Synthesis and evaluation of indole aspartyl ketones as novel caspase-3 inhibitors

Asian Journal of Chemistry

Volumn 23, Issue 12, 2011, Pages 5517-5520

  Sengupta, S ^a   Rao, G Venkateshwar ^a   Dubey, P K ^b  

^a Aurigene Discovery Technologies Limited   (India)

^b JNTUH COLLEGE OF ENGINEERING   (India)

Author keywords

Caspase inhibitors; Cysteine proteases; IDN 6556; Indole N acetic acid

Indexed keywords

EID: 80053547886     PISSN: 09707077     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. (a) E.S. Alnemri, D.J. Livingston, D.W. Nicholson, G. Salvesen, N.A. Thornberry, W.W. Wong and J.Y. Yuan, Cell, 87, 171 (1996)
2. (b) N.A. Thornberry, Chem. Biol., 5, R97 (1998)
3. (c)R.A. Black, S.R. Kronheim and P.R. Sleath, FEBS Lett., 247, 386 (1989).
4. (a) R.E. Ellis, J. Yuan and H.R. Horvitz, Ann. Rev. Cell Biol., 7, 663 (1991)
5. (b) J.C. Reed and K.J. Tomaselli, Curr. Opin. Biotechnol., 11, 586 (2000).
6. S. Kumar, Cell Death Differ., 14, 32 (2007).
7. J.C. Reed, Nat. Rev. Drug Discov., 1, 111 (2002).
8. I. Rodriguez, K. Matsuura, C. Ody, S. Nagata and P. Vassalli, J. Exp. Med., 184, 2067 (1996).
9. S.D. Linton, Curr. Top. Med. Chem., 5, 1697 (2005).
10. (a) R.E. Dolle, D. Hoyer, C.V. Prasad, S.J. Schmidt, C. Helaszek, R.E. Miller and M.A. Ator, J. Med. Chem., 37, 563 (1994)
11. (b) S.D. Linton, D.S. Karanewsky, R.J. Ternansky, J.C. Wu, B. Pham, L. Kodandapani, R. Smidt, J.L. Diaz, L.C. Fritz and K.J. Tomaselli, Bioorg. Med. Chem. Lett., 12, 2969 (2002)
12. (c) Y. Han, A. Giroux, E.L. Grimm, R. Aspiotis, S. Francoeur, C.I. Bayly, D.J. Mckay, S. Roy, S. Xanthoudakis, J.P. Vaillancourt, D.M. Rasper, J. Tam, P. Tawa, N.A. Thornberry, E.P. Paterson, M. Garcia-Calvo, J.W. Becker, J. Rotonda, D.W. Nicholson and R.J. Zamboni, Bioorg. Med. Chem. Lett., 14, 805 (2004).
13. D.S. Karanewsky, X. Bai, S.D. Linton, J.F. Krebs, J. Wu, B. Pham and K.J. Tomaselli, Bioorg. Med. Chem. Lett., 8, 2757 (1998).
14. D. Lee, S.A. Long, J.H. Murray, J.L. Adams, M.E. Nuttall, D.P. Nadeau, K. Kikly, J.D. Winkler, C.M. Sung, M.D. Ryan, M.A. Levy, P.M. Keller and W.E. DeWolf Jr., J. Med. Chem., 43, 2015 (2001).
15. N.C. Hoglen, L.S. Chen, C.D. Fisher, B.P. Hirakawa, T. Groessl and P.C. Contreras, J. Pharmacol. Exp. Ther., 309, 634 (2004).
16. K.L. Valentino, M. Gutierrez, R. Sanchez, M.J. Winship and D.A. Shapiro, Int. J. Clin. Pharmacol. Ther., 41, 441 (2003).
17. P. Sylvain, D. Yann, L. Valéry, G. Carmela, L. Carole, S. Coralie, D. Alexis, D. Frédéric, M. Thierry and A. Isabelle, Chem. Med. Chem., 4, 261 (2009).
18. C. Scott, C. Sobotka-Briner, D. Wilkins, R. Jacobs, J. Folmer, W. Frazee, R. Bhat, S. Ghanekar and D. Aharony, J. Pharmacol. Exp. Ther., 304, 433 (2003).
19. N. Oswaldo, R. Jose and A. Larry, J. Phys. Org. Chem., 7, 80 (1994).
20. W. Yang, J.C. Guastella, Y. Wang, L. Zhang, D. Xue, M. Tran, R. Woodward, S. Kasibhatla, B. Tseng, J. Drewe and S.X. Cai, J. Pharmacol., 140, 402 (2003).
21. Y. Wang, J.-C. Huang, Z.-L. Zhou, W. Yang, J. Guastella, J. Drewe and S.X. Cai, Bioorg. Med. Chem. Lett., 14, 1269 (2004).
22. H. Jaeschke, A. Farhood, S.X. Cai, B.Y. Tseng and M.L. Bajt, Toxicol. Appl. Pharm., 169, 77 (2000).
23. S.X. Cai, L. Guan, S. Jia, Y. Wang, W. Yang, B. Tseng and J. Drewe, Bioorg. Med. Chem. Lett., 14, 5295 (2004).
24. Y. Wang, L. Guan, S. Jia, B. Tseng, J. Drewe and S.X. Cai, Bioorg. Med. Chem. Lett., 15, 1379 (2005).
25. N.A. Thornberry, E.P. Peterson, J.J. Zhao, A.D. Howard, P.R. Griffin and K.T. Chapman, Biochemistry, 33, 3934 (1994).