Development of an Itraconazole-loaded nanostructured lipid carrier (NLC) formulation for pulmonary application

International Journal of Pharmaceutics

Volumn 419, Issue 1-2, 2011, Pages 329-338

  Pardeike, J ^a   Weber, S ^a   Haber, T ^b   Wagner, J ^b   Zarfl, H P ^c   Plank, H ^b   Zimmer, A ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b GRAZ UNIVERSITY OF TECHNOLOGY   (Austria)

^c Private Veterinary Surgery   (Austria)

Author keywords

Aerosol; Lipid nanoparticles; Nanostructured lipid carriers; Pulmonary application; Sterilization

Indexed keywords

ALMOND OIL; ARACHIS OIL; CARRIER PROTEINS AND BINDING PROTEINS; CORN OIL; GLYCEROL BEHENATE; GLYCEROL PALMITOSTEARATE; HYDROGENATED CASTOR OIL; ITRACONAZOLE; NANOSTRUCTURED LIPID CARRIER; OLEIC ACID; OLIVE OIL; SESAME SEED OIL; SOYBEAN OIL; STEARIC ACID; UNCLASSIFIED DRUG; WITEPSOL E 85;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LASER DIFFRACTION; NEBULIZATION; OSMOLARITY; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; ZETA POTENTIAL;

ADMINISTRATION, INHALATION; ANTIFUNGAL AGENTS; DIGLYCERIDES; DRUG CARRIERS; DRUG STABILITY; DRUG STORAGE; EXCIPIENTS; ITRACONAZOLE; LIPIDS; LUNG; NANOPARTICLES; NEBULIZERS AND VAPORIZERS; OLEIC ACID; PARTICLE SIZE; SOLUBILITY; STERILIZATION; TRANSITION TEMPERATURE;

EID: 80053561014     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.07.040     Document Type: Article

References (50)

1. 6 ed. European Pharmacopeia 2007
2. S. Benita, D. Friedman, and M. Weinstock Pharmacological evaluation of an injectable prolonged release emulsion of physostigmine in rabbits J. Pharm. Pharmacol. 38 1986 653 658 (Pubitemid 16038913)
3. H. Bunjes, and T. Unruh Characterization of lipid nanoparticles by differential scanning calorimetry, X-ray and neutron scattering Adv. Drug Deliv. Rev. 59 2007 379 402 (Pubitemid 47259221)
4. R. Cavalli, O. Caputo, E.C. Carlotti, M. Trotta, C. Scarnecchia, and M.R. Gasco Sterilization and freeze-drying of drug-free and drug-loaded solid lipid nanoparticles Int. J. Pharm. 148 1997 47 54 (Pubitemid 27152216)
5. P. Chattopadhyay, B.Y. Shekunov, D. Yim, D. Cipolla, B. Boyd, and S. Farr Production of solid lipid nanoparticle suspensions using supercritical fluid extraction of emulsions (SFEE) for pulmonary delivery using the AERx system Adv. Drug Deliv. Rev. 59 2007 444 453 (Pubitemid 47259225)
6. K. DeBeule Itraconazole pharmacology, clinical experience and future development Int. J. Antimicrob. Agents 6 1995 175 181
7. C. Freitas, and R.H. Müller Effect of light and temperature on zeta potential and physical stability in solid lipid nanoparticle (SLN) dispersion Int. J. Pharm. 168 1998 221 229 (Pubitemid 28349963)
8. F. Han, S. Li, R. Yin, H. Liu, and L. Xu Effect of surfactants on the formulation and characterization of a new type of colloidal drug delivery system: nanostructured lipid carriers Colloid Surface A 315 2008 210 216 (Pubitemid 350298857)
9. F.Q. Hu, S.P. Jiang, Y.Z. Du, H. Yuan, Y.Q. Ye, and S. Zeng Preparation and characteristics of monostearin nanostructured lipid carriers Int. J. Pharm. 314 2006 83 89
10. L.D. Hu, Y. Jia, and W. Ding Preparation and characterization of solid lipid nanoparticles loaded with epirubicin for pulmonary delivery Die Pharm. 65 2010 585 587
11. C. Jacobs, and R.H. Müller Production and characterization of a budesonide nanosuspension for pulmonary administration Pharm. Res. 19 2002 189 194 (Pubitemid 34165405)
12. P.A. Jaques, and C.S. Kim Measurement of total lung deposition of inhaled ultrafine particles in healthy men and women Inhal. Toxiccol. 12 2000 715 731
13. V. Jenning, and S.H. Gohla Encapsulation of retinoids in solid lipid nanoparticles (SLN) J. Microencapsul. 18 2001 149 158 (Pubitemid 32177833)
14. V. Jenning, K. Mäder, and S.H. Gohla Solid lipid nanoparticles (SLN) based on binary mixtures of liquid and solid lipids: a H-NMR study Int. J. Pharm. 205 2000 15 21
15. K. Jores, W. Mehnert, M. Drechsler, H. Bunjes, C. Johann, and K. Mäder Investigations on the structure of solid lipid nanoparticles (SLN) an oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy J. Control Release 95 2004 217 227 (Pubitemid 38230037)
16. J.Y. Jung, S.D. Yoo, S.H. Lee, K.H. Kim, D.S. Yoon, and K.H. Lee Enhanced solubility and dissolution rate of itraconazole by a solid dispersion technique Int. J. Pharm. 187 1999 209 218 (Pubitemid 29443901)
17. J.K. Kim, J.S. Park, and C.K. Kim Development of a binary lipid nanoparticles formulation of itraconazole for parenteral administration and controlled release Int. J. Pharm. 383 2010 209 215
18. J. Kuntsche, and H. Bunjes Influence of preparation conditions and heat treatment on the properties of supercooled smectic cholesteryl myristate nanoparticles Eur. J. Pharm. Biopharm. 67 2007 612 620 (Pubitemid 47576621)
19. J.M. Lauweryns, and J.H. Baert Alveolar clearance and the role of the pulmonary lymphatics Am. Rev. Respir. Dis. 115 1977 625 683 (Pubitemid 8074576)
20. Lucks, J.S., Müller, R.H., 1991. Medication vehicles made of solid lipid particles (solid lipid Nanospheres SLN), EP0000605497.
21. J.E. Mangino, and P.G. Pappas Itraconazole for the treatment of histoplasmosis and blastomycosis Int. J. Antimicrob. Agents 5 1995 219 225
22. K.A. Marr, R.A. Carter, F. Crippa, A. Wald, and L. Corey Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients Clin. Infect Dis. 34 2002 909 917 (Pubitemid 34229758)
23. W. Mehnert, and K. Mäder Solid lipid nanoparticles production, characterization and applications Adv. Drug Deliv. Rev. 47 2001 165 196 (Pubitemid 32324113)
24. K. Mitiri, R. Shegoka, S. Gohla, C. Anselimi, and R.H. Müller Lipid nanocarriers for dermal delivery of lutein: preparation, characterization, stability and performance Int. J. Pharm. 414 2011 267 275
25. R.H. Müller Zetapotential und Partikelladung in der Laborpraxis 1996 Wissenschaftliche Verlagsgesellschaft Stuttgart
26. R.H. Müller, A. Dingler, T. Schneppe, and S. Gohla Large Scale Production of Solid Lipid Nanoparticles (SLNTM) and Nanosuspensions (DissoCubesTM) 2000 Wise D
27. R.H. Müller, K. Mäder, and S. Gohla Solid lipid nanoparticles (SLN) for controlled drug delivery: a review of the state of art Eur. J. Pharm. Biopharm. 50 2000 161 177 (Pubitemid 30326695)
28. Müller, R.H., Mäder, K., Lippacher, A., Jenning, V., 1999. Fest-flüssig (halbfeste) Lipidpartikel (Nano-Compartiment-Carrier-NCC) und Verfahren zur Herstellung hochkonzentrierter Lipidpartikel. DE19945203A1.
29. R.H. Müller, and C. Olbrich Solid lipid nanoparticles: phagocytic uptake, in vitro cytotoxicity and in vitro biodegradation Die Pharm. 61 1999 462 467 (Pubitemid 29268766)
30. R.H. Müller, M. Radtke, and S.A. Wissing Nanostructured lipid matrices for improved microencapsulation of drugs Int. J. Pharm. 242 2002 121 128
31. R.H. Müller, M. Radtke, and S.A. Wissing Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations Adv. Drug Deliv. Rev. 54 2002 131 155
32. C. Olbrich, and R.H. Müller Enzymatic degradation of SLN-effect of surfactant and surfactant mixtures Int. J. Pharm. 180 1999 31 39 (Pubitemid 29131440)
33. R. Pandey, and G.K. Khuller Solid lipid particle-based inhalable sustained drug delivery system against experimental tuberculosis Tuberculosis 85 2005 227 235
34. J. Pardeike, A. Hommoss, and R.H. Muller Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products Int. J. Pharm. 366 2009 170 184
35. R.R. Patlolla, M. Chougule, A.R. Patel, T. Jackson, P.N. Tata, and M. Singh Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers J. Control Release 144 2010 233 241
36. J. Peeters, P. Neeskens, J.P. Tollenaere, P. Van Remoortere, and M.E. Brewster Characterization of the interaction of 2-hydroxypropyl-beta- cyclodextrin with itraconazole at pH 2, 4, and 7 J. Pharm. Sci. 91 2002 1414 1422
37. O.M. Peeters, N.M. Blaton, and C.J. De Ranter cis-2-sec-Butyl-4-{4-[4-(4- {[2-(2,4-dichlorophenyl)-2-(!H-1,2,4-triazol-1-ylmethyl)-1,3,-dioxolan-4-yl] methoxy}phenyl)-1-piperazinyl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3one (Itraconazole) Acta Crystallogr. C 52 1996 2225 2229
38. G. Pilcer, and K. Amighi Formulation strategy and use of excipients in pulmonary drug delivery Int. J. Pharm. 392 2010 1 19
39. C. Rudolph, U. Schillinger, A. Ortiz, K. RTabatt, C. Plank, R.H. Müller, and J. Rosenecker Application of novel solid lipid nanoparticles (SLN)-gene vector formulations based on dimeric HIV-1 TAT-Peptide in vitro and in vivo Pharm. Res. 21 2004 1662 1669 (Pubitemid 41184398)
40. A. Saupe, S.A. Wissing, A. Lenk, R.H. Müller, and C. Schmidt Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) - structural investigations on two different carrier systems Bio-Med. Mater. Eng. 15 2005 393 402 (Pubitemid 41330513)
41. N. Scholer, C. Olbrich, K. Tabatt, R.H. Muller, H. Hahn, and O. Liesenfeld Surfactant, but not the size of solid lipid nanoparticles (SLN) influences viability and cytokine production of macrophages Int. J. Pharm. 221 2001 57 67 (Pubitemid 32524035)
42. C. Schwarz, W. Mehnert, J.S. Lucks, and R.H. Müller Solid lipid nanoparticles (SLN) for controlled drug delivery I - production, characterization and sterilization J. Control Release 30 1994 83 94
43. E. Souto, S.A. Wissing, C.M. Barbosa, and R.H. Müller Development of a controlled release formulation based on SLN and NLC for topical clotrimazole delivery Int. J. Pharm. 278 2004 71 77 (Pubitemid 38670438)
44. K.M.G. Taylor, G. Taylor, I.W. Kellaway, and J. Stevens The stability of liposomes to nebulization Int. J. Pharm. 58 1990 57 61
45. V. Teeranachaideekul, R.H. Müller, and V.B. Junyaprasert Encapsulation of ascorbyl palmitate in nanostructured lipid carriers (NLC) - effects of formulation parameters on physicochemical stability Int. J. Pharm. 340 2007 198 206 (Pubitemid 47049784)
46. M. Üner, S.A. Wissing, G. Yener, and R.H. Müller Influence of surfactants on the physical stability of solid lipid nanoparticle (SLN) formulations Pharmazie 59 2004 331 332 (Pubitemid 38480731)
47. M.A. Videira, M.F. Botelho, A.C. Santos, L.F. Gouveia, J.J. de Lima, and A.J. Almeida Lymphatic uptake of pulmonary delivered radiolabelled solid lipid nanoparticles J. Drug Target 10 2002 607 613 (Pubitemid 36124361)
48. H. Weyhers, S. Ehlers, H. Hahn, E.B. Souto, and R.H. Muller Solid lipid nanoparticles (SLN) - effects of lipid composition on in vitro degradation and in vivo toxicity Pharmazie 61 2006 539 544 (Pubitemid 43989132)
49. X. Zhang, J. Liu, H. Qiao, H. Liu, J. Ni, W. Zhang, and Y. Shi Formulation optimization of dihydroartemisinin nanostructured lipid carrier using response surface methodology Powder Technol. 197 2010 120 128
50. A. zur Mühlen, C. Schwarz, and W. Mehnert Solid lipid nanoparticles (SLN) for controlled drug delivery: drug release and release mechanism Eur. J. Pharm. Biopharm. 45 1998 149 155 (Pubitemid 28167741)