Steroid Receptor RNA Activator - A nuclear receptor coregulator with multiple partners: Insights and challenges

Biochimie

Volumn 93, Issue 11, 2011, Pages 1966-1972

  Colley, Shane M ^a   Leedman, Peter J ^a,b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Cancer; Hormone action; Metabolism; Nuclear receptor coregulator; SLIRP; SRA; SRAP

Indexed keywords

DNA BINDING PROTEIN; ESTROGEN RECEPTOR; GENE PRODUCT; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID X RECEPTOR; RNA BINDING PROTEIN; SRA LOOP INTERACTING RNA BINDING PROTEIN; STEROID RECEPTOR RNA ACTIVATOR PROTEIN; STEROIDOGENIC FACTOR 1; THYROID HORMONE RECEPTOR; UNCLASSIFIED DRUG; UNTRANSLATED RNA;

ADIPOCYTE; BINDING AFFINITY; BREAST CANCER; CELL DIFFERENTIATION; HORMONE ACTION; HUMAN; MASS SPECTROMETRY; MUSCLE CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PROSTATE CANCER; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; RNA BINDING; RNA SEQUENCE; RNA TRANSCRIPTION; STEROIDOGENESIS; TRANSCRIPTION REGULATION;

EID: 80053576647     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2011.07.004     Document Type: Short Survey

References (57)

1. N.J. McKenna, and B.W. O'Malley Combinatorial control of gene expression by nuclear receptors and coregulators Cell 108 2002 465 474 (Pubitemid 34260872)
2. Y.A. Bulynko, and B.W. O'Malley Nuclear receptor coactivators: structural and functional biochemistry Biochemistry 2010
3. R.B. Lanz, N.J. McKenna, S.A. Onate, U. Albrecht, J. Wong, S.Y. Tsai, M.J. Tsai, and B.W. O'Malley A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex Cell 97 1999 17 27 (Pubitemid 29165886)
4. H. Kawashima, H. Takano, S. Sugita, Y. Takahara, K. Sugimura, and T. Nakatani A novel steroid receptor co-activator protein (SRAP) as an alternative form of steroid receptor RNA-activator gene: expression in prostate cancer cells and enhancement of androgen receptor activity Biochem. J. 369 2003 163 171 (Pubitemid 36175555)
5. E. Emberley, G.J. Huang, M.K. Hamedani, A. Czosnek, D. Ali, A. Grolla, B. Lu, P.H. Watson, L.C. Murphy, and E. Leygue Identification of new human coding steroid receptor RNA activator isoforms Biochem. Biophys. Res. Commun. 301 2003 509 515 (Pubitemid 36279269)
6. E. Leygue Steroid receptor RNA activator (SRA1): unusual bifaceted gene products with suspected relevance to breast cancer Nucl. Recept. Signal. 5 2007 e006
7. F. Hube, G. Velasco, J. Rollin, D. Furling, and C. Francastel Steroid receptor RNA activator protein binds to and counteracts SRA RNA-mediated activation of MyoD and muscle differentiation Nucleic Acids Res. 39 2011 513 525
8. T. Kurisu, T. Tanaka, J. Ishii, K. Matsumura, K. Sugimura, T. Nakatani, and H. Kawashima Expression and function of human steroid receptor RNA activator in prostate cancer cells: role of endogenous hSRA protein in androgen receptor-mediated transcription Prostate Cancer Prostatic Dis. 2006
9. S. Chooniedass-Kothari, M.K. Hamedani, S. Troup, F. Hube, and E. Leygue The steroid receptor RNA activator protein is expressed in breast tumor tissues Int. J. Cancer 118 2006 1054 1059 (Pubitemid 43157685)
10. R.B. Lanz, S.S. Chua, N. Barron, B.M. Soder, F. DeMayo, and B.W. O'Malley Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo Mol. Cell Biol. 23 2003 7163 7176 (Pubitemid 37210999)
11. R.B. Lanz, B. Razani, A.D. Goldberg, and B.W. O'Malley Distinct RNA motifs are important for coactivation of steroid hormone receptors by steroid receptor RNA activator (SRA) Proc. Natl. Acad. Sci. U S A 99 2002 16081 16086 (Pubitemid 35462752)
12. S. Chooniedass-Kothari, D. Vincett, Y. Yan, C. Cooper, M.K. Hamedani, Y. Myal, and E. Leygue The protein encoded by the functional steroid receptor RNA activator is a new modulator of ER alpha transcriptional activity FEBS Lett. 584 2010 1174 1180
13. C.M. Klinge, S.C. Jernigan, K.A. Mattingly, K.E. Risinger, and J. Zhang Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors alpha and beta by coactivators and corepressors J. Mol. Endocrinol. 33 2004 387 410 (Pubitemid 39429565)
14. E. Leygue, H. Dotzlaw, P.H. Watson, and L.C. Murphy Expression of the steroid receptor RNA activator in human breast tumors Cancer Res. 59 1999 4190 4193 (Pubitemid 29418723)
15. L.C. Murphy, S.L. Simon, A. Parkes, E. Leygue, H. Dotzlaw, L. Snell, S. Troup, A. Adeyinka, and P.H. Watson Altered expression of estrogen receptor coregulators during human breast tumorigenesis Cancer Res. 60 2000 6266 6271
16. S. Hussein-Fikret, and P.J. Fuller Expression of nuclear receptor coregulators in ovarian stromal and epithelial tumours Mol. Cell Endocrinol. 229 2005 149 160 (Pubitemid 40018093)
17. F. Hube, J. Guo, S. Chooniedass-Kothari, C. Cooper, M.K. Hamedani, A.A. Dibrov, A.A. Blanchard, X. Wang, G. Deng, Y. Myal, and E. Leygue Alternative splicing of the first intron of the steroid receptor RNA activator (SRA) participates in the generation of coding and noncoding RNA isoforms in breast cancer cell lines DNA Cell Biol. 25 2006 418 428 (Pubitemid 44175334)
18. C. Cooper, J. Guo, Y. Yan, S. Chooniedass-Kothari, F. Hube, M.K. Hamedani, L.C. Murphy, Y. Myal, and E. Leygue Increasing the relative expression of endogenous non-coding Steroid Receptor RNA Activator (SRA) in human breast cancer cells using modified oligonucleotides Nucleic Acids Res. 37 2009 4518 4531
19. C.E. Foulds, A. Tsimelzon, W. Long, A. Le, S.Y. Tsai, M.J. Tsai, and B.W. O'Malley Research resource: expression profiling reveals unexpected targets and functions of the human steroid receptor RNA activator (SRA) gene Mol. Endocrinol. 24 2010 1090 1105
20. I.T. Cavarretta, R. Mukopadhyay, D.M. Lonard, L.M. Cowsert, C.F. Bennett, B.W. O'Malley, and C.L. Smith Reduction of coactivator expression by antisense oligodeoxynucleotides inhibits ERalpha transcriptional activity and MCF-7 proliferation Mol. Endocrinol. 16 2002 253 270 (Pubitemid 34131224)
21. Y. Yan, G.P. Skliris, C. Penner, S. Chooniedass-Kothari, C. Cooper, Z. Nugent, A. Blanchard, P.H. Watson, Y. Myal, L.C. Murphy, and E. Leygue Steroid Receptor RNA Activator Protein (SRAP): a potential new prognostic marker for estrogen receptor-positive/node-negative/younger breast cancer patients Breast Cancer Res. 11 2009 R67
22. I.U. Agoulnik, and N.L. Weigel Coactivator selective regulation of androgen receptor activity Steroids 74 2009 669 674
23. E.C. Hatchell, S.M. Colley, D.J. Beveridge, M.R. Epis, L.M. Stuart, K.M. Giles, A.D. Redfern, L.E. Miles, A. Barker, L.M. Macdonald, P.G. Arthur, J.C. Lui, J.L. Golding, R.K. McCulloch, C.B. Metcalf, J.A. Wilce, M.C. Wilce, R.B. Lanz, W. O'Malley, and B.,P.J. Leedman SLIRP, a small SRA binding protein, is a nuclear receptor corepressor Mol. Cell 22 2006 657 668 (Pubitemid 43817609)
24. B. Xu, I. Gerin, H. Miao, D. Vu-Phan, C.N. Johnson, R. Xu, X.W. Chen, W.P. Cawthorn, O.A. MacDougald, and R.J. Koenig Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity PLoS ONE 5 2010 e14199
25. Q. Tong, G. Dalgin, H. Xu, C.N. Ting, J.M. Leiden, and G.S. Hotamisligil Function of GATA transcription factors in preadipocyte-adipocyte transition Science 290 2000 134 138
26. G. Caretti, R.L. Schiltz, F.J. Dilworth, M. Di Padova, P. Zhao, V. Ogryzko, F.V. Fuller-Pace, E.P. Hoffman, S.J. Tapscott, and V. Sartorelli The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation Dev. Cell 11 2006 547 560 (Pubitemid 44467725)
27. A. Kitamura, M. Nishizuka, K. Tominaga, T. Tsuchiya, T. Nishihara, and M. Imagawa Expression of p68 RNA helicase is closely related to the early stage of adipocyte differentiation of mouse 3T3-L1 cells Biochem. Biophys. Res. Commun. 287 2001 435 439 (Pubitemid 32917617)
28. S.M. Colley, and P.J. Leedman SRA and its binding partners: an expanding role for RNA-binding coregulators in nuclear receptor-mediated gene regulation Crit. Rev. Biochem. Mol. Biol. 44 2009 25 33
29. D. Ulveling, C. Francastel, and F. Hube When one is better than two: RNA with dual functions Biochimie 93 2011 633 644
30. H. Yao, K. Brick, Y. Evrard, T. Xiao, R.D. Camerini-Otero, and G. Felsenfeld Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA Genes Dev. 24 2010 2543 2555
31. F. Friedrichs, C. Zugck, G.J. Rauch, B. Ivandic, D. Weichenhan, M. Muller-Bardorff, B. Meder, N.E. El Mokhtari, V. Regitz-Zagrosek, R. Hetzer, A. Schafer, S. Schreiber, J. Chen, I. Neuhaus, R. Ji, N.O. Siemers, N. Frey, W. Rottbauer, H.A. Katus, and M. Stoll HBEGF, SRA1, and IK: three cosegregating genes as determinants of cardiomyopathy Genome Res. 19 2009 395 403
32. W. Dillmann Cardiac hypertrophy and thyroid hormone signaling Heart Fail. Rev. 15 2010 125 132
33. Y. Shi, M. Downes, W. Xie, H.Y. Kao, P. Ordentlich, C.C. Tsai, M. Hon, and R.M. Evans Sharp, an inducible cofactor that integrates nuclear receptor repression and activation Genes Dev. 15 2001 1140 1151 (Pubitemid 32417306)
34. G. Deblois, and V. Giguere Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation J. Steroid Biochem. Mol. Biol. 85 2003 123 131 (Pubitemid 37020884)
35. M. Watanabe, J. Yanagisawa, H. Kitagawa, K. Takeyama, S. Ogawa, Y. Arao, M. Suzawa, Y. Kobayashi, T. Yano, H. Yoshikawa, Y. Masuhiro, and S. Kato A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA EMBO J. 20 2001 1341 1352 (Pubitemid 32233974)
36. K.M. Coleman, V. Lam, B.M. Jaber, R.B. Lanz, and C.L.k. Smith SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity Biochem. Biophys. Res. Commun. 323 2004 332 338 (Pubitemid 39206289)
37. X. Zhao, J.R. Patton, S.L. Davis, B. Florence, S.J. Ames, and R.A. Spanjaard Regulation of nuclear receptor activity by a pseudouridine synthase through posttranscriptional modification of steroid receptor RNA activator Mol. Cell 15 2004 549 558 (Pubitemid 39141782)
38. X. Zhao, J.R. Patton, S.K. Ghosh, N. Fischel-Ghodsian, L. Shen, and R.A. Spanjaard Pus3p- and Pus1p-dependent pseudouridylation of steroid receptor RNA activator controls a functional switch that regulates nuclear receptor signaling Mol. Endocrinol. 21 2007 686 699
39. Y. Bykhovskaya, K. Casas, E. Mengesha, A. Inbal, and N. Fischel-Ghodsian Missense mutation in pseudouridine synthase 1 (PUS1) causes mitochondrial myopathy and sideroblastic anemia (MLASA) Am. J. Hum. Genet. 74 2004 1303 1308 (Pubitemid 38669331)
40. J.R. Patton, Y. Bykhovskaya, E. Mengesha, C. Bertolotto, and N. Fischel-Ghodsian Mitochondrial myopathy and sideroblastic anemia (MLASA): missense mutation in the pseudouridine synthase 1 (PUS1) gene is associated with the loss of tRNA pseudouridylation J. Biol. Chem. 280 2005 19823 19828 (Pubitemid 41379508)
41. E. Fernandez-Vizarra, A. Berardinelli, L. Valente, V. Tiranti, and M. Zeviani Nonsense mutation in pseudouridylate synthase 1 (PUS1) in two brothers affected by myopathy, lactic acidosis and sideroblastic anaemia (MLASA) J. Med. Genet. 44 2007 173 180 (Pubitemid 46580526)
42. S. Chooniedass-Kothari, M.K. Hamedani, C. Auge, X. Wang, S. Carascossa, Y. Yan, C. Cooper, D. Vincett, Y. Myal, S. Jalaguier, V. Cavailles, and E. Leygue The steroid receptor RNA activator protein is recruited to promoter regions and acts as a transcriptional repressor FEBS Lett. 584 2010 2218 2224
43. H. Li, S.K. Kolluri, J. Gu, M.I. Dawson, X. Cao, P.D. Hobbs, B. Lin, G. Chen, J. Lu, F. Lin, Z. Xie, J.A. Fontana, J.C. Reed, and X. Zhang Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3 Science 289 2000 1159 1164 (Pubitemid 30650723)
44. A. Pedram, M. Razandi, D.C. Wallace, and E.R. Levin Functional estrogen receptors in the mitochondria of breast cancer cells Mol. Biol. Cell 2006
45. R.V. Sionov, O. Cohen, S. Kfir, Y. Zilberman, and E. Yefenof Role of mitochondrial glucocorticoid receptor in glucocorticoid-induced apoptosis J. Exp. Med. 203 2006 189 201 (Pubitemid 43139657)
46. F. Morrish, N.E. Buroker, M. Ge, X.H. Ning, J. Lopez-Guisa, D. Hockenbery, and M.A. Portman Thyroid hormone receptor isoforms localize to cardiac mitochondrial matrix with potential for binding to receptor elements on mtDNA Mitochondrion 6 2006 143 148 (Pubitemid 43872024)
47. Q. Li, and J. Xu Identification and characterization of the alternatively spliced nuclear receptor coactivator-6 isoforms Int. J. Biol. Sci. 7 2011 505 516
48. K. Aquilano, P. Vigilanza, S. Baldelli, B. Pagliei, G. Rotilio, and M.R. Ciriolo Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis J. Biol. Chem. 285 2010 21590 21599
49. M.A. Rubio, J.J. Rinehart, B. Krett, S. Duvezin-Caubet, A.S. Reichert, D. Soll, and J.D. Alfonzo Mammalian mitochondria have the innate ability to import tRNAs by a mechanism distinct from protein import Proc. Natl. Acad. Sci. U S A 105 2008 9186 9191
50. J.M. Baughman, R. Nilsson, V.M. Gohil, D.H. Arlow, Z. Gauhar, and V.K. Mootha A computational screen for regulators of oxidative phosphorylation implicates SLIRP in mitochondrial RNA homeostasis PLoS Genet. 5 2009 e1000590
51. F. Sasarman, C. Brunel-Guitton, H. Antonicka, T. Wai, and E.A. Shoubridge LRPPRC and SLIRP interact in a ribonucleoprotein complex that regulates posttranscriptional gene expression in mitochondria Mol. Biol. Cell 21 2010 1315 1323
52. G.A. Brent The molecular basis of thyroid hormone action N. Engl. J. Med. 331 1994 847 853
53. B. Xu, and R.J. Koenig An RNA-binding domain in the thyroid hormone receptor enhances transcriptional activation J. Biol. Chem. 279 2004 33051 33056 (Pubitemid 39062947)
54. B. Xu, and R.J.W. Koenig Regulation of thyroid hormone receptor alpha2 RNA binding and subcellular localization by phosphorylation Mol. Cell Endocrinol. 245 2005 147 157 (Pubitemid 43049756)
55. C.H. Lee, P. Olson, and R.M. Evans Minireview: lipid metabolism, metabolic diseases, and peroxisome proliferator-activated receptors Endocrinology 144 2003 2201 2207 (Pubitemid 36629867)
56. B. Xu, W.H. Yang, I. Gerin, C.D. Hu, G.D. Hammer, and R.J. Koenig Dax-1 and steroid receptor RNA activator (SRA) function as transcriptional coactivators for steroidogenic factor 1 in steroidogenesis Mol. Cell Biol. 29 2009 1719 1734
57. V.R. Kelly, B. Xu, R. Kuick, R.J. Koenig, and G.D. Hammer Dax-1 up-regulates Oct4 expression in mouse embryonic stem cells via LRH-1 and SRA Mol. Endocrinol. 24 2010 2281 2291