Synergistic apoptosis-inducing antileukemic effects of arsenic trioxide and mucuna macrocarpa stem extract in human leukemic cells via a reactive oxygen species-dependent mechanism

Evidence-based Complementary and Alternative Medicine

Volumn 2012, Issue , 2012, Pages

  Chang, Yuan Shiun ^a   Lu, Kuan Hung ^a   Lee, Hui Ju ^b   Huang, Min Li ^c   Lai, Shang Chih ^d   Ho, Yu Ling ^e   Chi, Chin Wen ^f,g  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^c NATIONAL TAIPEI UNIVERSITY OF NURSING AND HEALTH SCIENCES   (Taiwan)

^d ASIA UNIVERSITY   (Taiwan)

^e HUNGKUANG UNIVERSITY   (Taiwan)

^f TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^g NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTILEUKEMIC AGENT; ARSENIC TRIOXIDE; BUTYLCRESOL; CASPASE 3; CASPASE 9; GLUTATHIONE; LIPOCORTIN 5; METHANOL; MUCUNA MACROCARPA EXTRACT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PLANT EXTRACT; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTILEUKEMIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENTIATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LEGUME; LEUKEMIA; LEUKEMIA CELL; LEUKEMIA CELL LINE; MEDICINAL PLANT; PLANT STEM; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN CLEAVAGE; WESTERN BLOTTING;

EID: 80053526158     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2012/921430     Document Type: Article

References (38)

1. Zhu J., Chen Z., Lallemand-Breitenbach V., De Thé H., How acute promyclocytic leukaemia revived arsenic Nature Reviews Cancer 2002 2 9 705 713 (Pubitemid 37328921)
2. Wang Z. Y., Chen Z., Acute promyelocytic leukemia: from highly fatal to highly curable Blood 2008 111 5 2505 2515
3. Tallman M. S., What is the role of arsenic in newly diagnosed APL? Best Practice and Research 2008 21 4 659 666
4. Tallman M. S., Altman J. K., Curative strategies in acute promyelocytic leukemia Hematology 2008 391 399
5. Miller W. H. Jr., Schipper H. M., Lee J. S., Singer J., Waxman S., Mechanisms of action of arsenic trioxide Cancer Research 2002 62 14 3893 3903 (Pubitemid 34792653)
6. Carney D., Arsenic trioxide mechanisms of actionlooking beyond acute promyelocytic leukemia Leukemia and Lymphoma 2008 49 10 1846 1851
7. Verstovsek S., Giles F., Quints-Cardama A., Perez N., Ravandi-Kashani F., Beran M., Freireich E., Kantarjian H., Arsenic derivatives in hematologic malignancies: a role beyond acute promyelocytic leukemia? Hematological Oncology 2006 24 4 181 188 (Pubitemid 46032891)
8. Fox E., Razzouk B. I., Widemann B. C., Xiao S., O'Brien M., Goodspeed W., Reaman G. H., Blaney S. M., Murgo A. J., Balis F. M., Adamson P. C., Phase 1 trial and pharmacokinetic study of arsenic trioxide in children and adolescents with refractory or relapsed acute leukemia, including acute promyelocytic leukemia or lymphoma Blood 2008 111 2 566 573
9. Litzow M. R., Lee S., Bennett J. M., Dewald G. W., Gallagher R. E., Jain V., Paietta E. M., Racevskis J., Rousey S. R., Mazza J. J., Tallman M. S., A phase II trial of arsenic trioxide for relapsed and refractory acute lymphoblastic leukemia Haematologica 2006 91 8 1105 1108 (Pubitemid 44204778)
10. Editorial Board of Zhong Hua Ben Cao, State Administration of Traditional Chinese Medicine, Zhong Hua Ben Cao (China Herbal) 1999 4 Shanghai, China Shanghai Scientific Technology Press
11. Lu K. H., Chang Y. F., Yin P. H., Chen T. T., Ho Y. L., Chang Y. S., Chi C. W., In vitro and in vivo apoptosis-inducing antileukemic effects of Mucuna macrocarpa stem extract on HL-60 human leukemia cells Integrative Cancer Therapies 2010 9 3 298 308
12. Pelicano H., Feng L., Zhou Y., Carew J. S., Hileman E. O., Plunkett W., Keating M. J., Huang P., Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism Journal of Biological Chemistry 2003 278 39 37832 37839 (Pubitemid 37175311)
13. Doudican N. A., Bowling B., Orlow S. J., Enhancement of arsenic trioxide cytotoxicity by dietary isothiocyanates in human leukemic cells via a reactive oxygen species-dependent mechanism Leukemia Research 2010 34 2 229 234
14. Ramos A. M., Aller P., Quercetin decreases intracellular GSH content and potentiates the apoptotic action of the antileukemic drug arsenic trioxide in human leukemia cell lines Biochemical Pharmacology 2008 75 10 1912 1923
15. Snchez Y., Amrn D., Fernndez C., De Blas E., Aller P., Genistein selectively potentiates arsenic trioxide-induced apoptosis in human leukemia cells via reactive oxygen species generation and activation of reactive oxygen species-inducible protein kinases (p38-MAPK, AMPK) International Journal of Cancer 2008 123 5 1205 1214
16. Lee H.-J., Su Y., Yin P.-H., Lee H.-C., Chi C.-W., PPAR /PGC-1 pathway in E-cadherin expression and motility of HepG2 cells Anticancer Research 2009 29 12 5057 5063. Erratum: vol. 30, no. 3, pp. 1033, 2010
17. Chou T. C., Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies Pharmacological Reviews 2006 58 3 621 681
18. Chou T. C., Drug combination studies and their synergy quantification using the Chou-Talalay method Cancer Research 2010 70 2 440 446
19. Fernndez C., Ramos A. M., Sancho P., Amrn D., De Blas E., Aller P., 12- O -tetradecanoylphorbol-13-acetate may both potentiate and decrease the generation of apoptosis by the antileukemic agent arsenic trioxide in human promonocytic cells: regulation by extracellular signal-regulated protein kinases and glutathione Journal of Biological Chemistry 2004 279 5 3877 3884 (Pubitemid 38140633)
20. Ralph S. J., Arsenic-based antineoplastic drugs and their mechanisms of action Metal-Based Drugs 2008 2008
21. Lai T.-Y., Yao C.-J., Yang C.-M., Chuang S.-E., Yan J.-L., Liu C.-Y., Chen S.-W., Yan K.-H., Lai G.-M., Targeting PML-RAR and oncogenic signaling pathways by Chinese herbal mixture Tien-Hsien liquid in acute promyelocytic leukemia NB4 cells Evidence-Based Complementary and Alternative Medicine 2011 2011 11
22. Pelicano H., Carew J. S., McQueen T. J., Andreeff M., Plunkett W., Keating M. J., Huang P., Targeting Hsp90 by 17-AAG in leukemia cells: mechanisms for synergistic and antagonistic drug combinations with arsenic trioxide and Ara-C Leukemia 2006 20 4 610 619
23. Peng C. Y., Jiang J., Zheng H. T., Liu X. S., Growth-inhibiting effects of arsenic trioxide plus epigenetic therapeutic agents on leukemia cell lines Leukemia and Lymphoma 2010 51 2 297 303
24. D'Autréaux B., Toledano M. B., ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis Nature Reviews Molecular Cell Biology 2007 8 10 813 824 (Pubitemid 47462134)
25. Chang Y. F., Hsu Y. C., Hung H. F., Lee H. J., Lui W. Y., Chi C. W., Wang J. J., Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells Nutrition and Cancer 2009 61 5 735 745
26. Wang J., Li L., Cang H., Shi G., Yi J., NADPH oxidase-derived reactive oxygen species are responsible for the high susceptibility to arsenic cytotoxicity in acute promyelocytic leukemia cells Leukemia Research 2008 32 3 429 436 (Pubitemid 351295909)
27. Pelicano H., Feng L., Zhou Y., Carew J. S., Hileman E. O., Plunkett W., Keating M. J., Huang P., Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism Journal of Biological Chemistry 2003 278 39 37832 37839 (Pubitemid 37175311)
28. Lu J., Chew E. H., Holmgren A., Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide Proceedings of the National Academy of Sciences of the United States of America 2007 104 30 12288 12293 (Pubitemid 47206130)
29. Jing Y., Dai J., Chalmers-Redman R. M. E., Tatton W. G., Waxman S., Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway Blood 1999 94 6 2102 2111 (Pubitemid 29430427)
30. Snchez Y., Simn G. P., Calvio E., De Blas E., Aller P., Curcumin stimulates reactive oxygen species production and potentiates apoptosis induction by the antitumor drugs arsenic trioxide and lonidamine in human myeloid leukemia cell lines Journal of Pharmacology and Experimental Therapeutics 2010 335 1 114 123
31. Wu Y. T., Wu S. B., Lee W. Y., Wei Y. H., Mitochondrial respiratory dysfunction-elicited oxidative stress and posttranslational protein modification in mitochondrial diseases Annals of the New York Academy of Sciences 2010 1201 147 156
32. Pervaiz S., Clément M. V., A permissive apoptotic environment: function of a decrease in intracellular superoxide anion and cytosolic acidification Biochemical and Biophysical Research Communications 2002 290 4 1145 1150 (Pubitemid 34694425)
33. Trachootham D., Lu W., Ogasawara M. A., Valle N. R. D., Huang P., Redox regulation of cell survival Antioxidants and Redox Signaling 2008 10 8 1343 1374
34. Huang P., Feng L., Oldham E. A., Keating M. J., Plunkett W., Superoxide dismutase as a target for the selective killing of cancer cells Nature 2000 407 6802 390 395
35. Franco R., Cidlowski J. A., Apoptosis and glutathione: beyond an antioxidant Cell Death and Differentiation 2009 16 10 1303 1314
36. Matsuda H., Yoshida K., Miyagawa K., Asao Y., Takayama S., Nakashima S., Xu F., Yoshikawa M., Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa Bioorganic and Medicinal Chemistry 2007 15 3 1539 1546 (Pubitemid 46038119)
37. Konoshima T., Kokumai M., Kozuka M., Tokuda H., Nishino H., Iwashima A., Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys Journal of Natural Products 1992 55 12 1776 1778 (Pubitemid 23023267)
38. Raynal N. J. M., Momparler L., Charbonneau M., Momparler R. L., Antileukemic activity of genistein, a major isoflavone present in soy products Journal of Natural Products 2008 71 1 3 7 (Pubitemid 351236385)