphoid tissue. Nat Med, 6, 686-8 (2000) (Pubitemid 30398793)