메뉴 건너뛰기




Volumn 33, Issue 5, 2011, Pages 573-582

Population pharmacokinetics of lopinavir/ritonavir (kaletra) in HIV-infected patients

Author keywords

HIV1; lopinavir; NONMEM; patients; ritonavir; therapeutic drug monitoring

Indexed keywords

ATAZANAVIR; BILIRUBIN; EFAVIRENZ; LOPINAVIR PLUS RITONAVIR; MELTREX; SAQUINAVIR; TENOFOVIR; UNCLASSIFIED DRUG;

EID: 80053562468     PISSN: 01634356     EISSN: 15363694     Source Type: Journal    
DOI: 10.1097/FTD.0b013e31822d578b     Document Type: Article
Times cited : (26)

References (76)
  • 4
    • 0036768328 scopus 로고    scopus 로고
    • Analysis of the virological response with respect to baseline viral phenotype and genotype in protease inhibitor-experienced HIV-1-infected patients receiving lopinavir/ritonavir therapy
    • Kempf DJ, Isaacson JD, King MS, et al. Analysis of the virological response with respect to baseline viral phenotype and genotype in protease inhibitor-experienced HIV-1-infected patients receiving lopinavir/ritonavir therapy. Antivir Ther. 2002;7:165-174. (Pubitemid 36427141)
    • (2002) Antiviral Therapy , vol.7 , Issue.3 , pp. 165-174
    • Kempf, D.J.1    Isaacson, J.D.2    King, M.S.3    Brun, S.C.4    Sylte, J.5    Richards, B.6    Bernstein, B.7    Rode, R.8    Sun, E.9
  • 5
    • 34447318665 scopus 로고    scopus 로고
    • Lopinavir/ritonavir: Appraisal of its use in HIV therapy
    • DOI 10.1358/dot.2007.43.4.1050793
    • Von Hentig N. Lopinavir/ritonavir: appraisal of its use in HIV therapy. Drugs Today. 2007;43:221-247. (Pubitemid 47177209)
    • (2007) Drugs of Today , vol.43 , Issue.4 , pp. 221-247
    • Von Hentig, N.1
  • 7
    • 0037032045 scopus 로고    scopus 로고
    • The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1)
    • Olson DP, Scadden DT, D'Aquila RT, et al. The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1). AIDS. 2002;16:1743-1747.
    • (2002) AIDS , vol.16 , pp. 1743-1747
    • Olson, D.P.1    Scadden, D.T.2    D'Aquila, R.T.3
  • 10
    • 52949129506 scopus 로고    scopus 로고
    • Trends in the prescription of antiretroviral drugs and impact on plasma HIV-RNA measurements
    • Jiménez-Nácher I, Garća B, Barreiro P, et al. Trends in the prescription of antiretroviral drugs and impact on plasma HIV-RNA measurements. J Antimicrob Chemother. 2008;62:816-822.
    • (2008) J Antimicrob Chemother , vol.62 , pp. 816-822
    • Jiménez-Nácher, I.1    Garća, B.2    Barreiro, P.3
  • 13
    • 0036720761 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 genotypic and pharmacokinetic determinants of the virological response to lopinavir-ritonavir containing therapy in protease inhibitorexperienced patients
    • Masquelier B, Breilh D, Neau D, et al. Human immunodeficiency virus type 1 genotypic and pharmacokinetic determinants of the virological response to lopinavir-ritonavir containing therapy in protease inhibitorexperienced patients. Antimicrob Agents Chemother. 2002;46:2926-2932.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 2926-2932
    • Masquelier, B.1    Breilh, D.2    Neau, D.3
  • 14
    • 0035174709 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic study of the human immunodeficiency virus protease inhibitor amprenavir after multiple oral dosing
    • DOI 10.1128/AAC.45.1.30-37.2001
    • Sadler BM, Gillotin CG, Lou Y, et al. Pharmacokinetic and pharmacodynamic study of the human immunodeficiency virus protease inhibitor amprenavir after multiple dosing. Antimicrob Agents Chemother. 2001; 45:30-37. (Pubitemid 32039089)
    • (2001) Antimicrobial Agents and Chemotherapy , vol.45 , Issue.1 , pp. 30-37
    • Sadler, B.M.1    Gillotin, C.2    Lou, Y.3    Stein, D.S.4
  • 15
    • 0033859133 scopus 로고    scopus 로고
    • Relationship between efficacy, tolerance, and plasma drug concentration of ritonavir in children with advanced HIV infection
    • DOI 10.1097/00007691-200008000-00007
    • Dumon C, Solas C, Thuret I, et al. Relationship between efficacy, tolerance, and plasma drug concentration of ritonavir in children with advanced HIV infection. Ther Drug Monit. 2000;22:402-408. (Pubitemid 30622111)
    • (2000) Therapeutic Drug Monitoring , vol.22 , Issue.4 , pp. 402-408
    • Dumon, C.1    Solas, C.2    Thuret, I.3    Chambost, H.4    Lacarelle, B.5    Michel, G.6    Durand, A.7
  • 18
    • 33749873761 scopus 로고    scopus 로고
    • A retrospective TDM database analysis of interpatient variability in the pharmacokinetics of lopinavir in HIV-infected adults
    • DOI 10.1097/01.ftd.0000245681.12092.d6, PII 0000769120061000000013
    • Van der Leur MR, Burger DM, la Porte C, et al. A retrospective TDM database analysis of interpatient variability in the pharmacokinetics of lopinavir in HIV-infected adults. Ther Drug Monit. 2006;28:650-653. (Pubitemid 44564064)
    • (2006) Therapeutic Drug Monitoring , vol.28 , Issue.5 , pp. 650-653
    • Van Der Leur, M.R.1    Burger, D.M.2    La Porte, C.J.L.3    Koopmans, P.P.4
  • 23
    • 33748170155 scopus 로고    scopus 로고
    • An update on therapeutic drug monitoring for antiretroviral drugs
    • DOI 10.1097/01.ftd.0000211825.57984.41, PII 0000769120060600000031
    • Back D, Gibbons S, Khoo S, et al. An update on therapeutic drug monitoring for antiretroviral drugs. Ther Drug Monit. 2006;28:468-473. (Pubitemid 44314939)
    • (2006) Therapeutic Drug Monitoring , vol.28 , Issue.3 , pp. 468-473
    • Back, D.1    Gibbons, S.2    Khoo, S.3
  • 25
    • 0037159936 scopus 로고    scopus 로고
    • PharmAdapt: A randomized prospective study to evaluate the benefit of therapeutic monitoring of protease inhibitors: 12 Week results
    • DOI 10.1097/00002030-200211220-00011
    • Clevenbergh P, Garraffo R, Durant J, et al. PharmAdapt: a randomized prospective study to evaluate the benefit of therapeutic monitoring of protease inhibitors: 12 week results. AIDS. 2002;16:2311-2315. (Pubitemid 35449017)
    • (2002) AIDS , vol.16 , Issue.17 , pp. 2311-2315
    • Clevenbergh, P.1    Garraffo, R.2    Durant, J.3    Dellamonica, P.4
  • 26
    • 33646819025 scopus 로고    scopus 로고
    • Pharmacologic optimization of protease inhibitors and nonnucleoside reverse transcriptase inhibitors (POPIN)-A randomized controlled trial of therapeutic drug monitoring and adherence support
    • Khoo SH, Lloyd J, Dalton M, et al. Pharmacologic optimization of protease inhibitors and nonnucleoside reverse transcriptase inhibitors (POPIN)-a randomized controlled trial of therapeutic drug monitoring and adherence support. J Acquir Immune Defic Syndr. 2006;41: 461-467.
    • (2006) J Acquir Immune Defic Syndr , vol.41 , pp. 461-467
    • Khoo, S.H.1    Lloyd, J.2    Dalton, M.3
  • 28
    • 59849103615 scopus 로고    scopus 로고
    • A randomized trial of therapeutic drug monitoring of protease inhibitors in antiretroviralexperienced HIV-1-infected patients
    • Demeter LM, Jiang H, Mukherjee AL, et al. A randomized trial of therapeutic drug monitoring of protease inhibitors in antiretroviralexperienced, HIV-1-infected patients. AIDS. 2009;23:357-368.
    • (2009) AIDS , vol.23 , pp. 357-368
    • Demeter, L.M.1    Jiang, H.2    Mukherjee, A.L.3
  • 29
    • 51649107032 scopus 로고    scopus 로고
    • Simultaneous population pharmacokinetic model for lopinavir and ritonavir in HIV-infected adults
    • Moltó J, Barbanoj MJ, Miranda C, et al. Simultaneous population pharmacokinetic model for lopinavir and ritonavir in HIV-infected adults. Clin Pharmacokinet. 2008;47:681-692.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 681-692
    • Moltó, J.1    Barbanoj, M.J.2    Miranda, C.3
  • 31
    • 72249122367 scopus 로고    scopus 로고
    • A population analysis of weight-related differences in lopinavir pharmacokinetics and possible consequences for protease inhibitor-näve and-experienced patients
    • Bouillon-Pichault M, Jullien V, Azria E, et al. A population analysis of weight-related differences in lopinavir pharmacokinetics and possible consequences for protease inhibitor-näve and-experienced patients. Antivir Ther. 2009;14:923-929.
    • (2009) Antivir Ther , vol.14 , pp. 923-929
    • Bouillon-Pichault, M.1    Jullien, V.2    Azria, E.3
  • 32
    • 77950787858 scopus 로고    scopus 로고
    • ADME pharmacogenetics: Investigation of the pharmacokinetics of the antiretroviral agent lopinavir coformulated with ritonavir
    • Lubomirov R, Iulio J, Fayet A, et al. ADME pharmacogenetics: investigation of the pharmacokinetics of the antiretroviral agent lopinavir coformulated with ritonavir. Pharmacogenet Genomics. 2010;20:217-230.
    • (2010) Pharmacogenet Genomics , vol.20 , pp. 217-230
    • Lubomirov, R.1    Iulio, J.2    Fayet, A.3
  • 34
    • 84856801184 scopus 로고    scopus 로고
    • Institut d'Investigacions Biomèdiques August Pi i Sunyer, Institut Cĺnic de Medicina I Dermatoloǵa. Interacciones HIV.com. Accessed January 25
    • Institut d'Investigacions Biomèdiques August Pi i Sunyer, Institut Cĺnic de Medicina I Dermatoloǵa. Interacciones HIV.com. Available at: http://www.interaccioneshiv.com. Accessed January 25, 2010.
    • (2010)
  • 39
    • 0002322365 scopus 로고    scopus 로고
    • Xpose - An S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM
    • DOI 10.1016/S0169-2607(98)00067-4, PII S0169260798000674
    • Jonsson EN, Karlsson MO. Xpose-an S-PLUS based population pharmacokinetic/pharmacodynamic model building aid for NONMEM. Comput Methods Programs Biomed. 1999;58:51-64. (Pubitemid 29049052)
    • (1999) Computer Methods and Programs in Biomedicine , vol.58 , Issue.1 , pp. 51-64
    • Jonsson, E.N.1    Karlsson, M.O.2
  • 40
    • 0019604592 scopus 로고
    • Some suggestions for measuring predictive performance
    • Sheiner LB, Beal SL. Some suggestions for measuring predictive performance. J Pharmacokinet Biopharm. 1981;9:503-512.
    • (1981) J Pharmacokinet Biopharm , vol.9 , pp. 503-512
    • Sheiner, L.B.1    Beal, S.L.2
  • 41
    • 0025338893 scopus 로고
    • Evaluation of population (NONMEM) pharmacokinetic parameter estimates
    • Vozeh S, Maitre PO, Stanski DR. Evaluation of population (NONMEM) pharmacokinetic parameter estimates. J Pharmacokinet Biopharm. 1990; 18:161-163.
    • (1990) J Pharmacokinet Biopharm , vol.18 , pp. 161-163
    • Vozeh, S.1    Maitre, P.O.2    Stanski, D.R.3
  • 42
    • 33750581706 scopus 로고    scopus 로고
    • Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide
    • Brendel K, Comets E, Laffont CM, et al. Metrics for external model evaluation with an application to the population pharmacokinetics of gliclazide. Pharm Res. 2006;23:2036-2049.
    • (2006) Pharm Res , vol.23 , pp. 2036-2049
    • Brendel, K.1    Comets, E.2    Laffont, C.M.3
  • 43
    • 80053572977 scopus 로고    scopus 로고
    • Normalized prediction distribution error for the evaluation of nonlinear mixed-models
    • June 13-15 Copenhagen, Denmark. Abstract 1085
    • Brendel K, Comets E, Laffont CM, et al. Normalized prediction distribution error for the evaluation of nonlinear mixed-models. In: 16 Population Approach Group Europe Meeting; June 13-15, 2007; Copenhagen, Denmark. Abstract 1085.
    • (2007) 16 Population Approach Group Europe Meeting
    • Brendel, K.1    Comets, E.2    Laffont, C.M.3
  • 46
    • 57749095660 scopus 로고    scopus 로고
    • Population pharmacokinetics of atazanavir in human immunodeficiency virus-infected patients
    • Solas C, Gagnieu MC, Ravaux I, et al. Population pharmacokinetics of atazanavir in human immunodeficiency virus-infected patients. Ther Drug Monit. 2008;30:670-673.
    • (2008) Ther Drug Monit , vol.30 , pp. 670-673
    • Solas, C.1    Gagnieu, M.C.2    Ravaux, I.3
  • 47
    • 65749113553 scopus 로고    scopus 로고
    • Population pharmacokinetics of ritonavir-boosted atazanavir in HIV-infected patients and healthy volunteers
    • Dickinson L, Boffito M, Back D, et al. Population pharmacokinetics of ritonavir-boosted atazanavir in HIV-infected patients and healthy volunteers. J Antimicrob Chemother. 2009;63:1233-1243.
    • (2009) J Antimicrob Chemother , vol.63 , pp. 1233-1243
    • Dickinson, L.1    Boffito, M.2    Back, D.3
  • 48
    • 70349985052 scopus 로고    scopus 로고
    • Influence of darunavir coadministration on nevirapine pharmacokinetics in HIV-infected patients: A population approach
    • Dailly E, Raffi F, Perré P, et al. Influence of darunavir coadministration on nevirapine pharmacokinetics in HIV-infected patients: a population approach. HIV Med. 2009;10:586-589.
    • (2009) HIV Med , vol.10 , pp. 586-589
    • Dailly, E.1    Raffi, F.2    Perré, P.3
  • 51
    • 67649960169 scopus 로고    scopus 로고
    • Influence of the cytochrome P450 2B6 genotype on population pharmacokinetics of efavirenz in human immunodeficiency virus patients
    • Cabrera SE, Santos D, Valverde MP, et al. Influence of the cytochrome P450 2B6 genotype on population pharmacokinetics of efavirenz in human immunodeficiency virus patients. Antimicrob Agents Chemother. 2009;53:2791-2798.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 2791-2798
    • Cabrera, S.E.1    Santos, D.2    Valverde, M.P.3
  • 52
    • 67349205036 scopus 로고    scopus 로고
    • Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals
    • Arab-Alameddine M, Iulio J, Buclin T, et al. Pharmacogenetics-based population pharmacokinetic analysis of efavirenz in HIV-1-infected individuals. Clin Pharmacol Ther. 2009;85:485-494.
    • (2009) Clin Pharmacol Ther , vol.85 , pp. 485-494
    • Arab-Alameddine, M.1    Iulio, J.2    Buclin, T.3
  • 53
    • 63849240305 scopus 로고    scopus 로고
    • In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function
    • Iulio J, Fayet A, Arab-Alameddine M, et al. In vivo analysis of efavirenz metabolism in individuals with impaired CYP2A6 function. Pharmacogenet Genomics. 2009;19:300-309.
    • (2009) Pharmacogenet Genomics , vol.19 , pp. 300-309
    • Iulio, J.1    Fayet, A.2    Arab-Alameddine, M.3
  • 54
    • 80053567935 scopus 로고    scopus 로고
    • Pharmacokinetics of lopinavir in the LPV/R-meltrex formulation compared to the LPV/R-soft gelatine capsule in HIV infected patients
    • Leyh M, Zipperich S,Winzer R, et al. Pharmacokinetics of lopinavir in the LPV/R-meltrex formulation compared to the LPV/R-soft gelatine capsule in HIV infected patients. Clin Med Ther. 2009;1:697-702.
    • (2009) Clin Med Ther , vol.1 , pp. 697-702
    • Leyh, M.1    Zipperich, S.2    Winzer, R.3
  • 57
    • 56749158797 scopus 로고    scopus 로고
    • Pharmacokinetics of atazanavir/ritonavir once daily and lopinavir/ritonavir twice and once daily over 72 h following drug cessation
    • Boffito M, Else L, Back D, et al. Pharmacokinetics of atazanavir/ritonavir once daily and lopinavir/ritonavir twice and once daily over 72 h following drug cessation. Antivir Ther. 2008;13:901-907.
    • (2008) Antivir Ther , vol.13 , pp. 901-907
    • Boffito, M.1    Else, L.2    Back, D.3
  • 59
    • 34447619487 scopus 로고    scopus 로고
    • Lopinavir/ritonavir pharmacokinetic profile: Impact of sex and other covariates following a change from twice-daily to once-daily therapy
    • DOI 10.1177/0091270007302564
    • Ofotokun I, Chuck SK, Binongo JN, et al. Lopinavir/ritonavir pharmacokinetic profile: impact of sex and other covariates following a change from twice-daily to once-daily therapy. J Clin Pharmacol. 2007; 47:970-977. (Pubitemid 47094097)
    • (2007) Journal of Clinical Pharmacology , vol.47 , Issue.8 , pp. 970-977
    • Ofotokun, I.1    Chuck, S.K.2    Binongo, J.N.3    Palau, M.4    Lennox, J.L.5    Acosta, E.P.6
  • 60
    • 50949107933 scopus 로고    scopus 로고
    • Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitors
    • Robbins B, Capparelli E, Chadwick E, et al. Pharmacokinetics of high-dose lopinavir-ritonavir with and without saquinavir or nonnucleoside reverse transcriptase inhibitors in human immunodeficiency virus-infected pediatric and adolescent patients previously treated with protease inhibitors. Antimicrob Agents Chemother. 2008;52:3276-3283.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3276-3283
    • Robbins, B.1    Capparelli, E.2    Chadwick, E.3
  • 63
    • 0030895312 scopus 로고    scopus 로고
    • Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations
    • Barry M, Gibbons S, Back D, et al. Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997;32:194-209. (Pubitemid 27122520)
    • (1997) Clinical Pharmacokinetics , vol.32 , Issue.3 , pp. 194-209
    • Barry, M.1    Gibbons, S.2    Back, D.3    Mulcahy, F.4
  • 64
    • 21744452887 scopus 로고    scopus 로고
    • Pharmacokinetic evidence for the induction of lopinavir metabolism by efavirenz
    • DOI 10.1111/j.1365-2125.2005.02369.x
    • Dailly E, Clotilde A, Raffi F, et al. Pharmacokinetic evidence for the induction of lopinavir metabolism by efavirenz. Br J Clin Phamracol. 2005;60:32-34. (Pubitemid 40942778)
    • (2005) British Journal of Clinical Pharmacology , vol.60 , Issue.1 , pp. 32-34
    • Dailly, E.1    Allavena, C.2    Raffi, F.3    Jolliet, P.4
  • 65
    • 77950345853 scopus 로고    scopus 로고
    • Factors influencing lopinavir and atazanavir plasma concentration
    • StöhrW, Back D, Dunn D, et al. Factors influencing lopinavir and atazanavir plasma concentration. J Antimicrob Chemother. 2010;65:129-137.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 129-137
    • Stöhr, W.1    Back, D.2    Dunn, D.3
  • 67
    • 49849104125 scopus 로고    scopus 로고
    • Prevalence of possible drug-drug interactions between antiretroviral agents in different age groups in a section of the private health care sector setting in South Africa
    • Katende-Kyenda NL, Lubbe MS, Serfontein HP, et al. Prevalence of possible drug-drug interactions between antiretroviral agents in different age groups in a section of the private health care sector setting in South Africa. J Clin Pharm Ther. 2008;33:393-400.
    • (2008) J Clin Pharm Ther , vol.33 , pp. 393-400
    • Katende-Kyenda, N.L.1    Lubbe, M.S.2    Serfontein, H.P.3
  • 68
    • 44449100609 scopus 로고    scopus 로고
    • Decrease of atazanavir and lopinavir plasma concentrations in a boosted double human immunodeficiency virus protease inhibitor salvage regimen
    • DOI 10.1128/AAC.01565-07
    • Von Hentig N, Kaykhin P, Stephan C, et al. Decrease of atazanavir and lopinavir plasma concentrations in a boosted double human immunodeficiency virus protease inhibitor salvage regimen. Antimicrob Agents Chemother. 2008;52:2273-2275. (Pubitemid 351758578)
    • (2008) Antimicrobial Agents and Chemotherapy , vol.52 , Issue.6 , pp. 2273-2275
    • Von Hentig, N.1    Kaykhin, P.2    Stephan, C.3    Babacan, E.4    Sturmer, M.5    Staszewski, S.6    Lotsch, J.7
  • 69
    • 0007887949 scopus 로고    scopus 로고
    • A multiple-dose randomized crossover drug interaction study between tenofovir DF and efavirenz indinavir or lopinavir/ritonavir
    • July 8-11 Buenos Aires, Argentina. Abstract 336
    • Flaherty J, Kearney B,Wolf J, et al. A multiple-dose, randomized, crossover, drug interaction study between tenofovir DF and efavirenz, indinavir, or lopinavir/ritonavir. In: 1st IAS Conference on HIV Pathogenesis & Treatment; July 8-11, 2001. Buenos Aires, Argentina. Abstract 336.
    • (2001) 1st IAS Conference on HIV Pathogenesis & Treatment
    • Flaherty, J.1    Kearney, B.2    Wolf, J.3
  • 70
    • 0011527430 scopus 로고    scopus 로고
    • Lack of clinically relevant drug-drug interactions between tenofovir DF and efavirenz indinavir lamivudine and lopinavir/ritonavir in healthy subjects
    • October 28-31 Athens, Greece. Abstract P171
    • Kearney BP, Flaherty J,Wolf J, et al. Lack of clinically relevant drug-drug interactions between tenofovir DF and efavirenz, indinavir, lamivudine, and lopinavir/ritonavir in healthy subjects. In: 8th European Conference on Clinical Aspects and Treatment of HIV Infection; October 28-31,2001. Athens, Greece. Abstract P171.
    • (2001) 8th European Conference on Clinical Aspects and Treatment of HIV Infection
    • Kearney, B.P.1    Flaherty, J.2    Wolf, J.3
  • 71
    • 26444476893 scopus 로고    scopus 로고
    • Comparison of lopinavir/r plasma levels with and without tenofovir as part of HAART in HIV-1 infected patients
    • April 1-3 Rome, Italy. Abstract 4.14
    • Scarsi K, Postelnick M, Murphy R. Comparison of lopinavir/r plasma levels with and without tenofovir as part of HAART in HIV-1 infected patients. In: 5th International Workshop on Clinical Pharmacology of HIV Therapy; April 1-3, 2004; Rome, Italy. Abstract 4.14.
    • (2004) 5th International Workshop on Clinical Pharmacology of HIV Therapy
    • Scarsi, K.1    Postelnick, M.2    Murphy, R.3
  • 72
    • 21844442316 scopus 로고    scopus 로고
    • Pharmacokinetic drug interaction of lopinavir/ritonavir in combination with tenofovir in experienced HIV+ patients
    • October 30-November 2 Washington, DC. Abstract A-445
    • Breilh D, Rouzes A, Djabarouti S, et al. Pharmacokinetic drug interaction of lopinavir/ritonavir in combination with tenofovir in experienced HIV+ patients. In: 44th Interscience Conference on Antimicrobial Agents and Chemotherapy; October 30-November 2, 2004; Washington, DC. Abstract A-445.
    • (2004) 44th Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Breilh, D.1    Rouzes, A.2    Djabarouti, S.3
  • 74
    • 0031751330 scopus 로고    scopus 로고
    • Ritonavir: Clinical pharmacokinetics and interactions with other anti-HIV agents
    • DOI 10.2165/00003088-199835040-00002
    • Hsu A, Granneman GR, Bertz RJ. Ritonavir. Clinical pharmacokinetics and interactions with other anti-HIV agents. Clin Pharmacokinet. 1998; 35:275-291. (Pubitemid 28491214)
    • (1998) Clinical Pharmacokinetics , vol.35 , Issue.4 , pp. 275-291
    • Hsu, A.1    Granneman, G.R.2    Bertz, R.J.3
  • 76
    • 37849040586 scopus 로고    scopus 로고
    • Influence of atazanavir 200 mg on the intracellular and plasma pharmacokinetics of saquinavir and ritonavir 1600/100 mg administered once daily in HIV-infected patients
    • Ford J, Boffito M, Maitland D, et al. Influence of atazanavir 200 mg on the intracellular and plasma pharmacokinetics of saquinavir and ritonavir 1600/100 mg administered once daily in HIV-infected patients. J Antimicrob Chemother. 2006;58:1009-1016.
    • (2006) J Antimicrob Chemother , vol.58 , pp. 1009-1016
    • Ford, J.1    Boffito, M.2    Maitland, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.