Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs

Chemico-Biological Interactions

Volumn 194, Issue 1, 2011, Pages 58-68

  Miller, Claudia P ^a,b,d   Manton, Christa A ^a,b   Hale, Randal ^a,b   Debose, LaKeisha ^a,b   Macherla, Venkat R ^c   Potts, Barbara C ^c   Palladino, Michael A ^c   Chandra, Joya ^a,b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c Nereus Pharmaceuticals Inc   (United States)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Apoptosis; Caspase 8; Leukemia; Oxidative stress; Proteasome inhibitors

Indexed keywords

CASPASE 8; NPI 0047; NPI 2053; NPI 2056; NPI 2070; NPI 2077; NPI 2078; NPI 2104; NPI 2151; PROTEASOME; SALINOSPORAMIDE A; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; LEUKEMIA CELL LINE; PROTEIN FUNCTION;

APOPTOSIS; CASPASE 8; HUMANS; LACTONES; LEUKEMIA; OXIDATIVE STRESS; PROTEASE INHIBITORS; PYRROLES; REACTIVE OXYGEN SPECIES; TUMOR CELLS, CULTURED;

EID: 80053560048     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.08.005     Document Type: Article

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