Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation

Haematologica

Volumn 96, Issue 10, 2011, Pages 1424-1432

  Santambrogio, Paolo ^a   Erba, Benedetta Gaia ^a   Campanella, Alessandro ^b,c   Cozzi, Anna ^a   Causarano, Vincenza ^a   Cremonesi, Laura ^a   Gallì, Anna ^d   Porta, Matteo Giovanni Della ^d   Invernizzi, Rosangela ^d   Levi, Sonia ^a,c  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b Research Unit of Molecular Neuroscience   (Italy)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^d UNIVERSITY OF PAVIA   (Italy)

Author keywords

Hereditary sideroblastic anemia; Iron acculumation; Iron starvation; JAK2 STA5; Mitochondrial ferritin; Refractory anemia with ringed sideblasts; ROS

Indexed keywords

CD71 ANTIGEN; FERRITIN; IRON REGULATORY FACTOR; JANUS KINASE 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; STAT5 PROTEIN;

APOPTOSIS; ARTICLE; CELL GRANULE; CONTROLLED STUDY; CYTOSOL; ERYTHROID PRECURSOR CELL; ERYTHROLEUKEMIA CELL; HEME SYNTHESIS; HEREDITARY SIDEROBLASTIC ANEMIA; HUMAN; HUMAN CELL; IRON METABOLISM; IRON RESPONSIVE ELEMENT; MITOCHONDRIAL IRON ACCUMULATION; MITOCHONDRION; PATHOGENESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; FERRITINS; GENE EXPRESSION; HEMATOPOIETIC STEM CELLS; HEME; HUMANS; IRON; JANUS KINASE 2; K562 CELLS; MICE; MITOCHONDRIA; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC;

EID: 80053625369     PISSN: 03906078     EISSN: 15928721     Source Type: Journal    
DOI: 10.3324/haematol.2011.042952     Document Type: Article

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