Immune mechanisms of corneal allograft rejection

Current Eye Research

Volumn 32, Issue 12, 2007, Pages 1005-1016

  Niederkorn, Jerry Y ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Corneal transplantation; Graft; Immune rejection; Keratoplasty

Indexed keywords

ANTIGEN PRESENTING CELL; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CORNEA TRANSPLANTATION; GRAFT REJECTION; HUMAN; IMMUNOPATHOGENESIS; NONHUMAN; PENETRATING KERATOPLASTY; PRIORITY JOURNAL; SHORT SURVEY; TH1 CELL; TH2 CELL; ALLOTRANSPLANTATION; ANIMAL; CORNEA; IMMUNE SYSTEM; IMMUNOLOGY; MACROPHAGE; PHYSIOLOGY; REVIEW;

ANIMALS; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; CORNEA; GRAFT REJECTION; HUMANS; IMMUNE SYSTEM; KERATOPLASTY, PENETRATING; MACROPHAGES; TRANSPLANTATION, HOMOLOGOUS;

EID: 39149083752     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.1080/02713680701767884     Document Type: Short Survey

References (106)

1. Kissam R. Ceratoplastice in man. New York Journal of Medicine. 1844;2:281-289.
2. May CH. Transplantation of a rabbit's eye into the human orbit. Arch Ophthalmol. 1887;16:47-53.
3. Zirm E. Eine erfolgreiche totale Keratoplastik. Albrecht von Graefes Arch Ophthalmol. 1906;64:580-593.
4. Darlington JK, Adrean SD, Schwab IR. Trends of penetrating keratoplasty in the United States from 1980 to 2004. Ophthalmology. 2006;113:2171-2175.
5. Group CCTSR. The collaborative corneal transplantation studies (CCTS). Effectiveness of histocompatibility matching in high-risk corneal transplantation. Arch Ophthalmol. 1992;110:1392-1403.
6. Billingham RE, Krohn PL, Medawar PB. Effect of cortisone on survival of skin homografts in rabbits. Br Med J. 1951;1:1157-1163.
7. Niederkorn JY. The immune privilege of corneal allografts. Transplantation. 1999;67:1503-1508.
8. Niederkorn JY. Mechanisms of corneal graft rejection: The sixth annual Thygeson Lecture, presented at the Ocular Microbiology and Immunology Group meeting, October 21, 2000. Cornea. 2001;20:675-679.
9. Coster DJ, Williams KA. The impact of corneal allograft rejection on the long-term outcome of corneal transplantation. Am J Ophthalmol. 2005;140:1112-1122.
10. Maumenee A. The influence of donor-recipient sensitization on corneal grafts. Am J Ophthalmol. 1951;34:142-152.
11. Khodadoust AA, Silverstein AM. Transplantation and rejection of individual cell layers of the cornea. Invest Ophthalmol. 1969;8:180-195.
12. Khodadoust AA, Silverstein AM. Induction of corneal graft rejection by passive cell transfer. Invest Ophthalmol. 1976;15:89-95.
13. Pepose JS, Nestor MS, Gardner KM, Foos RY, Pettit TH. Composition of cellular infiltrates in rejected human corneal allografts. Graefes Arch Clin Exp Ophthalmol. 1985;222:128-133.
14. Williams KA, Coster DJ. Penetrating corneal transplantation in the inbred rat: A new model. Invest Ophthalmol Vis Sci. 1985;26:23-30.
15. She SC, Steahly LP, Moticka EJ. A method for performing full-thickness, orthotopic, penetrating keratoplasty in the mouse. Ophthalmic Surg. 1990;21:781-785.
16. Ayliffe W, Alam Y, Bell EB, McLeod D, Hutchinson IV. Prolongation of rat corneal graft survival by treatment with anti-CD4 monoclonal antibody. Br J Ophthalmol. 1992;76:602-606.
17. He YG, Ross J, Niederkorn JY. Promotion of murine orthotopic corneal allograft survival by systemic administration of anti-CD4 monoclonal antibody. Invest Ophthalmol Vis Sci. 1991;32:2723-2728.
18. Niederkorn JY, Stevens C, Mellon J, Mayhew E. CD4+ T-cell-independent rejection of corneal allografts. Transplantation. 2006;81:1171-1178.
19. Yamada J, Kurimoto I, Streilein JW. Role of CD4+ T cells in immunobiology of orthotopic corneal transplants in mice. Invest Ophthalmol Vis Sci. 1999;40:2614-2621.
20. Niederkorn JY, Mellon J. Anterior chamber-associated immune deviation promotes corneal allograft survival. Invest Ophthalmol Vis Sci. 1996;37:2700-2707.
21. She SC, Moticka EJ. Ability of intracamerally inoculated B- and T-cell enriched allogeneic lymphocytes to enhance corneal allograft survival. Int Ophthalmol. 1993;17:1-7.
22. She SC, Steahly LP, Moticka EJ. Intracameral injection of allogeneic lymphocytes enhances corneal graft survival. Invest Ophthalmol Vis Sci. 1990;31:1950-1956.
23. Sonoda Y, Streilein JW. Orthotopic corneal transplantation in mice - Evidence that the immunogenetic rules of rejection do not apply. Transplantation. 1992;54:694-704.
24. Lowin B, Hahne M, Mattmann C, Tschopp J. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature. 1994;370:650-652.
25. Williams NS, Engelhard VH. Perforin-dependent cytotoxic activity and lymphokine secretion by CD4+ T cells are regulated by CD8+ T cells. J Immunol. 1997;159:2091-2099.
26. Hegde S, Niederkorn JY. The role of cytotoxic T lymphocytes in corneal allograft rejection. Invest Ophthalmol Vis Sci. 2000;41:3341-3347.
27. Hegde S, Beauregard C, Mayhew E, Niederkorn JY. CD4(+) T-cell-mediated mechanisms of corneal allograft rejection: Role of Fas-induced apoptosis. Transplantation. 2005;79:23-31.
28. Stuart PM, Yin X, Plambeck S, Pan F, Ferguson TA. The role of Fas ligand as an effector molecule in corneal graft rejection. Eur J Immunol. 2005;35:2591-2597.
29. Torres PF, De Vos AF, van der Gaag R, Martins B, Kijlstra A. Cytokine mRNA expression during experimental corneal allograft rejection. Exp Eye Res. 1996;63:453-461.
30. Zhu S, Dekaris I, Duncker G, Dana MR. Early expression of proinflammatory cytokines interleukin-1 and tumor necrosis factor-alpha after corneal transplantation. J Interferon Cytokine Res. 1999;19:661-669.
31. Pleyer U, Milani JK, Ruckert D, Rieck P, Mondino BJ. Determinations of serum tumor necrosis factor alpha in corneal allografts. Ocul Immunol Inflamm. 1997;5:149-155.
32. Rayner SA, King WJ, Comer RM, et al. Local bioactive tumour necrosis factor (TNF) in corneal allotransplantation. Clin Exp Immunol. 2000;122:109-116.
33. Yamada J, Streilein JW, Dana MR. Role of tumor necrosis factor receptors TNFR-I (P55) and TNFR-II (P75) in corneal transplantation. Transplantation. 1999;68:944-949.
34. Niederkorn JY, Mayhew E, Mellon J, Hegde S. Role of tumor necrosis factor receptor expression in anterior chamber-associated immune deviation (ACAID) and corneal allograft survival. Invest Ophthalmol Vis Sci. 2004;45:2674-2681.
35. Callanan D, Peeler J, Niederkorn JY. Characteristics of rejection of orthotopic corneal allografts in the rat. Transplantation. 1988;45:437-443.
36. Callanan DG, Luckenbach MW, Fischer BJ, Peeler JS, Niederkorn JY. Histopathology of rejected orthotopic corneal grafts in the rat. Invest Ophthalmol Vis Sci. 1989;30:413-424.
37. Roelen DL, van Beelen E, van Bree SP, van Rood JJ, Volker-Dieben HJ, Claas FH. The presence of activated donor HLA class I-reactive T lymphocytes is associated with rejection of corneal grafts. Transplantation. 1995;59:1039-1042.
38. Yamada J, Ksander BR, Streilein JW. Cytotoxic T cells play no essential role in acute rejection of orthotopic corneal allografts in mice. Invest Ophthalmol Vis Sci. 2001;42:386-392.
39. Ksander BR, Sano Y, Streilein JW. Role of donor-specific cytotoxic T cells in rejection of corneal allografts in normal and high-risk eyes. Transpl Immunol. 1996;4:49-52.
40. Niederkorn JY, Stevens C, Mellon J, Mayhew E. Differential roles of CD8+ and CD8- T lymphocytes in corneal allograft rejection in 'high-risk' hosts. Am J Transplant. 2006;6:705-713.
41. Bishop DK, Chan Wood S, Eichwald EJ, Orosz CG. Immunobiology of allograft rejection in the absence of IFN-gamma: CD8+ effector cells develop independently of CD4+ cells and CD40-CD40 ligand interactions. J Immunol. 2001;166:3248-3255.
42. Jones ND, Carvalho-Gaspar M, Luo S, Brook MO, Martin L, Wood KJ. Effector and memory CD8+ T cells can be generated in response to alloantigen independently of CD4+ T cell help. J Immunol. 2006;176:2316-2323.
43. Trambley J, Bingaman AW, Lin A, et al. Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection. J Clin Invest. 1999;104:1715-1722.
44. Zhai Y, Meng L, Busuttil RW, Sayegh MH, Kupiec-Weglinski JW. Activation of alloreactive CD8+ T cells operates via CD4-dependent and CD4-independent mechanisms and is CD154 blockade sensitive. J Immunol. 2003;170:3024-3028.
45. Ehlers N, Olsen T, Johnsen HE. Corneal graft rejection probably mediated by antibodies. Acta Ophthalmol (Copenh). 1981;59:119-125.
46. Hahn AB, Foulks GN, Enger C, et al. The association of lymphocytotoxic antibodies with corneal allograft rejection in high risk patients. The Collaborative Corneal Transplantation Studies Research Group. Transplantation. 1995;59:21-27.
47. Jager MJ, Vos A, Pasmans S, Hoekzema R, Broersma L, van der Gaag R. Circulating cornea-specific antibodies in corneal disease and cornea transplantation. Graefes Arch Clin Exp Ophthalmol. 1994;232:82-86.
48. Roy R, Boisjoly HM, Wagner E, et al. Pretransplant and posttransplant antibodies in human corneal transplantation. Transplantation. 1992;54:463-467.
49. van Dorp G, Volker-Dieben HJ, van Leeuwen A, Kok-Van Alphen CC, van Rood JJ. Major histocompatibility complex or HL-A antibodies in patients with a rejection reaction [proceedings]. Ophthalmologica. 1977;175:42.
50. Group TCCTSR. The collaborative corneal transplantation studies (CCTS). Effectiveness of histocompatibility matching in high-risk corneal transplantation. The Collaborative Corneal Transplantation Studies Research Group. Arch Ophthalmol. 1992;110:1392-1403.
51. Salisbury JD, Gebhardt BM. Blood group antigens on human corneal cells demonstrated by immunoperoxidase staining. Am J Ophthalmol. 1981;91:46-50.
52. Grunnet N, Kristensen T, Kissmeyer-Nielsen F, Ehlers N. Occurrence of lymphocytotoxic lymphocytes and antibodies after corneal transplantation. Acta Ophthalmol (Copenh). 1976;54:167-173.
53. Goslings WR, Yamada J, Dana MR, et al. Corneal transplantation in antibody-deficient hosts. Invest Ophthalmol Vis Sci. 1999;40:250-253.
54. Hegde S, Mellon JK, Hargrave SL, Niederkorn JY. Effect of alloantibodies on corneal allograft survival. Invest Ophthalmol Vis Sci. 2002;43:1012-1018.
55. Holan V, Vitova A, Krulova M, et al. Susceptibility of corneal allografts and xenografts to antibody-mediated rejection. Immunol Lett. 2005;100:211-213.
56. Bora NS, Gobleman CL, Atkinson JP, Pepose JS, Kaplan HJ. Differential expression of the complement regulatory proteins in the human eye. Invest Ophthalmol Vis Sci. 1993;34:3579-3584.
57. Lass JH, Walter EI, Burris TE, et al. Expression of two molecular forms of the complement decay-accelerating factor in the eye and lacrimal gland. Invest Ophthalmol Vis Sci. 1990;31:1136-1148.
58. Goslings WR, Prodeus AP, Streilein JW, Carroll MC, Jager MJ, Taylor AW. A small molecular weight factor in aqueous humor acts on C1q to prevent antibody-dependent complement activation. Invest Ophthalmol Vis Sci. 1998;39:989-995.
59. Hargrave SL, Mayhew E, Hegde S, Niederkorn J. Are corneal cells susceptible to antibody-mediated killing in corneal allograft rejection? Transpl Immunol. 2003;11:79-89.
60. Nickerson P, Steurer W, Steiger J, Zheng X, Steele AW, Strom TB. Cytokines and the Th1/Th2 paradigm in transplantation. Curr Opin Immunol. 1994;6:757-764.
61. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986;136:2348-2357.
62. Yamada J, Yoshida M, Taylor AW, Streilein JW. Mice with Th2-biased immune systems accept orthotopic corneal allografts placed in "high risk" eyes. J Immunol. 1999;162:5247-5255.
63. Le Moine A, Flamand V, Demoor FX, et al. Critical roles for IL-4, IL-5, and eosinophils in chronic skin allograft rejection. J Clin Invest. 1999;103:1659-1667.
64. Piccotti JR, Chan SY, Goodman RE, Magram J, Eichwald EJ, Bishop DK. IL-12 antagonism induces T helper 2 responses, yet exacerbates cardiac allograft rejection. Evidence against a dominant protective role for T helper 2 cytokines in alloimmunity. J Immunol. 1996;157:1951-1957.
65. VanBuskirk AM, Wakely ME, Orosz CG. Transfusion of polarized TH2-like cell populations into SCID mouse cardiac allograft recipients results in acute allograft rejection. Transplantation. 1996;62:229-238.
66. Hargrave SL, Hay, C, Mellon, J, Mayhew, E, Niederkorn, JY. Fate of MHC-matched corneal allografts in Th1-deficient hosts. Invest Ophthalmol Vis Sci. 2004;45:1188-1193.
67. Easty D, Entwistle C, Funk A, Witcher J. Herpes simplex keratitis and keratoconus in the atopic patient. A clinical and immunological study. Trans Ophthalmol Soc UK. 1975;95:267-276.
68. Ghoraishi M, Akova YA, Tugal-Tutkun I, Foster CS. Penetrating keratoplasty in atopic keratoconjunctivitis. Cornea. 1995;14:610-613.
69. Hargrave S, Chu Y, Mendelblatt D, Mayhew E, Niederkorn J. Preliminary findings in corneal allograft rejection in patients with keratoconus. Am J Ophthalmol. 2003;135:452-460.
70. Lyons CJ, Dart JK, Aclimandos WA, Lightman S, Buckley RJ. Sclerokeratitis after keratoplasty in atopy. Ophthalmology. 1990;97:729-733.
71. Harrison RJ, Klouda PT, Easty DL, Manku M, Charles J, Stewart CM. Association between keratoconus and atopy. Br J Ophthalmol. 1989;73:816-822.
72. Beauregard C, Stevens C, Mayhew E, Niederkorn JY. Cutting edge: Atopy promotes Th2 responses to alloantigens and increases the incidence and tempo of corneal allograft rejection. J Immunol. 2005;174:6577-6581.
73. Flynn TH, Ohbayashi M, Ikeda Y, Ono SJ, Larkin DF. Effect of allergic conjunctival inflammation on the allogeneic response to donor cornea. Invest Ophthalmol Vis Sci. 2007;48:4044-4049.
74. Hargrave SL, Mellon J, Niederkorn J. MHC matching improves corneal allograft survival in mice with Th2-immune bias. Transplant Proc. 2002;34:3413-3415.
75. Matesic D, Valujskikh A, Pearlman E, Higgins AW, Gilliam AC, Heeger PS. Type 2 immune deviation has differential effects on alloreactive CD4+ and CD8+ T cells. J Immunol. 1998;161:5236-5244.
76. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature. 1996;383:787-793.
77. Dvorak HF, Galli SJ, Dvorak AM. Cellular and vascular manifestations of cell-mediated immunity. Hum Pathol. 1986;17:122-137.
78. Larkin DF, Alexander RA, Cree IA. Infiltrating inflammatory cell phenotypes and apoptosis in rejected human corneal allografts. Eye. 1997;11:68-74.
79. Larkin DF, Calder VL, Lightman SL. Identification and characterization of cells infiltrating the graft and aqueous humor in rat corneal allograft rejection. Clin Exp Immunol. 1997;107:381-391.
80. Williams KA, White MA, Ash JK, Coster DJ. Leukocytes in the graft bed associated with corneal graft failure. Analysis by immunohistology and actuarial graft survival. Ophthalmology. 1989;96:38-44.
81. Brissette-Storkus CS, Reynolds SM, Lepisto AJ, Hendricks RL. Identification of a novel macrophage population in the normal mouse corneal stroma. Invest Ophthalmol Vis Sci. 2002;43:2264-2271.
82. Yamagami S, Ebihara N, Usui T, Yokoo S, Amano S. Bone marrow-derived cells in normal human corneal stroma. Arch Ophthalmol. 2006;124:62-69.
83. Yamamoto N, Einaga-Naito K, Kuriyama M, Kawada Y, Yoshida R. Cellular basis of skin allograft rejection in mice: Specific lysis of allogeneic skin components by non-T cells. Transplantation. 1998;65:818-825.
84. Slegers TP, Torres PF, Broersma L, van Rooijen N, van Rij G, van der Gaag R. Effect of macrophage depletion on immune effector mechanisms during corneal allograft rejection in rats. Invest Ophthalmol Vis Sci. 2000;41:2239-2247.
85. Nair S, Buiting AM, Rouse RJ, Van Rooijen N, Huang L, Rouse BT. Role of macrophages and dendritic cells in primary cytotoxic T lymphocyte responses. Int Immunol. 1995;7:679-688.
86. Niederkorn JY. The immunology of corneal transplantation. Dev Ophthalmol. 1999;30:129-140.
87. Niederkorn JY. Immunology and immunomodulation of corneal transplantation. Intern Rev Immunol. 2002;21:173-196.
88. Niederkorn JY. The immune privilege of corneal grafts. J Leukoc Biol. 2003;74:167-171.
89. Claerhout I, Kestelyn P, Debacker V, Beele H, Leclercq G. Role of natural killer cells in the rejection process of corneal allografts in rats. Transplantation. 2004;77:676-682.
90. Mayer K, Reinhard T, Reis A, Niehues T, Claas FH, Sundmacher R. Differential contribution of natural killer cells to corneal graft rejection in 3-week-old versus mature rats. Transplantation. 2003;76:578-582.
91. Ljunggren HG, Karre K. In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today. 1990;11:237-244.
92. Kitchens WH, Uehara S, Chase CM, Colvin RB, Russell PS, Madsen JC. The changing role of natural killer cells in solid organ rejection and tolerance. Transplantation. 2006;81:811-817.
93. LaRosa DF, Rahman AH, Turka LA. The innate immune system in allograft rejection and tolerance. J Immunol. 2007;178:7503-7509.
94. Maier S, Tertilt C, Chambron N, et al. Inhibition of natural killer cells results in acceptance of cardiac allografts in CD28-/- mice. Nat Med. 2001;7:557-562.
95. McNerney ME, Lee KM, Zhou P, et al. Role of natural killer cell subsets in cardiac allograft rejection. Am J Transplant. 2006;6:505-513.
96. Brierly SC, Izquierdo L Jr, Mannis MJ. Penetrating keratoplasty for keratoconus. Cornea. 2000;19:329-332.
97. Kirkness CM, Ezra E, Rice NS, Steele AD. The success and survival of repeat corneal grafts. Eye. 1990;4(Pt. 1):58-64.
98. Shimmura S, Tsubota K. Deep anterior lamellar keratoplasty. Curr Opin Ophthalmol. 2006;17:349-355.
99. Sugita J, Kondo J. Deep lamellar keratoplasty with complete removal of pathological stroma for vision improvement. Br J Ophthalmol. 1997;81:184-188.
100. Watson SL, Tuft SJ, Dart JK. Patterns of rejection after deep lamellar keratoplasty. Ophthalmology. 2006;113:556-560.
101. Panda A, Vanathi M, Kumar A, Dash Y, Priya S. Corneal graft rejection. Surv Ophthalmol. 2007;52:375-396.
102. Tuft SJ, Coster DJ. The corneal endothelium. Eye. 1990;4(Pt. 3):389-424.
103. Boisgerault F, Liu Y, Anosova N, Ehrlich E, Dana MR, Benichou G. Role of CD4+ and CD8+ T cells in allorecognition: Lessons from corneal transplantation. J Immunol. 2001;167:1891-1899.
104. Sano Y, Ksander BR, Streilein JW. Minor H, rather than MHC, alloantigens offer the greater barrier to successful orthotopic corneal transplantation in mice. Transpl Immunol. 1996;4:53-56.
105. Sano Y, Ksander BR, Streilein JW. Langerhans cells, orthotopic corneal allografts, and direct and indirect pathways of T-cell allorecognition. Invest Ophthalmol Vis Sci. 2000;41:1422-1431.
106. Sano Y, Streilein JW, Ksander BR. Detection of minor alloantigen-specific cytotoxic T cells after rejection of murine orthotopic corneal allografts: Evidence that graft antigens are recognized exclusively via the "indirect pathway." Transplantation. 1999;68:963-970.